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Pathogenicity of Trichosporon asahii in a murine model of disseminated trichosporonosis

Chinese Medical Journal 2008年第24期121卷 2557-2560页

作者： yang rong-ya wang wen-ling ao jun-hong hao zhen-feng zhang jie wang cong-min Department of Dermatology General Hospital of Beijing Military Region of PLA Beijing 100700 China

Background In recent years, superficial and deep mycoses caused by trichosporon were occasionally reported. In 2001, we reported the first case of disseminated trichosporonosis caused by Trichosporon asahfi （T. asahii） in China. In this study, the pathogenicity of T. asahii was investigated in a murine model of disseminated trichosporonosis. Methods Seventy-five mice were randomly divided into 7 groups. Each group was inoculated with T. asahii, through intradermal, gastrointestinal tract or intravenous injection. The mice in the experimental groups were given an intraperitoneal injection of cyclophosphamide （CY） to induce granulocytopenia. Mice in the therapeutic group were given both liposomal amphotericin B and fluconazole. The main viscera of the mice were examined by means of tissue culture and pathologic sections. Results In the two intravenous inoculation groups, T. asahfi was isolated from at least one organ in 10 of the 12 granulocytopenic mice and 2 of the 14 immunocompetent mice. Two of the 7 mice in the granulocytopenia group presented with lesions in the inoculation position, but none of the 30 mice in the granulocytopenia and the control group which were inoculated intradermally or through the gastrointestinal tract had viscera infection. In the therapeutic group, the ratio of consequently dead mice, the number of involved viscera, and the incidence of systemic infection were significantly less than the untreated group. Acute purulent inflammation and granulomatous inflammation were the main pathological changes in the course of the infection. Arthrospores and filaments were found in the focus. Conclusions T. asahii is an opportunistic pathogen that causes cutaneous and visceral infections in immunologically impaired hosts. An immunocompetent host was to be infected by the invading T. asahii. Several organs, namely the liver, lungs, kidneys, spleen and heart, were predisposed. The therapy of combining liposomal amphotericin B with fluconazole can preven

关键词： trichosporonosis Trichosporon asahii pathogenicity

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Alcohol drinking triggered decrease of oxidative balance score is associated with high all-cause and cardiovascular mortality in hypertensive individuals:findings from NHANES 1999–2014

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Journal of Geriatric Cardiology 2024年第8期21卷 779-790页

作者： Yu-jun zhang Jing-Jing SONG Jian-hao ZHAN Chu-Lin ZHOU ao LI Mao-Qi wang Ben-jie LI cong-cong DING Yi-Wei zhang Zi-Heng TAN Zai-Hua CHENG Xiao HUANG Department of Cardiology the Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchangChina Huankui Academy Nanchang UniversityNanchangChina School of Ophthalmology and Optometry of Nanchang University NanchangChina The Second Clinical Medical College Nanchang UniversityNanchangChina Queen Mary School Nanchang UniversityNanchangChina The First Clinical Medical College Nanchang UniversityNanchangChina Department of Cardiovascular Medicine Huzhou First People’s HospitalZhejiangChina

BACKGROUND Oxidative stress is closely associated with hypertensive *** oxidative balance score(OBS)measures oxidative stress exposure from dietary and lifestyle *** objective of this study was to investigate the association between OBS and mortality in hypertensive *** This study included 7823 hypertensive patients from the National Health and Nutrition Examination Survey(NHA-NES)*** models,including Cox regression,restricted cubic splines(RCS),Kaplan-Meier survival analysis,subgroup,and sensitivity analyses,were exploited to investigate the relationship between OBS and the risk of *** Controlling for all potential confounders,a significantly inverse association was observed between elevated OBS and all-cause[hazard ratio(HR)=0.90,95%CI:0.85-0.95]and cardiovascular mortality(HR=0.85,95%CI:0.75-0.95).With adjustment for covariates,significant associations between lifestyle OBS and mortality risks diminished,whereas associations between dietary OBS and these mortality risks remained robust(all-cause mortality:HR=0.91,95%CI:0.86-0.96;cardiovascular mortality:HR=0.85,95%CI:0.76-0.96).RCS demonstrated a linear relationship between OBS and all-cause and cardiovascular mortality risk(P_(nonlinear)=0.088 and P_(nonlinear)=0.447,respectively).Kaplan-Meier curves demonstrated that the mortality rate was lower with a high OBS(P<0.001).The consistency of the association was demonstrated in subgroup and sensitivity *** after stratification showed that among current drinkers,those with higher OBS had a lower risk of mortality compared with former or never *** In hypertensive individuals,there was a negative association between OBS and all-cause and cardiovascular *** hypertensive individuals,especially those currently drinking,to maintain high levels of OBS may be beneficial in improving their prognosis.

