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高分化甲状腺癌放射碘治疗后(131)~I核素显像联合SPECT/CT的诊断价值

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国际医学放射学杂志 2013年第1期 79-79页

作者： y.Maruoka K.Abe S.Baba T.Isoda H.Sawamoto y.Tanabe 范文骏 Departments of Clinical Radiology Graduate School of Medical SciencesKyushu UniversityMaidashi 3-1-1Higashi-kuFukuoka CityFukuoka 812-8582Japan

目的回顾性比较SPECT/CT和全身131I核素显像联合应用与仅行核素显像对于高分化甲状腺癌放射碘治疗后的新增诊断价值。材料与方法本回顾性研究经单位伦理委员会批准,无需签署知情同意书。研究包括2009年10月—2010年8月经放射碘治疗的高... 详细信息

目的回顾性比较SPECT/CT和全身131I核素显像联合应用与仅行核素显像对于高分化甲状腺癌放射碘治疗后的新增诊断价值。材料与方法本回顾性研究经单位伦理委员会批准,无需签署知情同意书。研究包括2009年10月—2010年8月经放射碘治疗的高分化甲状腺癌病人147例(男53例,女94例,平均年龄51岁)。每例病人均于放射碘治疗的同一天进行全身核素显像和SPECT/CT检查。全身核素显像中的每个放射性浓聚灶,根据甲状腺床内、淋巴结和远隔转移的摄取情况分为阳性和不能确定。采用常规McNemar检验对全身核素显像与SPECT/CT的检查结果进行比较评价。结果 SPECT/CT清晰地确定了甲状腺床内全身核素显像不能确定的全部5个"高摄取"病灶的起源(正常甲状腺残余组织或淋巴结转移)。对于核素显像诊断为转移淋巴结的108个放射性浓聚灶,其中的24个(22.2%)SPECT/CT改变了原来的结论(P<0.0001)。在SPECT/CT检查中,85个全身核素显像阳性的病灶中有1个证实为阴性(假阳性);在20个全身核素显像不能确定的病灶中,13个证实为阳性,7个证实为阴性。SPECT/CT检查还纠正了3个核素显像为假阴性的病灶。对于远隔转移灶,52个病灶中有24个(40%)的诊断结论被SPECT/CT修正(P<0.0001)。在SPECT/CT检查中,32个全身核素显像诊断为阳性的病灶中有1个被证实为阴性;20个全身核素显像不能确定的病灶中,11个证实为阳性,9个证实为阴性。对于全部147例病人,通过SPECT/CT检查改变了9例(6.1%)病人的临床分期和3例(2.0%)病人的治疗方案。结论与全身核素显像相比,SPECT/CT提高了131I在淋巴结转移和远隔转移内浓聚的发现和定位准确性。

关键词：放射碘全身病灶核素显像 SPECT/CT 甲状腺癌诊断价值高分化治疗后

准分子激光光学角膜切削术使潜伏的单疱病毒复活

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世界核心医学期刊文摘（眼科学分册） 2005年第6期1卷 50-50页

作者： Deai T. FukudaM. Tomoda y. 肖颖 Department of Ophthalmology KinkiUniversity School of Medicine377- 2 Ohno-Higashi Osaka-Sayama 589- 8511 Japan

Background: It has been reported that excimer laser irradiation might elicit herpes simplex virus (HSV) genome activation. We describe a clinical case in which HSV DNA sequenceswere detected quantitatively after phototherapeutic keratectomy (PTK). Case: A 90- year-old woman underwent excimer laser photokeratectomy for bilateral band-shaped keratopathy. Tear film was collected from both eyes using a Schirmer’ s strip before and 3 and 7 days after phototherapeutic keratectomy. Observations: HSV-DNA was quantified by a real-time polymerase chain reaction assay. HSV-DNA was detected only on the third day postoperatively in both eyes. The amount of viral DNA was 2.0× 103 (OD) and 1.3× 103 (OS) copies/sample, respectively. Conclusions: Excimer laser photokeratectomy stimulated viral shedding in the tear film. Ophthalmologists should be aware that laser irradiation can reactivate latent HSV.

