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Major Clinical Features and Epidemic Characteristics of Erosive Vulvar Lichen Planus:A Retrospective Analysis

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International Journal of Dermatology and Venereology 2024年第2期7卷 94-98页

作者： Ya-Kun Shao Kai-Lyu Sun Min yang wan Liu Yu Fu Jian-Min Chang Department of Dermatology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

Objective:Vulvar lichen planus(VLP),especially erosive VLP(EVLP),seriously affects women’s physiological function and quality of life.A retrospective analysis of erosive vulvar lichen planus(EVLP)was performed to raise awareness on this chronic,deforming,and painful vulvar ***:This observational retrospective study involved 40 patients with EVLP among 1,368 patients with vulvar disease from 2017 to *** patients’vulvar clinical features and extravulvar mucosal involvement were *** patients’pain and quality of life were evaluated with the numeric rating scale and the Dermatology Life Quality Index(DLQI),*** characteristics were reported using frequencies and proportions for categorical *** variables are expressed as mean±standard *** association between NRS score for pain and DLQI score was analyzed by Pearson’s correlation ***:EVLP accounted for 2.9%(40/1,368)of all cases of vulvar disease,and the median age at onset was 42 *** mostly occurred on the labia minora and ***(20/40)of the patients had extravulvar mucosal ***(42.5%)patients had oral lichen planus,and seven(17.5%)patients were diagnosed with vulvovaginal-gingival *** numeric rating scale score showed that 47.5%(19/40)of patients experienced mild pain,whereas 12.5%(5/40)described the pain as ***-one patients(77.5%,31/40)had dyspareunia,and nine patients had aggravated pain after sexual *** mean DLQI score was 9.1±6.0,with 37.5%(15/40)of patients indicating that EVLP had severely affected their *** numeric rating scale score for pain was significantly correlated with the DLQI score(P=0.007).Conclusion:EVLP can affect the quality of women’s lives and cause severe deformations and painful architectural *** description of the characteristics of EVLP in this report will benefit the diagnosis and early treatment of this disease.

关键词： erosive vulvar lichen planus multiple mucosal involvement pain assessment quality of life Dermatology Life Quality Index numeric rating scale

A Spleen Tyrosine Kinase’s Sky in Neuronal Degeneration

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Neuroscience Bulletin 2024年第2期40卷 273-276页

作者： wan-Yun Zhang Sen Lin Department of Neurology Xinqiao HospitalThe Second Afliated HospitalArmy Medical UniversityChongqing 400042China Chongqing Institute for Brain and Intelligence Guangyang Bay LaboratoryChongqing 400064China

With the growing elderly population,neurodegenerative disorders like Alzheimer's disease(AD)are emerging as a significant public health *** is widely acknowledged in the scientific community that the accumulation of neurotoxic aggregates,such as amyloid beta(Aβ),within the central nervous system is a major factor in the development of these ***,human genome-wide association studies have identified mutations in microglial receptors that may be linked to a number of neurodegenerative diseases[1].

关键词： Aβ Spleen Alzheimer

Growth of RB Population in the Conversion Phase of Chlamydia Life Cycle

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Communications on Applied Mathematics and Computation 2024年第1期6卷 90-112页

作者： Frederic Y.M.wan Department of Mathematics University of CaliforniaIrvineCA92697-3875USA

Upon infecting a host cell,the reticulate body(RB)form of the Chlamydia bacteria simply proliferates by binary fission for an extended *** data show only RB units in the infected cells 20 hours post infection(hpi),spanning nearly half way through the development *** data collected every 4 hpi,conversion to the elementary body(EB)form begins abruptly at a rapid rate sometime around 24 *** modeling proliferation and conversion as simple birth and death processes,it has been shown that the optimal strategy for maximizing the total(mean)EB population at host cell lysis time is a bang-bang control qualitatively replicating the observed conversion ***,the simple birth and death model for the RB proliferation and conversion to EB deviates in a significant way from the available data on the evolution of the RB population after the onset of RB-to-EB *** working with a more refined model that takes into account a small size threshold eligibility requirement for conversion noted in the available data,we succeed in removing the deficiency of the previous models on the evolution of the RB population without affecting the optimal bang-bang conversion strategy.

