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Matter and Radiation at Extremes 2023年第2期8卷 14-24页

作者： Céline S.Hue yang wan Eitan Y.Levine Victor Malka Department of Physics of Complex Systems Weizmann Institute of ScienceRehovotIsrael

Density downramp injection has been demonstrated to be an elegant and efficient approach for generating high-quality electron beams in laser wakefield *** studies have demonstrated the possibilities of generating electron beams with charges ranging from tens to hundreds of picocoulombs while maintaining good beam ***,the plasma and laser parameters in these studies have been limited to specific ranges or attention has been focused on separate physical processes such as beam loading,which affects the uniformity of the accelerating field and thus the energy spread of the trapped electrons,the repulsive force from the rear spike of the bubble,which reduces the transverse momentum P⊥of the trapped electrons and results in small beam emittance,and the laser evolution when traveling in the *** this work,we present a comprehensive numerical study of downramp injection in the laser wakefield,and we demonstrate that the current profile of the injected electron beam is directly correlated with the density transition parameters,which further affects the beam charge and energy *** fine-tuning the plasma density parameters,electron beams with high charge(up to several hundreds of picocoulombs)and low energy spread(around 1%FWHM)can be *** these results are supported by large-scale quasi-threedimensional particle-in-cell *** anticipate that the electron beams with tunable beam properties generated using this approach will be suitable for a wide range of applications.

关键词： tuning beam injection

A New Peptide with Membrane-permeable Function Derived from Human Circadian Proteins

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Acta Biochimica et Biophysica Sinica 2004年第9期36卷 629-636页

作者： Tao PENG, Ying-Hui LIU, Chun-Lei yang, Chao-Min wan, Yao-Qi wanG, and Zheng-Rong wanG* Department of Biomedical Engineering, School of Basic Medicine and Forensic, Sichuan University, Chengdu 610041, China Department of Biomedical Engineering School of Basic Medicine and Forensic Sichuan UniversityChengdu 610041 China

Basic peptides such as human immunodeficiency virus type 1 (HIV-1) Tat-(48-60) and Droso- phila Antennapedia-(43-58) have been reported to have a membrane permeability and a carrier function for intracellular protein delivery. Based on the fluorescence microscopic observations of the vascular endothelial cells (ECV-304) and the primary cultured neuroglial cells, we found that human Clock protein DNA-binding peptide [residue 35–47, hClock-(35-47)] had a translocation activity very similar to Tat-(48-60). The cellular uptake of hClock-(35-47) increases with the increase of incubation time and concentration. The internalization effect at 4 °C was same as that at 37 °C. Internalization of hClock-(35-47) was saturable and could be inhibited by the excess of the other MPPs. Moreover, The uptake of these peptides were significantly inhibited in the presence of heparan sulfate. These results strongly suggested that the hClock-(35-47) shared a common or very similar internalization pathway with other MPPs. Furthermore, we injected rat through the common carotid artery with hClock-(35-47)-FITC peptide, and cryostat sections of the brain were prepared and observed using a fluorescence microscope. Result showed that the peptide had the ability to translocate through the blood-brain barrier. It is promising to provide a new safe carrier for the intracellular and encephalic treatment.

关键词： membrane-permeable peptide (MPP) cell membrane hClock DNA-binding peptide blood-brain barrier

Naphthalene exerts non-target effects on the abundance of active fungi by stimulating basidiomycete abundance

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Journal of Mountain Science 2020年第8期17卷 2001-2010页

作者： LAN Li-ying ZHANG Li SHEN Ya ZHANG Jian yang wan-qin XU Zhen-feng LIU yang HE Shu-qin ZHOU Wei LI Han wanG Li-xia LIU Si-ning YOU Cheng-ming TAN Bo Institute of Ecology&Forestry Sichuan Agricultural UniversityChengdu 611130China Forestry Ecological Engineering in Upper Reaches of yangtze River Key Laboratory of Sichuan Province Chengdu 611130China School of Life Science Taizhou UniversityTaizhou 318000China College of Resources Sichuan Agricultural UniversityChengdu 611130China

As an arthropod biocide,naphthalene has been used in studies of the ecological functions of soil fauna for ***,its potential non-target effects on soil microorganisms may affect soil mineralization and litter decomposition ***,we conducted an experiment with naphthalene adding to soil surface at a rate of 100 g·m-2 per month to examine the potential non-target effects of this treatment on soil fungal phospholipid fatty acids(PLFAs),18 S rDNA gene copy numbers and community diversity in a subalpine forest of western Sichuan,*** results showed that naphthalene addition significantly increased fungal PLFAs but did not significantly alter fungal gene copy numbers.A total of 16 phyla,62 genera and 147 Operational taxonomic units(OTUs)were identified through Illumina Mi Seq sequencing *** and Ascomycota were the most abundant phyla in both the control and naphthalene addition *** addition did not affect the diversity or structure of the soil fungal community,but the increase in some genera of Basidiomycota might contribute to the increase in fungal PLFAs in the naphthalene addition *** results suggest that naphthalene exerts non-target effects on the active fungal abundance by stimulating the abundance of specific taxa in subalpine forest *** non-target effects of naphthalene on the fungal community should be taken into consideration when it is used to exclude soil fauna.