关键词： high finding Alcohol

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10B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source

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Nuclear Science and Techniques 2024年第8期35卷 58-68页

作者： Qiang Li Li‑Jiao wang Jing‑Yu Tang Xiang‑Biao Qiu zhen Chen Mao‑Yuan Zhao Chang‑jun Ning Kai Pan Wei Xu Tao Li Su‑Peng Lu Han Yi Rui‑Rui Fan Chang‑Qing feng rong zhang Xiao‑yang Sun Qi An hao‑Fan Bai Jiang‑Bo Bai jie Bao Ping Cao Qi‑Ping Chen Yong‑hao Chen Zeng‑Qi Cui An‑Chuan Fan Fan‑zhen feng min‑hao Gu Chang‑Cai Han Zi‑jie Han Guo‑Zhu He Yong‑Cheng He yang hong Yi‑Wei Hu Han‑Xiong Huang Wei Jiang Zhi‑jie Jiang zheng‑yao Jin ling Kang Bo Li Gong Li Xiao Li yang Li jie Liu rong Liu Shu‑Bin Liu Yi‑Na Liu Guang‑Yuan Luan jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Kang Sun Zhi‑Xin Tan Sheng‑Da Tang Jin‑Cheng wang Peng‑Cheng wang Zhao‑Hui wang Zhong‑Wei wen Xiao‑Guang Wu Xuan Wu cong Xia Yong‑Ji Yu Guo‑Hui zhang Hang‑Chang zhang Lin‑hao zhang Qi‑Wei zhang Xian‑Peng zhang Yu‑Liang zhang Yue zhang Zhi‑Yong zhang Zhi‑hao Zhou Ke‑jun Zhu Chong Zou Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China North Night Vision Science and Technology(Nanjing)Research Institute Co.Ltd Nanjing 211106China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China China Academy of Engineering Physics Institute of Nuclear Physics and ChemistryMianyang 621900China USTC archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China China Shipbuilding Trading Co. LtdBeijing 100044China

Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron *** complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and ***,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above *** white neutron source(Back-n)at the China Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to ***-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low *** this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the *** heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be *** particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.

关键词： Neutron resonance imaging 10B doped MCP detector White neutron source Sample nuclide identification

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The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-Yun Zhao Shao-Lin Xiong Xiang-yang wen Xin-Qiao Li Ce Cai Shuo Xiao Qi Luo wen-Xi Peng Dong-ya Guo zheng-Hua An Ke Gong Jin-Yuan Liao yan-Qiu zhang Yue Huang Lu Li Xing wen Fei zhang Jing Duan Chen-Wei wang Dong-Li Shi Peng zhang Qi-Bin Yi Chao-yang Li yan-Bing Xu Xiao-Hua Liang ya-Qing Liu Da-Li zhang Xi-Lei Sun Fan zhang Gang Chen Huan-Yu wang Sheng yang Xiao-Jing Liu min Gao Mao-Shun Li Jin-Zhou wang Xing Zhou Yi Zhao wang-Chen Xue Chao zheng Jia-cong Liu Xing-Bo Han Jin-ling Qi Jia Huang Ke-Ke zhang Can Chen Xiong-Tao yang Dong-jie Hou Yu-Sa wang Rui Qiao Xiang Ma Xiao-Bo Li Ping wang Xin-Ying Song Li-ming Song Shi-jie zheng Bing Li hong-Mei zhang Yue Zhu Wei Chen Jian-Jian He zhen zhang Jin Hou hong-jun wang yan-Chao hao Xiang-Yu wang Zong-Yuan yang Zhi-Long wen Zhi Chang Yuan-Yuan Du Rui Gao Xiao-Fei Lan yan-Guo Li Gang Li Xu-Fang Li Fang-jun Lu hong Lu Bin Meng feng Shi Hui wang Hui-zhen wang Yu-Peng Xu Jia-Wei yang Xue-Juan yang Shuang-Nan zhang Chao-Yue zhang Cheng-Mo zhang Zhi-Cheng Tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen mingjun Chen mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti wen Han Chiu Guk Cho ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression

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Cancer Communications 2023年第9期43卷 981-1002页

作者： Lin He hao Li Can Li Ze-Kun Liu Meng Lu Ren-Yu zhang Dong Wu Ding Wei jie Shao Man Liu hao-Lin Wei cong zhang Zhe wang ling-min Kong Zhi-Nan Chen Huijie Bian National Translational Science Centre for Molecular Medicine & Department of Cell Biology Fourth Military Medical UniversityXi'anShaanxiP. R. China Department of Gastroenterology the General Hospital of Western Theatre CommandChengduSichuanP. R. China State Key Laboratory of Cancer Biology Department of PathologyXijing Hospital and School of Basic MedicineFourth Military Medical UniversityXi'anShaanxiP. R. China

Background The mechanism of hepatitis B virus(HBV)-induced carcinogenesis remains an area of *** accumulation of hepatitis B surface antigen in the endoplasmic reticulum(ER)of hepatocytes stimulates persistent ER *** of the unfolded protein response(UPR)pathway of ER stress may play an important role in inflammatory cancer *** the protective UPR pathway is hijacked by cells as a tool for malignant transformation in HBV-related hepatocellular carcinoma(HCC)is still ***,we aimed to define the key molecule hyaluronan-mediated motility receptor(HMMR)in this process and explore its role under ER stress in HCC *** An HBV-transgenic mouse model was used to characterize the pathological changes during the tumor *** and transcriptomics analyses were performed to identify the potential key molecule,screen the E3 ligase,and define the activation *** real-time PCR and Western blotting were conducted to detect the expression of genes in tissues and cell *** reporter assay,chromatin immunoprecipitation,coimmunoprecipitation,immunoprecipitation,and immunofluorescence were employed to investigate the molecular mechanisms of HMMR under ER *** was used to clarify the expression patterns of HMMR and related molecules in human *** We found sustained activation of ER stress in the HBV-transgenic mouse model of *** was transcribed by c/EBP homologous protein(CHOP)and degraded by tripartite motif containing 29(TRIM29)after ubiquitination under ER stress,which caused the inconsistent expression of mRNA and *** expression of TRIM29 in the HCC progression regulated the dynamic expression of *** could alleviate ER stress by increasing autophagic lysosome *** negative correlation between HMMR and ER stress,positive correlation between HMMR and autophagy,and negative correlation between ER stress and

关键词： autophagy endoplasmic reticulum stress hepatitis B virus hepatocellular carcinoma HMMR TRIM29 ubiquitination and proteasomal degradation

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Advances in nuclear detection and readout techniques

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Nuclear Science and Techniques 2023年第12期34卷 281-358页

作者： Rui He Xiao‑yang Niu Yi wang hong‑Wei Liang hong‑Bang Liu Ye Tian hong‑Lin zhang Chao‑jie Zou Zhi‑Yi Liu Yun‑Long zhang Hai‑Bo yang Ju Huang hong‑Kai wang Wei‑Jia Han Bei Cao Gang Chen cong Dai Li‑min Duan Rui‑Rui Fan Fang‑Fa Fu Jian‑Hua Guo Dong Han Wei Jiang Xian‑Qin Li Xin Li Zhuo‑Dai Li Yu‑Tie Liang Shun Liao De‑Xu Lin Cheng‑ming Liu Guo‑Rui Liu jun‑Tao Liu Ze Long Meng‑Chen Niu hao Qiu Hu Ran Xiang‑ming Sun Bo‑Tan wang Jia wang Jin‑Xiang wang Qi‑Lin wang Yong‑Sheng wang Xiao‑Chuan Xia hao‑Qing Xie He‑Run yang hong Yin hong Yuan Chun‑Hui zhang Rui‑Guang Zhao Ran zheng Cheng‑Xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China Key Laboratory of Particle and Radiation Imaging Department of Engineering PhysicsTsinghua UniversityBeijing 100084China School of Integrated Circuits Dalian University of TechnologyDalian 116020China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Electronic Engineering School Heilongjiang UniversityHarbin 150080China Spallation Neutron Source Science Center Dongguan 523803China Micro‑electronic Department Harbin Institute of TechnologyHarbin 150001China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210034China Liaoning Academy of Materials Shenyang 110167China Istituto Nazionale di Fisica Nucleare Sezione di PerugiaPerugiaItaly School of Mathematics and Physics Chengdu University of TechnologyChengdu 620035China PLAC Key Laboratory of Quark and Lepton Physics(MOE)Central China Normal UniversityWuhan 430079China School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710129China State Key Lab of Superhard Materials College of PhysicsJilin UniversityChangchun 130012China School of Computer Science Northwestern Polytechnical UniversityXi’an 710129China

