Electroacupuncture Stimulation of Language-Implicated Acupoint Tongli(HT 5) in Healthy Subjects: An fMRI Evaluation Study

作     者：LI Lin-ling LIU Xiao-wu WU Fang TONG Dong-chang YE Li-ping TAO Hong-xing LIU Peng QIU Yun-hai YANG Wan-zhang 无

作者机构：Research Center for Neural Engineering Institute of Biomedical and Health Engineering Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Department of Rehabilitation Medicine the Sixth People's Hospital in Shenzhen (Nanshan Hospital) Engineering Research Center of Molecular and Neuro Imaging Ministry of Education School of Life Science and Technology Xidian University 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2018年第24卷第11期

页      面：822-829页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1005[医学-中医学] 1002[医学-临床医学] 100512[医学-针灸推拿学] 10[医学] 

基　　金：Supported by the Hundred Talents Program of Chinese Academy of Sciences(No.Y14408) Shenzhen Science and Technology Program(No.JC201005270293A,JC201104220257A and 201101017) National Natural Science Foundation of China(No.81471738) 

主　　题：electroacupuncture Tongli (HT 5) functional magnetic resonance imaging 

摘      要：Objective： To explore brain activations associated with electroacupuncture simulation at Tongli（HT 5） and its comparison with brain activations during picture-naming task. Methods： Twenty healthy subjects were enrolled in this study. Half of them received electroacupuncture stimulation at HT 5（ACUP group） and the other half of them received stimulation at a nonmeridian sham acupoint（SHAM group）. All subjects performed picture-naming task. Each subject finished two runs of functional magnetic resonance imaging examinations in one session and picture-naming task was performed before electroacupuncture stimulation. Subjective brain activations were obtained using generalized linear model and inter-group analyses were performed after that. Results： The electroacupuncture stimulation at HT 5 induced significant brain activations in both the anterior and posterior language regions, including the left inferior frontal gyrus, which was in consistent with activations induced during picture-naming task. Group analysis showed a tendency of increased activation of ACUP group in left inferior frontal gyrus compared with SHAM group（P〈0.05 FDR corrected）. Conclusions： Electroacupuncture treatment at the acupoint HT 5 has modulation effect on typical language-implicated brain regions in healthy subjects, which provides supporting evidence for beneficial effects of needling at HT 5 for recovery of language function in aphasia.