关键词：角膜切削术准分子激光单疱病毒眼科医生带状角膜病泪膜 DNA

激光多普勒速度计所测定的视网膜循环和一个早期全身性动脉粥样硬化指标之间的关系

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世界核心医学期刊文摘（眼科学分册） 2005年第7期1卷 30-30页

作者： Nagaoka T. Ishii y. Takeuchi T. 刘炜 Department of Ophthalmology Asahikawa Medical College Midorigaoka Higashi 2- 1- 1- 1 Asahikawa 078- 8510 Japan

PURPOSE. To examine the relation between intima- media thickness (IMT) in the common carotid artery, which is generally recognized as a marker of early atherosclerosis, and retinal circulatory parameters. METHODS. The vessel diameter and blood velocity of retinal arterioles were measured with laser Doppler, velocimetry (LDV) in 33 patientswith coronary artery disease (CAD), because they were thought to have general atherosclerosis. The retinal blood flow (RBF) and wall shear rate (WSR), an index of wall shear stress in retinal vessels, were calculated from the two parameters. The carotid IMT was evaluated with B- mode ultrasonography. RESULTS. The patients were divided into two groups: those with an IMT >0.70 mm and those with an IMT ≤ 0.70 mm. The blood velocity, WSR, and upstroke time in the retinal arterioles were signifi- cantly higher in the group with an IMT > 0.70 mm compared with the group with an IMT ≤ 0.70 mm. There were no significant differences in vessel diameter and RBF between the groups. Positive correlations were found between the carotid IMT and blood velocity (r=0.51, P=0.002) and WSR (r= 0.60, P=0.0001). Multiple regression analysis showed that the retinal WSR and blood velocity correlated independently with the IMT in patients with CAD. CONCLUSIONS. The present findings;from this pilot study suggest that the retinal circulatory parameters measured by LDV may be associated with systemic atherosclerosis. These results support recent studies showing an association between retinal microvascular changes and cardiovascular disease.

关键词：视网膜循环多普勒速度计血管直径壁切应力动脉硬化症血流速度心血管疾病中膜厚度小血管循环参数

1例费城染色体阳性的急性成淋巴细胞性白血病的老年患者出现浆液性视网膜脱离

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世界核心医学期刊文摘（眼科学分册） 2005年第7期1卷 15-15页

作者： yoshida A. Kawano y.- I. Eto T. 司冰心 Department of Ophthalmology Kyushu University Graduate School of Medical Science 3- 1- 1MaidashiHigashi- ku Fukuoka 812- 8582 Japan

Purpose: To describe an elderly woman who presented with a serous retinal detachment (SRD) as the first sign of Philadelphia- chromosome- positive acute lymphoblastic leukemia (Ph+ ALL). Design: Observational case report. Methods: A complete ophthalmic and systemic evaluation was performed on a 62- year- old woman because of decreased vision of 20/60 OD and 20/25 OS. Results: Fundus examination revealed a SRD involving the fovea. Fluorescein angiography disclosed multifocal spots of hyperfluorescence in the early phase, and diffuse subretinal accumulation of fluorescein in the late phase. She was diagnosedwith Ph+ ALL because of systemic findings. She underwent systemic chemotherapy and went into complete remission. Visual acuity improved to 20/20 in both eyes with resolution of the bilateral SRD. Conclusions: Our observations indicate that a sudden appearance of SRD, even in an elderly patient, warrants a thorough systemic screening for underlying leukemia. This is especially important, because prompt systemic chemotherapy can improve the visual acuity and the prognosis.

