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Intelligent production optimization method for a low pressure and low productivity shale gas well

Petroleum Exploration and Development 2022年第4期49卷 886-894页

作者： ZHU Qikang LIN Botao yang guang WANG Lijia CHEN Man College of Artificial Intelligence China University of PetroleumBeijing 102249China College of Safety and Ocean Engineering China University of PetroleumBeijing 102249China College of Information Science and Engineering China University of PetroleumBeijing 102249China Sichuan Shale Gas Exploration and Development Co.LTD Neijiang 641100China China National Petroleum Corporation Southwest Oil and Gas Field Company Sichuan Changning Natural Gas Development Co.Ltd Changning 644000China

Shale gas wells frequently suffer from liquid loading and insufficient formation pressure in the late stage of production.To address this issue,an intelligent production optimization method for low pressure and low productivity shale gas well is proposed.Based on the artificial intelligence algorithms,this method realizes automatic production and monitoring of gas well.The method can forecast the production performance of a single well by using the long short-term memory neural network and then guide gas well production accordingly,to fulfill liquid loading warning and automatic intermittent production.Combined with adjustable nozzle,the method can keep production and pressure of gas wells stable automatically,extend normal production time of shale gas wells,enhance automatic level of well sites,and reach the goal of refined production management by making production regime for each well.Field tests show that wells with production regime optimized by this method increased 15%in estimated ultimate reserve(EUR).Compared with the development mode of drainage after depletion recovery,this method is more economical and can increase and stabilize production effectively,so it has a bright application prospect.

关键词： shale gas low pressure and low productivity gas well production optimization artificial intelligence long short-term memory neural network adjustable nozzle

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Genomic insights into adaptation to bipedal saltation and desert-like habitats of jerboas

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Science China Life Sciences 2024年

作者： Simin Chai Yujie Chong Daiqing Yin Qiang Qiu Shixia Xu guang yang Southern Marine Science and Engineering guangdong Laboratory (guangzhou) Jiangsu Key Laboratory for Biodiversity and Biotechnology School of Life Sciences Nanjing Normal University School of Ecology and Environment Northwestern Polytechnical University

Jerboas is a lineage of small rodents displaying atypical mouse-like morphology with elongated strong hindlimbs and short forelimbs. They have evolved obligate bipedal saltation and acute senses, and been well-adapted to vast desert-like habitats. Using a newly sequenced chromosome-scale genome of the Mongolian five-toed jerboa(Orientallactaga sibirica), our comparative genomic analyses and in vitro functional assays showed that the genetic innovations in both protein-coding and non-coding regions played an important role in jerboa morphological and physiological adaptation. Jerboa-specific amino acid substitutions, and segment insertions/deletions(indels) in conserved non-coding elements(CNEs) were found in components of proteoglycan biosynthesis pathway(XYLT1 and CHSY1), which plays an important role in limb development. Meanwhile, we found specific evolutionary changes functionally associated with energy or water metabolism(e.g., specific amino acid substitutions in ND5 and indels in CNEs physically near ROR2) and senses(e.g., expansion of vomeronasal receptors and the FAM136A gene family) in jerboas. Further dual-luciferase reporter assay verified that some of the CNEs with jerboa-specific segment indels exerted a significantly different influence on luciferase activity, suggesting changes in their regulatory function in jerboas. Our results revealed the potential molecular mechanisms underlying jerboa adaptation since the divergence from the Eocene-Oligocene transition, and provided more resources and new insights to enhance our understanding of the molecular basis underlying the phenotypic diversity and the environmental adaptation of mammals.

