检索结果-南通市图书馆

CRL2.(APPBP2.-mediated TSPYL2.degradation counteracts human mesenchymal stem cell senescence

Science china(Life {1.) 2024年第3期67卷 460-474页

作者： Daoyuan huang Qian Zhao Kuan {1. Jinghui Lei Ying Jing Hongyu Li Chen Zhang Shuai Ma Shuhui Sun Yusheng Cai Guibin Wang Jing Qu Weiqi Zhang Si Wang Guang-Hui Liu Advanced Innovation Centerfor Human Brain Protection National Clinical Research Centerfor Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational MedicineCenter International Centerfor Aging and CancerBejing Municipal GeriatricMedical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of chinese Academy of {1. Beijing 100049China beijing {1. for Stem Cell and Regenerative Medicine Beijing100101China CAS Key Laboratory of Genomic and Precision Medicine Bejing Institute of Genomics and China National Center for BioinformationChinese Academy of SciencesBeijing 100101China institute for Stem Cell and Regeneration CASBeijing 100101China The Fifth People's Hospital of Chongqing Chongqing 400062China Sino-Danish Cllege University of Chinese Academy of SciencesBeijing101408China National Laboratory of Biomacromolecules CAS Center for Excelence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing100101China State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China

Cullin-RING E3 ubiquitin ligases(CRLs),the largest family of multi-subunit E3 ubiquitin ligases in eukaryotic cells,represent core cellular machinery for executing protein degradation and maintaining ***,we asked what roles Cullin proteins play in human mesenchymal stem cell(hMSC)homeostasis and *** this end,we conducted a comparative aging phenotype analysis by individually knocking down Cullin members in three senescence models:replicative senescent hMSCs,Hutchinson-Gilford Progeria Syndrome hMSCs,and Werner syndrome *** all family members,we found that CUL2.deficiency rendered hMSCs the most susceptible to *** investigate CUL2.specific underlying mechanisms,we then applied CRISPR/Cas9-mediated gene editing technology to generate CUL2.deficient human embryonic stem cells(hESCs).When we differentiated these into h MSCs,we found that CUL2.deletion markedly accelerates hMSC ***,we identified that CUL2.targets and promotes ubiquitin proteasome-mediated degradation of TSPYL2.a known negative regulator of proliferation)through the substrate receptor protein APPBP2.which in turn downregulates one of the canonical aging marker-P2.1}(waf1.cip1.,and thereby delays *** work provides important insights into how CRL2.(APPBP2.-mediated TSPYL2.degradation counteracts hMSC senescence,providing a molecular basis for directing intervention strategies against aging and aging-related diseases.

关键词： Cullins stem cell senescence aging proteostasis ubiquitination APPBP2 TSPYL2

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nuclear decay database in fission product mass region

引用

chinese Physics C 2024年第7期48卷 176-180页

作者：黄小龙杨东葛智刚王香涵刘洋阳金永利李剑 china Nuclear Data Center China Institute of Atomic EnergyBeijing 102413China College of Physics Jilin UniversityChangchun 130012China

Accurate and reliable nuclear decay databases are essential for fundamental and applied nuclear research ***,decay data are not usually as accurate as expected and need ***,a new {1. nuclear decay database in the fission product mass region(A=66−1.2.based on several major national evaluated data libraries has been developed under joint efforts in the CNDC working group.A total of 2.58 nuclides have been included in this decay *** main data formats,namely ENSDF and ENDF,have been *** the total meanβandγenergies,available data from total absorption gamma ray spectroscopy measurements have been *** some nuclides without experimental measurements,theoretically calculated values have been added.

关键词： nuclear decay data evaluation database fission product mass region

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Online Monitoring Method for Junction Temperature of SiC MOSFETs based on Temperature Sensitive Electrical Parameter

引用

CSEE Journal of Power and Energy Systems 2024年第4期10卷 1799-1807页

作者： Han Cao Puqi Ning Yunhao huang Xuhui Wen Wuhan Second Ship Design and Research institute Wuhan 430205China Key Laboratory of Power Electronics and Electric Drive Institute of Electrical EngineeringChinese Academy of SciencesBeijing 100190China institute of Electrical Engineering Chinese Academy of SciencesBeijing 100190China University of chinese Academy of {1. Beijing 100049China Collaborative Innovation Center of Electric Vehicles in beijing Beijing 100081China

Compared to Si devices,the junction temperature of SiC devices is more critical due to the reliability concern introduced by immature packaging technology applied to new *** paper proposes a practical SiC MOSFET junction temperature monitoring method based on the on-state voltage$\\boldsymbol{V}_{\\mathbf{ds}(\\mathbf{on})}$*** Section II of the paper,the temperature sensitivity of the on-state voltage$\\boldsymbol{V}_{\\mathbf{ds}(\\mathbf{on})}$is *** hardware of the measurement system is set up in Section III,which consists of an On-state Voltage Measurement Circuit(OVMC),the sampling and isolation ***,a calibration method based on the self-heating of the SiC MOSFET chip is presented in Section *** the final Section,the junction temperature is monitored synchronously according to the calibration *** proposed method is applied to a Buck converter and verified by both an Infrared Radiation(IR)camera and a Finite Element Analysis(FEA)tool.

