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Neddylation Regulation of Immune Responses

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Research 2024年第3期2023卷 545-559页

作者： Hongmei Mao Xin lin yi sun Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Institute for Immunology School of MedicineTsinghua UniversityBeijing 100084China Changping Laboratory Beijing 102206China Cancer Center of Zhejiang University Hangzhou 310029China Zhejiang Provincial Clinical Research Center for Cancer HangzhouZhejiang ProvinceChina Key Laboratory of Molecular Biology in Medical sciences HangzhouZhejiang ProvinceChina Research Center for Life science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China.

Neddylation plays a vital role in post-translational modification, intricately shaping the regulation of diverse biological processes, including those related to cellular immune responses. In fact, neddylation exerts control over both innate and adaptive immune systems via various mechanisms. specifically, neddylation influences the function and survival of innate immune cells, activation of pattern recognition receptors and GMP-AMP synthase–stimulator of interferon genes pathways, as well as the release of various cytokines in innate immune reactions. Moreover, neddylation also governs the function and survival of antigen-presenting cells, which are crucial for initiating adaptive immune reactions. In addition, neddylation regulates T cell activation, proliferation, differentiation, survival, and their effector functions, thereby ensuring an appropriate adaptive immune response. In this review, we summarize the most recent findings in these aspects and delve into the connection between dysregulated neddylation events and immunological disorders, especially inflammatory diseases. Lastly, we propose future directions and potential treatments for these diseases by targeting neddylation.

关键词： activation thereby initiating

swimming velocity of spherical squirmers in a square tube at finite fluid inertia

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Applied Mathematics and Mechanics(English Edition) 2024年第9期45卷 1481-1498页

作者： Tongxiao JIANG Deming NIE Jianzhong lin Institute of Fluid Mechanics China Jiliang UniversityHangzhou 310008China Key Laboratory of Impact and safety Engineering(Ningbo University) Ministry of EducationNingbo 315211China Institute of Fluid Engineering Zhejiang UniversityHangzhou 310027China

The three-dimensional lattice Boltzmann method(LBM)is used to simulate the motion of a spherical squirmer in a square tube,and the steady motion velocity of a squirmer with different Reynolds numbers(Re,ranging from 0.1 to 2)and swimming types is investigated and analyzed to better understand the swimming characteristics of microorganisms in different ***,as the Reynolds number increases,the effect of the inertial forces becomes significant,disrupting the squirmer's ability to maintain its theoretical ***,as the Reynolds number increases,the structure of the flow field around the squirmer changes,affecting its velocity of ***,the swimming velocity of the squirmer exhibits a quadratic relationship with the type of swimming and the Reynolds ***,the narrow tube exerts a significant inhibitory effect on the squirmer *** addition,although chirality does not directly affect the swimming velocity of the squirmer,it can indirectly affect the velocity by changing its motion mode.

关键词： spherical squirmer swimming characteristics swimming velocity fow structure

Incentive Feedback stackelberg strategy in Mean-Field Type stochastic Difference Games

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Journal of systems science & Complexity 2024年第4期37卷 1425-1445页

作者： GAO Wenhui lin yaning ZHANG Weihai school of Mathematics and statistics Shandong University of TechnologyZibo 255000China College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590China

This paper designs an incentive stackelberg strategy for the discrete-time stochastic systems with mean-field *** conditions for the existence of such a design are ***,the incentive strategy is obtained as a feedback form including the deviation of the state and its mathematical ***,the stability analysis is *** is found that the stability can be guaranteed by the *** addition,the specific algorithm is proposed and its effectiveness is checked by two examples.

关键词： Discrete-time mean-field stochastic systems incentive strategy stackelberg game teamoptimal solution

Experimental study on ice monitoring method for 10 kV transmission line with tangent tower in alpine landform

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High Voltage 2024年第1期9卷 182-194页

作者： lin yang Zhiqiang Chen yanpeng Hao Xinhao lin Lei yu yue Li Zhiyong yuan Licheng Li school of Electric Power South China University of TechnologyGuangzhouChina Electrical Power Research Institute China Southern Power GridGuangzhouChina Electric Power Research Institute of Guizhou Power Grid Co.Ltd. GuizhouChina

