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Science China Chemistry 2010年第6期53卷 1371-1377页

作者： yang tao,jiang chen,zhang wei & jiao kui key laboratory of eco-chemical engineering,ministry of education College of Chemistry and Molecular engineering,Qingdao University of Science and Technology,Qingdao 266042,China key laboratory of eco-chemical engineering Ministry of Education College of Chemistry and Molecular engineering Qingdao University of Science and Technology Qingdao China

A sensitive label-free DNA hybridization biosensing platform was fabricated based on the synergistic effect of polyaniline nanotubes (PANInt) and poly-L-lysine (pLys).The composite of pLys and PANInt was coated onto the carbon paste electrode (CPE) to form a uniform and very stable nanocomposite *** pLys in the composite film not only acts as a membrane to retain good electron transfer capability of PANInt even at physiological pH,but also possesses fine biocompatibility for *** probes with negatively charged phosphate groups were readily linked to the positively charged pLys surface due to the strong electrostatic *** synergistic effect of PANInt and pLys could significantly enhance the sensitivity of DNA hybridization *** phosphinothricin acetyltransferase (PAT) gene fragment from transgenic corn and the polymerase chain reaction amplification of the terminator of nopaline synthase gene from the real sample of a kind of transgenic soybean were detected by this DNA electrochemical biosensor via label-free impedance *** stable composite gives convenient permselectivity properties as a transducer material for the design of modern electrochemical impedance biosensor using [Fe(CN)6]3-/4as an indicator.

关键词： poly-L-lysine polyaniline nanotubes DNA electrochemical biosensor PAT gene NOS gene

Coupling analysis method of grouting construction with deformation response of adjacent existing tunnel

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Underground Space 2024年第2期15卷 312-330页

作者： Ping-wei jiang Zhi-hong zhang Hong Zheng Jin-kun Huang key laboratory of Urban Security and Disaster engineering of China ministry of education Beijing University of TechnologyBeijing 100124China China MCC17 Group Co.LTD MaanshanAnhui 243000China School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China

In the new tunnel under close distance through the existing tunnel risk source,the grouting scheme developed to compensate for stratum losses is still based on empirical methods,relying on the overburden thickness of existing *** can potentially lead to an excessively high or low probability of uplift of existing *** a coupled deformation analysis method between the grouting construction and adjacent existing tunnels is of great theoretical significance for developing grouting *** order to reasonably limit the design parameters of grouting construction,based on the theory of fluid–solid coupling elastic pore-column expansion and the theory of random media,the calculation method of stratum displacement which simultaneously considers the coexistence of grout compaction expansion and permeability diffusion mode is derived,and the accuracy of the calculation method is verified by engineering *** accuracy of this calculation method was verified through engineering *** with the deformation coordination condition,the existing tunnel is regarded as an elastic Euler-Bernoulli continuous beam,and the finite element coupling balance equation of the interaction between the existing tunnel and the surrounding soil is *** on this,a coupling calculation model of the grouting construction and the deformation response of the adjacent existing tunnel is *** with three times of grouting construction examples in the shield tunneling project of Beijing Metro Line 12 under the existing airport line,the reliability of the coupling calculation model to determine the grouting construction parameters is *** calculation parameters in the coupling calculation model have clear physical meanings,which can provide a theoretical basis for the grouting design of similar risk source projects.

关键词： Grouting Close-range underpass Tunnel Random medium theory Euler-Bernoulli continuous beam

Frontiers in high entropy alloys and high entropy functional materials

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Rare Metals 2024年第10期43卷 4639-4776页

