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论中亚东干文学的多元文化渊源

外国文学研究 2007年第2期29卷 166-173页

作者：杨建军兰州大学文学院

中国学术界的中亚东干文学研究尚在起步阶段,中亚东干族属华裔,他们的东干文学不仅保留了自身的中国文化底蕴,还融汇着伊斯兰文化、俄罗斯文化色彩。从东干文学与三种文化的渊源关系可见,东干族由进入中亚的中国回族发展而来,中国文化... 详细信息

中国学术界的中亚东干文学研究尚在起步阶段,中亚东干族属华裔,他们的东干文学不仅保留了自身的中国文化底蕴,还融汇着伊斯兰文化、俄罗斯文化色彩。从东干文学与三种文化的渊源关系可见,东干族由进入中亚的中国回族发展而来,中国文化是东干族的母族文化。中国文化对东干文学的影响具体体现在华裔民间文化给养、恋华之情两方面;伊斯兰教乃东干族长期坚守的宗教信仰,伊斯兰文化对东干文学的影响存在于民间文学给养、文学语言、人物事件、美学风格四个方面;俄罗斯文化是东干族客居的中亚地区的主流文化,俄罗斯文化对东干文学的影响具体表现在文学语言、文学题材、现实主义风格三个层面。论文主要通分析东干文学与多元文化的关系,从文化源流上廓清中亚东干文学的概貌。

关键词：东干文学中国文化伊斯兰文化俄罗斯文化

The First-in-Human Whole-Body Dynamic Pharmacokinetics Study of Aptamer

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Research 2024年第1期2023卷 119-130页

作者： Ding Ding Haitao Zhao Dali Wei Qinglai yang Cai yang Ruowen Wang Yumei Chen Lianghua Li Shuxian An Qian Xia Gang Huang jianjun Liu Zeyu Xiao Weihong Tan Institute of Molecular Medicine(IMM) Renji HospitalState Key Laboratory of Oncogenes and Related GenesShanghai Jiao Tong University School of Medicineand College of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Nuclear Medicine Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Center for Molecular Imaging Probes Cancer Research InstituteUniversity of South ChinaHengyangHunan 421001China The Key Laboratory of Zhejiang Province for Aptamers and Theranostics Zhejiang Cancer HospitalHangzhou Institute of Medicine(HIM)Chinese Academy of SciencesHangzhouZhejiang 310022China Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangshaHunan 410082China Shanghai Key Laboratory of Molecular Imaging Shanghai University of Medicine and Health SciencesShanghai 201318China Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of MedicineShanghai200127China

Serving as targeting ligands,aptamers have shown promise in precision ***,the lack of knowledge of the biosafety and metabolism patterns in the human body largely impeded aptamers’clinical *** bridge this gap,here we report the first-in-human pharmacokinetics study of protein tyrosine kinase 7 targeted SGC8 aptamer via in vivo PET tracking of gallium-68(^(68)Ga)radiolabeled *** specificity and binding affinity of a radiolabeled aptamer,named ^(68)Ga[Ga]-NOTA-SGC8,were maintained as proven in *** preclinical biosafety and biodistribution evaluation confirmed that aptamers have no biotoxicity,potential mutation risks,or genotoxicity at high dosage(40 mg/kg).Based on this result,a first-in-human clinical trial was approved and carried out to evaluate the circulation and metabolism profiles,as well as biosafety,of the radiolabeled SGC8 aptamer in the human *** advantage of the cutting-edge total-body PET,the aptamers’distribution pattern in the human body was acquired in a dynamic fashion.

关键词： metabolism dosage Whole

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中亚东干诗歌中的列宁形象比较研究

外国文学研究 2022年第2期44卷 135-145页

作者：杨建军兰州大学文学院

中亚东干文学,是丝绸之路沿线中亚三国华裔族群创作的文学,已引起多国学者关注。东干诗歌中的列宁形象与俄苏诗歌、中国诗歌中的列宁形象共时存在,三者之间有或显或隐的影响关系。东干诗歌中的列宁形象书写多采用自然意象,常把列宁比作... 详细信息

中亚东干文学,是丝绸之路沿线中亚三国华裔族群创作的文学,已引起多国学者关注。东干诗歌中的列宁形象与俄苏诗歌、中国诗歌中的列宁形象共时存在,三者之间有或显或隐的影响关系。东干诗歌中的列宁形象书写多采用自然意象,常把列宁比作春天和太阳,也常把列宁比作父亲,列宁的革命者人格还被东干诗人升华为民族精神的象征。东干诗歌与俄苏诗歌中的列宁形象有一致性,自然意象采用和人道主义关怀是两者共性,但在诗歌话语、自然情感、精神内涵等方面,东干诗歌有自身特性。东干诗歌与中国诗歌都受到俄苏文化影响,两者都致力表现列宁对革命建设带来的重要变革,中国诗歌偏向表现精神层面影响,东干诗歌偏重表现物质生活影响。东干诗歌中的列宁形象书写在海外华语文学中的启示性意义有四个方面:文学资源、文学互动、身份认同、读者接受。