Ice monitoring methods were applied for 110 kV and above transmission lines with tangent ***,the change in the vertical span is not considered,and a significant difference lies in the tower-conductor structure of 10 kV transmission *** this reason,a proposal is made about the ice monitoring method for the 10 kV transmission line with tangent tower in alpine landform,which includes the ice monitoring system based on pressure measurement and corresponding equivalent ice thickness calculating *** methods calculate the vertical span under different height difference coefficients.A finite element simulation model and a simulated ice load experiment system are established based on real conductors and *** and simulations under four simulated terrains are conducted within 2.5–20 mm ice thickness *** comparison is made between this method and the method without considering the change in vertical *** results show that the two methods are consistent and the relative errors are lower than�4%in simulation and�10%in experiment when the height difference coefficient is *** it is not 0,the relative errors of this method fall between t0.38%and t6.78%in simulation and−6.40%to t6.60%in experiment,while the relative errors of the method without considering the change in vertical span ranges between−11.13%and−20.23%in simulation and−11.65%to−23.20%in experiment.

关键词： methods tangent method

Global practical stabilization of the double integrator system with an imperfect sensor and subject to a bounded disturbance

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Control Theory and Technology 2024年第3期22卷 468-478页

作者： Zhiyuan Zhu yuanlong Li Zongli lin Department of Automation Shanghai Jiao Tong Universityand Key Laboratory of System Control and Information Processing of Ministry of EducationShanghai 200240China Charles L.Brown Department of Electrical and Computer Engineering University of VirginiaP.0.Box 400743CharlottesvilleVA 22904-4743USA

This paper is concerned with global practical stabilization of the double integrator system with an imperfect sensor and subject to an additive bounded output *** imperfect sensor nonlinearity possesses the nonlinear characteristics of saturation and dead *** of the presence of output dead zone and the additive disturbance,the states cannot be expected to driven into an arbitrarily small neighborhood of the *** solve the global practical stabilization problem,we proposes a low gain-based linear dynamic output feedback law,under which the first state enters and remains in a bounded set whose size is depended on the bound of disturbance and the range of dead zone and the second state enters and remains in a pre-specified arbitrarily small set,both in finite *** results illustrate the effectiveness of our proposed control method.

关键词： Output saturation Disturbance rejection Output dead zone Low gain feedback-linear output feedback Practical stabilization

Piezotronic neuromorphic devices:principle,manufacture,and applications

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International Journal of Extreme Manufacturing 2024年第3期6卷 363-385页

作者： Xiangde lin Zhenyu Feng yao Xiong Wenwen sun Wanchen yao yichen Wei Zhong lin Wang Qijun sun Department of Research Shanghai University of Medicine and Health Sciences Affiliated Zhoupu HospitalShanghai 201318People’s Republic of China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400People’s Republic of China Center on Nanoenergy Research School of Chemistry and Chemical EngineeringGuangxi UniversityNanning 530004People’s Republic of China shandong Zhongke Naneng Energy Technology Co. LtdDongying 257061People’s Republic of China Georgia Institute of Technology AtlantaGA 30332-0245United States of America

With the arrival of the era of artificial intelligence(AI)and big data,the explosive growth of data has raised higher demands on computer hardware and *** techniques inspired by biological nervous systems are expected to be one of the approaches to breaking the von Neumann *** neuromorphic devices modulate electrical transport characteristics by piezopotential and directly associate external mechanical motion with electrical output signals in an active manner,with the capability to sense/store/process information of external *** this review,we have presented the piezotronic neuromorphic devices(which are classified into strain-gated piezotronic transistors and piezoelectric nanogenerator-gated field effect transistors based on device structure)and discussed their operating mechanisms and related manufacture ***,we summarized the research progress of piezotronic neuromorphic devices in recent years and provided a detailed discussion on multifunctional applications,including bionic sensing,information storage,logic computing,and electrical/optical artificial ***,in the context of future development,challenges,and perspectives,we have discussed how to modulate novel neuromorphic devices with piezotronic effects more *** is believed that the piezotronic neuromorphic devices have great potential for the next generation of interactive sensation/memory/computation to facilitate the development of the Internet of Things,AI,biomedical engineering,etc.

