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DNA Damage,Apoptosis and C-myc,C-fos,and C-jun Overexpression Induced by Selenium in Rat Hepatocytes

Biomedical and Environmental Sciences 2006年第3期19卷 197-204页

作者： RI-AN YU CHENG-FENG yang xue-min CHEN Department of Occupational and Environmental Health MOE Key Laboratory of Environment and Health School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei China

Objective To study the effects of selenium on DNA damage, apoptosis and c-myc, c-fos, and c-jun expression in rat hepatocytes. Methods Sodium selenite at the doses of 5, 10, and 20 μmol/kg was given to rats by i.p. and there were 5 male SD rats in each group. Hepatocellular DNA damage was detected by single cell gel electrophoresis （or comet assay）. Hepatocellular apoptosis was determined by TUNEL （TdT-mediated dUTP nick end labelling） and flow cytometry. C-myc, c-fos, and c-jun expression in rat bepatocytes were assayed by Northern dot hybridization. C-myc, c-fos, and c-jun protein were detected by immunohistochemical method. Results At the doses of 5, 10, and 20μmol/kg, DNA damage was induced by sodium selenite in rat hepatocytes and the rates of comet cells were 34.40%, 74.80%, and 91.40% respectively. Results also showed an obvious dose-response relationship between the rates of comet cells and the doses of sodium selenite （r=0.9501, P〈0.01）. Sodium selenite at the doses of 5, 10, and 20μmol/kg caused c-myc, c-fos, and c-jun overexpression obviously. The positive brown-yellow signal for proteins of c-myc, c-fos, and c-jun was mainly located in the cytoplasm of bepatocytes with immunohistocbemical method. TUNEL-positive cells were detected in selenium-treated rat livers. Apoptotic rates （%） of selenium-treated liver cells at the doses of 5, 10, and 20 μmol/kg were （3.72±1.76）, （5.82±1.42）, and （11.76±1.87） respectively, being much higher than those in the control. Besides an obvious dose-response relationship between apoptotic rates and the doses of sodium selenite （r=0.9897, P〈0.01）, these results displayed a close relationship between DNA damage rates and apoptotic rates, and the relative coefficient was 0.9021, P〈0.01. Conclusion Selenium at 5-20μmol/kg can induce DNA damage, apoptosis, and overexpression of c-myc, c-fos, and c-jun in rat hepatocytes.

关键词： Selenium DNA damage Apoptosis C-myc C-fos C-jun

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Emissions of SO_2, NO and N_2O in a circulating fluidized bed combustor during co-firing coal and biomass

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Journal of Environmental Sciences 2007年第1期19卷 109-116页

作者： XIE Jian-jun yang xue-min ZHANG Lei DING Tong-li SONG Wen-li LIN Wei-gang Institute of Process Engineering Chinese Academy of Sciences Beijing 100080 China Graduate School of the Chinese Academy of Sciences Beijing 100039 China

This paper presents the experimental investigations of the emissions of SO2, NO and N20 in a bench scale circulating fluidized bed combustor for coal combustion and co-firing coal and biomass. The thermal capacity of the combustor is 30 kW. The setup is electrically heated during startup. The infuence of the excess air, the degree of the air staging, the biomass share and the feeding position of the fuels on the emissions of SO2, NO and N2O were studied. The results showed that an increase in the biomass shares resulted in an increase of the CO concentration in the flue gas, probably due to the high volatile content of the biomass. In co-firing, the emission of SO2 increased with increasing biomass share slightly, however, non-linear increase relationship between SO2 emission and fuel sulfur content was observed. Air staging significantly decreased the NO emission without raising the SO2 level. Although the change of the fuel feeding position from riser to downer resulted in a decrease in the NO emission level, no obvious change was observed for the SO2 level. Taking the coal feeding position R as a reference, the relative NO emission could significantly decrease during co-firing coal and biomass when feeding fuel at position D and keeping the first stage stoichiometry greater than 0.95. The possible mechanisms of the sulfur and nitrogen chemistry at these conditions were discussed and the ways of simultaneous reduction of SO2, NO and N2O were proposed.