作者： Wen-tao zhang Wen Huang Fu-Jie Yu Qi Zhao Xin-Dong Zhu tao Feng Yao jiang Xiao-Ming Li Xue-Fei Miao He Zhu Si Lan Xue-Qian Wang Bao-Long Shen Zhe Jia Feng-Qi zhang wei Wang Qi Liu yang Ren Xun-Li Wang Xiao-Ya Cui Xiao-yang Wang Ya-Nan chen Bing-Bing Fan Meng-Ru Li Qi-Long Gao Jia-Ming Guo Zeng-Bao jiao Zhi-Min Guo Yu-Ping Zhao Qian Yu Rui Huang Ling-Kun zhang Yi-Ping Lu Xu-Bo Li Huai-Jun Lin Yan Ma wei-Ming yang Zhi-Hua Shen Hai-Yan He Yong-Gang Sun Yong-jiang Huang De-Zhuang Wang Qing-Feng Liu Fei-yang Wang Hui Liu Hong-Hui Wu Li-Qiang Wang yang Lu Nan Wang Tian-Li Wang wei-Bing Liao Yi-Han Wang Yuan Wu Yu-Zhen Yin Jie Pan Yi zhang Qing Wang Jian-yang zhang tao yang Yasir Sohail Jin-Yu zhang Hua Ji Qiang Li wei-Di Liu Zhi-Gang chen Xiong-Jun Liu Wen Ma Liang Mao Zhen-Duo Wu School of Materials Science and engineering Nanjing University of Science and Technology jiangsu key laboratory for Advanced Metallic Materials School of Materials Science and Engineering Southeast University Department of Physics City University of Hong Kong School of Materials Science and engineering Tianjin University School of Physics and Microelectronics Zhengzhou University Department of Mechanical engineering Research Institute for Advanced Manufacturing The Hong Kong Polytechnic University Center of Electron Microscopy and State key laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University key laboratory of Solidification Control and Digital Preparation Technology (Liaoning Province) School of Materials Science and Engineering Dalian University of Technology Institute of Advanced Wear & Corrosion Resistance and Functional Materials Jinan University School of Mechanics and Civil engineering China University of Mining and Technology School of Physical Sciences Great Bay University School of Materials Science andengineering Harbin Institute of Technology State key laboratory of Materials-Oriented chemical engineering College of Chemical Engineering Nanjing Tech University Beijing Advanced Innovation Center for Materials Genome engineering Research Institute for Carbon Neutrality University of Science and Technology Beijing Department of Mechanical engineering The University of Hong Kong School of Computing Macquarie University key laboratory of Optoelectronic Devices and Systems of ministry of education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University State key laboratory for Advanced Metals and Materials University of Science and Technology Beijing State key laboratory of Materials Processing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Institute of materials Shanghai University Department of Materials Science and engineering C

Owing to their exceptional properties, high-entropy alloys(HEAs) and high-entropy materials have emerged as promising research areas and shown diverse applications. Here,the recent advances in the field are comprehensively reviewed,organized into five sections. The first section introduces the background of HEAs, covering their definition, significance,application prospects, basic properties, design principles, and microstructure. The subsequent section focuses on cutting-edge high-entropy structural materials, highlighting developments such as nanostructured alloys, grain boundary engineering,eutectic systems, cryogenic alloys, thin films, micro-nano-lattice structures, additive manufacturing, high entropy metallic glasses, nano-precipitate strengthened alloys, composition modulation, alloy fibers, and refractory systems. In the following section, the emphasis shifts to functional materials, exploring HEAs as catalysts, magneto-caloric materials, corrosion-resistant alloys, radiation-resistant alloys, hydrogen storage systems, and materials for biomedicine. Additionally, the review encompasses functional high-entropy materials outside the realm of alloys, including thermoelectric, quantum dots, nanooxide catalysts, energy storage materials, negative thermal expansion ceramics,and high-entropy wave absorption materials. The paper concludes with an outlook, discussing future directions and potential growth areas in the field. Through this comprehensive review,researchers, engineers, and scientists may gain valuable insights into the recent progress and opportunities for further exploration in the exciting domains of high-entropy alloys and functional materials.

关键词： Cutting-edge structural materials Cutting-edgefunctional materials High entropy alloys

Surface engineering on MnO_(2)nanorods by La single atoms to accelerate oxygen reduction kinetics

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Rare Metals 2024年第9期43卷 4302-4311页

作者： zhang-Long He Liu-Qi Wang Min jiang Jia-Nan Xie Shan Liu Jin-Can Ren Rui Sun Wen-Bin Lv wei-Bin Guo Yu-Ling Liu Bing Li Qi Liu Hao He School of Materials Science and engineering Changsha University of Science and TechnologyChangsha 410000China School of Materials Science and engineering Nanjing University of Science and TechnologyNanjing 210094China School of Materials Science and engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Physics City University of Hong KongHong Kong 999077China

Surface engineering,which modulates the electronic structure and adsorption/desorption properties of electrocatalysts,is one of the key strategies for improving the catalytic ***,we demonstrate a facile solid-phase reaction for surface engineering of MnO_(2)to boost the oxygen reduction *** reaction with surface hydroxy groups,La single atoms with loading amount up to 2.7 wt%are anchored onto a-MnO_(2)*** surface engineering,the oxygen reduction reaction(ORR)kinetics is significantly improved with the half-wave potential from 0.70 to 0.84 V,the number of transferred electrons from 2.5 to 3.9 and the limiting current density from 4.8 to 6.0 mA·cm^(-2).In addition,the catalyst delivers superior discharge performance in both alkaline and neutral metal–air *** functional theory(DFT)calculations reveal that atomic La modulates the surface electronic configuration of MnO_(2),reduces its d-band center and thus lowers the OOH*and O*reaction energy *** work provides a new route for rational design of highly active electrocatalyst and holds great potential for application in various catalytic reactions.