“A Craftsman Must Sharpen His Tools to Do His Job,”said *** detection and readout techniques are the foundation of particle physics,nuclear physics,and particle astrophysics to reveal the nature of the ***,they are being increasingly used in other disciplines like nuclear power generation,life sciences,environmental sciences,medical sciences,*** article reviews the short history,recent development,and trend of nuclear detection and readout techniques,covering Semiconductor Detector,Gaseous Detector,Scintillation Detector,Cherenkov Detector,Transition Radiation Detector,and Readout *** explaining the principle and using examples,we hope to help the interested reader underst and this research field and bring exciting information to the community.

关键词： Silicon detector Wide bandgap detector Time projection chamber(TPC) Multigap resistive plate chamber detector(MRPC) Scintillation detector Calorimeters Cherenkov detector Transition radiation detector Artificial intelligence Trigger-less readout

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临床分离阿萨希毛孢子菌IGS1区克隆及RFLP分析

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中华皮肤科杂志 2008年第8期41卷 512-514页

作者：夏志宽杨蓉娅王文岭敖俊红王聪敏张洁北京军区总医院皮肤科 100026

目的明确临床分离的5株阿萨希毛孢子菌（rasahii）基因间隔区（IGS1）的序列，分析rasahfi种内基因多态性。方法用玻璃珠法分别提取临床分离5株rasahi及标准对照株总DNA，用ITS及IGS1区特异引物，PCR扩增目的区域，IGS1区扩增产物纯化... 详细信息

目的明确临床分离的5株阿萨希毛孢子菌（rasahii）基因间隔区（IGS1）的序列，分析rasahfi种内基因多态性。方法用玻璃珠法分别提取临床分离5株rasahi及标准对照株总DNA，用ITS及IGS1区特异引物，PCR扩增目的区域，IGS1区扩增产物纯化后进行克隆、测序，测序结果分别提交到基因库，获取登录号。用BLAST和CLUSTALX1．83软件对序列进行比对分析。分别用限制性内切酶HapⅡ、MboI、AluI、HhaI对ITS及IGS1区PCR产物进行酶切及RFLP分析。结果6株菌均成功扩增出长度约为540bp的ITS区及643bp的IGS1区基因片段，IGS1区序列相似性为97％～99％。RFLP分析发现，菌株BZP07003IGS1区HapⅡ酶切结果及菌株BZP07004IGSl区HhaI酶切结果与其他菌株不同，MboI及AluI酶切6株菌结果无差异，ITS区6株菌酶切结果无差异。结论rasahiiIGS1区种内存在差异。HhaI及HapⅡ可用于rasahii种内多态性的分析研究，临床分离5株菌存在3种酶切结果，初步提示rasahii临床分离株可能具有种内多态性及遗传差异。

关键词：毛孢子菌属序列分析 DNA 多态性限制性片段长度

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倒U型槽中天然气管道泄漏扩散模拟

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消防科学与技术 2019年第5期38卷 699-702页

作者：张琳邓雅军侯昊王会杰敖尚民北京石油化工学院机械工程学院深水油气管线关键技术与装备北京市重点实验室北京102617 中国石油管道局工程有限公司河北廊坊065000 佛山市华禅能燃气设计有限公司广东佛山528000

建立了商业体户内倒U型槽中天然气管道泄漏扩散的数学模型,对泄漏口向下时不同管径、泄漏口孔径和泄漏速度下天然气在倒U型槽中的扩散过程进行模拟,确定了不同条件下泄漏气体触发报警器的时间以及倒U型槽的最佳安全高度。结果表明:管径... 详细信息

