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Asiaticoside improves diabetic nephropathy by reducing inflammation, oxidative stress, and fibrosis: An in vitro and in vivo study

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World Journal of Diabetes 2024年第10期15卷 2111-2122页

作者： Lan-Gen Zhuang Rong Zhang Guo-Xi Jin xiao-yan pei Qiong Wang xiao-Xu Ge Department of Endocrinology The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233004Anhui ProvinceChina Department of Nephrology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Endocrinology Tongren Hospital Affiliated to Shanghai Jiao Tong UniversityShanghai 200336China

BACKGROUND Diabetic nephropathy(DN)is a severe microvascular complication of diabetes characterized by inflammation,oxidative stress,and renal ***(AC)exhibits anti-inflammatory,antioxidant,and anti-fibrotic properties,suggesting potential therapeutic benefits for *** study aimed to investigate the protective effects of AC against DN and elucidate the underlying mechanisms involving the nuclear factor erythroid 2-related factor 2(NRF2)/heme oxygenase-1(HO-1)antioxidant *** The effects of AC on high glucose(HG)-induced proliferation,inflammation,oxidative stress,and fibrosis were evaluated in rat glomerular mesangial cells(HBZY-1)in vitro.A streptozotocin-induced DN rat model was established to assess the in vivo impact of AC on renal injury,inflammation,oxidative stress,and *** involvement of the NRF2/HO-1 pathway was examined using pharmacological inhibition studies in the cell *** AC inhibited HG-induced HBZY-1 cell proliferation and significantly improved various indicators of DN in rats,including reduced body weight,and elevated blood glucose,serum creatinine,blood urea nitrogen,and 24-h urine *** in vitro and in vivo studies demonstrated that AC decreased inflammation and oxidative stress by reducing interleukin(IL)-6,IL-8,tumor necrosis factor-alpha,reactive oxygen species,and malondialdehyde levels while increasing superoxide dismutase ***,AC suppressed the expression of fibrogenic markers such as collagen I,collagen IV,and *** activated NRF2 expression in the nucleus and increased HO-1 and NAD(P)H dehydrogenase(Quinone)1 protein expression in renal tissues and HG-induced HBZY-1 *** AC improves DN by reducing inflammation,oxidative stress,and fibrosis through the activation of the NRF2/HO-1 signaling *** findings not only highlight AC as a promising therapeutic candidate for DN but also underscore the potential of targeting the NRF2/HO-1 pathway in

关键词： Asiaticoside Diabetic nephropathy Inflammation Renal fibrosis Reactive oxygen species

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SUSTAINABLE URBAN-RURAL RELATION IN RAPID URBANIZATION AREAS——Case of Transformation of "Urban Village" in Guangzhou

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Chinese Geographical Science 2005年第3期15卷 212-218页

作者： WEI Li-hua yan xiao-pei College of Architecture ＆ Civil Engineering South China University of Technology Guangzhou 510640 P. R. China Center for Urban ＆ Regional Studies Sun Yat-Sen University Guangzhou 510275 P. R. China

Many studies have been made concerning the problems, characteristics, formation, transformation measures, etc. of urban village from sociology, urban planning and geography, etc., which have made insightful analysis. However, most of these studies started mainly from the standpoint of the city govemment, drumming for the land- scape-oriented urbanization, namely pulling-down the urban village and constructing the splendid residence or business buildings. The article maintains that the most important thing the city government should do is to pay much attention to the sustainable living of urban villagers, who would lose their main income source, namely, the collective dividend and the family housing rent. The single method of compensation has been proved to be harmful to the villagers＇ community, in which some young villagers relying on rent were no longer to do anything but stay at home. On the other hand, considering the floating population has become the main stream of renters in urban villages, the emergence of urban villages was inevitable and would continue to exist in a long time under the socio-economic transition in urban China and globalization. Based on the analysis above, the transformation of urban village should take more concerns on the housing demands of floating population besides compensation for local villagers. Meanwhile, it is necessary to avoid the “landscape-oriented urbanization” without the “peasant-to-citizen” transformation.

