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Recent advances in understanding the role of miRNAs in exosomes and their therapeutic potential

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Journal of Integrative Agriculture 2017年第4期16卷 753-761页

作者： MIAO xiang-yang Institute of Animal Sciences Chinese Academy of Agricultural Sciences Beijing 100193 P.R.China

MicroRNAs （miRNAs）are small endogenous non-protein coding RNAs that range in size from 19-25 nucleotides. Thousands of miRNA genes have been identified in a variety of organisms, suggesting genetic exchange and distribution among species, miRNAs negatively regulate gene expression by binding to the 3＂-untranslated regions （3＂-UTRs） of their target genes and play an important role in growth, development and the occurrence of diseases. In this review, we summarize the recent advances in the understanding of the role of miRNAs in exosomes and their therapeutic potential, as well as provide an overview of the basic characteristics of miRNAs.

关键词： miRNA gene expression gene regulation gene transcription exosomes non-coding RNA

Production of Transgenic Animals Using Spermatogonial Stem Cells

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Agricultural Sciences in China 2011年第5期10卷 762-768页

作者： MIAO xiang-yang Institute of Animal Sciences Chinese Academy of Agricultural Sciences Beijing 100193 P.R.China

Spermatogonial stem cells （SSCs） are a type of adult stem cell found in male *** cells have the capacity for self renewal and are capable of differentiating in the niche of *** are also the only adult stem cells in a normal postnatal body that undergo self-renewal throughout life,transferring genetic information to the *** a technique for transplanting SSCs was first described by Brinster and his colleagues in 1994,more and more researchers have become interested in exploring the possibility of utilizing adult SSCs to generate transgenic *** this mini-review,we attempt to summarize the current research progress in the area of spermatogonial stem cells including the source,types and differentiation of the SSCs,and the application on transgenic animals,with a particular focus on the strategy of SSCs delivery including seminiferous tubule injection and spermatogonial stem cell transplantation.

关键词： spermatogonial stem cells transgenic animal seminiferous tubule injection transplantation

Efficient dynamic pruning on largest scores first (LSF) retrieval

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Frontiers of Information Technology & Electronic Engineering 2016年第1期17卷 1-14页

作者： Kun JIANG Yue-xiang yang College of Computer National University of Defense Technology

Inverted index traversal techniques have been studied in addressing the query processing performance challenges of web search engines, but still leave much room for improvement. In this paper, we focus on the inverted index traversal on document-sorted indexes and the optimization technique called dynamic pruning, which can efficiently reduce the hardware computational resources required. We propose another novel exhaustive index traversal scheme called largest scores first(LSF) retrieval, in which the candidates are first selected in the posting list of important query terms with the largest upper bound scores and then fully scored with the contribution of the remaining query terms. The scheme can effectively reduce the memory consumption of existing term-at-atime(TAAT) and the candidate selection cost of existing document-at-a-time(DAAT) retrieval at the expense of revisiting the posting lists of the remaining query terms. Preliminary analysis and implementation show comparable performance between LSF and the two well-known baselines. To further reduce the number of postings that need to be revisited, we present efficient rank safe dynamic pruning techniques based on LSF, including two important optimizations called list omitting(LSF_LO) and partial scoring(LSF_PS) that make full use of query term importance. Finally, experimental results with the TREC GOV2 collection show that our new index traversal approaches reduce the query latency by almost 27% over the WAND baseline and produce slightly better results compared with the Max Score baseline, while returning the same results as exhaustive evaluation.

关键词： Inverted index, Index traversal, Query latency, Largest scores first (LSF) retrieval, Dynamic pruning

A Novel Design of a Pre-separation Panel Structure to Protect Against the Impact of an Explosion in an Aircraft Plenum Chamber

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Acta Mechanica Solida Sinica 2024年第1期37卷 166-180页

作者： Zongxing Liu xiang yang Jun Liu School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China COMAC Shanghai Aircraft Design and Research Institute Shanghai 201210China

To reduce the damage of the pressurizing panel structure of a fuselage caused by an explosion at the“least risk bomb location”in an aircraft structure,a new pre-separation panel structure was designed to resist blast ***,the dynamic strain response and morphology of impact damage of the new pre-separation panel were measured in an impact damage ***,the commercial software LS-DYNA was used to calculate the propagation of the blast shock wave,and the results were compared with empirical equations to verify the rationality of the numerical calculation ***,the fluid–structure coupling method was used to calculate the damage process of the pre-separation panel structure under the impact of an explosion wave and an impact *** calculated results were in good agreement with the test results,which showed the rationality of the calculation method and the *** residual strength of the damaged pre-separation panel was significantly higher than that of the original damaged *** results show that the new pre-separation panel structure is reasonable and has certain significance for guiding the design of plenum chambers with strong resistance to implosion for aircraft fuselages.

