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Use of Evidence-Based Research Approach in RCTs of Acupuncture-Related Therapies for Primary Dysmenorrhea: A Meta-Research

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Chinese Journal of Integrative Medicine 2024年第6期30卷 551-558页

作者： HU Xiao-yi TIAN Zi-yu chen huan HU Xiang-yu MING Tian-yu PENG hao-xuan JIAO Rui-min SHI Lan-jun XIU Wen-cui yang Ji-wei gang Wei-juan JING Xiang-hong Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijingChina Department of Traditional Chinese Medicine Beijing Puren HospitalBeijing100062China

Objective To assess the use of evidence-based research(EBR)approach in randomized controlled trials(RCTs)of acupuncture-related therapies for primary dysmenorrhea(PD).Methods PubMed,EMBASE,Cochrane Library,China National Knowledge Infrastructure,Wanfang Database,Chinese Biomedical Database,and China Science and Technology Journal Database were searched from January 2013 to December 2022 for RCTs of acupuncture on *** full text and references of each RCT were read to assess whether systematic reviews(SRs)or other types of studies with similar research questions and end-users’perspectives were cited to justify and design the *** addition,the discussion section were analyzed to evaluate whether trials placed the new result in the existing SRs to draw a *** logistic regression was used to find variables that associated with 3 aspects of EBR approach:(1)citing clinical studies for justification,(2)citing relevant studies that obtain the perspectives of end users,and(3)citing clinical studies for results *** Of 473 RCTs included,45.67%(216)of the trials cited relevant similar studies,21.56%(102)referenced to the studies that collected end-users’perspectives,and 10.99%(52)placed result in the context of the previous *** RCTs appropriately applied EBR *** all the included studies,3.17%(15)of the trials used SRs to inform study questions but none of them used updated SRs with acceptable quality;1.05%(5)of the trials cited SRs of end-user’s perspectives in the justification and design of the study,and only 1 trial added results in existing SR to draw a *** of publication,language,funding,registration,ethical approval and number of sites were significantly associated with 1 of the 3 aspects of EBR *** Few RCTs in acupuncture-related therapies for PD used the EBR approach to minimize research ***,research institutes,funding agencies,ethics committees,journals and peer

关键词： evidence-based research acupuncture therapy primary dysmenorrhea randomized controlled trial systematic review end-usersperspective meta-research

Simulation and test of the SLEGS TOF spectrometer at SSRF

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Nuclear Science and Techniques 2023年第3期34卷 171-184页

作者： Kai-Jie chen Long-Xiang Liu Zi-Rui hao yu-gang Ma Hong-Wei Wang Gong-Tao Fan Xi-Guang Cao Hang-Hua Xu Yi-Fei Niu Xin-Xiang Li Xin-Rong Hu yu-Xuan yang Sheng Jin pan Kuang School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China University of Chinese Academy of Science Beijing 100080China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China School of Nuclear Science and Technology University of South ChinaHengyang 421001China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450052China

The Shanghai laser electron gamma source(SLEGS)is a powerful tool for exploring photonuclear physics,such as giant dipole resonance(GDR)and pygmy dipole resonance,which are the main mechanisms of collective nuclear *** goal of the SLEGS neutron time-of-flight(TOF)spectrometer is to measure GDR and specific nuclear structures in the energy region above the neutron *** SLEGS TOF spectrometer was designed to hold 20 sets of EJ301 and LaBr3 ***4 was used to simulate the efficiency of each detector and the entire spectrometer,which provides a reference for the selection of detectors and layout of the SLEGS TOF *** the events of 208Pb,implementations of coincidence and time-of-flight technology for complex experiments are available;thus,and neutron decay events can be *** performance of SLEGS TOF spectrometer was systematically evaluated using offline experiments,in which the time resolution reached approximately 0.9 ns.

关键词： SLEGS Time-of-flight Photoneutron nuclear reaction

Steroidal constituents from Helleborus thibetanus and their cytotoxicities

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Chinese Journal of Natural Medicines 2019年第10期17卷 778-784页

作者： LI yu-Ze ZHANG Hua-Wei FAN hao LIANG Xiao-Fei SONG Bei chen huan huanG Wen-Li yuE Zheng-gang SONG Xiao-Mei LIU Jian-Li Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationCollege of Life SciencesNorthwest UniversityXi'an 710069China Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization School of PharmacyShaanxi University of Chinese MedicineXianyang 712046China

Thibetanosides E-H(1-4),four new steroidal constituents including three rare sulfonates(2-4),were isolated from the roots and rhizomes of Helleborus thibetanus,together with nine known steroidal compounds(5-13).Their structures were elucidated by detailed spectroscopic analysis,including 1D and 2D NMR techniques and chemical *** this study,compounds 2-13 were evaluated for their cytotoxic activities against HCT116,A549 and HepG2 tumor cell lines in *** them,compound 8(thibetanoside C)showed cytotoxicities against A549 cells(IC50 39.6±1.9μmol·L^-1)and HepG2 cells(IC50 41.5±1.1μmol·L^-1),*** 9(23S,24S)-24-[(O-β-D-fucopyranosyl)oxy]-3β,23-dihydroxy-spirosta-5,25(27)-diene-1β-yl O-(4-O-acetyl-α-L-rhamnopyranosyl)-(1→2)-O-[β-D-xylopyranosyl-(1→3)]-α-L-arabinopyranoside)showed cytotoxicity against HCT116 cells(IC5033.6±2.1μmol·L^-1).

关键词： Helleborus thibetanus Steroidal constituents Structure identification Cytotoxic activity

Ultra-compact lithium niobate microcavity electro-optic modulator beyond 110 GHz

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Chip 2022年第4期1卷 29-36页

作者： Bing-cheng pan Hong-Xuan Liu hao-chen Xu Yi-Shu huang huan Li Ze-Jie yu Liu Liu Yao-cheng Shi Dao-Xin Dai State Key Laboratory for Modern Optical Instrumentation Centre for Optical and Electromagnetic ResearchCollege of Optical Science and EngineeringInterna-tional Research Center for Advanced PhotonicsZhejiang UniversityZijingang CampusHangzhou 310058China Ningbo Research Institute Zhejiang Uni-versityNingbo 315100China Jiaxing Key Laboratory of Photonic Sensing&Intelligent Imaging Jiaxing 314000China Intelligent Optics&Photonics Re-search Center Jiaxing Research Institute Zhejiang UniversityJiaxing 314000China

A lithium-niobate-on-insulator(LNOI)electro-optic(EO)modulator based on a 2×2 FP-cavity was designed and realized with an ultra-compact footprint and an ultra-high bandwidth.A comprehensive analysis on the present LNOI FP-cavity modulator was conducted to reveal the dependence of modulation bandwidth and modulation effi-ciency on the cavity Q-factor and the operation wavelength detuning to the *** particular,the 2×2 FP cavity was designed to achieve an optimal Q factor by reducing the reflectivity of reflectors and the cavity length,thus reducing the photon lifetime in the *** ultra-short effective cavity length of only∼50μm was achieved for the designed LNOI FP-cavity modulator,with itsfootprint being as compact as∼4×500μm *** was demonstrated theoretically that the modulation bandwidth could be improved significantly to be over 200 GHz by utilizing the peaking enhancement *** fabricated device exhibited an excess loss of∼1 dB and an extinction ratio of∼20 dB in experiments,while the measured 3-dB bandwidth was higher than 110 GHz(beyond the maximal range of the facilities in experiments).Up till now,to our best knowledge,this has been the first LNOI microcavity modulator with a bandwidth higher than 110 ***,high-quality eye-diagrams of 100 Gbps on-off keying(OOK)and 140 Gbps 4-pulse amplitude modulation(PAM4)signals were demonstrated experimentally,and the energy consumption for the OOK signals was as low as 4.5 fJ/bit.