关键词： Naphthalene Illumina sequencing Phospholipid fatty acids Soil fungi Soil fauna

鸦胆子中苦木素类成分及其抗炎机制的研究进展

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中国野生植物资源 2024年第9期43卷 88-95页

作者：王文敏吴佳辉石凌钰万阳冯育林温泉陈道峰江西中医药大学江西南昌330004 中药固体制剂制造技术国家工程研究中心江西南昌330006 复旦大学药学院上海201203

鸦胆子是我国传统中药之一,其主要活性化学成分是苦木素类化合物,具有抗肿瘤、抗炎、抗病毒等药理作用。本文通过整理、归纳和分析现有的苦木素类化合物研究成果,探讨具有抗炎活性的化合物结构的异同及其作用机制。苦木素类化合物中的A... 详细信息

鸦胆子是我国传统中药之一,其主要活性化学成分是苦木素类化合物,具有抗肿瘤、抗炎、抗病毒等药理作用。本文通过整理、归纳和分析现有的苦木素类化合物研究成果,探讨具有抗炎活性的化合物结构的异同及其作用机制。苦木素类化合物中的A环、C环和D环上的α,β-不饱和酮、糖基、烯键的取代能影响其抗炎活性。这些化合物主要通过调控细胞内信号传导通路NF-κB发挥抗炎作用,此外,它们还能抑制多种促炎因子的表达,包括TNF-α、IL-6、IL-β等,从而有效地抑制炎症反应。苦木素类化合物的抗炎活性可能与其抗补体活性相关,特别是与补体蛋白C3a和C5a有关。

关键词：鸦胆子苦木素结构抗炎机制

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四川省农业农村现代化实现度与耦合协调度评价

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江西农业学报 2024年第3期36卷 117-127页

作者：王正源郭耀辉杨万宝杜兴端刘宗敏四川省农业科学院农业信息与农村经济研究所四川成都610000

基于统计年鉴等相关数据,构建了四川省农业农村现代化发展水平评价指标体系,对该省及其21个市(州)农业现代化与农村现代化的实现度和耦合协调度进行了测算和分析。结果表明:(1)四川省农业农村现代化整体水平偏低,农村现代化实现度普遍... 详细信息

基于统计年鉴等相关数据,构建了四川省农业农村现代化发展水平评价指标体系,对该省及其21个市(州)农业现代化与农村现代化的实现度和耦合协调度进行了测算和分析。结果表明:(1)四川省农业农村现代化整体水平偏低,农村现代化实现度普遍高于农业现代化实现度,成都和攀枝花两市进入农业农村现代化加速实现阶段,绵阳等11个市(州)处于农业农村现代化转型升级阶段,达州等8个市(州)处于农业农村现代化起步阶段。(2)四川省平均协调程度处于初级协调水平,攀枝花市达到高度协调水平,成都和雅安市处于中级协调水平,达州和巴中处于濒临失调状态,其他16个市(州)处于初级协调或勉强协调水平。(3)农业产业体系整体效率仍显不足,农产品加工产值相对滞后;农业生产体系科技活动人员仍未充分发挥作用,农机化水平也存在较大差异;农业经营体系中的农业企业和家庭农场发展较慢,农业服务机构尚未得到有效落实。鉴于此,提出了加强顶层设计,确保农业农村现代化发展相关规划的落地落实;加强农业农村协同发展,以农业现代化带动农村现代化;加强农业产业体系、生产体系、经营体系的协同发展等对策建议。

关键词：农业农村现代化指标体系耦合协调度标准值法四川省

Sirolimus can promote the disappearance of renal angiomyolipoma associated with tuberous sclerosis complex:a prospective cohort study

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World Journal of Pediatrics 2024年第6期20卷 602-610页

作者： Shuo Dun yang-yang wang Lin wan Qiu-Hong wang Qian Lu Xiao-Yan yang Qi Zhang Hui-Min Chen Lu-Peng Qiu Li-Ping Zou Medical School of Chinese PLA Beijing 100853China Department of Pediatrics The First Medical CenterChinese PLA General HospitalBeijing 100853China Center of Epilepsy Beijing Institute for Brain DisordersBeijing 100069China

Background Renal angiomyolipoma(RAML)is the most common kidney lesion in patients with tuberous sclerosis complex(TSC),affecting about 80%of *** is a benign tumor that grows over time,usually bilaterally,and can easily lead to kidney complications such as acute ***,we investigated the efficacy and safety of sirolimus in children with TSC-associated RAML and explored the factors affecting tumor disappearance under sirolimus treatment through subgroup *** A prospective cohort study was *** was initiated at 1 mg/(m^(2)×day),and dose adjustments were made by a 2-week titration period to attain a trough blood concentration of 5-10 ng/*** disappearance of RAML in chil-dren after sirolimus treatment was observed,and Cox regression was used to screen the factors affecting tumor *** One hundred and twenty-six patients who met the criteria were *** 3 months,6 months,12 months,and 24 months of follow-up,tumors disappeared in 18(14.3%),30(23.8%),39(31.0%),and 42(33.3%)children,*** disappeared in 50(39.7%)children by the last visit of each individual,and 30(60%)of them occurred within 6 *** multivariate Cox regression analysis showed that patients with a smaller maximum tumor diameter at baseline had a higher tumor disappearance ***-six(29%)patients had stomatitis during the entire treatment period,and no serious *** Sirolimus could promote the disappearance of TSC-related *** disappearance rate was correlated with the maximum diameter at baseline,and the smaller the tumor was,the higher the disappearance *** is well tolerated in the treatment of RAML associated with TSC.

关键词： Angiomyolipoma mTOR inhibitor Sirolimus Tuberous sclerosis

Multifunctional 2-(2-hydroxyphenyl)benzoxazoles: Ready synthesis,mechanochromism, fluorescence imaging, and OLEDs

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Chinese Chemical Letters 2024年第10期35卷 223-227页

作者： Kangmin wang Liqiu wan Jingyu wang Chunlin Zhou Ke yang Liang Zhou Bijin Li Chongqing Key Laboratory of Natural Product Synthesis and Drug Research School of Pharmaceutical SciencesChongqing UniversityChongqing 401331China jiangsu Key Laboratory of Advanced Catalytic Materials&Technology School of Petrochemical EngineeringChangzhou UniversityChangzhou 213164China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

Triphenylamine(TPA)-containing 2-(2-hydroxyphenyl)benzoxazoles(2a-2c)have been synthesized via a highly efficient rhodium-catalyzed C–H/C–H cross-coupling *** 2a is a novel mechanofluorochromic material with blue-shifted mechanochromic *** 2b and 2c presented opposite mechanochromic *** 2b,the enol-form emission enhanced,and the ketoform emission blue-shift after *** contrast,2c exhibited the weak enol-form emission disappeared and the keto-form emission slightly red-shift after grinding *** estrone-containing2b-based water-dispersed nanoparticles(NPs)exhibit apparent dual-emission and were applied for fluorescence *** addition,bis(TPA)-containing 2c-based devices exhibit dual-emission with good performance and a singlet exciton yield of 92%,which breaks through the theoretical upper limit of 25%in conventional fluorescent *** is one of the highest exciton utilization values recorded for the ESIPT molecules with a dual emission system.

关键词： Rhodium-catalyzed 2-(2'-Hydroxyphenyl)benzoxazoles Mechanochromism Fluorescence images OLEDS

SsdchA is a novel secretory cellobiohydrolase driving pathogenicity in Sclerotinia sclerotiorum

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The Crop Journal 2024年第2期12卷 493-502页

作者： yangui Chen Yijuan Ding Siqi Zhao Nan yang Zhaohui Wu Ping Zhang Hongmei Liao Mengquan Dong yang Yu Huafang wan Wei Qian Integrative Science Center of Germplasm Creation in Western China(Chongqing)Science City College of Agronomy and BiotechnologySouthwest UniversityChongqing 400715China Academy of Agricultural Sciences Southwest UniversityChongqing 400715China Engineering Research Center of South Upland Agriculture Ministry of EducationChongqing 400715China College of Plant Protection Southwest UniversityChongqing 400715China