关键词： Pre-separation panel structure Explosive response Residual strength Aircraft plenum chamber Least risk bomb location

Synthesis and Crystal Structure of a Dinuclear Cu(Ⅱ) Complex [Cu(C_(13)H_9N_2O)Cl]_2·(CH_3CN)_2 with Ligand 2-Benzimidazol

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Chinese Journal of Structural Chemistry 2007年第2期26卷 149-152页

作者： LI Qing-xiang yang xiang-Liang XU Hui-Bi Hubei Key Laboratory of Novel Chemical Reactor andGreen Chemical Technology Wuhan Institute of Technology Wuhan 430073 China College of Life Science Huazhong University of Science and Technology Wuhan 430074 China

A new dinuclear copper complex, [Cu（C13HgN2O）Cl]2.（CH3CN）2 （C30H24C12Cu2N6O2）, has been synthesized and characterized by X-ray structure determination. It crystallizes in the triclirile system, space group P1, with a = 7.6677（14）, b = 9.2375（17）, c = 11.227（2） ]A, α = 81.338（3）,β = 88.173（4）, γ = 66.199（3）°, V = 718.9（2） ]A^3, Z = 1, Mr = 698.53, F（000） = 354, Dc = 1.613 g/cm^3, μ（MoKa） = 1.705 mm^-1, the final R = 0.0645 and wR = 0.1364 for 2474 unique reflections with 1809 observed ones （I 〉 20（I））. In the title complex, each copper（H） atom is located at the center of a distorted tetrahedron consisting of four coordinate atoms （one nitrogen atom, two oxygen anions, and one chlorine atom）. Two copper（Ⅱ） atoms are bridged by two oxygen anions （O（1） and O（la）） of two phenolates to form a Cu（Ⅱ）-Cu（Ⅱ） binuclear entity, and the distance between two copper（Ⅱ） atoms is 3.0144（15） A.

关键词： 2-benzimidazol phenolate Cu(Ⅱ) complex crystal structure

Modeling Dislocations at Different Scales

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Communications in Computational Physics 2006年第3期1卷 383-424页

作者： yang xiang Department of Mathematics Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong

In this article,we give an introduction to the basic theory of dislocations and some dislocation models at different length *** are line defects in *** continuum theory of dislocations works well at the length scale of several lattice constants away from the *** the region surrounding the dislocations(core region),the crystal lattice is heavily distorted,and atomistic models are used to describe the atomic arrangement and related *** Peierls-Nabarro models of dislocations incorporate the atomic features into the continuum theory,therefore provide an alternative way to understand the dislocation core *** numerical simulation of the collective motion and interactions of dislocations,known as dislocation dynamics,is becoming a more and more important tool for the investigation of the plastic behaviors of *** simulation methods for dislocation dynamics are also reviewed in this article.

关键词： Dislocations modeling dislocation dynamics Peierls-Nabarro model

Neurological rehabilitation of stroke patients via motor imaginary-based brain-computer interface technology

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Neural Regeneration Research 2011年第28期6卷 2198-2202页

作者： Hongyu Sun yang xiang Mingdao yang Department of Computer Science and Technology Tongji University Shanghai 201804 China College of Information and Electrical Engineering Shandong University of Science and Technology China Key Laboratory of Embedded System and Service Computing Ministry of Education of the People＇s Republic of China Tongji University Shanghai 201804 China Qingdao Economic ＆ Technical Development Area First People＇s Hospital Qingdao 266555 Shangdong Province China

The present study utilized motor imaginary-based brain-computer interface technology combined with rehabilitation training in 20 stroke patients. Results from the Berg Balance Scale and the Holden Walking Classification were significantly greater at 4 weeks after treatment （P 〈 0.01）, which suggested that motor imaginary-based brain-computer interface technology improved balance and walking in stroke patients.

关键词： brain-computer interface motor cortex neuronal plasticity rehabilitation stroke neural regeneration

Progress in the development and application of plant-based antiviral agents

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Journal of Integrative Agriculture 2017年第12期16卷 2772-2783页

作者： LI xiang-yang SONG Bao-an State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering/Key Laboratory of Green Pesticide andAgricultural Bioengineering Ministry of Education/Guizhou University Guiyang 550025 P.R. China

Plant virus disease is one of the major causes of biological disasters in agriculture worldwide. Given the complexity of transmission media and plant disease infection mechanisms, the prevention and control of plant viral diseases is a great challenge, and an efficient green pesticide is urgently needed. For this reason, when developing candidate drug leads to regulate plant viruses, pesticide experts have focused on characteristics such as low pesticide resistance, eco-friendliness, and novel mechanism. Researchers have also theoretically investigated the molecular targets of viruses infecting agricultural crops. Antiviral screening models have been constructed based on these molecular targets, and the mechanisms of commercial drugs and high-activity compounds have been extensively investigated. After screening, some compounds have been applied in the field and found to have good commercial prospects; these drugs may be used to create new green antiviral pesticides to control plant viruses. This paper reviews the screening, mode of action, development and application of recently used plant-based antiviral agents.

关键词： research progress antiviral agents screening model action mechanism drug development and application

Impact of Climate Change and Grazing on Temperate Steppe

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Journal of Integrative Agriculture 2014年第6期13卷 1155-1156页

作者： HOU xiang-yang Member of JIA Editorial Board Key Laboratory of Grassland Resources and Ecology Ministry of Agriculture/Grassland Research Institute/Research Center of the Eurasian Temperate Grasslands Chinese Academy of Agricultural Sciences

Ecosystem of eastern Eurasian steppe is facing more and more challenges of global issues such as climate change, food and ecological security and human excessive utilization since the 21st century. Facing on the increasingly prominent international issues, it is very essential for relevant countries, international organizations and domestic counterparts to enhance systematic and mutual cooperation and exchanges to carry out scientific research and develop protection practice on the Eurasian steppe.

关键词： Impact of Climate Change and Grazing on Temperate Steppe