关键词： piezotronics neuromorphic devices strain-gated transistors piezoelectric nanogenerators synaptic transistors

A systematic review on COVID-19 related research in HVAC system and indoor environment

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Energy and Built Environment

Energy and Built Environment 2024年第6期5卷 970-983页

作者： yaolin lin Jiajun Wang Wei yang lin Tian Christhina Candido school of Environment and Architecture University of Shanghai for Science and TechnologyShanghaiChina200093 Faculty of Architecture Building and PlanningThe University of MelbourneMelbourneAustralia3010 school of Engineering RMIT UniversityMelbourneAustralia3000

The on-going COVID-19 pandemic has wrecked havoc in our society,with short and long-term consequences to people’s lives and livelihoods-over 651 million COVID-19 cases have been confirmed with the number of deaths exceeding 6.66 *** people stay indoors most of the time,how to operate the Heating,Ventilation and Air-Conditioning(HVAC)systems as well as building facilities to reduce airborne infections have become hot research *** paper presents a systematic review on COVID-19 related research in HVAC systems and the indoor ***,it reviews the research on the improvement of ventilation,filtration,heating and air-conditioning systems since the onset of ***,various indoor environment improvement measures to minimize airborne spread,such as building envelope design,physical barriers and vent position arrangement,and the possible impact of COVID-19 on building energy consumption are ***,it provides comparisons on the building operation guidelines for preventing the spread of COVID-19 virus from different ***,recommendations for future studies are provided.

关键词： COVID-19 HVAC systems Facilities management Building operation guidelines Healthy indoor environments

A Numerical Calculation Algorithm of the Inclination Function Based on the Representation of sO(3) Group

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Acta Mathematicae Applicatae sinica 2024年第1期40卷 137-148页

作者： yu-xiao Wei Wen-lin Tang Department of Geophysics School of Geology Engineering and GeomaticsChang’An UniversityXi’an710064China Key Laboratory of Electronics and Information Technology for space systems National Space Science CenterChinese Academy of SciencesBeijing100190China

In the determination of the Earth gravity field in satellite geodesy, the inclination functions represent the projection of data observed along the orbital plane of a satellite orbit into the sphere in the terrestial reference frame. The inclination functions in this work is studied from a group theoretical perspective. The inclination functions are proved to generate a representation of the sO(3) group. An orthogonal relation of the inclination functions is derived and some recurrence relations for the inclination functions are given, based on which an algorithm to calculate the inclination functions is proposed.

关键词： sO(3)group inclination function satellite geodesy representation of sO(3)

Upcycling electroplating sludge into bioengineering-enabled highly stable dual-site Fe-Ni_(2)P@C electrocatalysts for efficient oxygen evolution

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Nano Research 2024年第8期17卷 6984-6992页

作者： Jiawen Liu Zunpeng Zuo Feng Gao Kai yi Jiahui lin Mengye Wang Zhang lin Feng Huang state Key Laboratory of Optoelectronic Materials and Technologies School of MaterialsSun Yat-Sen UniversityGuangzhou 510275China Department of Chemistry City University of Hong KongHong Kong 999077China school of Metallurgy and Environment Central South UniversityChangsha 410083China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou 341000China

The advancement of bimetallic catalysts holds significant promise for the innovation of oxygen evolution reaction(OER)*** from adsorbate evolution mechanism(AEM)and lattice oxygen oxidation mechanism(LOM),the incorporation of dual active sites has the potential to foster novel OER pathways,such as the coupled oxygen evolution mechanism(COM),which can surpass the limitations of OER and elevate catalytic *** this study,uniformly distributed Fe/Ni dual-site Fe-Ni_(2)P@C electrocatalysts are crafted by upcycling metals in electroplating sludge via an eco-friendly and sustainable microbial engineering *** findings indicate that a substantial number of defects emerge at the Ni2P crystal during the OER process,laying the groundwork for lattice oxygen ***,the displacement of Ni/Fe in the crystal lattice intensifies the asymmetry of the electronic structure at the metal active sites,facilitating the deprotonation *** research introduces an innovative paradigm for the synthesis of effective and robust transition metal-based OER catalysts,with implications for sustainable energy generation technologies.

关键词： oxygen evolution reaction dual active sites adsorbate evolution mechanism lattice oxygen mechanism bioengineering