关键词： Lithium niobate Microcavity Electro-optic Modulator

Commissioning of laser electron gamma beamline SLEGS at SSRF

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Nuclear Science and Techniques 2022年第7期33卷 103-114页

作者： Hong-Wei Wang Gong-Tao Fan Long-Xiang Liu Hang-Hua Xu Wen-Qing Shen yu-gang Ma Hiroaki Utsunomiya Long-Long Song Xi-Guang Cao Zi-Rui hao Kai-Jie chen Sheng Jin yu-Xuan yang Xin-Rong Hu Xin-Xiang Li pan Kuang Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai201800China University of Chinese Academy of Science Beijing100049China Fudan University Shanghai200433China Department of Physics Konan UniversityKobe658-8501Japan ShanghaiTech University Shanghai201210China Zhengzhou University Zhengzhou450001China

The Shanghai Laser Electron Gamma Source(SLEGS)is a powerful gamma source that provides MeV gamma-ray beams for nuclear science and *** was developed as one of the 16 beamline stations in the Phase Ⅱ Project of the Shanghai Synchrotron Radiation *** slant-scattering mode is for the first time systematically employed in laser Compton scattering at SLEGS to produce energy-tunable quasi-monoenergetic gamma-ray *** SLEGS officially completed its commissioning from July to December *** rays in the energy range of 0.25-21.7 MeV with a flux of 2.1×10^(4)-1.2×10^(7) photons/s and an energy spread of 2-15% were produced during the *** paper reports the results from commissioning the SLEGS beamline.

关键词： SLEGS Laser Compton scattering Slant-scattering mode Backscattering mode

3D printed collagen/silk fibroin scaffolds carrying the secretome of human umbilical mesenchymal stemcells ameliorated neurological dysfunction after spinal cord injury in rats

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Regenerative Biomaterials 2022年第1期9卷 52-66页

作者： Chong chen Hai-huan Xu Xiao-Yin Liu yu-Sheng Zhang Lin Zhong You-Wei Wang Lin Xu pan Wei Ya-Xing chen Peng Liu chen-Ru hao Xiao-Li Jia Nan Hu Xiao-yang Wu Xiao-Song Gu Li-Qun chen Xiao-Hong Li Academy of Medical Engineering and Translational Medicine Tianjin University92 Weijin RoadNankai DistrictTianjin 300072China Tianjin Key Laboratory of Neurotrauma Repair Pingjin Hospital Brain CenterCharacteristic Medical Center of People’s Armed Police Forces220 Chenglin RoadDongli DistrictTianjin 300162China Department of Neurosurgery West China Medical SchoolWest China HospitalSichuan UniversityGuoxue Lane 37Wuhou DistrictChengduSichuan 610041China National Engineering Research Center for Biomaterials College of Biomedical EngineeringSichuan University29 Wangjiang RoadWuhou DistrictChengduSichuan 610064China Department of Hematology The First Affiliated Hospital of Chengdu Medical College278 Baoguang Avenue middle sectionXindu DistrictChengduSichuan 610500China Medical Psychology Section Hubei General Hospital of Armed Police Force475 Minzhu RoadWuchang DistrictWuhanHubei 430071China Department of Neurosurgery The First People’s Hospital of Long Quan yi DistrictYuyang Road Yihe 3 GroupLongquanyi District201 Cheng DuSi Chuan 610000China

