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High Expression of ERCC1 Is a Poor Prognostic Factor in Chinese Patients with Non-small Cell Lung Cancer Receiving Cisplatin-based Therapy

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Chinese Journal of Cancer Research 2010年第4期22卷 296-302页

作者： Qing-zhi Guo jie Wang Hua Bai Tong-tong An Meina Wu Jun Zhao Lu yang Jian-chun Duan Yu-yan Wang zhi-jie Wang Key laboratory of Carcinogenesis and Translational Research （Ministry of Education） Department of Medical Oncology Peking University Cancer Hospital ＆ Institute Beijing 100142 China

Objective： to determine the role of excision repair cross-complementing group 1 gene （ERCC1） and ribonucleotide reductase subunit M1 （RRM1） expression in predicting response and survival in Chinese patients with advanced stage non-small cell lung cancer （NSCLC） treated with platinum-based chemotherapy. Methods： Formalin-fixed, paraffin-embedded biopsy tissues were retrospectively obtained from 160 advanced NSCLC patients. mRNA expression levels of ERCC1 and RRM1 were determined by real-time PCR. Results： Associations between mRNA expression level of ERCC1 and RRM1 and clinic-pathologic parameters were analyzed. One handred and forty two （88.75%） specimens were successfully amplified. mRNA expression level of ERCC1 and RRM1 was negatively associated with tumor response. ERCC1 expression levels ranged from 0.01 to 78.79 [median 0.63, mean 4.25 and standard deviation （SD） 9.23] and RRM1 from 0.00 to 30.91 （median 0.63, mean 0.87 and SD 3.36）. By adopting cut-off values according to median expression levels, we found that MST in patients with low ERCC1 mRNA levels was significantly longer in overall population than in patients with higher levels （18.63 versus 13.69 months, log-rank 5.73, P=0.017）, but we did not found the survival benefit of the patients with low expression level of RRM1. （19.07 versus 14.88, log-rank 1.66, P=0.197）. Further, in the multivariable Cox regression model analysis we found that low level of ERCC1 expression, the presence of weight loss and target therapy, were significant prognostic factors for survival. Conclusion： ERCC1 expression is associated with patients’ survival in Chinese advanced NSCLC patients treated with platinum-based regimen and may serve as a biomarker in predicting tumor response and clinical outcome in the patient population.

关键词： ERCC1 RRM1 NSCLC Platinum-based chemotherapy mRNA Realtime PCR

Female Fertility： Is it Safe to Freeze.

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Chinese Medical Journal 2015年第3期128卷 390-397页

作者： Lu Zhang Li-Ying yan Xu zhi jie Yah jie Qiao Department of Obstetrics and Gynecology Center for Reproductive Medicine Peking University Third Hospital Key Laboratory of Assisted Reproduction Ministry of Education Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction Beijing 100191 China

Objective： To evaluate the safety and risk of cryopreservation in female fertility preservation. Data sources： The data analyzed in this review were the English articles from 1980 to 2013 from journal databases, primarily PubMed and Google scholar. The criteria used in the literature search show as tbllowing：（ 1 ） human; embryo; cryopreservation/freezing/vitrification, （2） human; oocyte/immature oocyte; cryopreservation/freezing/vitrification, （3） human; ovarian tissue transplantation; cryopreservation/ freezing/vitrification, （4） human; aneuploidy/DNA damage/epigenetic; cryopreservation/freezing/vitrification, and （5） human; fertility preservation; maternal age. Study selection： The risk ratios based on survival rate, maturation rate, fertilization rate, cleavage rate, implantation rate. pregnancy rate. and clinical risk rate were acquired from relevant meta-analysis studies. These studies included randomized controlled trials or studies with one of tile primary outcome measures covering cryopreservation of human mature oocytes, embryos, and ovarian tissues within the last 7 years （from 2006 to 2013. since the pregnancy rates of oocyte vitrification were significantly increased due to the improved techniques）. The data involving immature oocyte cryopreservation obtained from individual studies was also reviewed by the at, thors. Results： Vitrifications of mature oocytes and embryos obtained better clinical outcomes and did not increase the risks of DNA damage, spindle configuration, embryonic aneuploidy, and genomic imprinting as compared with fresh and slow-freezing procedures, respectively. Conclusions： Both embryo and oocyte vitrifications are safe applications in female fertility preservation.