关键词： urban-rural relation rapid urbanization areas Guangzhou urban village

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STUDY ON THE URBAN TRANSPORT AND LAND-USE OF GUANGZHOU

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Chinese Geographical Science 2000年第2期10卷 144-150页

作者： CAO xiao-shu yanG Fan yan xiao-pei (Center for Urban and Regional Studies, Zhongshan University, Guangzhou 510275, P.R.China) Center for Urban and Regional Studies Zhongshan University Guangzhou P. R. China

Changes in transport are likely to preduce changes in land use, and these long-term effects of transport policy may be of considerable potential importance. There is a growing movement, "The New Urbanism", which seeks to reconnect transport with land use and in particular to eslablish transitoriented development where higher-density,mixed-use areas are built around high-quality transit systems. Based on analysis on development and Pattern of urban transport inGuangzhou, this paper researches composition of urban transportation and struclure of travel pattern. The urban transport system development and change in urban form as well as change in land use are closely related. The urban transport, system required and promnoted by the high-density land-use pattern. There are many problems in the urban transportation and land-use, one of the resolving is integration of urban transport planning and land-use planning.

关键词： urban transport land-use Guangzhou City

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Spatially selective p-type doping for constructing lateral WS_(2) p-n homojunction via low-energy nitrogen ion implantation

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Light(Science & Applications) 2024年第6期13卷 1159-1169页

作者： Yufan Kang Yongfeng pei Dong He Hang Xu Mingjun Ma Jialu yan Changzhong Jiang Wenqing Li Xiangheng xiao School of Physics and Technology Key Lab of Artificial Micro-and Nano-Structures of Ministry of EducationWuhan UniversityWuhanChina

The construction of lateral p-n junctions is very important and challenging in two-dimensional(2D)semiconductor manufacturing *** researches have demonstrated that vertical p-n junction can be prepared simply by vertical stacking of 2D ***,interface pollution and large area scalability are challenges that are difficult to overcome with vertical stacking *** 2D lateral p-n homojunction is an effective strategy to address these *** selective p-type doping of 2D semiconductors is expected to construct lateral p-n *** this work,we have developed a low-energy ion implantation system that reduces the implanted energy to 300 ***-energy implantation can form a shallow implantation depth,which is more suitable for modulating the electrical and optical properties of 2D ***,we utilize low-energy ion implantation to directly dope nitrogen ions into few-layer WS_(2) and successfully realize a precise regulation for WS_(2) with its conductivity type transforming from n-type to bipolar or even p-type ***,the universality of this method is demonstrated by extending it to other 2D semiconductors,including WSe_(2),SnS_(2) and MoS_(2).Based on this method,a lateral WS_(2) p-n homojunction is fabricated,which exhibits significant rectification characteristics.A photodetector based on p-n junction with photovoltaic effect is also prepared,and the open circuit voltage can reach to 0.39 *** work provides an effective way for controllable doping of 2D semiconductors.

关键词： implantation doping Spatial

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GATA binding protein 2 mediated ankyrin repeat domain containing 26 high expression in myeloid-derived cell lines

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World Journal of Stem Cells 2024年第5期16卷 538-550页

作者： yang-Zhou Jiang Lan-Yue Hu Mao-Shan Chen xiao-Jie Wang Cheng-Ning Tan pei-pei Xue Teng Yu xiao-yan He Li-Xin Xiang yan-Ni xiao xiao-Liang Li Qian Ran Zhong-Jun Li Li Chen Laboratory of Radiation Biology Department of Blood TransfusionLaboratory Medicine CenterThe Second Affiliated HospitalThird Military Medical UniversityChongqing 400037China Hematopoietic Acute Radiation Syndrome Medical and Pharmaceutical Basic Research Innovation Center Ministry of Education of the People’s Republic of ChinaChongqing 400037China