关键词： Surface engineering Single atoms Electron injection Oxygen reduction reaction Metal-air batteries

Electrochemical biosensing for dsDNA damage induced by PbSe quantum dots under UV irradiation

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Chinese chemical Letters 2010年第6期21卷 716-719页

作者： Chuan Xia Yin tao yang wei zhang Xiao Dong Zhou kui jiao key laboratory of eco-chemical engineering Ministry of EducationCollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China

An electrochemical sensor for the detection of the natural double-stranded DNA(dsDNA) damage induced by PbSe quantum dots(QDs) under UV irradiation was *** biosensing membranes were prepared by successively assembling 3- mercaptopropionic acid,polycationic poly(diallyldimethyl ammonium) and dsDNA on the surface of the gold *** of dsDNA was fulfilled by immersing the sensing membrane electrode in PbSe QDs suspension and illuminating it with an UV lamp. Cyclic voltammetry was utilized to detect dsDNA damage with Co(phen)_3^(3+) as the electroactive *** UV irradiation,Pb^(2+) ions liberated from the PbSe QDs under the UV irradiation and the reactive oxygen species(ROS) generated in the presence of the PbSe QDs also under the UV irradiation were the three factors of inducing the dsDNA *** synergistic effect of the three factors might dramatically enhance the damage of *** electrochemical sensor provided a simple method for detecting DNA damage,and may be used for investigating the DNA damage induced by other QDs.

关键词： PbSe QDs dsDNA damage UV irradiation Co(phen)33+ ROS

Direct electrocatalytic reduction of p-nitrophenol at room temperature ionic liquid modified electrode

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Chinese chemical Letters 2008年第10期19卷 1156-1158页

作者： wei Sun Mao Xia yang Qiang jiang kui jiao College of Chemistry and Molecular engineering Key Laboratory of Eco-Chemical Engineering of Ministry of Education Qingdao University of Science and Technology Qingdao 266042 PR China

Direct electrochemical reduction ofp-nitrophenol （PNP） was investigated on a room temperature ionic liquid N-butylpyridinium hexafluorophosphate （BPPF6） modified carbon paste electrode （CILE）. The cathodic peak potential was positively shifted and the peak currents were increased compared to that obtained on traditional carbon paste electrode （CPE）. The results indicated that the presence of ionic liquid BPPF6 on the electrode surface showed excellent catalytic ability to the electrochemical reduction of PNP. The electrochemical behaviors of PNP on the CILE were investigated by cyclic voltammetry and the conditions such as the scan rate, the buffer pH, the substrate concentration were optimized. The electrochemical parameters were further calculated with the results of the electron transfer number （n）, the charge-transfer coefficient （α） and the surface concentration （Гr） as 1.76, 0.37 and 2.47 × 10^-9 mol/cm^2, respectively, for the selected reductive peak. The results indicated that PNP showed an irreversible adsorption-controlled electrode process on the CILE.

关键词： N-Butylpyridinium hexafluorophosphate Ionic liquid p-Nitrophenol Cyclic voltammetry Electrocatalysis

Study of tree shrew biology and models: A booming and prosperous field for biomedical research

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Zoological Research 2024年第4期45卷 877-909页

作者： Yong-Gang Yao Li Lu Rong-Jun Ni Rui Bi Ceshi chen Jia-Qi chen Eberhard Fuchs Marina Gorbatyuk Hao Lei Hongli Li Chunyu Liu Long-Bao Lv Kyoko Tsukiyama-Kohara Michinori Kohara Claudia Perez-Cruz Gregor Rainer Bao-Ci Shan Fang Shen An-Zhou Tang Jing Wang wei Xia Xueshan Xia Ling Xu Dandan Yu Feng zhang Ping Zheng Yong-Tang Zheng Jumin Zhou jiang-Ning Zhou key laboratory of Genetic Evolution and Animal Models Yunnan Key Laboratory of Animal Models and Human Disease MechanismsKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility) and National Resource Center for Non-Human PrimatesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China KIZ-CUHK Joint laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China Mental Health Center and Psychiatric laboratory West China HospitalSichuan UniversityChengduSichuan 610041China Sichuan Clinical Medical Research Center for Mental Disorders ChengduSichuan 610044China German Primate Center Leibniz Institute of Primate ResearchGöttingen 37077Germany Department of Optometry and Vision Science School of OptometryUniversity of Alabama at BirminghamBirminghamAL 35294USA State key laboratory of Magnetic Resonance and Atomic and Molecular Physics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhanHubei 430071China Wuhan National laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanHubei 430074China Soong Ching Ling Institute of Maternity and Child Health International Peace Maternity and Child Health HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Transboundary Animal Diseases Center Joint Faculty of Veterinary MedicineKagoshima UniversityKagoshima-cityKagoshima 890-8580Japan Department of Microbiology and Cell Biology Tokyo Metropolitan Institute of Medical ScienceTokyo 156-8506Japan Pharmacology Department CinvestavMexico City 07360Mexico Department of Medicine University of FribourgFribourg CH-1700Switzerland Beijing engineering Research Center of Radiog