关键词： Chlamydia Life cycle Optimal control Maximal infectious spread Specie competitive survival

Synthesis of Diverse Oxetane Amino Acids via Visible-Light-Induced Photocatalytic Decarboxylative Giese-Type Reaction

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Chinese Journal of Chemistry 2024年第12期42卷 1341-1346页

作者： Haoliang Shi Yi wan Yongqiang Zhang Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism Shanghai Key Laboratory of New Drug Designand School of PharmacyEast China University of Science and TechnologyShanghai200237 China

The divergent synthesis of versatile 3,3′-disubstituted oxetane amino acids by utilizing visible-light-induced photocatalytic decarboxylative Giese-type reaction has been demonstrated.3-Methyleneoxetane-derived substrates are readily available in a single-step and highly reactive as radical acceptors,allowing the production of versatile oxetaneγ-andα-amino acids in high yields.A distinct ring strain release-driven radical addition mechanism was preliminarily *** preparative power was further highlighted by the application in the synthesis of oxetane-containing dipeptides and azetidine amino acids,as well as the transformation of the product into novel oxetane-containing spiro-heterocycle pharmacophore.

关键词： Photoredox catalysis Decarboxylative Giese-type reaction Oxetane amino acids Amino acids Synthesis Radical reactions

差别对待与人才工作幸福感:组织自尊和绩效压力感的中介及年龄差异

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中国临床心理学杂志 2022年第5期30卷 1068-1073页

作者：阳毅万杨王璇湖南师范大学商学院长沙410081 湖南航天机电设备与特种材料研究所长沙410221

目的:探讨组织差别对待与人才工作幸福感的关系,以及组织自尊和绩效压力感的中介作用及年龄差异。方法:以工作满意度和情绪耗竭衡量工作幸福感,对22家企业的人才进行网络问卷调查,获得293份有效数据。结果:①差别对待与工作满意度和情... 详细信息

目的:探讨组织差别对待与人才工作幸福感的关系,以及组织自尊和绩效压力感的中介作用及年龄差异。方法:以工作满意度和情绪耗竭衡量工作幸福感,对22家企业的人才进行网络问卷调查,获得293份有效数据。结果:①差别对待与工作满意度和情绪耗竭显著正相关;②组织自尊和绩效压力感的中介效应显著,且中介效应之间的差异显著;③低年龄组中,差别对待对绩效压力感的影响显著;④高年龄组中,差别对待对组织自尊的影响显著。结论:对于人才的工作幸福感而言,差别对待经由组织自尊和绩效压力感产生“双刃剑”效应。差别对待的工作满意度提升效应大于削弱效应,年长人才对差别对待的反应更加积极。

关键词：差别对待工作幸福感组织自尊绩效压力感年龄

Predicting Traffic Flow Using Dynamic Spatial-Temporal Graph Convolution Networks

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Computers, Materials & Continua 2024年第3期78卷 4343-4361页

作者： Yunchang Liu Fei wan Chengwu Liang School of Computer and Data Science Henan University of Urban ConstructionPingdingshan467036China School of Electrical and Control Engineering Henan University of Urban ConstructionPingdingshan467036China

Traffic flow prediction plays a key role in the construction of intelligent transportation ***,due to its complex spatio-temporal dependence and its uncertainty,the research becomes very *** of the existing studies are based on graph neural networks that model traffic flow graphs and try to use fixed graph structure to deal with the relationship between ***,due to the time-varying spatial correlation of the traffic network,there is no fixed node relationship,and these methods cannot effectively integrate the temporal and spatial *** paper proposes a novel temporal-spatial dynamic graph convolutional network(TSADGCN).The dynamic time warping algorithm(DTW)is introduced to calculate the similarity of traffic flow sequence among network nodes in the time dimension,and the spatiotemporal graph of traffic flow is constructed to capture the spatiotemporal characteristics and dependencies of traffic *** combining graph attention network and time attention network,a spatiotemporal convolution block is constructed to capture spatiotemporal characteristics of traffic *** on open data sets PEMSD4 and PEMSD8 show that TSADGCN has higher prediction accuracy than well-known traffic flow prediction algorithms.

关键词： Intelligent transportation graph convolutional network traffic flow DTW algorithm attention mechanism

Hollow Multi-shelled Structure Photoelectric Materials: Multiple Shells Bring Novel Properties

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Chemical Research in Chinese Universities 2024年第3期40卷 413-427页

作者： SU Fengmei wan Jiawei wanG Dan State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese AcademyofSciencesBeijing 100049P.R.China

Hollow multi-shelled structures(HoMSs)have made significant strides across a wide spectrum of scientific investigations since the inception of the sequential templating approach(STA)in 2009,revealing distinctive temporal-spatial ordering *** recent establishment of a mathematical model for STA has not only demystified the formation of concentration waves within the STA process but also extended its relevance to gentler solutionbased systems,thereby broadening the HoMs ***,focusing on photoelectric applications,this review first summarizes the unique temporal-spatial ordering features of ***,the greatly enhanced properties of light capture and absorption,exciton separation,and transfer are deeply ***,we conclude with a perspective on the potential challenges and burgeoning opportunities that lie ahead in the advancement of HoMs development.

关键词： Hollow multi-shelled structure Photoelectric conversion Sequential templating approach Light absorption Chargetransfer

高雄激素血症对PCOS患者新鲜周期胚胎移植妊娠结局的影响

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中华生殖与避孕杂志 2023年第6期43卷 606-611页

作者：李卓杨纨杨蕊李蓉北京大学第三医院妇产科生殖医学中心北京100191

目的:探究高雄激素血症对多囊卵巢综合征(polycystic ovarian syndrome,PCOS)患者进行新鲜周期移植后妊娠结局的影响。方法:回顾性队列研究分析2015年1月至2019年12月期间在北京大学第三医院妇产科生殖医学中心进行新鲜胚胎移植助孕的87... 详细信息

目的:探究高雄激素血症对多囊卵巢综合征(polycystic ovarian syndrome,PCOS)患者进行新鲜周期移植后妊娠结局的影响。方法:回顾性队列研究分析2015年1月至2019年12月期间在北京大学第三医院妇产科生殖医学中心进行新鲜胚胎移植助孕的876例PCOS患者的临床资料,根据助孕治疗前血清雄激素水平是否升高(血清睾酮≥2.53 nmol/L或/和雄烯二酮≥11.5 nmol/L)分为高雄激素组(n=274)及非高雄激素组(n=602),比较两组患者妊娠结局,观察高雄激素血症对早期流产及早产妊娠结局的影响。结果:高雄激素组患者年龄[(30.23±3.63)岁]、体质量指数[(25.66±4.16)kg/m 2]、黄体生成素/卵泡刺激素水平(1.38±0.95)与非高雄激素组患者[(31.22±3.76)岁,P<0.001;(24.45±4.06)kg/m 2,P<0.001;0.99±2.06,P=0.004]相比,差异均有统计学意义。高雄激素组早期流产率[28.8%(79/274)]、早产率19.6%(32/163)与非高雄激素组[18.8%(113/602),P=0.001;8.9%(41/459),P<0.001]相比明显升高,活产率59.5%(163/274)比非高雄激素组[76.2%(459/602),P<0.001]明显下降。多因素分析调整混杂因素后结果仍具有统计学意义,高雄激素组患者活产率明显下降(a OR=2.248,95%CI:1.641~3.080),早期流产风险(a OR=1.869,95%CI:1.329~2.630)、早产风险(a OR=0.403,95%CI:0.240~0.675)明显增加。高雄激素是早期流产、活产和早产的独立影响因素。结论:高雄激素血症增加PCOS患者辅助生殖助孕后早期流产及早产风险,降低活产率。

关键词：高雄激素血症多囊卵巢综合征胚胎移植早期流产早产活产

Elucidating the structure-activity relationship of Cu-Ag bimetallic catalysts for electrochemical CO_(2) reduction

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Journal of Energy Chemistry 2024年第6期93卷 345-351,I0009页

作者： Qining Huang Lili wan Qingxuan Ren Jingshan Luo Institute of Photoelectronic Thin Film Devices and Technology State Key Laboratory of Photovoltaic Materials and CellsKey Laboratory of Photoelectronic Thin Film Devices and Technology of TianjinMinistry of Education Engineering Research Center of Thin Film Photoelectronic TechnologyNankai UniversityTianjin 300350China Frontiers Science Center for New Organic Matter Nankai UniversityTianjin 300071China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China

Developing bimetallic catalysts is an effective strategy for enhancing the activity and selectivity of electrochemical CO_(2) reduction reactions,where understanding the structure-activity relationship is essential for catalyst ***,we prepared two Cu-Ag bimetallic catalysts with Ag nanoparticles attached to the top or the bottom of Cu *** tested in a flow cell,the Cu-Ag catalyst with Ag nanoparticles on the bottom achieved a faradaic efficiency of 54%for ethylene production,much higher than the catalyst with Ag nanoparticles on the *** catalysts were further studied in the H-cell and zero-gap MEA *** was found that placing the two metals in the intensified reaction zone is crucial to triggering the tandem reaction of bimetallic *** work elucidates the structure-activity relationship of bimetallic catalysts for CO_(2) reduction and demonstrates the importance of considering both catalyst structures and cell characteristics to achieve high activity and selectivity.

关键词： Electrochemical CO_(2)reduction Bimetallic catalyst Cu-Ag Structure-activity relationship