关键词： Embryo Cryopreservation Oocyte Cryopreservation: Ovarian Tissue Cryopreservation

A Fast Algorithm for Improving the Visual Distance in Fog

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Semiconductor Photonics and Technology 2009年第4期15卷 241-246页

作者： yanG Wei XIAO zhi-tao YU Jian yan zhi-jie School of Information and Communication Engineering Tianjin Polytechnic University Tianjin 300160 CHN School of Computer Science and Technology Tianjin University Tianjin 300072 CHN

Images captured outdoor usually degenerate because of the bad weather conditions,among which fog,one of the widespread phenomena,affects the video quality *** physical features of fog make the video blurred and the visible distance shortened,seriously impairing the reliability of the video *** order to satisfy the requirement of image processing in real-time,the normal distribution curve fitting technology is used to fit the histogram of the sky part and the region growing method is used to segment the region of *** for the non-sky part,a method of self-adaptive interpolation to equalize the histogram is adopted to enhance the contrast of the *** results show that the method works well and will not cause block effect.

关键词： fog image interpolation region growing histogram equalization fast algorithm normaldistribution

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压痕塑性变形诱导非晶合金的晶化

物理学报 2007年第2期56卷 999-1003页

作者：闫志杰李金富周尧和仵彦卿上海交通大学金属基复合材料国家重点实验室上海交通大学环境科学与工程学院上海200030

利用透射电镜研究了Zr65Al7.5Ni10Cu12.5Ag5非晶合金的Vickers压痕内微观结构的变化.结果发现,压痕塑性变形诱导非晶合金发生了晶化,在压头棱角下面的区域内有尺寸大于1μm的晶体析出.选区电子衍射分析表明,该析出相是稳定的CuZr2或NiZr... 详细信息

利用透射电镜研究了Zr65Al7.5Ni10Cu12.5Ag5非晶合金的Vickers压痕内微观结构的变化.结果发现,压痕塑性变形诱导非晶合金发生了晶化,在压头棱角下面的区域内有尺寸大于1μm的晶体析出.选区电子衍射分析表明,该析出相是稳定的CuZr2或NiZr2四方晶体,而没有析出该非晶合金在加热过程中的初生相二十面体准晶相,说明非晶合金的机械稳定性与热稳定性是有区别的.打压痕过程中的温度升高是可以忽略的,本工作进一步证实了塑性变形诱导非晶合金晶化的主要动力是粘性流动而非局部热效应.

关键词：非晶合金塑性变形粘性流动局部热效应

Influence of amorphous degree on crystallization kinetics of Zr_(60)Al_(15)Ni_(25) bulk metallic glass

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Transactions of Nonferrous Metals Society of China 2011年第2期21卷 300-306页

作者：马强闫志杰郝维新胡勇太原科技大学材料科学与工程学院太原030024

The microstructure of as-cast Zr60Al15Ni25 bulk metallic glass was investigated by high-resolution transmission electron microscopy. It is found that there exist numerous short-range order regions （SRORs） in the metallic glass though it is identified to be amorphous by X-ray diffraction method. Furthermore, the amorphous degree shows a close correlation with the microstructure of corresponding mother ingot. The crystallization kinetics was investigated by differential scanning calorimetry under isochronal and isothermal conditions. The results show that the crystallization is triggered by the growth of the pre-existing SRORs and the growth is three-dimension diffusion-controlled. The amorphous degree of Zr60Al15Ni25 bulk metallic glass considerably influences its crystallization kinetics, namely, the more homogeneous distribution of atoms results in a more sluggish nucleation behavior.