关键词： Junction temperature Silicon Carbide(SiC)MOSFET TSEP

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An elastic-plastic constitutive framework for micropolar continua

An elastic-plastic constitutive framework for micropolar con...

引用

第五届国际非线性力学会议

作者： Zhu-ping huang~1.Geng-kai Hu~2.Hong-wu Zhang~3 (1.LTCS and Department of Mechanics,Peking University,{1. 1.0871.china 2.Department of applied Mechanics,{1. institute of Technology,{1. 1.0081.china 3.SAIL,Department of Engineering Mechanics,Dalian University of Technology,Dalian 1.602.,china)

＜正＞In this paper,a rate-type constitutive framework in micropolar plasticity is presented. In order to describe the plastic dissipation in the deformation process,a set of internal variables is introduced,thus the Helmholtz free energy can be expressed as a function of the non-symmetric strain,rotation and internal *** the introduction of the loading（yield） surfaces both in the non-symmetric strain and rotation space,and in the work conjugate non-symmetric stress and couple stress space,a loading-unloading criterion for a micropolar plastic material is suggested,and three types of material response,namely hardening,softening and perfectly plastic behaviors are *** on a mechanical postulate of non-negative work proposed by the present authors,the normality condition and the corresponding incremental constitutive relations are *** present results can be applied for the description of path-dependent mechanical behaviors of micropolar elastic-plastic materials.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Escape probability for isotropic emitters near Kerr black hole with astrometric

引用

Communications in Theoretical Physics 2024年第5期76卷 128-133页

作者： Yu-Xuan Han Qing-Hua Zhu Qing-Guo huang CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical sciences University of Chinese Academy of SciencesNo.19A Yuquan RoadBeijing 100049China Department of Physics Chongqing UniversityChongqing 401331China School of Fundamental Physics and Mathematical sciences Hangzhou {1. for Advanced Study UCASHangzhou 310024China

The paper investigates the escape probability for isotropic emitters near a Kerr black *** propose a new approach to obtain the escape probability in a general manner,going beyond previous case-by-case *** approach is based on studies of the black hole shadow with astrometric observable and can be applied to emitters with an arbitrary 4-velocities and locations,even to the emitters outside of the equatorial *** also consider representative examples illustrating how escape probabilities vary with distance,velocity,and inclination ***,this new approach provides an effective method for studying escape probabilities near Kerr black holes.

关键词： Kerr black hole photon escape probability isotropic emitters

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

2.4,5-涕丙酸的NMR手性分离条件

引用

分析测试学报 2003年第2期22卷 48-51页

作者：黄桂兰李重九防化研究院第六研究所北京102205 中国农业大学理学院应用化学系北京100094

以1.2.二苯基二氨基乙烷 (简称DPEDA ,化合物1.的(1.,2.)体 (简称(R)_1.为手性溶剂 (CSA) ,解决了外消旋2.4,5_涕丙酸(化合物2.在氯仿溶剂中溶解性不良的问题 ,并且化合物2.1.谱获得了出色的手性分离效果 ;通过研究包括温度、浓度、底... 详细信息

以1.2.二苯基二氨基乙烷 (简称DPEDA ,化合物1.的(1.,2.)体 (简称(R)_1.为手性溶剂 (CSA) ,解决了外消旋2.4,5_涕丙酸(化合物2.在氯仿溶剂中溶解性不良的问题 ,并且化合物2.1.谱获得了出色的手性分离效果 ;通过研究包括温度、浓度、底物与CSA的摩尔比、CSA结构等影响化学位移不等价的因素得出结论 ,对于手性中心CH ,在化合物2.(R)_1.摩尔比为2.1. ,提高底物浓度和降低测试温度有利于增加手性分离度 ;而对于与手性中心相连的CH3,增大(R)_1.比例,减小底物浓度,提高测试温度 ,有利于增大ΔδH;化合物1.(1.,2.)体 (简称(S)_1.与(R)_1.有相同的手性分离作用 ;另外还对各影响因素的作用机理进行了探讨。

关键词： 1.2.苯基二氨基乙烷 2.4,5-涕丙酸手性溶剂 NMR 化学位移不等价对映异构体

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An optimal flow rate allocation model of the oilfield treated oil pipeline network

