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Structural engineered living materials

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Nano Research 2024年第2期17卷 715-733页

作者： yang Geng Zian Jia ling Li 635 Prices Fork Road Department of Mechanical EngineeringVirginia Polytechnic Institute and State UniversityBlacksburg VA24061USA

Biological structural materials not only exhibit remarkable mechanical properties but also often embody dynamic characteristics such as environmental responsiveness,autonomy,and self-healing,which are difficult to achieve in conventional engineering *** merging materials science,synthetic biology,and other disciplines,engineered living materials(ELMs)provide a promising solution to combine living organisms with abiotic components,thus facilitating the construction of functional“living”*** natural materials,ELMs possess vitality and hold immense application potential in areas such as medicine,electronics,and construction,captivating increasing research attention *** an emerging branch of ELMs,structural ELMs aim to mimic living biological structural materials by achieving desired mechanical performance while maintaining important“living”*** we summarize the recent progress and provide our perspectives for this emerging research *** first summarize the superiority of structural ELMs by reviewing biological structural materials and biomimetic material design ***,we provide a systematic discussion on the definition and classifications of structural ELMs,their mechanical performance,and physiological ***,we summarize some critical challenges faced by structural ELMs and highlight directions of future *** hope this review article can provide a timely summary of the state of the art and relevant perspectives for future development of structural ELMs.

关键词： structural materials engineered living materials(ELMs) structural ELMs composites mechanical properties

Overexpression of wild-type HRAS drives non-alcoholic steatohepatitis to hepatocellular carcinoma in mice

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Zoological Research 2024年第3期45卷 551-566页

作者： Chen ling Su-Su Liu Yu-Ya Wang Gui-Tao Huo Yan-Wei yang Nan Xu Hong Wang Yong Wu Yu-fa Miao Rui Fu Yu-Wei Zhao Chang-fa fan College of Life Sciences Northwest UniversityProvincial Key Laboratory of Biotechnology of Shaanxi ProvinceXi’anShaanxi 710069China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China National Center for Safety Evaluation of Drugs National Institutes for Food and Drug Control(NIFDC)Beijing 100176China Division of HIV/AIDS and Sexually Transmitted Virus Vaccines Institute for Biological Products ControlNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China Division of Laboratory Animal Monitoring Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China

Hepatocellular carcinoma(HCC),a prevalent solid carcinoma of significant concern,is an aggressive and often fatal disease with increasing global incidence rates and poor therapeutic *** etiology and pathological progression of non-alcoholic steatohepatitis(NASH)-related HCC is multifactorial and ***,no single animal model can accurately mimic the full NASH-related HCC pathological progression,posing considerable challenges to transition and mechanistic ***,a novel conditional inducible wild-type human HRAS overexpressed mouse model(HRAS-HCC)was established,demonstrating 100%morbidity and mortality within approximately one month under normal dietary and lifestyle *** symptoms of HCC such as ascites,thrombus,internal hemorrhage,jaundice,and lung metastasis were successfully replicated in ***-depth pathological features of NASH-related HCC were demonstrated by pathological staining,biochemical analyses,and typical marker gene *** murine anti-PD-1 and sorafenib treatment effectively prolonged mouse survival,further confirming the accuracy and reliability of the *** on protein-protein interaction(PPI)network and RNA sequencing analyses,we speculated that overexpression of HRAS may initiate the THBS1-COL4A3 axis to induce NASH with severe fibrosis,with subsequent progression to ***,our study successfully duplicated natural sequential progression in a single murine model over a very short period,providing an accurate and reliable preclinical tool for therapeutic evaluations targeting the NASH to HCC continuum.