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Recent development of three-dimension printed graphene oxide and MXene-based energy storage devices

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Tungsten 2024年第1期6卷 196-211页

作者： Liang-Hao Yu Xin Tao Shang-Ru Feng Jin-Tao Liu Lin-Lin Zhang guang-Zhen Zhao guang Zhu Key Laboratory of Spin Electron and Nanomaterials of Anhui Higher Education Institutes Suzhou UniversitySuzhou 234000China Key Laboratory of Leather of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China

The research for three-dimension(3D)printing carbon and carbide energy storage devices has attracted widespread exploration interests.Being designable in structure and materials,graphene oxide(GO)and MXene accompanied with a direct ink writing exhibit a promising prospect for constructing high areal and volume energy density devices.This review not only summarizes the recent advances in 3D printing energy storage devices including printing methods,ink rheological properties,and different energy storage systems,but also discusses the printing methods related to energy storage.In addition,the binder or additive free of two-dimensional carbide materials is quite important for the present electrochemical energy storage devices,which also are presented.

关键词： 3D printing Two-dimensional materials Energy storage device Ink theological MXene

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Human ESC-derived vascular cells promote vascular regeneration in a HIF-1α dependent manner

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Protein & Cell 2024年第1期15卷 36-51页

作者： Jinghui Lei Xiaoyu Jiang Daoyuan Huang Ying Jing Shanshan yang Lingling Geng Yupeng Yan Fangshuo Zheng Fang Cheng Weiqi Zhang Juan Carlos Izpisua Belmonte guang-Hui Liu Si Wang Jing Qu Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational Medicine Center Intermational Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration CASBeijing 100101China The Fifth People's Hospital of Chongqing Chongqing 400062China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China National Laboratory of Biomacromolecules CAs Center for Excellence in BiomacromoleculesInstitute of BiophysicsBeijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China China National Center for Bioinformation Beijing 100101China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Beijing 101408China Aging Biomarker Consortium China Altos Labs San DiegoCA 92121United State

Hypoxia-inducible factor(HIF-1α),a core transcription factor responding to changes in cellular oxygen levels,is closely associated with a wide range of physiological and pathological conditions.However,its differential impacts on vascular cell types and molecular programs modulating human vascular homeostasis and regeneration remain largely elusive.Here,we applied CRISPR/Cas9-mediated gene editing of human embryonic stem cells and directed differentiation to generate HIF-ia-deficient human vascular cells including vascular endothelial cells,vascular smooth muscle cells,and mesenchymal stem cells(MsCs),as a platform for discovering cell type-specific hypox-ia-induced response mechanisms.Through comparative molecular profiling across cell types under normoxic and hypoxic conditions,we provide insight into the indispensable role of HIF-1αin the promotion of ischemic vascular regeneration.We found human MSCs to be the vascular cell type most susceptible to HIF-1a deficiency,and that transcriptional inactivation of ANKZF1,an effector of HIF-1a,impaired pro-angiogenic processes.Altogether,our findings deepen the understanding of HIF-ia in human angiogenesis and support further explorations of novel therapeutic strategies of vascular regeneration against ischemic damage.

关键词： HIF-1 human ESC vascular cell regeneration

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Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity

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Signal Transduction and Targeted Therapy 2024年第1期9卷 259-270页

作者： Yan Sun Xiu-Na yang Shuang-Shuang yang Yi-Zhu Lyu Bing Zhang Kai-Wen Liu Na Li Jia-Chen Cui guang-Xiang Huang Cheng-Lin Liu Jie Xu Jian-Qing Mi Zhu Chen Xiao-Hu Fan Sai-Juan Chen Shuo Chen Shanghai Institute of Hematology National Research Center for Translational MedicineState Key Laboratory of Medical GenomicsRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Department of Hematology Second Hospital of Dalian Medical UniversityDalian 116023China National Facility for Protein Science Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Legend Biotech China Nanjing 211112China Shanghai Immune Therapy Institute Shanghai Cancer InstituteState Key Laboratory of Oncogenes and Related GenesRenji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Wondercel Biotechnology Shenzhen 518052China

Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity,safeguarding receptor activation,and facilitating amplification of signal transduction across the cellular membrane.However,cell-surface antigeninduced multimerization(dubbed AIM herein)has not yet been consciously leveraged in chimeric antigen receptor(CAR)engineering for enriching T cell-based therapies.We co-developed ciltacabtagene autoleucel(cilta-cel),whose CAR incorporates two B-cell maturation antigen(BCMA)-targeted nanobodies in tandem,for treating multiple myeloma.Here we elucidated a structural and functional model in which BCMA-induced cilta-cel CAR multimerization amplifies myeloma-targeted T cell-mediated cytotoxicity.Crystallographic analysis of BCMA–nanobody complexes revealed atomic details of antigen–antibody hetero-multimerization whilst analytical ultracentrifugation and small-angle X-ray scattering characterized interdependent BCMA apposition and CAR juxtaposition in solution.BCMA-induced nanobody CAR multimerization enhanced cytotoxicity,alongside elevated immune synapse formation and cytotoxicity-mediating cytokine release,towards myeloma-derived cells.Our results provide a framework for contemplating the AIM approach in designing next-generation CARs.

关键词： cytotoxicity Antigen elevated

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Successful splenic artery embolization in a patient with Behçet’s syndrome-associated splenic rupture:A case report

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1184-1188页

作者： guang-Zhao Zhu Dong-Hua Ji Department of Interventional Therapy The First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina

BACKGROUND Splenic rupture associated with Behçet’s syndrome(BS)is extremely rare,and there is no consensus on its management.In this case report,a patient with BSassociated splenic rupture was successfully treated with splenic artery embolization(SAE)and had a good prognosis after the intervention.CASE SUMMARY The patient was admitted for pain in the left upper abdominal quadrant.He was diagnosed with splenic rupture.Multiple oral and genital aphthous ulcers were observed,and acne scars were found on his back.He had a 2-year history of BS diagnosis,with symptoms of oral and genital ulcers.At that time,he was treated with oral corticosteroids for 1 month,but the symptoms did not alleviate.He underwent SAE to treat the rupture.On the first day after SAE,the patient reported a complete resolution of abdominal pain and was discharged 5 d later.Three months after the intervention,a computed tomography examination showed that the splenic hematoma had formed a stable cystic effusion,suggesting a good prognosis.CONCLUSION SAE might be a good choice for BS-associated splenic rupture based on good surgical practice and material selection.

关键词： Splenic artery embolization Behçet’s syndrome Splenic rupture Case report

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Amorphous NiMo_(3)S_(13)/nickel foam integrated anode for lithium-ion batteries

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Tungsten 2024年第2期6卷 438-446页

作者： Ming-Xin Shi Min Wu Shan-Shan Xiao Shan-Ping Liu Rui-Qi Yao Ying-Qi Li Yong-Hui Wang yang-guang Li Hua-Qiao Tan Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Faculty of ChemistryNortheast Normal UniversityChangchun 130024China School of Materials Science and Engineering Jilin Jianzhu UniversityChangchun 130118China Institute Charles Gerhardt Montpellier Universite de MontpellierCentre National de la Recherche Scientifi quePlace E.Bataillon34095 Montpellier Cedex 05France

Although crystalline anode materials with long-range ordered lattice structure are in favor of facilitating the electron transfer,their structures are easily disrupted during long-term cycling due to the continuous embedding/de-embedding of lithium ions.In contrast,the amorphous materials have abundant defects and lithium ion storage sites,refl ecting a superior reaction kinetics and long-term cycling stability.Here,we synthesize an integrated hybrid anode by in-situ loading amorphous NiMo_(3)S_(13)nanosheets on nickel foam substrate.Benefi ting from the introduction of Ni^(2+)that amorphizes the molybdenumsulfur clusters,the assembled lithium ion battery based on the integrated NiMo_(3)S_(13)/nickel foam anode delivers a specifi c capacity up to 1659 mA·h·g^(−1)at a current density of 0.6 A·g^(−1)and exhibits superior rate/cycling performance.

