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Parkinson’s disease-associated VPs35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkinmediated mitophagy

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Translational Neurodegeneration 2021年第2期10卷 240-256页

作者： kai yu Ma Michiel R.Fokkens Fulvio Reggiori Muriel Mari Dineke s.Verbeek Department of Genetics University of GroningenUniversity Medical Center GroningenGroningenThe Netherlands Department of Biomedical sciences of Cells and systems University of GroningenUniversity Medical Center GroningenGroningenThe Netherlands

Background:Mitochondrial dysfunction plays a prominent role in the pathogenesis of Parkinson’s disease(PD),and several genes linked to familial PD,including PINK1(encoding PTEN-induced putative kinase 1[PINK1])and PARK2(encoding the E3 ubiquitin ligase Parkin),are directly involved in processes such as mitophagy that maintain mitochondrial *** dominant p.D620N variant of vacuolar protein sorting 35 ortholog(VPs35)gene is also associated with familial PD but has not been functionally connected to PINK1 and ***:To better mimic and study the patient situation,we used CRIsPR-Cas9 to generate heterozygous human sH-sy5y cells carrying the PD-associated D620N variant of *** cells were treated with a protonophore carbonyl cyanide m-chlorophenylhydrazone(CCCP)to induce the PINK1/Parkin-mediated mitophagy,which was assessed using biochemical and microscopy ***:Mitochondria in the VPs35-D620N cells exhibited reduced mitochondrial membrane potential and appeared to already be damaged at steady *** a result,the mitochondria of these cells were desensitized to the CCCPinduced collapse in mitochondrial potential,as they displayed altered fragmentation and were unable to accumulate PINK1 at their surface upon this ***,Parkin recruitment to the cell surface was inhibited and initiation of the PINK1/Parkin-dependent mitophagy was ***:Our findings extend the pool of evidence that the p.D620N mutation of VPs35 causes mitochondrial dysfunction and suggest a converging pathogenic mechanism among VPs35,PINK1 and Parkin in PD.

关键词： VPs35 PINK1 Parkin Mitophagy Mitochondrial membrane potential Parkinson’s disease

Hydrogen-induced marginal growth model for the synthesis of graphene by arc discharge

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science China(Technological sciences) 2021年第5期64卷 1074-1080页

作者： ZHANG Da yE kai LIANG Feng DAI yongNian Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming 650093China state Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Kunming University of Science and TechnologyKunming 650093China

High-quality graphene is prepared by arc discharge with low cost under hydrogen atmosphere. However, the growth mechanism of graphene synthesis by arc discharge remains unclear. In this paper, the hydrogen-induced marginal growth(HIMG) model is deduced to study the growth mechanism of graphene by combining experiment with numerical simulation results. First, the characteristics of thick edges and thin middle and containing hydrogen are verified by transmission electron microscopy and Raman spectroscopy, respectively. In addition, numerical simulation provides the chemical species and temperature range of graphene growth. second, the marginal growth pattern of hydrogen transfer and carbon addition is introduced because the C–H and C–C reduce configuration energy and island energy, respectively. Meanwhile, the stacking growth at the margin of the graphene island leads to the longitudinal growth of graphene because of the Van der Waals force and the effect of self-assembly,increasing the number of graphene layers. Finally, graphene sheets with a small amount of hydrogen are deposited on the inner wall after annealing. The investigation of the growth mechanism of graphene under hydrogen atmosphere lays a foundation for the large-scale preparation of graphene by arc discharge.

关键词： hydrogen graphene growth mechanism hydrogen-induced marginal growth model arc discharge

Design of novel NisiAly alloys in marine salt-spray environment:PartⅠ.Al-si-y and Ni-si-y subsystems

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Journal of Materials science & Technology 2021年第29期88卷 66-78页

作者： kai Xu Keke Chang yong Du Liping Wang Key Laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201China Center of Materials science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China state Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083China

MCrAly(M=Ni,Co,NiCo)alloys have been widely used as a bond layer for thermal barrier coatings(TBCs).However;oxides form discontinuously on MCrAly surface in the marine environment since Cr_(2)O_(3)can react with NaCl and H_(2)O at temperatures above 500℃.Replacing Cr with other alloying elements(such as si)might prevent severe salt-spray corrosion *** save time and efforts in materials design of the Ni-si-Al-y system;we obtained the thermodynamic descriptions of the ternary compounds by coupling the CALPHAD(CALculation of PHAse Diagrams)approach and first-principles *** and eighteen ternary compounds were evaluated and calculated in the Al-si-y and Ni-si-y systems;*** diagrams of the two systems were depicted after a series of experimental Al/Ni-si-RE(RE denotes rare earth elements,including La,Ce,Pr,Nd,sm,Gd,Dy,Ho,and Er)systems being *** is found that the RE elements with the same reference states tend to form ternary compounds with the same crystal *** model-based descriptions are the basis for the research and development of novel NisiAly alloys in resisting high-temperature corrosion.

关键词： Ternary compounds NisiAly CALPHAD Formation enthalpy Rare earth elements

Efficient synthesis of lithium rare-earth tetrafluoride nanocrystals via a continuous flow method

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Nano Research 2020年第10期13卷 2837-2846页

作者： Jinsong sui Junyu yan kai Wang Guangsheng Luo The state Key Lab of Chemical Engineering Department of Chemical EngineeringTsinghua UniersityBeijing 100084China

As an important upconversion illuminant material, LiREF4 nanocrystals were efficiently synthesized in a continuous reactor with the assistant of a new precursor solution. The employed trioctylamine solvent in the solution had a strong interaction with HF, and helped to avoid the generation of unnecessary solid components as LiF and NH4REF4 during the reaction. A silicon carbide reactor was developed to carry out the synthesis reaction, where LiyF4:yb,Er/Ho/Tm quickly nucleated in 5 min at 300℃. The reaction time to successfully prepare 15 nm sized nanocrystals was less than 30 min, and the space-time yield of the flow synthesis method was 14.8 times that of a control group batch reaction. The prepared nanocrystals had a strong illuminant ability, which could find its use in the area of security mark printing.

关键词： lithium rare earth tetrafluoride upconversion illuminant nanocyrstal silicon carbide reactor flow chemistry

高塑性纳米准晶Mg-1.92Zn-0.34y合金的热变形行为

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稀有金属材料与工程 2025年第1期54卷 184-190页

作者：曾崎王少阳荣鹏朱凯张英波高川云胡云峰成都飞机工业(集团)有限责任公司四川成都610092 西南交通大学材料科学与工程学院四川成都610031

纳米准晶增强Mg-Zn-y合金室温具有超高延伸率,具有较广阔的应用前景,需进一步研究其热变形行为,为后续加工提供理论和应用基础。本工作采用半固态+热挤压的复合工艺制备了含有纳米准晶颗粒的Mg-1.92Zn-0.34y(质量分数,下同)合金,探究本... 详细信息

纳米准晶增强Mg-Zn-y合金室温具有超高延伸率,具有较广阔的应用前景,需进一步研究其热变形行为,为后续加工提供理论和应用基础。本工作采用半固态+热挤压的复合工艺制备了含有纳米准晶颗粒的Mg-1.92Zn-0.34y(质量分数,下同)合金,探究本合金在250、300和350℃温度和10^(-3)、10^(-2)和10^(-1)s^(-1)应变速率条件下的高温变形机制,着重研究微量纳米准晶颗粒对Mg-1.92Zn-0.34y合金热变形行为的影响。结果表明:半固态+热挤压的复合工艺制备了高塑性纳米准晶Mg-1.92Zn-0.34y合金,其室温下抗拉延伸率为44%±2.6%,抗拉强度为258±2.0 MPa,屈服强度为176±1.6 MPa。通过本构关系获得平均变形激活能达到271.7812 k J/mol,其应力指数为6.7838;Mg-1.92Zn-0.34y合金具有较好的热塑性,在研究条件下无失稳现象,表明纳米准晶颗粒能够强化其变形能力;最佳热加工区域是:330~350℃,10^(-3)~10^(-2)s^(-1),即高温低应变速率区。

关键词： Mg-Zn-y合金纳米准晶高温压缩本构方程高塑性

Lanthanide-based microlasers:synthesis,structures,and biomedical applications

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Nano Research 2024年第1期17卷 97-111页

作者： Qian Zhang yawei Liu kai Liu Hongjie Zhang Engineering Research Center of Advanced Rare Earth Materials(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing 100084China state Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Xiangfu Laboratory Jiaxing 314102China

The large size of lasers limits their applications in confined spaces,such as in biosensing and in vivo brain tissue *** this regard,micron-sized lasers have been *** exhibit great potential for biological detecting,remote sensing,and depth tracking due to their small sizes,sensitive properties of their spectral fingerprints,and flexible positional modulation in the ***-based luminescent materials that possess long excited-state lifetime,narrow emission bandwidth,and upconversion behaviors are promising as gain mediums for novel *** addition,lanthanide-based microlasers could be generated under natural ambient conditions with pumped or continuous light sources,which significantly promotes the practical applications of *** progress in the design,synthesis,and biomedical applications of lanthanide-based microlasers has been outlined in this *** ions doped and upconverted lanthanide-based microlasers are highlighted,which exhibit advantageous structures,miniaturized dimensions,and high lasing *** applications of lanthanide-based microlasers are further discussed,the upconverted microlasers show great advantages for biological applications owing to their tunable excitation and emission characteristics and excellent environmental ***,perspectives and challenges in the field of lanthanide-based microlasers are presented.

关键词： microlasers lanthanide-based luminescent materials upconversion nanoparticles biological applications

Dynamic shear modulus and damping ratio characteristics of undisturbed marine soils in the Bohai sea,China

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Earthquake Engineering and Engineering Vibration 2022年第2期21卷 297-312页

作者： Zhang yan Zhao kai Peng yanjv Chen Guoxing Institute of Geotechnical Engineering Nanjing Tech UniversityNanjing 210009China Civil Engineering and Earthquake Disaster Prevention Center of Jiangsu Province Nanjing 210009China National Institute of Natural Hazards Ministry of Emergency ManagementBeijing 100085China

This paper presents results from a series of stress-controlled undrained cyclic triaxial tests on the undisturbed marine silty clay,silt,and fine sand soils obtained from the Bohai sea,*** is placed on the major factors for predominating the dynamic shear modulus(G)and damping ratio(λ)in the shear strain amplitude(γ_(a))from 10^(-5) to 10^(-2),involving depth,sedimentary facies types,and water content of marine *** empirical equations of the small-strain shear modulus(G_(max))and damping ratio(λ_(min))using a single-variable of depth H are established for the three marine soils.A remarkable finding is that the curves of shear modulus reduction(G/G_(max))and the damping ratio(λ)with increasing γ_(a) of the three marine soils can be simply determined through a set of explicit expressions with the two variables of depth H and water content *** finding is validated by independent experimental data from the *** the similar depths,the G value of the marine soils of terrestrial facies is the largest,followed b_(y) the neritic facies,and the G value of the marine soils of abyssal facies is the *** sedimentary facies types of the marine soils have slight effect on theλ*** significant finding is that the shear modulus reduction curves plotted against the γ_(a) of the three marine soils at the similar depths are significantly below those of the corresponding terrigenous soils,while the damping curves plotted against γ_(a) are just the *** results presented in this paper serve as a worthful reference for the evaluation of seabed seismic site effects in the Bohai sea due to lack of experimental data.

关键词： Bohai sea marine sediments dynamic shear modulus damping ratio sedimentary facies

Plasmon-induced trap filling at grain boundaries in perovskite solar cells

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Light(science & Applications) 2021年第11期10卷 2233-2244页

作者： kai yao siqi Li Zhiliang Liu yiran ying Petr Dvořák Linfeng Fei TomášŠikola Haitao Huang Peter Nordlander Alex K-y.Jen Dangyuan Lei Institute of Photovoltaics/Department of Materials science and Engineering Nanchang UniversityNanchang330031China Department of Applied Physics The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Department of Materials science and Engineering City University of Hong KongKowloonHong KongChina Institute of Physical Engineering Brno University of TechnologyTechnická2Brno61669Czech Republic Laboratory for Nanophotonics Department of Physics and AstronomyDepartment of Electrical and Computer EngineeringRice UniversityHoustonTexas77005USA

The deep-level traps induced by charged defects at the grain boundaries(GBs)of polycrystalline organic-inorganic halide perovskite(OIHP)films serve as major recombination centres,which limit the device ***,we incorporate specially designed poly(3-aminothiophenol)-coated gold(Au@PAT)nanoparticles into the perovskite absorber,in order to examine the influence of plasmonic resonance on carrier dynamics in perovskite solar *** changes in the photophysical properties of the OIHP films reveal that plasmon excitation could fill trap sites at the GB region through photo-brightening,whereas transient absorption spectroscopy and density functional theory calculations correlate this photo-brightening of trap states with plasmon-induced interfacial *** a result,the device achieved the best efficiency of 22.0%with robust operational *** work provides unambiguous evidence for plasmon-induced trap occupation in OIHP and reveals that plasmonic nanostructures may be one type of efficient additives to overcome the recombination losses in perovskite solar cells and thin-film solar cells in general.

关键词： perovskite grain absorber

Gaussian limit for determinantal point processes with J-Hermitian kernels

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science China Mathematics 2023年第6期66卷 1359-1374页

作者： Zhaofeng Lin yanqi Qiu kai Wang shanghai Center for Mathematical sciences Fudan UniversityShanghai 200438China Institute of Mathematics and Hua Loo-Keng Key Laboratory of Mathematics Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China school of Mathematical sciences Fudan UniversityShanghai 200433China

We show that the central limit theorem for linear statistics over determinantal point processes with J-Hermitian kernels holds under fairly general *** particular,we establish the Gaussian limit for linear statistics over determinantal point processes on the union of two copies of Rdwhen the correlation kernels are J-Hermitian translation-invariant.

关键词： determinantal point process J-Hermitian kernel linear statistics central limit theorem translation-invariantkernel