关键词： HRAS THBS1 HCC driver factor NASH Fibrosis Cirrhosis HCC Treatment evaluation

Pt(100)/NO+CO体系随机共振的理论研究

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高等学校化学学报 1999年第3期20卷 428-431页

作者：周宝晶杨灵法辛厚文中国科学技术大学化学物理系

在远离平衡的条件下，ＮＯ在Ｐｔ（１００）表面进行的催化还原反应表现出化学振荡和化学多稳态等复杂的动力学行为．利用Ｆｉｎｋ等提出的反应模型，通过计算机模拟对体系的控制参量进行周期调制和随机调制，在简单双稳区以及振荡与稳... 详细信息

在远离平衡的条件下，ＮＯ在Ｐｔ（１００）表面进行的催化还原反应表现出化学振荡和化学多稳态等复杂的动力学行为．利用Ｆｉｎｋ等提出的反应模型，通过计算机模拟对体系的控制参量进行周期调制和随机调制，在简单双稳区以及振荡与稳态的共存区，观察到随机共振（ＳｔｏｃｈａｓｔｉｃＲｅｓｏｎａｎｃｅ：ＳＲ）现象．通过对比两处ＳＲ现象的规律，发现在一定条件下。

关键词：随机共振表面催化一氧化氮一氧化碳还原

Polarization control of above-threshold ionization spectrum in elliptically polarized two-color laser fields

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Chinese Physics B 2024年第4期33卷 136-144页

作者：金发成杨慧慧宋晓红李飞杜玲玲薛红杰魏丽敏白悦刘浩翔王兵兵杨玮枫 faculty of Science Xi'an Aeronautical InstituteXi'an 710077China School of Physics and Optoelectronic Engineering Hainan UniversityHaikou 570288China Center for Theoretical Physics Hainan UniversityHaikou 570288China Laboratory of Optical Physics Beijing National Laboratory for Condensed Matter PhysicsInstitute of PhysicsChinese Academy of SciencesBeijing 100190China College of Science Shantou UniversityShantou 515063China University of Chinese Academy of Sciences Beijing 100049China

We study the above-threshold ionization(ATI)process of atoms exposed to fundamental and high-frequency lasers with arbitrary ellipticity by applying the frequency-domain *** is found that the angular-resolved ATI spectrum is sensitive to ellipticities of two lasers and emitted angles of the *** for the photon energy of the highfrequency laser more than atomic ionization potential,the width of plateau tends to a constant with increasing ellipticity of fundamental field,the dip structure disappears with increasing ellipticity of the high-frequency *** the help of the quantum channel analysis,it is shown that the angular distribution depends mainly on the ellipticity of high-frequency field in the case that its frequency is ***,one can see that the maximal and minimal energies in quantum numerical results are in good agreement with the classical *** investigation may provide theoretical support for experimental research on polarization control of ionization in elliptically polarized two-color laser fields.

关键词： above-threshold ionization two-color laser polarization control

Flow Boiling Heat Transfer Characteristics and Delayed Dry-Out Ability of Non-Azeotropic Mixtures R245fa/R134a in Microchannels

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Journal of Thermal Science 2024年第3期33卷 1174-1188页

作者： LU Yongjie ling Yongjun ZHUANG Yuan LI Chenyang OUyang Hongsheng HAN Xiaohong Key Laboratory of Refrigeration and Cryogenic Technology of Zhejiang Province Institute of Refrigeration and CryogenicsZhejiang UniversityHangzhou310007China Zhejiang Zhongguang Electrical Co. Ltd.Lishui323000China State Key Lab for Fluorine Greenhouse Gases Replacement and Control Treatment Zhejiang Research Institute of Chemical IndustryHangzhou310014China