关键词： Molybdenum-sulfur clusters Amorphous Integrated anode Crystalline Lithium-ion batteries

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The E3 ubiquitin ligase TRAF6 controls CTLA-4 turnover and promotes T-cell-mediated antitumor immunity

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Cellular & Molecular Immunology 2024年第1期21卷 97-99页

作者： Xiao-Liang Jie Hua Guo guang-Biao Zhou State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College100021 BejingChina

Yu et al.[1]reported that the tumor necrosis factor(TNF)receptor OX40(CD134)-TNF receptor-associated factor 6(TRAF6)axis mediates Lys63-linked ubiquitination and subsequent lysosomal degradation of cytotoxic T-lymphocyte antigen 4(CTLA-4),leading to the enhancement of CD8^(+)T-cell-mediated antitumor immunity.Their findings unveil a previously unknown mechanism in controlling the stability of the immune checkpoint CTLA-4 and provide a potential therapeutic target for the improvement of Tcell-based immunotherapy.

关键词： immunity OX40 ubiquitin

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The tangential k-Cauchy-Fueter type operator and Penrose type integral formula on the generalized complex Heisenberg group

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 181-190页

作者： REN guang-zhen SHI Yun KANG Qian-qian Department of Mathematics Zhejiang International Studies UniversityHangzhou 310023China Department of Mathematics Zhejiang University of Science and TechnologyHangzhou 310023China

The tangential k-Cauchy-Fueter operator and k-CF functions are counterparts of the tangential Cauchy–Riemann operator and CR functions on the Heisenberg group in the theory of several complex variables,respectively.In this paper,we introduce a Lie group that the Heisenberg group can be imbedded into and call it generalized complex Heisenberg.We investigate quaternionic analysis on the generalized complex Heisenberg.We also give the Penrose integral formula for k-CF functions and construct the tangential k-Cauchy-Fueter complex.

关键词： the generalized complex Heisenberg group the tangential k-Cauchy-Fueter type operator Penrose-type integral formula

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Influence of Vanes and Blades on Ingress in Axial Rim Seal for Turbine Stages

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Journal of Thermal Science 2024年第3期33卷 833-846页

作者： REN Ran DU Qiang LIU guang ZENG Yanlian XIE Lei Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing100190China National Key Laboratory of Science and Technology on Advanced Light-duty Gas-turbine Beijing100190China School of Aeronautics and Astronautics University of Chinese Academy of SciencesBeijing100190China

Hot gas ingestion refers to the phenomenon of mainstream hot gas flowing into the space cavity of a turbine wheel.Previous studies have found that mainstream annulus pressure distribution plays an important role in hot gas ingestion,but due to its complexity,the mechanism of the interaction between mainstream flow and hot gas ingestion remains unclear.This paper adopts the URANS method,and three sealing flow rates are considered,named C_(w)=0,C_(w)=500,and C_(w)=5000.The time-averaged annulus pressure distribution shows that an increase in the sealing flow decreases the pressure value,and the effects of the sealing flow on the pressure distribution of the leading edge of the blade are much more influential than that of the trailing edge of the vane.The unsteady pressure time-space distribution in the annulus indicates that a time-space tilted distribution of pressure at the rim exits when the sealing flow exists.This phenomenon is mainly due to the strong feedback mechanism of the sealing flow to the annulus pressure field.A comparison of the pressure and mean radial velocity distribution of the mainstream shows that the ingestion mainly occurs on the blade side,where the pressure is lower than on the vane side.The flow characteristics at the wheel rim are analyzed with a sealing flow rate C_(w)=5000,and under these conditions,both pressure-induced ingestion and ingestion caused by a passage vortex can be inferred.The three-dimensional and inertial effects of the mainstream at the wheel rim lead to the generation of separation vortices on the blade side,and the presence of separation vortices leads to ingestion along the blade side.At the same time,pressure on the blade side will cause the fluid to have a radial inward flow tendency,which will promote the formation of separation vortices,leading to more serious ingestion in the high-pressure region on the blade side.The blade pressure field can be more significant than the vane trailing pressure field in the rim seal ingestion,and it contributes some explanations

关键词： separation vortex unsteady rim seal the effect of blade on ingestion

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