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雁鹅菌菌丝培养条件优化研究

食品安全导刊 2024年第2期 140-143页

作者：刘会敬阳焱红朱斐淇曾静莫寒杨期辉衡阳师范学院南岳学院生命科学系湖南衡阳421000 衡阳师范学院生命科学学院湖南衡阳421000 南岳山区生物资源保护与利用湖南省重点实验室湖南衡阳421000

为优化雁鹅菌菌丝的培养条件,以菌丝生长速度为评价指标,通过单因素试验分别确定雁鹅菌菌丝生长培养基的最佳碳源、氮源以及无机盐,并通过比较不同的营养元素浓度对雁鹅菌菌丝生长速度的影响,确定各营养元素的最佳添加区间,后续采用正... 详细信息

为优化雁鹅菌菌丝的培养条件,以菌丝生长速度为评价指标,通过单因素试验分别确定雁鹅菌菌丝生长培养基的最佳碳源、氮源以及无机盐,并通过比较不同的营养元素浓度对雁鹅菌菌丝生长速度的影响,确定各营养元素的最佳添加区间,后续采用正交试验法优化雁鹅菌菌丝生长培养基中各营养元素的组合。结果表明,最佳碳源为可溶性淀粉,最佳氮源为胰蛋白胨,最佳无机盐为氯化钙。雁鹅菌菌丝生长培养基的最优组合为可溶性淀粉浓度5 g·L^(-1),胰蛋白胨浓度3 g·L^(-1),培养基中氯化钙浓度1.00 g·L^(-1)。

关键词：雁鹅菌菌丝生长培养条件正交试验

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Microtubes with gradient decellularized porcine sciatic nerve matrix from microfluidics for sciatic nerve regeneration

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Bioactive Materials 2023年第3期21卷 511-519页

作者： Binghui Jin Yunru Yu Xiangxiang Chen yanhong yang Yushan Xiong Young Jun Im Yuanjin Zhao Jian Xiao Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhouZhejiang Province325035China Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing210096China College of Pharmacy Chonnam National UniversityGwangju61186Republic of Korea Wenzhou Institute University of Chinese Academy of SciencesWenzhouZhejiang325001China

Long-range peripheral nerve defect is a severe and worldwide *** the increasing development of tissue engineering,the excellent ability of nerve extracellular matrix(ECM)in peripheral nerve injury(PNI)has been widely studied and ***,we present a novel microtube that contains gradient decellularized porcine sciatic nerve ECM hydrogel(pDScNM-gel)from microfluidics for sciatic nerve *** pDScNM is confirmed to enhance cell proliferation and migration,and improve the axon growth of primary dorsal root ganglions(DRGs)in a concentration-related *** behaviors were also achieved when cells were co-cultured in a gradient pDScNM *** in vivo sciatic nerve regeneration and functional recovery were also demonstrated by assembling the gradient pDScNM microtubes with a medical silicon *** results indicated that the microtubes with gradient pDScNM could act as a promising alternative for repairing peripheral nerve defects and showed great potential in clinical use.

关键词： Microfiber Peripheral nerve injury Extracellular matrix Microfluidics Nerve regeneration

Oligomeric donor with appropriate crystallinity for organic solar cells

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Chinese Chemical Letters 2024年第2期35卷 289-294页

作者： Kaiming yang Min Lv yanhong Chang Kun Lu Zhixiang Wei CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Department of Environmental Science and Engineering University of Science and Technology BeijingBeijing 100083China Beijing Key Laboratory of Resource Treatment of Typical Industrial Pollutants Beijing 100083China

Improving the performance of all-small-molecule organic solar cells(ASM-OSCs)largely depends on the design and application of novel donors with appropriate *** molecular conjugation is an effective method for regulating molecular stacking and *** this work,we successfully designed and synthesized two novel acceptor-donor-donor-donor-acceptor(A-D-D-D-A)type oligomeric donors with three dithieno[2,3-d:2′,3′-d′]benzo[1,2-b:4,5-b']dithiophene(DTBDT)as the central unit,named as 3DTBDT-Cl and 3DTBDT,depending on with and without chlorine substitution on the thiophene side *** found that the introduction of chlorine atoms makes the blend films display stronger crystallinity but with large-scale phase separation morphology and more defects,which eventually leads to a power conversion efficiency(PCE)of only 10.83%,whereas the blend films based 3DTBDT with appropriate crystallinity achieved 13.74%*** with 3DTBDT-Cl/L8-BO,the 3DTBDT/L8-BO films exhibited a nanoscale bi-continuous interpenetrating network morphology with a smaller domain size and more suitable crystallinity,which guarantees the corresponding devices obtained more efficient exciton dissociation,efficient charge transport,reduced bimolecular recombination,and performed more balanced carrier *** results demonstrated that regulating the crystallinity of oligomeric donors to obtain the desired phase separation morphology in the blend films could facilitate further improving the performance of ASM-OSCs.

关键词： Linked donor unit Oligomeric donors Crystallinity regulation Organic solar cells

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楸树远缘杂交种花器官性状变异分析

植物研究 2024年第2期44卷 220-231页

作者：曹文昱王军辉杨艳红麻文俊李放周林召熊星月胡晓亮马贯羊赵鲲洛阳市农林科学院洛阳471023 中国林业科学研究院林业研究所北京100091 河南省林业资源监测院郑州450045

为明确楸树(Catalpa bungei)远缘杂交种花器官性状的表型变异程度和变异规律,以12株楸树远缘杂交种为材料,采用方差分析、相关分析、聚类分析等统计分析方法,对楸树远缘杂交种的花期物候特征、花序性状、花朵性状和花色性状指标进行研... 详细信息

为明确楸树(Catalpa bungei)远缘杂交种花器官性状的表型变异程度和变异规律,以12株楸树远缘杂交种为材料,采用方差分析、相关分析、聚类分析等统计分析方法,对楸树远缘杂交种的花期物候特征、花序性状、花朵性状和花色性状指标进行研究。结果表明:楸树远缘杂交种的花期物候特征差异明显,楸梓杂交种为假三叉分枝,花芽分化能力强,嫁接当年持续多轮开花,花期长达100 d以上,表现出母本性状。楸梓杂交种的花器官特征差异显著,花序轴共7~9轮侧枝,主轴为无限花序,侧枝为二歧聚伞花序,从底层到顶层过度为聚伞花序,处于楸树有限花序到梓树无限花序的过渡性状。花总长度、花筒直径、花筒长度、花冠宽度、花梗长度、雌蕊长度、花药长度、雄蕊长度、不育雄蕊长度的变幅分别为35.42~50.36,10.84~16.13,16.57~24.68,31.58~44.87,9.07~31.99,19.44~27.52,4.85~5.89,13.93~21.10,3.66~6.79 mm,变异系数为10.88%~31.02%,多样性指数(H’)为1.36~1.93,并以9个性状指标将12株杂交种聚为大花型、中花型、小花型3类。楸树杂交种间花色差异显著,以L*、a*、b*值将12株杂交种的唇瓣花斑颜色聚为3类,分别是粉紫色型、紫红色型和紫色型。

关键词：楸树远缘杂交花器官遗传变异

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Decoding the Cellular Trafficking of Prion-like Proteins in Neurodegenerative Diseases

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Neuroscience Bulletin 2024年第2期40卷 241-254页

作者： Chenjun Hu Yiqun Yan yanhong Jin Jun yang Yongmei Xi Zhen Zhong Department of Neurology of the Second Afliated Hospital and Department of Human Anatomy Histology and EmbryologyZhejiang University School of MedicineHangzhou 310058China Department of Physiology and Department of Cardiology of the Second Afliated Hospital Zhejiang University School of MedicineHangzhou 310058China Division of Human Reproduction and Developmental Genetics Women’s Hospital and Institute of GeneticsZhejiang University School of MedicineHangzhou 310006China

The accumulation and spread of prion-like proteins is a key feature of neurodegenerative diseases(NDs)such as Alzheimer’s disease,Parkinson's disease,or Amyotrophic Lateral *** a process known as‘seeding’,prion-like proteins such as amyloid beta,microtubule-associated protein tau,α-synuclein,silence superoxide dismutase 1,or transactive response DNA-binding protein 43 kDa,propagate their misfolded conformations by transforming their respective soluble monomers into *** and molecular evidence of prion-like propagation in NDs,the clinical relevance of their‘seeding’capacities,and their levels of contribution towards disease progression have been intensively studied over recent *** review unpacks the cyclic prion-like propagation in cells including factors of aggregate internalization,endo-lysosomal leaking,aggregate degradation,and *** on the importance of the role of prion-like protein aggregates in NDs,whether causal or consequent,are also *** lead to a greater understanding of ND pathogenesis and increased potential for therapeutic strategies.

关键词： Neurodegenerative diseases Prion-like propagation Seeding Endocytosis Endolyosomal leaking Degradation

高场强MRIT1灌注成像联合DWI成像在评估乳腺癌新辅助化疗疗效中的价值

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昆明医科大学学报 2024年第7期45卷 148-153页

作者：张正杨艳红冯再辉詹路江普金仙段茜婷红河州第三人民医院放射影像科云南个旧661000

目的评估高场强磁共振T1灌注成像联合扩散加权成像(DWI)在乳腺癌新辅助化疗疗效评估中的潜在价值。方法回顾性收集126例乳腺癌患者的临床和影像学数据,包括化疗前后的T1灌注成像和DWI成像数据。使用多因素二元Logistic回归分析探讨不同... 详细信息

目的评估高场强磁共振T1灌注成像联合扩散加权成像(DWI)在乳腺癌新辅助化疗疗效评估中的潜在价值。方法回顾性收集126例乳腺癌患者的临床和影像学数据,包括化疗前后的T1灌注成像和DWI成像数据。使用多因素二元Logistic回归分析探讨不同影像学参数与新辅助化疗疗效之间的关系,并建立预测模型。结果T1灌注参数和DWI成像参数,包括时间-信号强度曲线(TIC)下面积、达峰时间、流入速率、最大增强、ADC值均为评估乳腺癌新辅助化疗疗效的相关性因素(P<0.05)。基于这些相关性参数建立的多因素Logistic回归模型用于预测化疗疗效的准确率为91.3%。结论磁共振T1灌注成像联合DWI成像在乳腺癌新辅助化疗疗效评估中具有潜在的临床应用前景。通过对磁共振T1灌注成像联合DWI成像参数的综合分析,可以更准确地预测乳腺癌患者新辅助化疗的疗效,为治疗决策提供有力支持。

关键词：磁共振灌注成像扩散加权成像乳腺癌新辅助化疗

THE STRUCTURE-PRESERVING METHODS FOR THE DEGASPERIS-PROCESI EQUATION

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Journal of Computational Mathematics 2019年第4期37卷 475-487页

作者： Yuze Zhang Yushun Wang yanhong yang Department of Applied Mathematics The Hongkong Polytechnic University China Jiangsu Key Laboratory of NSLSCS School of Mathematical Sciences Nanjing Normal University Nanjing 210023 China Department of Mathematics College of Taizhou Nanjing Normal University Taizhou 225300 China

This paper gives several structure-preserving schemes for the Degasperis-Procesi equation which has bi-Hamiltonian structures consisted of both complex and non-local Hamiltonian differential operators. For this sake, few structure-preserving schemes have been proposed so far. In our work, based on one of the bi-Hamiltonian structures, a symplectic scheme and two new energy-preserving schemes are constructed. The symplecticity comes straightly from the application of the implicit midpoint method on the semi-discrete system which is proved to remain Hamiltonian, while the energy conservation is derived by the combination of the averaged vector field method of second and fourth order, respectively. Some numerical results are presented to show that the three schemes do have the advantages in numerical stability, accuracy in long time computing and ability to preserve the invariants of the DP equation.

关键词： Degasperis-Procesi equation bi-Hamiltonian structure Structure-preserving scheme Fourier pseudospectral method

立德树人背景下党的二十大精神融入大学生劳动精神培育研究

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科技资讯 2024年第10期22卷 5-8页

作者：秦可殊殷程程王纪雯朱杏琳杨艳红冯霖昊山东工商学院公共管理学院山东烟台264000

党的二十大报告提出,全面贯彻党的教育方针,落实立德树人根本任务,培养“德智体美劳”全面发展的社会主义建设者和接班人。劳动教育是中国特色社会主义教育体系的重要组成部分,代表了社会主义建设者和接班人的劳动精神面貌。劳动价值取... 详细信息

党的二十大报告提出,全面贯彻党的教育方针,落实立德树人根本任务,培养“德智体美劳”全面发展的社会主义建设者和接班人。劳动教育是中国特色社会主义教育体系的重要组成部分,代表了社会主义建设者和接班人的劳动精神面貌。劳动价值取向和劳动技能水平是新时期大学生应具备的中华优秀传统文化和现代精神品质的重要组成部分。结合立德树人,响应党的二十大有关劳动精神号召的同时,提出了新时代大学生劳动精神培育的建议和措施,并对大学生劳动精神的培育渠道进行了研究和建设。培育新时代大学生的劳动精神,树立正确积极的劳动观念,坚定理想信念,弘扬劳动精神,帮助他们夯实走中国现代化新道路的精神基础,汇聚精神力量。

关键词：党的二十大精神立德树人劳动精神劳动教育

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Five-view three-dimensional reconstructionfor ultrafast dynamic imaging of pulsedradiation sources

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Matter and Radiation at Extremes 2024年第2期9卷 63-73页

作者： Jianpeng Gao Liang Sheng Xinyi Wang yanhong Zhang Liang Li Baojun Duan Mei Zhang yang Li Dongwei Hei Department of Engineering Physics Tsinghua UniversityBeijing 100084China National Key Laboratory of Intense Pulsed Radiation Simulation and Effect Northwest Institute of Nuclear TechnologyXi’an 710024China

Multiaxial neutron/x-ray imaging and three-dimensional (3D) reconstruction techniques play a crucial role in gaining valuable insights intothe generation and evolution mechanisms of pulsed radiation sources. Owing to the short emission time (∼200 ns) and drastic changes of thepulsed radiation source, it is necessary to acquire projection data within a few nanoseconds in order to achieve clear computed tomography3D imaging. As a consequence, projection data that can be used for computed tomography image reconstruction at a certain moment are oftenavailable for only a few angles. Traditional algorithms employed in the process of reconstructing 3D images with extremely incomplete datamay introduce significant distortions and artifacts into the final image. In this paper, we propose an iterative image reconstruction methodusing cylindrical harmonic decomposition and a self-supervised denoising network algorithm based on the deep image prior method. Weaugment the prior information with a 2D total variation prior and a 3D deep image prior. Single-wire Z-pinch imaging experiments have beencarried out at Qin-1 facility in five views and four frames, with a time resolution of 3 ns for each frame and a time interval of 40 ns betweenadjacent frames. Both numerical simulations and experiments verify that our proposed algorithm can achieve high-quality reconstructionresults and obtain the 3D intensity distribution and evolution of extreme ultraviolet and soft x-ray emission from plasma.

关键词： frames image sources