Microchannel flow boiling heat transfer has the advantages of strong heat dissipation capacity,good temperature uniformity,and compact *** is an excellent way to thermally manage electronic devices,but when the heat flux exceeds CHF(Critical Heat Flux),the heat transfer performance deteriorates as the working fluid dries ***-azeotropic mixtures have the potential to effectively delay or avoid dry-out during the boiling process due to their temperature slide characteristics which causes the mass transfer *** understand the influence of non-azeotropic mixtures on microchannel flow boiling,using the phase-change microchannel heat sink as the research object,the experiments on the flow boiling heat transfer performance of R245fa/R134a mixtures under different working conditions were carried out,and the characteristics of flow boiling heat transfer were obtained under the different working conditions,and comparison was developed with those of pure substance *** results demonstrated that a small amount of low-boiling-point components in the high-boiling-point working fluid inhibited boiling heat transfer to some extent,and lowered the average heat transfer coefficient under the non-dryout condition slightly lower than that of the pure substance;however,it also effectively delayed the onset of local dry-out and prevented significant deterioration in thermal transfer performance under the lower mass flow rate and higher heat flux,which could enhance the heat sink's stability.

关键词： microchannel flow boiling non-azeotropic mixture heat transfer characteristics dry-out

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对象、方法与理念:家庭民俗学发展谫论

青海民族大学学报（社会科学版） 2024年第3期50卷 134-148页

作者：孟令法扬州大学江苏扬州225009 北京师范大学北京100875

作为民俗学的一个研究视角,家庭民俗学有着丰硕的成果积累———从民俗学初创期的以家庭为方法,到21世纪的以家庭为对象,均体现了家庭之于民俗学发展的实际功能,而后者则促进了人们对家庭及其成员角色的反思。家庭民俗学与社会学或人类... 详细信息

作为民俗学的一个研究视角,家庭民俗学有着丰硕的成果积累———从民俗学初创期的以家庭为方法,到21世纪的以家庭为对象,均体现了家庭之于民俗学发展的实际功能,而后者则促进了人们对家庭及其成员角色的反思。家庭民俗学与社会学或人类学,乃至传统民俗学的外向型家庭研究不同,它不仅是具有家国情怀的内向型研究,且积淀于儒学思想的“家”论述,萌发于救亡图存的民众启蒙,开启于现象学的日常生活研究,成就于“感受生活的民俗学”,发展于实践民俗学“启蒙”之用的“家”基础。家庭民俗学的家庭虽是一个社会概念,但其不仅包括父系,也包括母系以及拟亲属关系,而其在资料获取的方法层面,则为家乡民俗学和“多民族的一国民俗学”研究奠定了前提。总之,家庭民俗学并不止于家庭及其成员本身,而是认识社会的一个起点以及形塑自我人格的基本路径。

关键词：家庭民俗学自我家庭血缘结构研究对象方法论

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长骨干骺端软骨母细胞瘤2例

中国临床医学影像杂志 2024年第8期35卷 607-608页

作者：杨晓楠王得志孙玲玲郑璐崔久法青岛大学附属医院山东青岛266003 诸城市人民医院放射科山东潍坊262200

病例例1,女,15岁。因“右上肢疼痛半年余”就诊。患者半年前无明显诱因出现右上肢疼痛、活动受限。体格检查:右上肢疼痛伴轻度压痛、活动受限,无肢体肿胀,无肢体麻木感,无皮肤感觉障碍。实验室检查未见异常。CT平扫示右肱骨上段干骺端... 详细信息

病例例1,女,15岁。因“右上肢疼痛半年余”就诊。患者半年前无明显诱因出现右上肢疼痛、活动受限。体格检查:右上肢疼痛伴轻度压痛、活动受限,无肢体肿胀,无肢体麻木感,无皮肤感觉障碍。实验室检查未见异常。CT平扫示右肱骨上段干骺端地图样骨质破坏,大小约1.6cm×3.0cm×2.8cm,边缘硬化,骨皮质局部不连续,病灶平均CT值为65HU,内部可见细小点状钙化;病灶周围无明显软组织肿块(图1)。MRI示病灶与肌肉相比,T_(1)WI上呈等信号,T_(2)WI上呈稍高信号,内见多发液-液平面,周围骨髓腔及肩关节腋囊明显水肿(图2)。右肩关节可见水样信号。MR增强上病灶实质部分强化,液液平面区域无强化/外周强化,水肿的液囊亦见强化(图3)。