BACKGROUND Thrombocytopenia 2,an autosomal dominant inherited disease characterized by moderate thrombocytopenia,predisposition to myeloid malignancies and normal platelet size and function,can be caused by 5’-untranslated region(UTR)point mutations in ankyrin repeat domain containing 26(ANKRD26).Runt related transcription factor 1(RUNX1)and friend leukemia integration 1(FLI1)have been identified as negative regulators of ***,the positive regulators of ANKRD26 are still *** To prove the positive regulatory effect of GATA binding protein 2(GATA2)on ANKRD26 *** Human induced pluripotent stem cells derived from bone marrow(hiPSC-BM)INTRODUCTION Ankyrin repeat domain containing protein 26(ANKRD26)acts as a regulator of adipogenesis and is involved in the regulation of feeding behavior[1-3].The ANKRD26 gene is located on chromosome 10 and shares regions of homology with the primate-specific gene family *** to the Human Protein Atlas database,the ANKRD26 protein is localized to the Golgi apparatus and vesicles,and its expression can be detected in nearly all human tissues[4].Moreover,UniProt annotation revealed that ANKRD26 is localized in the centrosome and contains coiled-coil domains formed by spectrin helices and ankyrin repeats[5,6].The most common disease related to ANKRD26 is thrombocytopenia 2(THC2),which is a rare autosomal dominant inherited disease characterized by lifelong mild-to-moderate thrombocytopenia and mild bleeding[7-9].Caused by the variants in the 5’-untranslated region(UTR)of ANKRD26,THC2 is defined by a decrease in the number of platelets in circulating blood and results in increased bleeding and decreased clotting ability[8,10].Due to the point mutations that occur in the 5’-UTR of ANKRD26,its negative transcription factors(TFs),Runt related transcription factor 1(RUNX1)and friend leukemia integration 1(FLI1),lose their repression effect[11].The persistent expression of ANKRD26 increases the activi

关键词： Ankyrin repeat domain containing 26 GATA binding protein 2 Thrombocytopenia 2 Transcriptional regulation Myeloid-derived cell lines

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广州信息密集服务业的空间发展及其对城市地域结构的影响

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地理科学 1999年第5期19卷 405-410页

作者：阎小培中山大学城市与区域研究中心广东广州510275

采用第三产业普查资料，深入分析了改革开放以来广州信息密集服务业的发展水平、空间发展特征和原因及其对城市地域结构的影响，揭示了信息密集服务业发展与城市地域运动的关系。

关键词：信息密集服务业空间发展城市地域结构广州

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Effects of microplastic polystyrene,simulated acid rain and arbuscular mycorrhizal fungi on Trifolium repens growth and soil microbial community composition

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Pedosphere 2024年第2期34卷 424-437页

作者： Wanlin LI yan xiao College of Agro-grassland Science Nanjing Agricultural UniversityNanjing 210095China

Microplastic pollution is a global and ubiquitous environmental problem in the oceans as well as in the terrestrial *** examined the fate of microplastic polystyrene(MPS)beads in experimental soil in the presence and absence of symbiotic arbuscular mycorrhizal fungi(AMF)and simulated acid rain(SAR)to determine whether the combinations of these three factors altered the growth of white clover Trifolium *** found that MPS,SAR,or AMF added singly to soil did not alter *** growth or *** contrast,MPS and AMF together significantly reduced shoot biomass,while SAR and MPS together significantly reduced soil available phosphorus independent of AMF *** polystyrene,AMF,and SAR together significantly reduced soil NO_(3)^(-)-*** mycorrhizal fungi added singly also enriched the beneficial soil bacteria(genus Solirubrobacter),while MPS combined with AMF significantly enriched the potential plant pathogenic fungus *** mycorrhizal fungi inoculation with MPS increased the abundance of soil hydrocarbon degraders independent of the presence of *** addition,the abundance of soil nitrate reducers was increased by MPS,especially in the presence of AMF and ***,SAR alone increased the abundance of soil pathogens within the fungal community including antibiotic *** findings indicate that the coexistence of MPS,SAR,and AMF may exacerbate the adverse effects of MPS on soil and plant health.

关键词： acid deposition arbuscular mycorrhizal fungi symbiosis hydrocarbon degradation microbial alpha diversity microplastic pollution pathogen

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Sliced Average Variance Estimation for Tensor Data

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 630-655页

作者： Chuan-quan LI pei-wen xiao Chao YING xiao-hui LIU School of Statistics Jiangxi University of Finance and EconomicsNanchang 330013China Key Laboratory of Data Science in Finance and Economics Jiangxi University of Finance and EconomicsNanchang 330013China Biostatistics and Medical Informatics University of Wisconsin MadisonMadison 53726USA

Tensor data have been widely used in many fields,e.g.,modern biomedical imaging,chemometrics,and economics,but often suffer from some common issues as in high dimensional *** to find their low-dimensional latent structure has been of great interest for *** this end,we develop two efficient tensor sufficient dimension reduction methods based on the sliced average variance estimation(SAVE)to estimate the corresponding dimension reduction *** first one,entitled tensor sliced average variance estimation(TSAVE),works well when the response is discrete or takes finite values,but is not■consistent for continuous response;the second one,named bias-correction tensor sliced average variance estimation(CTSAVE),is a de-biased version of the TSAVE *** asymptotic properties of both methods are derived under mild *** and real data examples are also provided to show the superiority of the efficiency of the developed methods.

关键词： tensor data sliced average variance estimation sufficient dimension reduction central subspace

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THE SPATIAL DIVISION OF INDUSTRIES OF THE PEARL RIVER DELTA IN THE 1990s: CHARACTERISTICS AND TRENDSS

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Chinese Geographical Science 2001年第1期11卷 63-69页

作者： XU Yong-jian,yan xiao-pei,XU Xue-qiang (Center for Urban and Regional Studies, Zhongshan University, Guangzhou 510275, P. R. China) Center for Urban and Regional Studies Zhongshan University Guangzhou P. R. China

The article analyzed the spatial division of industries of the Pearl River Delta (PRD) in the 1990s, a period that witnessed the deepening of the reform and opening policies and continued rapid development of the region. By adopting the index of specialization, the extent of specialization, its change and its spatial distribution in the region are measured and demonstrated. The research revealed that, despite the trend of more balanced development of the secondary sector between the PRD and the rest of the province, in the PRD, it is the unbalanced development that dominated and the spatial division of the secondary sector has been shaped. The tertiary industry has also been experiencing unbalance development and the spatial division of the tertiary sector has been emerging, its extent of concentration appearing even more evident than that of the secondary sector. The author also discussed the linkage between the spatial division of the two sectors. In the end of the paper, the trends of the spatial division of the industries in the PRD are forecasted.

关键词： Pearl River Delta spatial division of industries characteristics and trends

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Construction of a predictive model for acute liver failure after hepatectomy based on neutrophil-to-lymphocyte ratio and albuminbilirubin score

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1087-1096页

作者： xiao-pei Li Zeng-Tao Bao Li Wang Chun-yan Zhang Wen yang Department of Family Planning and Assisted Reproductive Technology The First People’s Hospital of LianyungangLianyungang 222000Jiangsu ProvinceChina Department of Gastrointestinal Surgery The First People’s Hospital of LianyungangLianyungang 222000Jiangsu ProvinceChina Department of Laboratory Medicine The First People’s Hospital of LianyungangLianyungang 222000Jiangsu ProvinceChina Department of Gynecology The First People’s Hospital of LianyungangLianyungang 222000Jiangsu ProvinceChina

BACKGROUND Acute liver failure(ALF)is a common cause of postoperative death in patients with hepatocellular carcinoma(HCC)and is a serious threat to patient *** neutrophil-to-lymphocyte ratio(NLR)is a common inflammatory indicator that is associated with the prognosis of various diseases,and the albumin-bilirubin score(ALBI)is used to evaluate liver function in liver cancer ***,this study aimed to construct a predictive model for postoperative ALF in HCC tumor integrity resection(R0)based on the NLR and ALBI,providing a basis for clinicians to choose appropriate treatment *** To construct an ALF prediction model after R0 surgery for HCC based on NLR and *** In total,194 patients with HCC who visited The First People’s Hospital of Lianyungang to receive R0 between May 2018 and May 2023 were enrolled and divided into the ALF and non-ALF *** compared differences in the NLR and ALBI between the two *** risk factors of ALF after R0 surgery for HCC were screened in the univariate *** risk factors were analyzed by multifactorial logistic *** then constructed a prediction model of ALF after R0 surgery for HCC.A receiver operating characteristic curve,calibration curve,and decision curve analysis(DCA)were used to evaluate the value of the prediction *** Among 194 patients with HCC who met the standard inclusion criteria,46 cases of ALF occurred after R0(23.71%).There were significant differences in the NLR and ALBI between the two groups(P<0.05).The univariate analysis showed that alpha-fetoprotein(AFP)and blood loss volume(BLV)were significantly higher in the ALF group compared with the non-ALF group(P<0.05).The multifactorial analysis showed that NLR,ALBI,AFP,and BLV were independent risk factors for ALF after R0 surgery in *** predictive efficacy of NLR,ALBI,AFP,and BLV in predicting the occurrence of ALT after R0 surgery for HCC was average[area under the curve(AUC)NLR=0.767,AUCALB

关键词： Acute liver failure Hepatocellular carcinoma Hepatectomy Neutrophil-to-lymphocyte ratio Albumin-bilirubin score

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