The tree shrew(Tupaia belangeri)has long been proposed as a suitable alternative to non-human primates(NHPs)in biomedical and laboratory research due to its close evolutionary relationship with *** recent years,significant advances have facilitated tree shrew studies,including the determination of the tree shrew genome,genetic manipulation using spermatogonial stem cells,viral vector-mediated gene delivery,and mapping of the tree shrew brain ***,the limited availability of tree shrews globally remains a substantial challenge in the ***,determining the key questions best answered using tree shrews constitutes another *** shrew models have historically been used to study hepatitis B virus(HBV)and hepatitis C virus(HCV)infection,myopia,and psychosocial stress-induced depression,with more recent studies focusing on developing animal models for infectious and neurodegenerative *** these efforts,the impact of tree shrew models has not yet matched that of rodent or NHP models in biomedical *** review summarizes the prominent advancements in tree shrew research and reflects on the key biological questions addressed using this *** emphasize that intensive dedication and robust international collaboration are essential for achieving breakthroughs in tree shrew *** use of tree shrews as a unique resource is expected to gain considerable attention with the application of advanced techniques and the development of viable animal models,meeting the increasing demands of life science and biomedical research.

关键词： Tree shrew Animal model Neurodegenerative diseases Infectious diseases Neuroscience Phenome

Searching for^(76)Ge neutrinoless double beta decay with the CDEX-1B experiment

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Chinese Physics C 2024年第10期48卷 11-22页

作者： Bing-tao zhang Jun-Zheng Wang Li-tao yang Qian Yue Ke-Jun Kang Yuan-Jing Li Hai-Peng An C.Greeshma Jian-Ping Chang Yun-Huan chen Jian-Ping cheng Wen-Han Dai Zhi Deng Chang-Hao Fang Xin-Ping Geng Hui Gong Qiu-Ju Guo Xu-Yuan Guo Li He Sheng-Ming He Jin-wei Hu Han-Xiong Huang Tu-chen Huang Hai-tao Jia Xi jiang S.Karmakar Hao-Bin Li Jian-Min Li Jin Li Qian-Yun Li Ren-Ming-Jie Li Xue-Qian Li Yu-Lan Li Yi-Fan Liang Bin Liao Fong-Kay Lin Shin-Ted Lin Jia-Xuan Liu Shu-kui Liu Yan-Dong Liu Yu Liu Yuan-Yuan Liu Zhong-Zhi Liu Hao Ma Yu-Cai Mao Qi-Yuan Nie Jin-Hua Ning Hui Pan Ning-Chun Qi Jie Ren Xi-Chao Ruan Ze She Manoj Kumar Singh Tian-Xi Sun Chang-Jian Tang wei-You Tang yang Tian Guang-Fu Wang Li Wang Qing Wang Yu-Feng Wang Yun-Xiang Wang Henry-Tsz-King Wong Shi-Yong Wu Yu-cheng Wu Hao-yang Xing Rui Xu Yin Xu tao Xue Yu-Lu Yan Nan Yi Chun-Xu Yu Hai-Jun Yu Jian-Feng Yue Ming Zeng Zhi Zeng Feng-Shou zhang Lei zhang Zhen-Hua zhang Zhen-Yu zhang Kang-Kang Zhao Ming-Gang Zhao Ji-Fang Zhou Zu-Ying Zhou Jing-Jun Zhou key laboratory of Particle and Radiation Imaging(ministry of education)and Department of engineering Physics Tsinghua UniversityBeijing 100084 Department of Physics Tsinghua UniversityBeijing 100084 Institute of Physics Academia SinicaTaipei 11529 NUCTECH Company Beijing 100084 YaLong River Hydropower Development Company Chengdu 610051 College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875 College of Physics Sichuan UniversityChengdu 610065 School of Physics Peking UniversityBeijing 100871 Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413 Sino-French Institute of Nuclear and Technology Sun Yat-sen UniversityZhuhai 519082 School of Physics Nankai UniversityTianjin 300071 Department of Physics Banaras Hindu UniversityVaranasi 221005 Department of Physics Beijing Normal UniversityBeijing 100875

We operated a p-type point contact high purity germanium(PPCGe)detector(CDEX-1B,1.008 kg)in the China Jinping Underground laboratory(CJPL)for 500.3 days to search for neutrinoless double beta(0νββ)decay of^(76)Ge.A total of 504.3 kg⋅day effective exposure data was *** anti-coincidence and the multi/single-site event(MSE/SSE)discrimination methods were used to suppress the background in the energy region of interest(ROI,1989–2089 keV for this work)with a factor of 23.A background level of 0.33 counts/(keV⋅kg⋅yr)was *** lower limit on the half life of^(76)Ge 0νββdecay was constrained as T_(1/2)^(0ν)>1.0×10^(23)yr(90%C.L.),corresponding to the upper limits on the effective Majorana neutrino mass:<3.2–7.5 eV.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector ^(76)Ge

Aldh2 deficiency plays a dual role in lung tumorigenesis and tumor progression

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Genes & Diseases 2024年第3期11卷 144-147页

作者： Hongjia zhang Xueqian Sun Zhanming Li Tingting Liu Fang zhang Xinyu Meng Kaimi Li Jianhua Xu wei He Bo Jing Tong Wang Na Ni Beibei Sun Feng Yao Yadi Wu Qi Wang Jing Du Eugene Y.Chin Binhua P.Zhou Ping jiang Lishun Wang Jiong Deng key laboratory of Cell Differentiation and Apoptosis of Chinese Minister of education Department of PathophysiologyShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai key laboratory for Tumor Microenvironment and Inflammation Shanghai Jiao Tong University School of MedicineShanghai200025China Department of Pathology Kunming Medical UniversityKunmingYunnan 650500China Medical Research Center Binzhou Medical University HospitalBinzhouShandong 256600China Center for Traditional Chinese Medicine and Gut Microbiota Minhang HospitalFudan UniversityShanghai 201100China Department of Radiation Oncology Yantai Affiliated Hospital of Binzhou Medical UniversityYantaiShandong 264100China Department of Pathology Molecular Pathology Research CenterPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of laboratory Medicine Shanghai Pulmonary Hospital Affiliated Tongji UniversityShanghai 200080China Department of Physiology School of Basic Medical SciencesWeifang Medical UniversityWeifangShandong 261021China Department of Thoracic Surgery Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China Department of Molecular and Celular Biochemistry Markey Cancer CenterUniversity of Kentucky College of MedicineLexingtonKY40506USA Department of Respiratory Medicine The Second Affiliated HospitalDalian Medical UniversityDalianLiaoning116023China Peninsular Cancer Center Binzhou Medical UniversityYantaiShandong 264003China

Alcohol consumption contributes to global mortality and cancer ***(ACE),the oxidized metabolite of alcohol,is highly reactive towards DNA,resulting in DNA *** can be detoxified to acetate by acetaldehyde dehydrogenase... 详细信息

关键词： mortality damage ALDH2

Simultaneous electrochemical DNA hybridization assay for PAT and FMV 35S gene sequence using quantum dots as labels

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Chinese chemical Letters 2008年第10期19卷 1244-1247页

作者： jiang Hua Zhong Peng Qin wei Sun kui jiao College of Chemistry and Molecular engineering Key Laboratory of Eco-Chemical Engineering of Ministry of Education Qingdao University of Science and Technology Qingdao 266042 China

An electrochemical method for the simultaneous detection of two different DNA sequences from PAT and FMV 35S gene sequence using CdS and PbS quantum dots （QDs） as labels was described. The QDs were readily functionalized with oligonucleotides as electrochemical DNA probes and selectively hybridized to the complementary sequences immobilized on the microplate. The QDs anchored on the hybrids were dissolved in the solution by the oxidation of HNO3 and further detected by a sensitive differential pulse anodic stripping voltammetric method （DPASV）. The DPASV signals of the oxidation of Cd^2＋ and Pb^2＋ ions present in the solution were different and reflected the identity of corresponding ssDNA targets sequences.

关键词： Electrochemical DNA assay Quantum dots Differential pulse anodic stripping voltammetry Microplate Simultaneous detection