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Chemical Research in Chinese Universities 2014年第6期30卷 1051-1056页

作者： LU Taotao NIE Junqi CHEN Zuxing yang guichun LU Cuifen Hubei Collaborative Innovation Center for Advanced Organochemical Materials Key Laboratory for the Synthesis and Application of Organic Functional Molecules Ministry of Education Hubei University Wuhan 430062 P. R. China

The asymmetric alkylation reactions induced by non-cross-linked polystyrene supported cyclosulfamide chiral auxiliary occurred in moderate to good yields with a very high stereoselectivity（e.e.〉99%）. Compared to non-supported cyclosulfamide chiral auxiliary, this chiral auxiliary can be recovered by simple precipitation and filtration, and could be reused at least four cycles without appreciable reduction in the yield or stereoselectivity.

关键词： Polystyrene Cyclosulfarnide Chiral auxiliary Alkylation reaction

Scope and Limitations of Optical Pure Hydantoins as Chiral Auxiliaries in Asymmetric Mannich Reactions

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Chemical Research in Chinese Universities 2016年第2期32卷 219-225页

作者： CHEN Feng LU Cuifen NIE Junqi CHEN Zuxing yang guichun Hubei Collaborative Innovation Center for Advanced Organochemical Materials & Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules Hubei University Wuhan 430062 P. R. China

The Mannich reaction of various 5-substituted and N-acyl substituted chiral hydantoins with a series of aldimines smoothly occurred with full stereochemical control. These Mannich adducts have been cleaved by alcoholysis to afford several synthetically useful chiral building blocks like β-amino esters and β-lactams in good yields and in enantiopure form.

关键词： Scope Limitation Hydantoin Chiral auxiliary Mannich reaction

Enantioselective Chlorocyclization of Olefinic Amides with 1,3-Dichloro-5,5-Dimethylhydantoin（DCDMH） Catalyzed by（DHQD）2PHAL

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Wuhan University Journal of Natural Sciences 2018年第3期23卷 259-264页

作者： ZHOU Qingjun GUO Chao LI Xiwang HE Pei yang guichun DONG Chune Hubei Collaborative Innovation Center for Advanced Organochemical Materials & Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules Hubei University Wuhan 430062 Hubei China School of Pharmaceutical Sciences Wuhan UniversityWuhan 430071 Hubei China

An efficient catalytic asymmetric chlorocyclization of olefinic amides with 1,3-dichloro-5,5-dimethylhydantoin（DCDMH） using hydroquinidine 1,4-phthalazinediyl diether（（DHQD）_2 PHAL） as organocatalyst has been developed. Series of chiral chloro substituted isobenzofuran-1（3 H）-imine derivatives were obtained in good yields（up to 85%） and enantioselectivities（up to 70% ee）.

关键词： Catalyzed by Dimethylhydantoin Enantioselective Chlorocyclization of Olefinic Amides with 1 3-Dichloro-5 DCDMH

Fast-response fluorescent probe with favorable water solubility for highly sensitive imaging of endogenous tyrosinase in living cells and zebrafish model

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Chinese Chemical Letters 2021年第5期32卷 1785-1789页

作者： Zheng Li Xiaofeng Xia Yu You Cuifen Lu guichun yang Chao Ma Junqi Nie Qi Sun Shuilin Wu Jun Ren Feiyi Wang Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials&Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules&State Key Laboratory of Biocatalysis and Enzyme Engineering Hubei UniversityWuhan 430062China Key Laboratory for Green Chemical Process of Ministry of Education and School of Chemistry and Environmental Engineering Wuhan Institute of TechnologyWuhan 430205China

Tyrosinase(TYR) is an important polyphenolic oxidase enzyme and usually regards as a biomarker of melano ma *** effective tracking TYR activity in vivo will help to study the mechanism of TYR in living organisms and forecasts related *** this study,we present a novel TYR-activatable fluo rescent probe(CHMC-DOPA) for tracking TYR activity in vitro and in ***-DOPA is constructed by incorporating dopamine(DOPA) moiety into a fluorescent chloro-hydroxyl-merocyanine(CHMC)*** exposure to TYR,the dopamine unit in CHMC-DOPA is oxidized to a dopaquinone derivative,and an intramolecular photo-induced electron transfer(PET) process between CHMC fluorophore and o-dopaquinone will take place,the fluorescence of CHMC-DOPA is quenched ***,the evaluation of TYR activity is established in terms of the relationship between fluorescence quenching efficiency and TYR *** our experiments,CHMC-DOPA shows various advantages,such as fast response(8 min),low concentration of TYR activation(0.5 U/mL),good water-solubility,as well as the lowest detection limit(0.003 U/mL) compared with previously reported ***,CHMCDO PA also exhibits excellent cell membrane permeability and low cytotoxicity,which is successfully used to monitor endogenous TYR activity in living cancer cells and zebrafish ***-DOPA performs well,and we anticipate that this newly designed novel platform will provide an alternative for high effective monitoring TYR activity in biosystems.

关键词： Fast-response Fluorescent probe Tyrosinase Good biocompatibility Fluorescence imaging

External-Oxidant-Free Electrochemical Oxidative Trifluoromethylation of Arenes Using CF3SO2Na as the CF3 Source

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Chinese Journal of Chemistry 2019年第8期37卷 817-820页

作者： Yong Deng Fangling Lu Siqi You Tianrui Xia Yifan Zheng Cuifen Lu guichun yang Zuxing Chen Meng Gao Aiwen Lei Ministry-of-Educotion Key Laboratory for the Synthesis and Application of Organic Functional Molecule & School of Chemistry and Chemical Engineering Hubei UniversityWuhanHubei 430072China National Research Center for Carbohydrate Synthesis Jiangxi Normal UniversityNanchangJiangxi 330022China College of Chemistry and Molecular Sciences the Institute for Advanced Studies(IAS)Wuhan UniversityWuhanHubei 430072China

Summary of main observation and conclusion An efficient and environmentally benign electrochemical oxidative radical C-H trifluoromethylation of arenes by employing Langlois reagent as the CF3 source was developed in this *** transition metal catalysts nor external chemical oxidants were required in this trifluoromethylation *** reaction could be conducted in gram scale with high reaction efficiency.