关键词：中亚东干诗歌列宁形象海外华语文学俄苏诗歌中国诗歌

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论中亚东干文学的家园意识

外国文学研究 2015年第2期37卷 135-141页

作者：杨建军兰州大学文学院

东干文学用中亚东干族华人自创的东干文书写,东干文学属海外华人文学的一支。本文以东干书面文学为研究对象,研究中亚东干文学的家园意识。本文认为,东干文学的地理家园意识归属于中亚和中国两地,中亚"唐人村"家园书写展示了海外华人乡... 详细信息

东干文学用中亚东干族华人自创的东干文书写,东干文学属海外华人文学的一支。本文以东干书面文学为研究对象,研究中亚东干文学的家园意识。本文认为,东干文学的地理家园意识归属于中亚和中国两地,中亚"唐人村"家园书写展示了海外华人乡土文学的魅力。东干文学的文化家园意识中,俄罗斯文化、突厥文化、中国文化、伊斯兰文化等是构成元素,"伊儒交融"型文化是核心元素。东干文学对海外华人共同面对的家园问题的书写的启示意义有三方面:文化家园建构、文化家园传承、文化家园认同。

关键词：中亚东干文学家园意识家园建构海外华人文学

Allosterically activating SHP2 by oleanolic acid inhibits STAT3-Th17 axis for ameliorating colitis

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2598-2612页

作者： Jinbo Hu Wen Liu Yi Zou Chenyang Jiao Jiazhen Zhu Qiang Xu jianjun Zou yang Sun Wenjie Guo State Key Laboratory of Pharmaceutical Biotechnology Nanjing Drum Tower HospitalSchool of Life SciencesNanjing UniversityNanjing 210093China Department of Clinical Pharmacology Nanjing First HospitalNanjing Medical UniversityNanjing 210006China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXuzhou 221004China

Src homology 2 domain-containing tyrosine phosphatase 2(SHP2)is an essential tyrosine phosphatase that is pivotal in regulating various cellular signaling pathways such as cell growth,differentiation,and *** activation of SHP2 has been shown to have a therapeutic effect in colitis and Parkinson's ***,the identification of SHP2 activators and a complete understanding of their mechanism is *** used a two-step screening assay to determine a novel allosteric activator of SHP2 that stabilizes it in an open *** acid was identified as a suitable *** binding to R362,K364,and K366 in the active center of the PTP domain,oleanolic acid maintained the active open state of SHP2,which facilitated the binding between SHP2 and its *** oleanolic acid-activated SHP2 hindered Th17 differentiation by disturbing the interaction between STAT3 and IL-6Rαand inhibiting the activation of ***,via the activation of SHP2 and subsequent attenuation of the STAT3-Th17 axis,oleanolic acid effectively mitigated colitis in *** protective effect was abrogated by SHP2 knockout or administration of the SHP2 inhibitor *** findings underscore the potential of oleanolic acid as a promising therapeutic agent for treating inflammatory bowel diseases.

关键词： Oleanolic acid SHP2 STAT3 Th17 Colitis Allosteric activator

PFA-fixed Hsp6Osp-loaded dendritic cells as a vaccine for the control of mouse experimental allergic encephalomyelitis

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Cellular & Molecular Immunology 2014年第2期11卷 169-174页

作者： Feng Liu Hui Zheng Yuanyuan Qi Xue Wang jianjun yang Miaomiao Han Hart Zhang Hong Jiang These authors contributed equally to this work.

We have shown that Hsp6Osp-loaded immature dendritic cells （DC/sp） can protect mice from the induction of experimental allergic encephalomyelitis （EAE） by inducing Qa-l-restricted CD8＋ T regulatory （Treg） cells. The binding half-life between Qa-1 and Hsp6Osp is particularly short and leads to an unstable Qa- l/peptide complex that significantly decreases the efficacy of this vaccination. To prevent Qa-l/Hsp6Osp complex dissociation, we utilized paraformaldehyde （PFA） fixation to stabilize the formation of the Qa-l/Hsp6Osp complex and maximize the function of DC/sp as a vaccine to control autoimmune diseases. Compared with the non-fixed DC/sp, the fixed DC/sp （FDC/sp） showed an enhanced ability to activate Qa-l-restricted Hsp6Osp-specific CD8＋T cells in vitro and prevented EAE in vivo. Importantly, the FDC/sp maintained immune activity following cryopreservation for I week or after storage for 72 h at 4 ~C. These results indicate that PFA fixation can sustain or increase the efficacy of DC/sp by improving the stability of the Qa-l/Hsp6Osp complex on the surface of the DC/sp. In addition, PFA fixation creates a time window for DC/sp storage, transport and application. Our d^tn ~u^p__~t ~ nnt^nti^l clinic^l ..~e nf FDCI^n ~ ~ vnccine fnr the nr^v~ntinn and treatment of autnimm.n~_ di_~_~__

