Recent advances in understanding the role of miRNAs in exosomes and their therapeutic potential

作     者：MIAO Xiang-yang 

作者机构：Institute of Animal Sciences Chinese Academy of Agricultural Sciences Beijing 100193 P.R.China 

出 版 物：《Journal of Integrative Agriculture》 (农业科学学报（英文版）)

年 卷 期：2017年第16卷第4期

页      面：753-761页

核心收录：

学科分类：07[理学] 08[工学] 09[农学] 071007[理学-遗传学] 090102[农学-作物遗传育种] 0710[理学-生物学] 0832[工学-食品科学与工程（可授工学、农学学位）] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 0905[农学-畜牧学] 0906[农学-兽医学] 0901[农学-作物学] 0703[理学-化学] 0902[农学-园艺学] 0836[工学-生物工程] 0713[理学-生态学] 

基　　金：supported by a grant from the Major Science and Technology Project of New Variety Breeding of Genetically Modified Organisms(2009ZX08008-004 and 2008ZX08008-003) the National High Technology Research Development Program of China(863 Program,2008AA10Z140) the National Natural Science Foundation of China(30571339) the Agricultural Science and Technology Innovation Program(ASTIP-IAS05) the Innovation Research Foundation of Chinese Academy of Agricultural Sciences(2004-CAAS-1) the Basic Research Fund for Central Public Research Institutes of Chinese Academy of Agricultural Sciences(Y2016JC22,2013ywf-zd-2) 

主　　题：miRNA gene expression gene regulation gene transcription exosomes non-coding RNA 

摘      要：MicroRNAs （miRNAs）are small endogenous non-protein coding RNAs that range in size from 19-25 nucleotides. Thousands of miRNA genes have been identified in a variety of organisms, suggesting genetic exchange and distribution among species, miRNAs negatively regulate gene expression by binding to the 3＂-untranslated regions （3＂-UTRs） of their target genes and play an important role in growth, development and the occurrence of diseases. In this review, we summarize the recent advances in the understanding of the role of miRNAs in exosomes and their therapeutic potential, as well as provide an overview of the basic characteristics of miRNAs.