关键词：软骨母细胞瘤体层摄影术,X线计算机磁共振成像

双源双能量CT视觉评估和定量分析对椎体骨髓水肿的诊断价值

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放射学实践 2024年第1期39卷 115-120页

作者：张发平束玲玲戴春宏邢斌宋方朱通安徽省皖南康复医院放射科安徽241000 安徽省皖南康复医院骨一科安徽241000

目的:探讨双源双能量CT(DECT)虚拟去钙(VNCa)技术中视觉评估(VE)和定量分析对椎体骨髓水肿(BME)的诊断价值。方法:回顾性分析2020年8月至2022年4月60例胸腰椎新鲜骨折(观察组)及60例陈旧性骨折(对照组)患者的临床及影像资料。以MRI结果... 详细信息

目的:探讨双源双能量CT(DECT)虚拟去钙(VNCa)技术中视觉评估(VE)和定量分析对椎体骨髓水肿(BME)的诊断价值。方法:回顾性分析2020年8月至2022年4月60例胸腰椎新鲜骨折(观察组)及60例陈旧性骨折(对照组)患者的临床及影像资料。以MRI结果为参考,将DECT的VE结果与之对比,分析1.75和1.45斜率对BME的诊断效能;比较新鲜与陈旧性骨折的定量参数(vCT、rCT、CaD、FF、ΔvCT)差异并绘制ROC曲线,采用Z检验比较曲线下面积(AUC)差异;进一步评估VE与定量参数联合的诊断效能。结果:1.75与1.45斜率VE诊断新鲜与陈旧性骨折的敏感度分别为88.0%、69.3%,特异度分别为93.8%、87.5%,1.75斜率的诊断符合率为90.3%,高于1.45斜率的78.7%,差异有统计学意义(χ^(2)=7.987,P<0.05)。椎体新鲜与陈旧性骨折的vCT、rCT、FF、ΔvCT值差异均有统计学意义(P均<0.05),其中ΔvCT值的AUC值最高(0.96),诊断阈值为28.5 HU时,敏感度、特异度分别为89.3%、96.2%,与其他定量参数差异均有统计学意义(P均<0.05)。VE的Youden指数(0.82)高于vCT(0.62)而略低于ΔvCT(0.86);VE与定量参数联合的AUC值(0.95)低于ΔvCT。结论:VNCa技术VE和定量分析对椎体骨髓水肿均具有较高的诊断效能,两者联合的诊断价值不高。

关键词：椎体骨髓水肿双能量CT 虚拟去钙技术骨折压缩性视觉评估

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圈养山魈总能和粗蛋白摄入的初步研究

四川动物 2013年第1期32卷 93-96页

作者：桓宗锦刘选珍余建秋田昕杨发玲陈松涛成都市野生动物研究所成都610081

为了探明圈养山魈总能、粗蛋白的摄入量,选用成都动物园健康山魈20只,分成成年组(4个重复)和幼年组,分别在春季(4月)、夏季(7月)、秋季(9月)进行了三期饲养试验,每期4周。结果表明,季节间山魈每天的总能和粗蛋白的摄入差异不显著(P>0.0... 详细信息

为了探明圈养山魈总能、粗蛋白的摄入量,选用成都动物园健康山魈20只,分成成年组(4个重复)和幼年组,分别在春季(4月)、夏季(7月)、秋季(9月)进行了三期饲养试验,每期4周。结果表明,季节间山魈每天的总能和粗蛋白的摄入差异不显著(P>0.05);成年山魈每天摄入总能和粗蛋白分别为6544.47kJ、44.54g;幼年山魈每天摄入总能和粗蛋白分别为3401.37kJ、23.52g,成年山魈每天总能和粗蛋白摄入显著高于幼年山魈(P<0.05);成年山魈每天单位体重(kg)总能和粗蛋白的摄入为291.40kJ、1.97g。

关键词：山魈总能粗蛋白摄入