Although implantation of biomaterials carrying mesenchymal stem cells(MSCs)is considered as a promising strategy for ameliorating neural function after spinal cord injury(SCI),there are still some challenges including poor cell survival rate,tumorigenicity and ethics *** performance of the secretome derived from MSCs was more stable,and its clinical transformation was more *** antibody array demonstrated that the secretome of MSCs contained 79 proteins among the 174 proteins ***-dimensional(3D)printed collagen/silk fibroin scaffolds carrying MSCs secretome improved hindlimb locomotor function according to the Basso–Beattie–Bresnahan scores,the inclined-grid climbing test and electrophysiological *** with locomotor function recovery,3D printed collagen/silk fibroin scaffolds carrying MSCs secretome could further facilitate nerve fiber regeneration,enhance remyelination and accelerate the establishment of synaptic connections at the injury site compared to 3D printed collagen/silk fibroin scaffolds alone group according to magnetic resonance imaging,diffusion tensor imaging,hematoxylin and eosin staining,Bielschowsky’s silver staining,immunofluorescence staining and transmission electron *** results indicated the implantation of 3D printed collagen/silk fibroin scaffolds carrying MSCs secretome might be a potential treatment for SCI.

关键词： spinal cord injury secretome mesenchymal stem cells 3D printing collagen silk fibroin

亚稳平衡吸附态与亚稳平衡系数关系的热力学研究

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高等学校化学学报 2005年第3期26卷 476-479页

作者：马子川潘纲魏雨陈灏中国科学院生态环境研究中心北京100085 河北师范大学化学学院石家庄050016

在相同温度、压力、p H值和离子强度等条件下 ,同一种金属离子在无机矿物表面上发生的吸附反应可以形成能量不同的吸附状态 (如 Zn可以边 -边和角 -角两种方式吸附在水锰矿表面上 ) ,因而反应终了时吸附质可处于不同的亚稳平衡吸附态 (M... 详细信息

在相同温度、压力、p H值和离子强度等条件下 ,同一种金属离子在无机矿物表面上发生的吸附反应可以形成能量不同的吸附状态 (如 Zn可以边 -边和角 -角两种方式吸附在水锰矿表面上 ) ,因而反应终了时吸附质可处于不同的亚稳平衡吸附态 (MEA) .应用 MEA理论 ,针对吸附反应 A+H2 O =x A1 +y A2 +H2 O,推导出实际吸附反应“平衡常数”(Kreal)与亚稳平衡系数 (Km e)的热力学关系式 ,从理论上分析了吸附反应 MEA状态的变化对实际吸附反应平衡性质的影响 .分析结果表明 ,Kme值与两种 MEA状态之间的能量差呈指数关系 ,通过影响吸附反应的 MEA状态 (包括能量和组成 )的反应动力学因素可影响吸附平衡常数和吸附等温式 (线 )等吸附热力学性质 .

关键词：不可逆吸附 MEA理论热力学吸附平衡性质亚稳平衡态吸附

Data analysis guidelines for single‑cell RNA‑seq in biomedical studies and clinical applications

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Military Medical Research 2023年第4期10卷 529-553页

作者： Min Su Tao pan Qiu‑Zhen chen Wei‑Wei Zhou Yi Gong gang Xu huan‑yu Yan Si Li Qiao‑Zhen Shi Ya Zhang Xiao He Chun‑Jie Jiang Shi‑Cai Fan Xia Li Murray J.Cairns Xi Wang Yong‑Sheng Li State Key Laboratory of Reproductive Medicine Nanjing Medical UniversityNanjing 211166China College of Biomedical Information and Engineering the First Affiliated Hospital of Hainan Medical UniversityHainan Medical UniversityHaikou 571199HainanChina College of Bioinformatics Science and Technology Harbin Medical UniversityHarbin 150081HeilongjiangChina Department of Immunology Nanjing Medical UniversityNanjing 211166China Department of Laboratory Medicine Women and Children’s Hospital of Chongqing Medical UniversityChongqing 401174China Baylor College of Medicine HoustonTX 77030USA Shenzhen Institute for Advanced Study University of Electronic Science and Technology of ChinaShenzhen 518110GuangdongChina School of Biomedical Sciences and Pharmacy Faculty of Health and Medicinethe University of NewcastleUniversity DriveCallaghanNSW 2308Australia Precision Medicine Research Program Hunter Medical Research InstituteNew Lambton HeightsNSW 2305Australia