关键词： autoimmune disease dendritic cells Hsp6Osp PFA fixation Qa-l-restricted CD8+ T cells

Grassland-type ecosystem stability in China differs under the influence of drought and wet events

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Journal of Arid Land 2024年第5期16卷 615-631页

作者： CAO Wenyu BAI jianjun YU Leshan School of Geography and Tourism Shaanxi Normal UniversityXi'an 710119China International Business School Shaanxi Normal UniversityXi'an 710119China

Ecological stability is a core issue in ecological research and holds significant implications forhumanity. The increased frequency and intensity of drought and wet climate events resulting from climatechange pose a major threat to global ecological stability. Variations in stability among different ecosystemshave been confirmed, but it remains unclear whether there are differences in stability within the sameterrestrial vegetation ecosystem under the influence of climate events in different directions and ***'s grassland ecosystem includes most grassland types and is a good choice for studying this *** study used the Standardized Precipitation Evapotranspiration Index-12 (SPEI-12) to identify thedirections and intensities of different types of climate events, and based on Normalized DifferenceVegetation Index (NDVI), calculated the resistance and resilience of different grassland types for 30consecutive years from 1990 to 2019 (resistance and resilience are important indicators to measurestability). Based on a traditional regression model, standardized methods were integrated to analyze theimpacts of the intensity and duration of drought and wet events on vegetation stability. The resultsshowed that meadow steppe exhibited the highest stability, while alpine steppe and desert steppe had thelowest overall stability. The stability of typical steppe, alpine meadow, temperate meadow was at anintermediate level. Regarding the impact of the duration and intensity of climate events on vegetationecosystem stability for the same grassland type, the resilience of desert steppe during drought was mainlyaffected by the duration. In contrast, the impact of intensity was not significant. However, alpine steppewas mainly affected by intensity in wet environments, and duration had no significant impact. Ourconclusions can provide decision support for the future grassland ecosystem governance.

关键词： grassland ecosystem stability resistance resilience different climate types drought climate event wet climate event

Single transmembrane GPCR modulating proteins:neither single nor simple

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Protein & Cell 2024年第6期15卷 395-402页

作者： Meng Wang jianjun Lyu Chao Zhang Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Hubei Topgene Research Institute of Hubei Topgene Biotechnology Co. LtdEast Lake High-Tech Development ZoneWuhan 430205China Fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center)Tongji UniversityShanghai 200092China

The discovery of G-protein coupled receptor(GPCR)accessory proteins has fundamentally redefined the pharmacological concept of GPCR signaling,demonstrating a more complex molecular basis for receptor specificity on the plasma membrane and impressionable downstream intracellular *** accessory proteins not only contribute to the proper folding and trafficking of receptors but also exhibit selectable receptor preferences.

关键词： specificity GPCR neither

安装变频调速装置的复杂注水系统运行优化研究

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石油学报 2007年第2期28卷 124-128页

作者：杨建军刘扬战红青岛理工大学山东青岛266033 大庆石油学院黑龙江大庆163318

以轴功率最小为目标函数,以限制水量平衡、注水压力、调速泵转速、泵排量为约束条件,建立了安装变频调速装置的复杂注水系统运行参数优化数学模型。针对复杂注水系统的运行特点,采用改进遗传算法对运行优化模型进行了求解,同时优化了变... 详细信息

以轴功率最小为目标函数,以限制水量平衡、注水压力、调速泵转速、泵排量为约束条件,建立了安装变频调速装置的复杂注水系统运行参数优化数学模型。针对复杂注水系统的运行特点,采用改进遗传算法对运行优化模型进行了求解,同时优化了变频泵的位置和运行参数。改进遗传算法采用实数编码,并对适应函数进行了调整,采用随机多父辈适应函数值加权交叉法,改进了变异操作。在操作过程中,给出了泵排量和变频调速的处理方法,大大减少了不可行解的产生,使该算法的优化性能得到了提高。用算例说明了该优化方法的有效性。

关键词：注水系统运行参数优化变频调速泵数学模型改进遗传算法