关键词： circulating fluidized bed (CFB) combustion SO2 NO N2O co-firing biomass

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Effect of CaO and CaCO3 on Reduction Rate of Iron Ore Pellets Containing Carbon

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Journal of Iron and Steel Research International 2000年第2期7卷 1-5页

作者： yang xue-min XIE Yu-sheng WANG Da-guang HUANG Dian-bing KONG Ling-tan yang Tian-jun Institute of Chemical Metallurgy CAS University of Science and Technology Beijing

The effect of metallurgical fluxes CaO and CaCO3 on the reduction rate of iron ore pellets containing carbon in nitrogen atmosphere has been studied by a weight-loss thermal balance. The experimental results showed that adding CaO or CaCO3 can promote reduction reaction as the added CaO or CaCO3 probably decrease the apparent activation energy of iron ore concentrate-carbon-CaO or CaCO3 reaction, and the reduction rate constant changes with mass percent of CaO and CaCO3.　The kinetic analysis also showed that the rate-controlling step of the reaction is inner gas diffusion.

关键词： iron ore pellet containing carbon reduction rate CaO CaCO3

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调控一体化模式下电力系统多设备运行故障状态实时监测方法

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电气开关 2024年第3期62卷 35-38页

作者：郝丽萍杨强杜娟皮定贵申国华杨敏雪贵州电网有限责任公司六盘水供电局贵州六盘水553000 贵州电网有限责任公司安顺供电局贵州安顺561000 贵州电网有限责任公司培训与评价中心贵州贵阳550000 贵州电网有限责任公司铜仁供电局贵州铜仁554300

在调控一体化模式下,电力系统多设备运行故障状态的实时监测至关重要。因此提出调控一体化模式下电力系统多设备运行故障状态实时监测方法。首先采集和预处理调控一体化模式下电力系统多设备的运行数据,并将其进行归一化处理。然后采用... 详细信息

在调控一体化模式下,电力系统多设备运行故障状态的实时监测至关重要。因此提出调控一体化模式下电力系统多设备运行故障状态实时监测方法。首先采集和预处理调控一体化模式下电力系统多设备的运行数据,并将其进行归一化处理。然后采用灰色关联分析方法进行特征提取并将其作为模型的输入。最后通过构建的门控循环单元神经网络模型完成对调控一体化模式下电力系统多设备运行故障状态的实时监测。经过实验验证,该方法的故障识别速率快,准确度高,说明其故障状态实时监测效果具有实际应用价值。

关键词：调控一体化故障状态灰色关联分析门控循环单元

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Denaturation Kinetics of N-Acetyl-β-D-glucosaminidase from Scylla serrata in Urea Solution

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Chemical Research in Chinese Universities 2011年第6期27卷 996-999页

作者： LIN Jian-cheng LI Hua-liang CHEN Liang-hua yang xue-min WANG qin CHEN Qing-xi Key Laboratory of Coastal and Wetland Ecosystems Ministry of EducationSchool of Life SciencesXiamen UniversityXiamen 361005P.R.China Department of Blood Transfusion Xiamen Maternity and Child Health HospitalXiamen 361003P.R.China Department of Food and Biological Engineering Zhangzhou Institute of TechnicalZhangzhou 363000P.R.China

N-Acetyl-β-D-glucosaminidase（NAGase, EC 3.***.1.52）, which catalyzes the cleavage of N-acetylgluco- samine polymers, plays important roles in the molting, digestion of chitinous foods in green crab. In the study, the efforts of urea on the activity of NAGase purified from the viscera of green crab（Scylla serrata） have been studied. The results show that appropriate concentrations of urea can lead to reversible inactivation of the enzyme, and the value of the inhibitor concentration leading to 50% of enzyme activity lost（IC50） is estimated to be 0.63 mol/L. The inactivation kinetics has been studied via the kinetic method of the substrate reaction. The rate constants of inactivation have been determined. The value of k＋0 is larger than that of k′＋0, indicating the free enzyme molecule is more fragile than the enzyme-substrate complex in urea solution. It is suggested that the presence of the substrate offers the marked protection of this enzyme against inactivation by urea.

关键词： Green crab(Scylla serrata) N-Acetyl-β-D-glucosaminidase Urea Reversible inactivation kinetics

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Phase-Field Simulation of Sintering Process:A Review

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1165-1204页

作者： ming xue min Yi State Key Laboratory ofMechanics and Control forAerospace Structures&Institute for Frontier Science&Key Laboratory for Intelligent Nano Materials and Devices of ministry of Education&College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics(NUAA)Nanjing210016China

Sintering,a well-established technique in powder metallurgy,plays a critical role in the processing of high melting point materials.A comprehensive understanding of structural changes during the sintering process is essential for effective product *** phase-field method stands out for its unique ability to simulate these structural *** its widespread application,there is a notable absence of literature reviews focused on its usage in sintering ***,this paper addresses this gap by reviewing the latest advancements in phase-field sintering models,covering approaches based on energy,grand potential,and entropy *** characteristics of various models are extensively discussed,with a specific emphasis on energy-based models incorporating considerations such as interface energy anisotropy,tensor-form diffusion mechanisms,and various forms of rigid particle motion during ***,the paper offers a concise summary of phase-field sintering models that integrate with other physical fields,including stress/strain fields,viscous flow,temperature field,and external electric *** conclusion,the paper provides a succinct overview of the entire content and delineates potential avenues for future research.

关键词： Phase-field model review sintering additive manufacturing

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Successful treatment of Purpureocillium lilacinum pulmonary infection with isavuconazole: A case report

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World Journal of Clinical Cases 2024年第10期12卷 1772-1777页

作者： xue-Lin yang Jun-Yu Zhang Jian-min Ren Department of Emergency Medicine Lishui Central HospitalLishui 323000Zhejiang ProvinceChina Department of Hematology Lishui Central HospitalLishui 323000Zhejiang ProvinceChina Department of Clinical Laboratory The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina

BACKGROUND Purpureocillium lilacinum(***)is a saprophytic fungus widespread in soil and *** a causative agent,it is very rarely detected in humans,most commonly in the *** SUMMARY In this article,we reported the case of a 72-year-old patient with chronic lymphocytic leukemia who was admitted with cough and *** tomography revealed an infection in the right lower *** lavage fluid culture and metagenomic next-generation sequencing were ultimately confirmed to have a pulmonary infection with *** was eventually discharged with good outcomes after treatment with *** Pulmonary infection with *** was exceedingly *** currently there are no definitive therapeutic agents,there are reports of high resistance to amphotericin B and fluconazole and good sensitivity to second-generation *** present report is the first known use of isavuconazole for pulmonary *** *** provides new evidence for the characterization and treatment of clinical *** lung infections.

关键词： Purpureocillium lilacinum Pulmonary infection Isavuconazole Case report

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Design and fabrication of self-suspending aluminum-plastic/semiconductor photocatalyst devices for solar energy conversion

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Journal of Environmental Sciences 2024年第2期136卷 615-625页

作者： Zhi-Ang Zhao Jingyun Mao Chengjing Lu Shuangqiao yang Qingrong Qian Qinghua Chen Hun xue Xiaoli Sun min-Quan yang College of Environmental and Resource Sciences College of Carbon Neutral Modern IndustryFujian Key Laboratory of Pollution Control and Resource ReuseFujian Normal UniversityFuzhou 350007China State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan UniversityChengdu 610065China

The design and synthesis of self-suspending photocatalyst device with easy recyclability is important for practical ***,this work utilizes aluminum-plastic package waste as raw material to prepare an aluminum-plastic supported TiO_(2)(AP-TiO_(2))photocatalyst device through 3D printing design and surface deposition method.A series of characterizations were carried out to explore the structure,morphology and performance of the AP-TiO_(2)*** UV light illumination,the AP-TiO_(2)-50 efficiently degrade 93.6%tetracycline hydrochloride(THC)after 4 hr,which increases by 8.3%compared with that of TiO_(2)powder suspension system with the same catalyst *** on it,AP-ZnO,AP-CdS,AP-g-C_3N_4and AP-Pt-TiO_(2)are also fabricated,and applied in photocatalytic degradation and hydrogen evolution,which all exhibit higher photoactivities than powder suspension *** work provides a new avenue for the fabrication of advanced recyclable photocatalyst ***,the work offers a novel sight for the high-value utilization of aluminum-plastic package waste,which has positive implications for environmental protection.

