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托珠单抗在儿童风湿免疫性疾病中应用的安全性研究

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中国新药与临床杂志 2024年第6期43卷 426-431页

作者：刘红霞谢婷朱彦谭波宇杨巧玲郝胜上海市儿童医院/上海交通大学医学院附属儿童医院药学部上海200062 上海市儿童医院/上海交通大学医学院附属儿童医院肾脏风湿免疫科上海200062

目的分析托珠单抗在儿童风湿免疫性疾病中应用的安全性,为临床用药提供参考。方法收集2016年1月1日—2022年8月9日使用托珠单抗治疗风湿免疫性疾病患儿的临床资料,对不良事件(AE)的发生率及影响因素、分布、发生时间和转归等进行回顾性... 详细信息

目的分析托珠单抗在儿童风湿免疫性疾病中应用的安全性,为临床用药提供参考。方法收集2016年1月1日—2022年8月9日使用托珠单抗治疗风湿免疫性疾病患儿的临床资料,对不良事件(AE)的发生率及影响因素、分布、发生时间和转归等进行回顾性分析。结果共纳入53例使用托珠单抗治疗的患儿,全身型幼年特发性关节炎48例、干燥综合征1例、自身免疫疾病(自身炎症性疾病)2例、幼年特发性关节炎(多关节型)1例。多发性大动脉炎1例,AE发生率为87%(46/53),主要AE为高甘油三酯血症(60%)、肝损伤(49%)、高胆固醇血症(30%)、高胆红素血症(8%)、中性粒细胞减少(9%)、超敏反应(8%)等。导致停药的主要AE为超敏反应,高胆固醇血症的发生与更高的给药剂量相关,肝损伤的发生与更高年龄和更高体重指数相关。AE大部分较轻,可自行恢复正常,持续用药率96%(44/46)。结论儿童使用托珠单抗治疗后相关AE发生率较高,超敏反应可导致停药,用药期间需要予以关注。虽然大部分患儿只发生轻度肝损伤,仍需警惕严重肝衰竭的发生可能。

关键词：托珠单抗安全血脂异常化学性与药物性肝损伤自身免疫疾病超敏反应

Synthesis of 11H-Indeno[1,2-b]quinolines via the Friedliinder Reaction

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Chinese Chemical Letters 2006年第2期17卷 187-190页

作者： Feng XU Ding qiao yang Kai ling JIANG Wei GUO School of Chemistry and Environment South China Normal University Guangzhou 510631

The nine new 11H-indeno[1,2-b]quinolines were synthesized in high yield with sodium ethoxide as a catalyst via the Friedlander condensation reaction, The possible reaction mechanism was proposed.

关键词： Fricdlander reaction 2-nitro-3 6-dimethoxybenzaldehyde,11H-indeno[1,2-b]quino-lines 2-amino-3,6-dimethoxybenzaldehyde.

某农药污染地块土壤异味调查评估、治理修复及效果评估

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环境生态学 2024年第7期6卷 112-117页

作者：陈敏毅王众山姚珏君赵威光史怡杨巧玲广州市环境技术中心广州市水与海洋环境监测站广东广州510235 水电水利规划设计总院北京100012 生态环境部土壤与农业农村生态环境监管技术中心北京100012

目前国内建设用地调查、风险评估、修复及效果评估主要针对人体健康,未考虑地块土壤异味的环境风险影响。本研究以某废弃农药厂为例,开展土壤异味调查评估、治理修复及效果评估工作。地块土壤主要异味物质包括乙苯、苯酚、间二甲苯、对... 详细信息

目前国内建设用地调查、风险评估、修复及效果评估主要针对人体健康,未考虑地块土壤异味的环境风险影响。本研究以某废弃农药厂为例,开展土壤异味调查评估、治理修复及效果评估工作。地块土壤主要异味物质包括乙苯、苯酚、间二甲苯、对二甲苯、苯乙烯、甲苯、邻二甲苯。基于暴露模型计算土壤异味控制值,结合土壤样品仪器分析结果,初步确定异味控制范围5 635.88 m^(2);结合土壤样品嗅觉分析结果,综合确定土壤异味控制范围6 885.80 m^(2)。修复后土壤仪器分析和嗅觉分析结果均符合控制目标,判定土壤异味修复效果评估合格。本研究形成了建设用地土壤异味调查评估、修复及效果评估方法流程,可为其他地块开展相关工作提供参考。

关键词：污染地块异味调查评估土壤修复效果评估

Structural engineering of Sb-based electrode materials to enhance advanced sodium-ion batteries

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Rare Metals 2024年第10期43卷 4777-4806页

作者： Zheng yang qiao-ling Kang Rui-Wang Li-Jing Yan Xian-He Meng Ting-Li Ma College of Materials and Chemistry Jiliang University

Antimony （Sb） is recognized as a potential electrode material for sodium-ion batteries （SIBs） due to its huge reserves,affordability,and high theoretical capacity(660 mAh·g-1).However,Sb-based materials experience significant volume expansion during cycling,leading to comminution of the active substance and limiting their practical use in ***,the volume expansion issue of Sb-based materials during charging/discharging must be solved to create high-performance *** paper presents a detailed review of structural engineering of Sb-based electrode materials,focusing on the performance effects of different kinds of structures on advanced performance ***,the future development and the challenges of Sb-based materials are *** paper can provide specific perspectives on the structure construction and optimization of Sb-based anode materials so as to promote the rapid development and practical applications of SIBs.

关键词： Sb-based electrode Sodium-ion batteries Structural engineering

Structural engineered living materials

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Nano Research 2024年第2期17卷 715-733页

作者： yang Geng Zian Jia ling Li 635 Prices Fork Road Department of Mechanical EngineeringVirginia Polytechnic Institute and State UniversityBlacksburg VA24061USA

Biological structural materials not only exhibit remarkable mechanical properties but also often embody dynamic characteristics such as environmental responsiveness,autonomy,and self-healing,which are difficult to achieve in conventional engineering *** merging materials science,synthetic biology,and other disciplines,engineered living materials(ELMs)provide a promising solution to combine living organisms with abiotic components,thus facilitating the construction of functional“living”*** natural materials,ELMs possess vitality and hold immense application potential in areas such as medicine,electronics,and construction,captivating increasing research attention *** an emerging branch of ELMs,structural ELMs aim to mimic living biological structural materials by achieving desired mechanical performance while maintaining important“living”*** we summarize the recent progress and provide our perspectives for this emerging research *** first summarize the superiority of structural ELMs by reviewing biological structural materials and biomimetic material design ***,we provide a systematic discussion on the definition and classifications of structural ELMs,their mechanical performance,and physiological ***,we summarize some critical challenges faced by structural ELMs and highlight directions of future *** hope this review article can provide a timely summary of the state of the art and relevant perspectives for future development of structural ELMs.

关键词： structural materials engineered living materials(ELMs) structural ELMs composites mechanical properties

Study on the flow structure in curved open channels with suspended vegetation using multi relaxation time lattice Boltzmann method

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Journal of Hydrodynamics 2024年第2期36卷 300-315页

作者： He-fang Jing qiao-ling Zhang Wei-hong Wang Zong-ning Zhang School of Mathematics and Information Science North Minzu UniversityYinchuan750021China School of Civil Engineering North Minzu UniversityYinchuan750021China Department of Basic Courses Zhengzhou University of Science and TechnologyZhengzhou450064China

Suspended vegetation in rivers,lakes,reservoirs and canals can change flow structure,which will in turn affect the sediment transport and cause the variation of water ecological *** order to study the characteristics of bend flow through suspended vegetation,three-dimensional numerical simulations are carried out by using the multi-relaxation-time lattice Boltzmann method(MRT-LBM).The drag force induced by vegetation is added in the velocity correction in the equilibrium distribution and a hybrid format combined bounce and specular reflection scheme is applied in the solid-fluid *** the validation of this model,six cases are designed to conduct the numerical simulations according to the root depth and the arrangement of *** simulated results show that the suspended vegetation can redistribute the flow structure in curved open *** the arrangement of suspended vegetation,the main flow moves to the side without vegetation,and the distribution of velocity tends to be balanced when vegetation is arranged on the entire cross section,the range of circulating current is reduced from the whole cross section to the local position without vegetation,however,the circulating current can still exist in the curve where the suspended vegetation enters less than half of the water *** addition,it can also be concluded that the suspended vegetation can affect the lateral gradient of flow velocity,and the bed shear stress in the curved channel.

关键词： Multi-relaxation-time lattice Boltzmann method(MRT-LBM) suspended vegetation curved open channel circulating current bed shearstress

HLA-DRB genotype and specific IgE responses in patients with allergies to penicillins

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Chinese Medical Journal 2006年第6期119卷 458-466页

作者： yang Jing qiao Hai-ling ZHANG Yue-wen JIA Linojing TIAN Xin GAO Na Department of Clinical Pharmacology School of MedicineZhengzhou University Zhengzhou 450052 China