关键词： Zr6oAl15Ni25 metallic glass short-range order crystallization kinetics

解读马克思的“重建个人所有制”——简评我国产权制度改革的目标取向

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西部论坛 2011年第1期21卷 1-5页

作者：晏智杰北京大学经济学院北京100871

我国产权制度改革的最终目标应当是马克思所说的"在生产资料共同占有的基础上重建个人所有制"。"个人所有制"不应理解为消费品个人所有、私有制或者生产资料脱离价值形态的单纯物质形态的个人所有,而应当理解为在共同占有生产资料的基础... 详细信息

我国产权制度改革的最终目标应当是马克思所说的"在生产资料共同占有的基础上重建个人所有制"。"个人所有制"不应理解为消费品个人所有、私有制或者生产资料脱离价值形态的单纯物质形态的个人所有,而应当理解为在共同占有生产资料的基础上,每个社会成员都能依靠自己的劳动和其他贡献实际确立其所有权的个人所有制。当前的国有制仍然是政府部门或机构所有。应当继续推进产权制度改革,以马克思的"个人所有制"为基本方向,积极探索真正实现生产资料共有基础上的个人所有权的具体形式。

关键词：个人所有制产权制度改革国有企业国有制股份制生产资料共有政府部门所有制马克思

铸锭凝固组织对相应非晶合金晶化过程中二十面体准晶相形成动力学的影响

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物理学报 2005年第10期54卷 4556-4561页

作者：同育全申宝成甘玉生闫志杰太原科技大学材料科学与工程学院太原030024

通过在真空电弧熔炼炉内对合金铸锭进行反复熔炼处理,获得到了凝固组织不同的Zr65Al7·5Cu12·5Ni10Ag5合金铸锭.在相同的制备条件下,由凝固组织不同的合金铸锭通过吸铸法制备得到了薄片非晶合金.利用差示扫描量热法(DSC)对非晶合金的... 详细信息

通过在真空电弧熔炼炉内对合金铸锭进行反复熔炼处理,获得到了凝固组织不同的Zr65Al7·5Cu12·5Ni10Ag5合金铸锭.在相同的制备条件下,由凝固组织不同的合金铸锭通过吸铸法制备得到了薄片非晶合金.利用差示扫描量热法(DSC)对非晶合金的晶化动力学进行了分析.x射线衍射谱表明,在Zr65Al7·5Cu12·5Ni10Ag5非晶合金晶化过程中,二十面体准晶相(I相)作为初生相析出.Kissinger分析结果表明,合金铸锭的凝固组织细化,相对应的非晶合金发生晶化时,I相形成与分解的有效激活能都增大,说明非晶合金及析出的I相的热稳定性都提高.从结构的遗传性角度就合金铸锭凝固组织对相应非晶合金晶化过程中二十面体准晶相的形成动力学的影响进行了讨论.

关键词：二十面体准晶相晶化动力学凝固组织非晶合金合金铸锭形成动力学晶化过程二十面体准晶相真空电弧熔炼

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关于中国经济学的指导思想问题

西安财经学院学报 2005年第6期18卷 5-7页

作者：晏智杰北京大学经济学院北京100871

当代中国经济学教学和研究,不应以传统的马克思主义政治经济学为指导思想,也不应以西方经济学为指导思想。必须以当代中国的马克思主义———邓小平理论和“三个代表”重要思想为指导,借鉴和吸收马克思主义经济学和西方经济学的科学成果... 详细信息

当代中国经济学教学和研究,不应以传统的马克思主义政治经济学为指导思想,也不应以西方经济学为指导思想。必须以当代中国的马克思主义———邓小平理论和“三个代表”重要思想为指导,借鉴和吸收马克思主义经济学和西方经济学的科学成果,立足中国的基本国情,解决中国的经济问题,才能实现发展创新。

关键词：马克思主义政治经济学西方经济学中国经济学指导思想

Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-Fan yang zhi-Cheng Zhang Qi Dai Xiao-yan Bao Lin-jie Wu Ya-Xin Qin Xin Tan Xiao-yan Sun Xu-Fang Ying zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin