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Analysis of Unstable Chromosome Aberrations in simulation of Partial Body Exposures with Gamma Rays

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Journal of Environmental science and Engineering 2010年第12期4卷 18-27页

作者： M. syaifudin y. Lusiyanti y.s. lee C.M. Kang Center for Technology of Radiation safety and Metrology National Nuclear Energy Agency Jl. Lebakbulus Raya No. 49 PO BOX 7043 JKSKL Jakarta Selatan 12070 Indonesia Laboratory of Radiation Effects Korea Institute of Radiological and Medical Sciences （K1RAMS） 215-4 Gongneung-Dong Nowon-Ku Seoul Republic of Korea Laboratory of Radiation Cytogenetics and Epidemiology Korea Institute of Radiological and Medical Sciences （KIRA MS） 215-4 Gongneung-Dong Nowon-Ku Seoul Republic of Korea

Accidentally or occupationally exposures to ionizing radiation generally involving the partial-body exposures and this may pose significant health hazards that are indicated by chromosome aberration （CA） induction. In this experiment, the quantification of the frequencies of CA was carried out based on cytogenetic analyses of peripheral blood samples obtained from 4 healthy volunteers as a result of simulation of partial-body exposures. The percentages of mixtures of blood samples irradiated in vitro with 2 Gy of gamma rays were 10, 25, 50, 75 and 100.0%. Lymphocytes were cultured and first-division metaphase cells were collected after culture times of 48 h and then harvested with standard procedures. The results showed that frequencies of unstable CA were depended on the percentage/portion of irradiated blood. All frequencies of observed CA was lower than that of calculated from 100% exposed blood, except in one case, indicating a phenomena of＂dilution＂ of unirradiated into irradiated lymphocytes though there could be a bystander effects taken place. The increasing in frequency for 25-100% portions was also comparable with other similar experiments. The quantification of CAs in lymphocytes is an important methodology of dose assessment for partial-body exposure to ionizing radiation, however, the scenario of exposure should be determined.

关键词： Unstable chromosome aberrations biological dosimetry partial-body irradiation lymphocyte

语言半球优势与Theta爆发式经颅磁刺激治疗卒中后失语

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中国康复理论与实践 2016年第3期22卷 282-285页

作者：何维佳李月裳梁慧康梁浩云黄家星香港中文大学内科及药物治疗学系香港中文大学耳鼻咽喉-头颈外科学系

语言的大脑半球优势影响卒中后失语症的恢复。在语言功能重建过程中,半球优势呈动态变化。Theta爆发式经颅磁刺激治疗耗时更短,强度更大,已证实有利于卒中后失语症的恢复。本文还结合语言的半球优势,对theta爆发式经颅磁刺激临床应用中... 详细信息

语言的大脑半球优势影响卒中后失语症的恢复。在语言功能重建过程中,半球优势呈动态变化。Theta爆发式经颅磁刺激治疗耗时更短,强度更大,已证实有利于卒中后失语症的恢复。本文还结合语言的半球优势,对theta爆发式经颅磁刺激临床应用中的刺激模式、治疗时机、语言区的定位方法进行讨论,并探讨相关的评定方法和随访时间。

关键词：脑卒中失语症 theta爆发式经颅磁刺激康复综述

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang sonata s y yau Kwok-Fai so Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNs Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina state Key Laboratory of Brain and Cognitive science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

A comparative study on polypropylene separators coated with different inorganic materials for lithium-ion batteries

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Frontiers of Chemical science and Engineering 2017年第3期11卷 346-352页

作者： Linghui yu Jiansong Miao yi Jin Jerry y.s. Lin school for Engineering of Matter Transport and Energy Arizona State University Tempe AZ 85287 USA state Key Laboratory of Operation and Control of Renewable Energy & storage systems China Electric Power Research Institute Beijing 100192 China

Coating commercial porous polyolefin separators with inorganic materials can improve the thermal stability of the polyolefin separators and hence improve the safety of lithium-ion batteries. several different inorganic materials have been studied for the coating. However, there lacks a study on how different the properties of separators, in inorganic materials affect terms of thermal stability and cell performance. Herein, we present such a study on coating a commercial polypropylene separator with four inorganic materials, i.e., Al2O3, siO2, ZrO2 and zeolite. All inorganic coatings have improved thermal stability of the separators although with differences. The coating layers add 28%-45% of electrical resistance compared with the pure polypropylene separator, but all the cells prepared with the coated polypropylene separators have the same electrical chemical performance as the uncoated separator in terms of rate capability and capacities at different temperatures.

关键词： lithium-ion battery battery.s.fety composite separator porosity tortuosity

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by.s.ow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Plasma enhanced diamond deposition on steel and si substrates

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Acta Metallurgica sinica(English Letters) 2009年第5期22卷 321-329页

作者： y.s. Li y. Tang Wo Chen Q. yang C.Xiao A. Hirose Plasma Physics Laboratory University of Saskatchewan Saskatoon SK S7N 5E2 Canada Department of Mechanical Engineering University of Saskatchewan Saskatoon S7N 5A9 Canada

Diamond growth on Fe-Cr-Al-si steel and si substrates was comparatively investigated in microwave plasma enhanced chemical vapor deposition （MPCVD） reactor with different deposition parameters. Adherent nanocrystalline diamond films were directly deposited on this steel substrate under a typical deposition condition, whereas microcrystalline diamond films were produced on si wafer. With increasing CH4 concentration, reaction pressure, or the total gas flow rate, the quality of nanocrystalline diamond films formed on Fe-Cr-Al-si substrates is gradually deteriorated in terms of density and adhesion. This impaired diamond quality on steels is primarily associated with a combined effect by the substrate composition and the specific process conditions that favor excessive nucleation of diamond.

关键词： Plasma CVD Diamond film steel si

synthesis and Characterization of Ordered Meso-Macro-Porous silica Membranes on a Porous Alumina support

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Tsinghua science and Technology 2010年第4期15卷 377-384页

作者： Duo Li y.s. Lin V.V. Guliants Department of Chemical Engineering Arizona State University AZ 85287 USA Department of Chemical and Materials Engineering University of Cincinnati OH 45221 USA

Macroporous silica materials with ordered three-dimensional pore structure can be easily prepared by the template-directed sol-gel process. However, it is still a challenge to prepare them in membrane form on a porous support, which limits their applications. In this work, we have demonstrated the feasibility of ob- taining a three-dimensional ordered macroporous silica membrane on macroporous alumina support using poly-methyl methacrylate （PMMA） spheres as the template. PMMA spheres were packed on the top of an Anopore-alumina support by filtration of a PMMA aqueous suspension. silica sol obtained by an acid-catalyzed sol-gel process was infiltrated into the voids among the spheres. Drying induced stress caused the membrane to crack or peel off from the top of the support. This can be minimized by annealing the PMMA template layer before the introduction of silica sol which increases the mechanical strength of the template. Calcination or solvent extraction to remove the template produced a highly ordered three-dimensional macroporous silica membrane with spherical pores connected by windows in the mesoporous range. The results show that the PMMA-templated infiltration method is effective in preparing three-dimensional ordered macroporous silica membranes on a porous support.

关键词： macroporous ordered silica membrane

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy.s.ructure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they.s.abilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Nonlinear study of the dynamic behavior of a string-beam coupled system under combined excitations

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Acta Mechanica sinica 2011年第6期27卷 1034-1051页

作者： y.s. Hamed M. sayed D.-X. Cao W. Zhang Department of Engineering Mathematics Faculty of Electronic Engineering Menouf 32952 Egypt College of Mechanical Engineering Beijing University of Technology 100022 Beijing China Department of Mathematics and statistics Faculty of Science Taif University Taif E1-Haweiah EO. Box 888 Zip Code 21974 Kingdom of Saudi Arabia （KSA）

In this paper,the nonlinear dynamic behavior of a string-beam coupled system subjected to external,parametric and tuned excitations is *** governing equations of motion are obtained for the nonlinear transverse vibrations of the string-beam coupled system which are described by a set of ordinary differential equations with two degrees of *** case of 1：1 internal resonance between the modes of the beam and string,and the primary and combined resonance for the beam is *** method of multiple scales is utilized to analyze the nonlinear responses of the string-beam coupled system and obtain approximate solutions up to and including the second-order *** resonance cases are extracted and *** of the system is studied using frequency response equations and the phase-plane *** solutions are carried out and the results are presented graphically and *** effects of the different parameters on both response and stability of the system are *** reported results are compared to the available published work.

关键词： 1:1 internal resonance - string-beam - Multiple scales Chaotic response stability