关键词： TiO_(2) Self-suspending Photocatalyst device Aluminum plastic

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Two polyoxovanadoborates with over 100 nuclei assembled from a {V_(14)Co_(12)B_(72)} cluster

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Science China Chemistry 2024年第8期67卷 2578-2585页

作者： Shuang-xue Wu Yu-Jiao Dong yang yang Chao Qin Chun-Yi Sun Wei Guan Xin-Long Wang Zhong-min Su Key Laboratory of Polyoxometalate and Reticular Material Chemistry of ministry of Education Northeast Normal UniversityChangchun 130024China School of Chemistry and Environmental Engineering Changchun University of Science and TechnologyChangchun 130013China Key Laboratory of Advanced Materials of Tropical Island Resources Hainan UniversityHaikou 570228China

Combining theoretical prediction and experimental exploration, the first sandwich-type polyoxovanadoborate(POVB) with an odd number of nuclei, [V_(11)B_(26)O_(73)(OH)_(10)]^(8-)(1), was discovered under hydrothermal conditions. Density-functional theory(DFT)gives a rationalization for the existence of this structure and the structural feature is consistent with the {V_NB_(2N+X)}(X = 2, 4, 6, 8)general formula. Excitingly, when Co and 1,10-phenanthroline(phen) are introduced into the synthesis of vanadoborates system,a 100-nuclei [Co_6(phen)_(10)(H_(2)O)_8][V_(14)Co_(12)B_(72)O_(144)(OH)_(20)]·28H_(2)O(2) and a 102-nuclei [Co_6(phen)_(14)(H_(2)O)_(4)][V_(14)Co_(12)B_(72)O_(144)(OH)_(20)]·23H_(2)O(3) with the same core structure of [V_(14)Co_(12)B_(72)]^(12-)are obtained. The vase-shaped [V_(14)Co_(12)B_(72)] polyanion is a multilayered sandwich-type structure containing seven distinct structural layers and is the largest known POVB. Furthermore, 2demonstrates exceptional thermal and chemical stability and serves as an efficient and stable catalyst for the photoreduction of carbon dioxide.

关键词： boronate metallic materials polyoxovanadoborates density functional theory photocatalysis CO_(2)reduction

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Machine learning for predicting fatigue properties of additively manufactured materials

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Chinese Journal of Aeronautics 2024年第4期37卷 1-22页

作者： min YI ming xue Peihong CONG yang SONG Haiyang ZHANG Lingfeng WANG Liucheng ZHOU Yinghong LI Wanlin GUO State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China Institute for Frontier Science Nanjing University of Aeronautics and AstronauticsNanjing 210016China College of Aerospace Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Shenyang Engine Research Institute Shenyang 110015China Liaoning Key Laboratory of Impact Dynamics on Aero Engine Shenyang 110015China Science and Technology on Plasma Dynamics Laboratory Air Force Engineering UniversityXi’an 710038China

Fatigue properties of materials by Additive Manufacturing(AM) depend on many factors such as AM processing parameter, microstructure, residual stress, surface roughness, porosities, post-treatments, etc. Their evaluation inevitably requires these factors combined as many as possible, thus resulting in low efficiency and high cost. In recent years, their assessment by leveraging the power of Machine Learning(ML) has gained increasing attentions. A comprehensive overview on the state-of-the-art progress of applying ML strategies to predict fatigue properties of AM materials, as well as their dependence on AM processing and post-processing parameters such as laser power, scanning speed, layer height, hatch distance, built direction, post-heat temperature,etc., were presented. A few attempts in employing Feedforward Neural Network(FNN), Convolutional Neural Network(CNN), Adaptive Network-Based Fuzzy Inference System(ANFIS), Support Vector Machine(SVM) and Random Forest(RF) to predict fatigue life and RF to predict fatigue crack growth rate are summarized. The ML models for predicting AM materials' fatigue properties are found intrinsically similar to the commonly used ones, but are modified to involve AM features. Finally, an outlook for challenges(i.e., small dataset, multifarious features,overfitting, low interpretability, and unable extension from AM material data to structure life) and potential solutions for the ML prediction of AM materials' fatigue properties is provided.

关键词： Additive manufacturing Machine learning Fatigue life Fatigue crack growth rate Prediction

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