建立了商业体户内倒U型槽中天然气管道泄漏扩散的数学模型,对泄漏口向下时不同管径、泄漏口孔径和泄漏速度下天然气在倒U型槽中的扩散过程进行模拟,确定了不同条件下泄漏气体触发报警器的时间以及倒U型槽的最佳安全高度。结果表明:管径对触发报警器的时间和倒U型槽的最佳安全高度几乎没有影响;泄漏速度越大,触发报警器的时间越长,倒U型槽的最佳安全高度越大;泄漏口孔径越大,触发报警器所需的时间越短,倒U型槽的最佳安全高度越大。

关键词：倒U型槽天然气泄漏数学模型扩散模拟安全防护

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Diagnosis and Treatment of Cholangiocarcinoma: A Consensus from Surgical Specialists of China

引用

Journal of Huazhong University of Science and Technology(Medical Sciences) 2014年第4期34卷 469-475页

作者： Jian-qiang Cai Shou-wang Cai wen-ming cong min-shan Chen Ping Chen Xiao-ping Chen yan-ling Chen Yi-fa Chen Chao-liu Dai Qiang Huang Zhi-yong Huang Bo Jiang Bin Jiang Ke-wei Jiang Bo Li Zong-fangLi Li-jian Liang Bin Liu Hui-chun Liu Lian-xin Liu Qing-guang Liu rong Liu Ying-bin Liu Jian-guo Lu Shi-chun Lu Yi Lu Yi-lei Mao Bin Mei jun Niu Bao-gang Peng Xiao Qin Yu-dong Qiu Guang-yi wang yao-don wangg Zhi-ming wang Ren-hua Wan ya-fu Wu Bao-cai Xing feng Xia Ge-liang Xu Jia-mei yang Xiao-fang Yu Yong Zeng Yong-yi Zeng Bi-xiang zhang Bin-hao zhang Qi-yu zhang Shui-jun zhang Wan-guang zhang Yong-jie zhang Zhi-wei zhang Dong Zhou Wei-ping Zhou Cancer Institute and Hospital Chinese Academy of Medical Sciences Chinese PLA General Hospital Eastern Hepatobiliary Surgery Hospital of Second Military Medical University Sun yat-sen University Cancer Center Daping Hospital of Third Military Medical University Tongji Hospital Tongji Medical CollegeHuazhong University of Science and Technology Fujian Medical University Union Hospital Shengjing Hospital of China Medical University Anhui Provincial Hospital Hunan Provincial People’s Hospital Taihe Hospital Affiliated to Hubei University of Medicine Peking University People’s Hospital West China Hospital Sichuan University The Second Affiliated Hospital of Xi’an Jiao Tong University The First Affiliated Hospital Sun Yat-sen University First Affiliated Hospital of Kunming Medical University The First Affiliated Hospital of Bengbu Medical College The First Affiliated Hospital of Harbin Medical University The First Affiliated Hospital of Xi’an Jiao Tong University Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Tangdu Hospital of Fourth Military Medical University Peking Union Medical College Hospital Qilu Hospital of Shandong University The First Affiliated Hospital of Guangxi Medical University Nanjing Drum Tower Hospital The First Affiliated Hospital of Jilin University Fujian Provincial Hospital Xiangya Hospital of Central South University The First Affiliated Hospital of Nanchang University Beijing Cancer Hospital Southwest Hospital of Third Military Medical University Shenzhen People’s Hospital The First Affiliated Hospital of Fujian Medical University The First Affiliated Hospital of wenzhou Medical University The First Affiliated Hospital of zhengzhou University Fujian Provincial Cancer Hospital

Cholangiocarcinoma refers to malignant tumors that develop in epithelial lining of biliary system, and it is divided into two categories according to tumor location, intrahepatic cholangiocarcinoma （ICC） and extrahepatic cholangiocarcinoma （ECC）. ICC occurs from the epithelial cells of the intrahepatic bile duct, its branches and interlobular biliary tree; and ECC is divided into hilar cholangiocarcinoma and distal cholangiocarcinoma by the circumscription at the confluence of cystic duct and the common hepatic duct.

关键词： A Consensus from Surgical Specialists of China Diagnosis and Treatment of Cholangiocarcinoma

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