Background Because of the pivotal role of the human leukocyte antigen （HLA） class II molecules in regulating the immune response and their extensive polymorphism, it is not surprising that particular HLA class II alleles have been implicated in susceptibility to allergic diseases and in restriction of the IgE responses to a variety of allergens. We investigated the relationship between HLA-DRB genotype and allergies to various penicillins and explored HLA-DRB restriction of IgE responses to these derivatives of penicillin.Methods Radioallergosorbent test was used to examine 8 kinds of specific IgE antibodies （4 major and 4 minor antigenic determinants） in the sera of 248 patients with an allergy to penicillins and 101 healthy subjects without any allergic reaction. Some （113 patients and 87 healthy control subjects） were chosen from all subjects to type for HLA-DRB alleles by sequence specific primer-polymerase chain reaction.Results Compared with control subjects, a sign/ficantly increased frequency of DR9 was present in 77 patients with allergic reactions, with immediate hypersensitive reaction and with urticaria （P = 0.011; P = 0.019; P = 0.005 respectively）. Conversely, a significantly decreased frequency of DR14.1 was found in 80 patients with positive IgE antibodies, with immediate reaction and with urticaria compared with control group （P = 0.024; P = 0.038; P = 0.038）. A possible excess of HLA-DR17 was found in subjects who were responsive to benzylpenicilloyl compared with those were not （X^2 = 5.134, P = 0.023）, and of HLA-DR4 was found in subjects responsive to phenoxomethylpenicillanyl （PVA, X^2 = 4.057, P = 0.044）.Conclusion I-ILA-DRB gene may be involved in allergy to pcnicillins through modulating spvcific serum IgE to penicillins.

关键词： hypersensitivity HLA-DRB gene immunoglobulin E penicillins

Subdural effusion associated with COVID-19 encephalopathy: A case report

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World Journal of Clinical Cases 2024年第10期12卷 1799-1803页

作者： Zhi-Yuan Xue Zhong-Lin Xiao Ming Cheng Tao Xiang Xiao-Li Wu qiao-ling Ai yang-ling Wu Tao yang Department of Rehabilitation Medicine Chengdu Jinniu District People’s HospitalChengdu 610000Sichuan ProvinceChina Department of Rehabilitation Medicine The General Hospital of the Western Theater Command of the People’s Liberation Army of ChinaChengdu 610000Sichuan ProvinceChina

BACKGROUND The precise mechanism by which severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)impacts the central nervous system remains unclear,with manifestations spanning from mild symptoms(e.g.,olfactory and gustatory deficits,hallucinations,and headache)to severe complications(e.g.,stroke,seizures,encephalitis,and neurally demyelinating lesions).The occurrence of single-pass subdural effusion,as described below,is extremely *** SUMMARY A 56-year-old male patient presented with left-sided limb weakness and slurred speech as predominant clinical *** comprehensive imaging and diagnostic assessments,he was diagnosed with cerebral infarction complicated by hemorrhagic transformation affecting the right frontal,temporal,and parietal *** addition,an intracranial infection with SARS-CoV-2 was identified during the rehabilitation process;consequently,an idiopathic subdural effusion ***,the subdural effusion underwent absorption within 6 d,with no recurrence observed during the 3-month *** Subdural effusion is a potentially rare intracranial complication associated with SARS-CoV-2 infection.

关键词： Cerebral infarction Hemorrhagic transformation Subdural effusion COVID-19 encephalopathy Novel coronavirus infection Brain fog Case report

Towards kernelizing the classifier for hyperbolic data

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Frontiers of Computer Science 2024年第1期18卷 17-31页

作者： Meimei yang qiao LIU Xinkai SUN Na SHI Hui XUE School of Computer Science and Engineering Southeast UniversityNanjing 210096China MOE Key Laboratory of Computer Science and Information Integration(Southeast University) Nanjing 210096China

Data hierarchy,as a hidden property of data structure,exists in a wide range of machine learning applications.A common practice to classify such hierarchical data is first to encode the data in the Euclidean space,and then train a Euclidean ***,such a paradigm leads to a performance drop due to distortion of data embedding in the Euclidean *** relieve this issue,hyperbolic geometry is investigated as an alternative space to encode the hierarchical data for its higher ability to capture the hierarchical *** methods cannot explore the full potential of the hyperbolic geometry,in the sense that such methods define the hyperbolic operations in the tangent plane,causing the distortion of data *** this paper,we develop two novel kernel formulations in the hyperbolic space,with one being positive definite(PD)and another one being indefinite,to solve the classification tasks in hyperbolic *** PD one is defined via mapping the hyperbolic data to the Drury-Arveson(DA)space,which is a special reproducing kernel Hilbert space(RKHS).To further increase the discrimination of the classifier,an indefinite kernel is further defined in the Krein ***,we design a 2-layer nested indefinite kernel which first maps hyperbolic data into the DA spaces,followed by a mapping from the DA spaces to the Krein *** experiments on real-world datasets demonstrate the superiority ofthe proposed kernels.

关键词： data hierarchy hyperbolic cgeometry drury-arveson space krein space