Enantioselective Chlorocyclization of Olefinic Amides with 1,3-Dichloro-5,5-Dimethylhydantoin（DCDMH） Catalyzed by（DHQD）2PHAL

作     者：ZHOU Qingjun GUO Chao LI Xiwang HE Pei YANG Guichun DONG Chune 

作者机构：Hubei Collaborative Innovation Center for Advanced Organochemical Materials & Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules Hubei University Wuhan 430062 Hubei China School of Pharmaceutical Sciences Wuhan UniversityWuhan 430071 Hubei China 

出 版 物：《Wuhan University Journal of Natural Sciences》 (武汉大学学报（自然科学英文版）)

年 卷 期：2018年第23卷第3期

页      面：259-264页

核心收录：

学科分类：08[工学] 081201[工学-计算机系统结构] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

基　　金：Supported by the Fundamental Research Funds for the Central Universities of China(2015306020201) 

主　　题：Catalyzed by Dimethylhydantoin Enantioselective Chlorocyclization of Olefinic Amides with 1 3-Dichloro-5 DCDMH 

摘      要：An efficient catalytic asymmetric chlorocyclization of olefinic amides with 1,3-dichloro-5,5-dimethylhydantoin（DCDMH） using hydroquinidine 1,4-phthalazinediyl diether（（DHQD）_2 PHAL） as organocatalyst has been developed. Series of chiral chloro substituted isobenzofuran-1（3 H）-imine derivatives were obtained in good yields（up to 85%） and enantioselectivities（up to 70% ee）.