关键词： External-Oxidant-Free Electrochemical Oxidative Trifluoromethylation CF3SO2Na CF3

Effects of Crop Stubble on Physicochemical Properties of Continuous Cropping Soil and Cucumber Yield and Quality

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Natural Resources 2012年第3期3卷 88-94页

作者： Yuyan Wang Zhongwei Wang guichun yang Li Wang Yi Zheng Institute of Economic Botany Jilin Academy of Agricultural Sciences Gongzhuling China Institute of Economic Botany Jilin Academy of Agricultural Sciences Gongzhuling China Eco-Agriculture Research Center Binzhou Vocational College Binzhou China

By a pot experiment, two kinds of crop stubble (wheat, soybean) were added into continuous cropping soil of cucumber according to different quantity (0.5%, 1% and 2%), the effects of different kinds of stubble and quantity on the continuous cropping soil and growth of cucumber were investigated. The results showed that two kinds of crop stubble significantly decreased soil bulk density, and increased total porosity of soil. Each of all treatments significantly decreased the accumulation of salinity in soil within the entire growth period of cucumber. 2% wheat stubble treatment had the biggest drop in soil EC in the later period of cucumber growth. Soybean stubble treatment had the lesser effect on soil EC. Wheat and soybean stubble promoted the growth of cucumber, increased the yield of cucumber, and improved the quality of cucumber. 2% of wheat stubble treatment had a biggest increase in cucumber yield, which increased the yield by 34.23% compared with the control.

关键词： Wheat Soybean Stubble Continuous Cropping Cucumber Sick Soil Yield and Quality Physicochemical Properties

亚硝基苯参与的电化学串联环化反应构建喹啉/吡咯

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有机化学 2024年第3期44卷 1021-1030页

作者：杨帆方婷杨桂春高梦湖北大学化学化工学院、有机功能分子合成与应用教育部重点实验室武汉430062 武汉大学化学与分子科学学院武汉430072

报道了一种多取代喹啉/吡咯杂环化合物的电化学合成新方法.反应以亚硝基苯和贫电子内炔为起始物,在无需额外金属催化剂、室温条件下,通过阴极单电子还原的策略,选择性地还原亚硝基苯产生亚硝基自由基,随后与炔烃进行串联环化反应,绿色... 详细信息

报道了一种多取代喹啉/吡咯杂环化合物的电化学合成新方法.反应以亚硝基苯和贫电子内炔为起始物,在无需额外金属催化剂、室温条件下,通过阴极单电子还原的策略,选择性地还原亚硝基苯产生亚硝基自由基,随后与炔烃进行串联环化反应,绿色、高效地合成了一系列具有高附加值的多取代喹啉/吡咯杂环化合物.

关键词：电化学合成串联环化亚硝基苯

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聚合物支载合成杂环化合物的研究进展

有机化学 2002年第12期22卷 936-942页

作者：杨桂春陈祖兴胡春玲湖北大学化学与材料科学学院武汉430062

聚合物支载的反应与传统的经典液相反应相比 ,具有独特的优点 ,广泛应用于杂环化合物的合成 .综述了近年来杂环化合物的固相和液相合成研究 .

关键词：聚合物支载杂环化合物研究进展可溶性聚合物固相合成

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微波辅助聚合物支载的有机反应

有机化学 2002年第4期22卷 289-293页

作者：杨桂春陈祖兴胡春玲湖北大学化学与材料科学学院武汉430062

微波辐射下 ,聚合物支载的有机反应易于进行 ,操作简便 ,反应速率高 ,反应时间短 ,产率高 ,纯度好 ,聚合物载体稳定 .

关键词：有机反应聚合物微波辐射偶联反应缩合反应加成反应酯化反应成环反应

“学术资本主义”与大学教师学术职业角色的转换

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教育科学 2016年第5期32卷 47-52页

作者：杨超张桂春云南师范大学高等教育与区域发展研究院云南昆明650500 辽宁师范大学教育学院辽宁大连116029

"学术资本主义"是指"大学及其教师为确保外部资金所进行的市场活动或具有市场特点的活动",它以市场为逻辑,通过市场与知识的联姻,使大学呈现出明显的市场化特征。20世纪80年代后,在学术资本主义的影响下,西方发达国家大学教师学术职业... 详细信息

"学术资本主义"是指"大学及其教师为确保外部资金所进行的市场活动或具有市场特点的活动",它以市场为逻辑,通过市场与知识的联姻,使大学呈现出明显的市场化特征。20世纪80年代后,在学术资本主义的影响下,西方发达国家大学教师学术职业角色发生了由"学者"到"创业者"、由"基础研究者"到"应用研究者"、由"公共知识分子"到"专业知识分子"、由"立法者"到"阐释者"的转换。这种转变,一方面适应了时代变迁对大学教师职业角色的新要求,另一方面也导致了大学教师本体角色的式微与逐步消解,同时也对我国大学教师的学术职业角色产生了深刻影响。因此,要辩证地思考我国出现的"学术资本主义"现象与西方学术资本主义的联系性和差异性,重塑我国大学教师学术职业角色的价值认知和学术职业制度环境,从而明确大学教师学术职业角色的责任担当。

关键词：学术资本主义大学教师学术职业角色转换