The necrotrophic fungus, Sclerotinia sclerotiorum, employs an array of cell wall-degrading enzymes(CWDEs), including cellulase, to dismantle host cell walls. However, the molecular mechanisms through which S. sclerotiorum degrades cellulose remain elusive. Here, we unveil a novel secretory cellobiohydrolase, SsdchA, characterized by a signal peptide and a Glyco_hydro_7(GH7) domain. SsdchA exhibits a robust expression of during early infection stages. Interestingly, colony morphology and growth rates remain unaffected across the wild-type, SsdchA deletion strains and SsdchA overexpression strains on potato dextrose agar(PDA) medium. Nevertheless, the pathogenicity and cellobiohydrolase activity decreased in the SsdchA deletion strains, but enhanced in the SsdchA overexpression strains. Moreover,the heterologous expression of SsdchA in Arabidopsis thaliana leads to reduced cellulose content and heightened susceptibility to S. sclerotiorum. Collectively, our data underscore the pivotal role of the novel cellobiohydrolase SsdchA in the pathogenicity of S. sclerotiorum.

关键词： Cellobiohydrolase Cellulose Pathogenicity Sclerotinia sclerotiorum Secretory protein SsdchA

Electroacupuncture Stimulation of Language-Implicated Acupoint Tongli(HT 5) in Healthy Subjects: An fMRI Evaluation Study

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Chinese Journal of Integrative Medicine 2018年第11期24卷 822-829页

作者： LI Lin-ling LIU Xiao-wu WU Fang TONG Dong-chang YE Li-ping TAO Hong-xing LIU Peng QIU Yun-hai yang wan-zhang Research Center for Neural Engineering Institute of Biomedical and Health Engineering Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Department of Rehabilitation Medicine the Sixth People's Hospital in Shenzhen (Nanshan Hospital) Engineering Research Center of Molecular and Neuro Imaging Ministry of Education School of Life Science and Technology Xidian University

Objective： To explore brain activations associated with electroacupuncture simulation at Tongli（HT 5） and its comparison with brain activations during picture-naming task. Methods： Twenty healthy subjects were enrolled in this study. Half of them received electroacupuncture stimulation at HT 5（ACUP group） and the other half of them received stimulation at a nonmeridian sham acupoint（SHAM group）. All subjects performed picture-naming task. Each subject finished two runs of functional magnetic resonance imaging examinations in one session and picture-naming task was performed before electroacupuncture stimulation. Subjective brain activations were obtained using generalized linear model and inter-group analyses were performed after that. Results： The electroacupuncture stimulation at HT 5 induced significant brain activations in both the anterior and posterior language regions, including the left inferior frontal gyrus, which was in consistent with activations induced during picture-naming task. Group analysis showed a tendency of increased activation of ACUP group in left inferior frontal gyrus compared with SHAM group（P〈0.05 FDR corrected）. Conclusions： Electroacupuncture treatment at the acupoint HT 5 has modulation effect on typical language-implicated brain regions in healthy subjects, which provides supporting evidence for beneficial effects of needling at HT 5 for recovery of language function in aphasia.

关键词： electroacupuncture Tongli (HT 5) functional magnetic resonance imaging

Metabolomic Analysis in Saliva and Different Brain Regions of Older Mice with Postoperative Delirium Behaviors

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Biomedical and Environmental Sciences 2024年第2期37卷 133-145页

作者： LIU Xiao CAO Ying LIN Xiao wan GAO Dan yang MIAO Hui Hui LI Tian Zuo Department of Anesthesiology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

Objective Postoperative delirium(POD)has become a critical challenge with severe consequences and increased incidences as the global population ***,the underlying mechanism is yet *** study aimed to explore the changes in metabolites in three specific brain regions and saliva of older mice with postoperative delirium behavior and to identify potential non-invasive *** Eighteen-month-old male C57/BL6 mice were randomly assigned to the anesthesia/surgery or control *** tests were conducted 24 h before surgery and 6,9,and 24 h after *** C3(C3)and S100 calcium-binding protein B protein(S100beta)levels were measured in the hippocampus,and a metabolomics analysis was performed on saliva,hippocampus,cortex,and amygdala *** In total,43,33,38,and 14 differential metabolites were detected in the saliva,hippocampus,cortex,and amygdala,respectively.“Pyruvate”“alpha-linolenic acid”and“2-oleoyl-1-palmitoy-snglycero-3-phosphocholine”are enriched in one common pathway and may be potential non-invasive biomarkers for *** changes were observed in the three brain regions,with the upregulation of 1-methylhistidine and downregulation of *** Dysfunctions in energy metabolism,oxidative stress,and neurotransmitter dysregulation are implicated in the development of *** identification of changes in the level of salivary metabolite biomarkers could aid in the development of noninvasive diagnostic methods for POD.

关键词： Metabolomic Postoperative delirium(POD) Mechanism Biological marker