引用

Petroleum 2024年第1期10卷 93-100页

作者： Hai Li Tianyou Fan Kun Wang Xueyuan Long Yu He Meng Wang Wen Cheng Qian huang Huirong huang Weichao Yu Petrochina Southwest Oil&Gasfield Company Chengdu 610056China china Petroleum Planning&Engineering {1. Beijing 100083China School of Petroleum Engineering Chongqing University of Science and TechnologyChongqing 401331China Pipechina Oil&Gas Control Center Dongtucheng RoadChaoyang DistrictBeijing 100028China

Oilfield treated oil pipeline network is the link connecting the upstream oilfields and the downstream *** to the differences in operating costs and transportation fee between different pipelines and the fluctuation in the demand and sales prices of the treated oil,there is an optimal flow allocation plan for the pipeline network to make the oilfield company obtain the highest social and economic *** this study,a mixed integer nonlinear programming(MINLP)model is developed to determine the optimal flow rate allocation plan of the large-scale and complex treated oil pipeline network,and both the social and economic benefits are considered *** optimization objective is the multi-objective which includes the largest user satisfaction and the highest economic *** model constraints include the oilfield production capacity,refinery demand,pipeline transmission capacity,flow,pressure,and temperature of the node and station,and the pipeline hydraulic and thermal *** 3.7 is utilized for the programming of the off-line calculation procedure and the MINLP model,and GUROBI 9.0.2.is served as the MINLP ***,the model is applied to a real treated oil pipeline network located in{1.,and three optimization scenarios are *** social benefit,the values of the user satisfaction of each refinery and the total network are 1.before and after optimization for scenarios 1.2.and *** economic benefit,the annual revenue can be increased by 0.2.7,0.2.3,and 0.548 billion yuan after the optimization in scenario 1.2.and 3,respectively.

关键词： Treated oil pipeline network Flow rate allocation Optimal User satisfaction Economic benefit

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Frontiers in high entropy alloys and high entropy functional materials

引用

Rare Metals 2024年第10期43卷 4639-4776页

作者： Wen-Tao Zhang Wen huang Fu-Jie Yu Qi Zhao Xin-Dong Zhu Tao Feng Yao Jiang Xiao-Ming Li Xue-Fei Miao He Zhu Si Lan Xue-Qian Wang Bao-Long Shen Zhe Jia Feng-Qi Zhang Wei Wang Qi Liu {1. Ren Xun-Li Wang Xiao-Ya Cui Xiao-{1. Wang Ya-Nan Chen Bing-Bing Fan Meng-Ru Li Qi-Long Gao Jia-Ming Guo Zeng-Bao Jiao Zhi-Min Guo Yu-Ping Zhao Qian Yu Rui huang Ling-Kun Zhang Yi-Ping Lu Xu-Bo Li Huai-Jun Lin Yan Ma Wei-Ming {1. Zhi-Hua Shen Hai-Yan He Yong-Gang Sun Yong-Jiang huang De-Zhuang Wang Qing-Feng Liu Fei-{1. Wang Hui Liu Hong-Hui Wu Li-Qiang Wang {1. Lu Nan Wang Tian-Li Wang Wei-Bing Liao Yi-Han Wang Yuan Wu Yu-Zhen Yin Jie Pan Yi Zhang Qing Wang Jian-{1. Zhang Tao {1. Yasir Sohail Jin-Yu Zhang Hua Ji Qiang Li Wei-Di Liu Zhi-Gang Chen Xiong-Jun Liu Wen Ma Liang Mao Zhen-Duo Wu School of Materials Science and Engineering Nanjing University of Science and Technology Jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and Engineering Southeast University Department of Physics City University of Hong Kong School of Materials Science and Engineering Tianjin University School of Physics and Microelectronics Zhengzhou University Department of Mechanical Engineering Research Institute for Advanced Manufacturing The Hong Kong Polytechnic University Center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University Key Laboratory of Solidification Control and Digital Preparation Technology (Liaoning Province) School of Materials Science and Engineering Dalian University of Technology institute of Advanced Wear & Corrosion Resistance and Functional Materials Jinan University School of Mechanics and Civil Engineering China University of Mining and Technology School of Physical sciences Great Bay University School of Materials Science andEngineering Harbin Institute of Technology State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University beijing Advanced Innovation Center for Materials Genome Engineering Research Institute for Carbon Neutrality University of Science and Technology Beijing Department of Mechanical Engineering The University of Hong Kong School of Computing Macquarie University Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing State Key Laboratory of Materials Processing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology institute of materials Shanghai University Department of Materials Science and Engineering C

Owing to their exceptional properties, high-entropy alloys(HEAs) and high-entropy materials have emerged as promising research areas and shown diverse applications. Here,the recent advances in the field are comprehensively reviewed,organized into five sections. The first section introduces the background of HEAs, covering their definition, significance,application prospects, basic properties, design principles, and microstructure. The subsequent section focuses on cutting-edge high-entropy structural materials, highlighting developments such as nanostructured alloys, grain boundary engineering,eutectic systems, cryogenic alloys, thin films, micro-nano-lattice structures, additive manufacturing, high entropy metallic glasses, nano-precipitate strengthened alloys, composition modulation, alloy fibers, and refractory systems. In the following section, the emphasis shifts to functional materials, exploring HEAs as catalysts, magneto-caloric materials, corrosion-resistant alloys, radiation-resistant alloys, hydrogen storage systems, and materials for biomedicine. Additionally, the review encompasses functional high-entropy materials outside the realm of alloys, including thermoelectric, quantum dots, nanooxide catalysts, energy storage materials, negative thermal expansion ceramics,and high-entropy wave absorption materials. The paper concludes with an outlook, discussing future directions and potential growth areas in the field. Through this comprehensive review,researchers, engineers, and scientists may gain valuable insights into the recent progress and opportunities for further exploration in the exciting domains of high-entropy alloys and functional materials.

关键词： Cutting-edge structural materials Cutting-edgefunctional materials High entropy alloys

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Meta-Auto-Decoder:a Meta-Learning-Based Reduced Order Model for Solving Parametric Partial Differential Equations

引用

Communications on applied {1. and Computation 2024年第2期6卷 1096-1130页

作者： Zhanhong Ye Xiang huang Hongsheng Liu Bin Dong beijing International Center for Mathematical Research Peking UniversityBeijing 100871China School of Computer Science and Technology University of Science and Technology of ChinaHefei 230027AnhuiChina Central Software institute Huawei Technologies Co.LtdHangzhou 310007ZhejiangChina Center for Machine Learning Research Peking UniversityBeijing 100871China

Many important problems in science and engineering require solving the so-called parametric partial differential equations(PDEs),i.e.,PDEs with different physical parameters,boundary conditions,shapes of computational domains,*** reduced order modeling techniques accelerate the solution of the parametric PDEs by projecting them onto a linear trial manifold constructed in the ofline *** methods often need a predefined mesh as well as a series of precomputed solution snapshots,and may struggle to balance between the efficiency and accuracy due to the limitation of the linear *** the nonlinear representation of neural networks(NNs),we propose the Meta-Auto-Decoder(MAD)to construct a nonlinear trial manifold,whose best possible performance is measured theoretically by the decoder *** on the meta-learning concept,the trial manifold can be learned in a mesh-free and unsupervised way during the pre-training *** adaptation to new(possibly heterogeneous)PDE parameters is enabled by searching on this trial manifold,and optionally fine-tuning the trial manifold at the same *** numerical experiments show that the MAD method exhibits a faster convergence speed without losing the accuracy than other deep learning-based methods.

关键词： Parametric partial differential equations(PDEs) Meta-learning Reduced order modeling Neural networks(NNs) Auto-decoder

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The new challenges for the development of NH_(3)-SCR catalysts under new situation of energy transition in power generation industry

引用

chinese Chemical Letters 2024年第6期35卷 95-103页

作者： Feibin Wei Yongfang Rao Yu huang Wei Wang Hui Mei Science and Technology on Thermostructural Composite Materials Laboratory School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Key Laboratory of Aerosol Chemistry and Physics State Key Laboratory of Loess and Quaternary Geology(SKLLQG)Institute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China Center of Excellence in Quaternary Science and Global Change Chinese Academy of SciencesXi’an 710061China University of chinese Academy of {1. Beijing 100049China Department of Environmental Science and Engineering Xi’an Jiaotong UniversityXi’an 710049China

NH_(3)-SCR was one of the most promising de NO_x technologies and it has been widely applied in industrial NO_x ***,with the further development of energy transformation in power generation sector,the development of NH_(3)-SCR catalysts is facing some new *** is becoming an urgent problem to solve low catalytic activity and stability of NH_(3)-SCR catalysts at the working condition of ultra-low temperature(≤2.0℃)and high concentrations of H_(2.O+SO_(2. due to the gradual deployment of new energy power ***,the traditional coal-fired power plants would need flexible operation with the increasing share of renewable energy *** NH_(3)-SCR catalysts which were applied in coal-fired power industry would be requested to work in a wide temperature window from 2.0℃ to 500℃ in the near ***,in this review,we summarized the progress of NH_(3)-SCR catalysts in solving these different industrial problems in recent *** the research directions which were deserved to be focused on the development of NH_(3)-SCR catalysts for the energy transition of power generation sector are proposed.

关键词： NH_(3)-SCR NOx reduction Power generation Ultra-low temperature Wide temperature windows

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：