The application of single-cell RNA sequencing(scRNA-seq)in biomedical research has advanced our understanding of the pathogenesis of disease and provided valuable insights into new diagnostic and therapeutic *** the expansion of capacity for high-throughput scRNA-seq,including clinical samples,the analysis of these huge volumes of data has become a daunting prospect for researchers entering this ***,we review the workflow for typical scRNA-seq data analysis,covering raw data processing and quality control,basic data analysis applicable for almost all scRNA-seq data sets,and advanced data analysis that should be tailored to specific scientific *** summarizing the current methods for each analysis step,we also provide an online repository of software and wrapped-up scripts to support the *** and caveats are pointed out for some specific analysis tasks and *** hope this resource will be helpful to researchers engaging with scRNA-seq,in particular for emerging clinical applications.

关键词： Single-cell RNA-sequencing(scRNA-seq) Data analysis Biomedical research Clinical applications

Trim21 depletion alleviates bone loss in osteoporosis via activation of YAP1/β-catenin signaling

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Bone Research 2023年第4期11卷 819-833页

作者： Ri-Xu Liu Rong-He Gu Zhi-Peng Li Zhi-Quan hao Qin-Xiao Hu Zhen-Yan Li Xiao-gang Wang Wang Tang Xiao-He Wang yu-Kai Zeng Zhen-Wei Li Qiu Dong Xiao-Feng Zhu Di chen Ke-Wei Zhao Rong-Hua Zhang Zhen-gang Zha huan-Tian Zhang Department of Bone and Joint Surgery the First Affiliated Hospital of Jinan UniversityKey Laboratory of Regenerative Medicine of Ministry of EducationJinan UniversityGuangzhou 510630 GuangdongChina Department of Orthopedic and Spine Surgery The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120 GuangdongChina School of Basic Medical Sciences of Guangxi Medical University the Fifth Affiliated Hospital of Guangxi Medical UniversityNanning 530022 GuangxiChina Key Laboratory of Big Data-Based Precision Medicine School of Engineering MedicineBeihang University100191 BeijingChina Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization College of PharmacyJinan UniversityGuangzhou 510630 GuangdongChina Research Center for Computer-aided Drug Discovery Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences518005 ShenzhenChina Guangzhou Key Laboratory of Chinese Medicine Research on Prevention and Treatment of Osteoporosis the Third Affiliated Hospital of Guangzhou University of Chinese Medicine510375 GuangzhouChina

Despite the diverse roles of tripartite motif(Trim)-containing proteins in the regulation of autophagy,the innate immune response,and cell differentiation,their roles in skeletal diseases are largely *** recently demonstrated that Trim21 plays a crucial role in regulating osteoblast(OB)differentiation in ***,how Trim21 contributes to skeletal degenerative disorders,including osteoporosis,remains ***,human and mouse bone specimens were evaluated,and the results showed that Trim21 expression was significantly elevated in bone tissues obtained from osteoporosis ***,we found that global knockout of the Trim21 gene(KO,Trim2^(1-/-))resulted in higher bone mass compared to that of the control *** further demonstrated that loss of Trim21 promoted bone formation by enhancing the osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)and elevating the activity of OBs;moreover,Trim21 depletion suppressed osteoclast(OC)formation of RAW264.7 *** addition,the differentiation of OCs from bone marrow-derived macrophages(BMMs)isolated from Trim21^(-/-)and Ctsk-cre;Trim21^(f/f)mice was largely compromised compared to that of the littermate control ***,YAP1/β-catenin signaling was identified and demonstrated to be required for the Trim21-mediated osteogenic differentiation of *** importantly,the loss of Trim21 prevented ovariectomy(OVX)-and lipopolysaccharide(LPS)-induced bone loss in vivo by orchestrating the coupling of OBs and OCs through YAP1 *** current study demonstrated that Trim21 is crucial for regulating OB-mediated bone formation and OC-mediated bone resorption,thereby providing a basis for exploring Trim21 as a novel dual-targeting approach for treating osteoporosis and pathological bone loss.

关键词： YAP1 osteoporosis depletion