关键词：费城染色体右眼视力荧光造影眼底检查化学治疗报道提示左眼视力多灶性观察性强荧光

非小细胞肺癌:MR动态对比增强与扩散加权成像检测肺癌对化疗的早期反应

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国际医学放射学杂志 2012年第1期 78-78页

作者： H.yabuuchi M.Hatakenaka K.Takayama y.Matsuo S.Sunami T.Kamitani 管宇 Department of Clinical Radiology Graduate School of Medical SciencesKyushu University3-1-1 MaidashiHigashi-kuFukuoka 812-8582Japan

目的评估MR动态对比增强成像和扩散加权成像检测非小细胞肺癌(NSCLC)病人对化疗早期反应的能力。材料与方法本研究经机构审查委员会审批并获得受试者书面

关键词：动态对比增强扩散加权 MR 早期反应成像检测小细胞肺癌

动脉自旋标记3 T MRI检测阿尔茨海默病

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国际医学放射学杂志 2010年第1期 96-96页

作者： T.yoshiura A.Hiwatashi T.Noguchi K.yamashita y.Ohyagi A.Monji 陈仁彪 Department of Clinical Radiology Graduate School of Medical SciencesKyushu University3-1-1 MaidashiHigashi-kuFukuoka812-8582Japan

本研究的目的是确定3.0T MRI动脉自旋标记技术是否可用于区分阿尔茨海默病病人和认知功能正常者。20例阿尔茨海默病病人和23个认知功能正常的对照组在3.0T MR设备上应用动脉自旋标记进行成像。计算出局部绝对脑血流量图。此外,通过感觉... 详细信息

本研究的目的是确定3.0T MRI动脉自旋标记技术是否可用于区分阿尔茨海默病病人和认知功能正常者。20例阿尔茨海默病病人和23个认知功能正常的对照组在3.0T MR设备上应用动脉自旋标记进行成像。计算出局部绝对脑血流量图。此外,通过感觉运动皮质的脑血流量来获得标准化的局部脑血流量图

关键词：自旋标记认知功能阿尔茨海默病 T MRI 动脉

腮腺肿瘤:动态增强MRI加用扩散加权MRI能提高定性诊断的准确性吗?

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国际医学放射学杂志 2009年第1期32卷 76-76页

作者： H. yabuuchi y. Matsuo T. Kamitani T. Setoguchi T. Okafuji H. Soeda 王大丽 Department of Clinical Radiology Graduate School of Medical Sciences Kyushu University 3 -1 -1 Maidashi Higashi -ku Fukuoka 812-8582 Japan

目的明确动态增强MRI加扩散加权成像（DWI）在鉴别腮腺良恶性肿瘤的价值。材料和方法本项回顾性研究经机构委员会批准，免除知情同意。分析了47例病人50个病灶（36个良性、14个恶性）。所有病人都接受了扩散加权MRI和动态增强MRI。

关键词：动态增强MRI 扩散加权MRI 定性诊断腮腺肿瘤腮腺良恶性肿瘤加用扩散加权成像委员会

吉西他滨标准剂量与小剂量疗法在胰腺癌中的比较:一项前瞻性随机研究

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世界核心医学期刊文摘（胃肠病学分册） 2006年第8期2卷 51-51页

作者： Sakamoto H. Kitano M. Suetomi y. M. Kudo 郑世成(译) 王顺涛(校) 不详 Department of Gastroenterology and Hepatology Kinki University School of Medicine 377 -20hno-Higashi Osaka-Sayama 589 -8511 Japan

Background: A prospective, randomized study was performed to determine whether gemcitabine infusion at a low dose (250 mg/m2) is comparable or superior to the standard-dose infusion (1000 mg/m2) in terms of the survival period, clinical benefit, and frequency of adverse effects in patients with advanced pancreatic adenocarcinoma. Methods: Twenty-five patients who were histologically proven to have locally advanced pancreatic cancer or pancreatic cancer with distant metastases were initially enrolled in the present study. They were treated with gemcitabine infusion at either a dose of 1000 mg/m2 over 30 min (the standard regimen) on days 1, 8, and 15 of every 4- week cycle or at a dose of 250 mg/m2 over 30 min every week. Survival time, response rate, time to treatment failure, clinical benefit response, and adverse effects were compared between the two groups. Results: Twenty-one patients received gemcitabine for more than 1 month. The median survival period was 7.2 months for patients who received the low-dose infusion regimen, in contrast to 5.2 months for patients administered the standard-dose infusion regimen. The time to treatment failure was 5.6 months for patients in the low-dose infusion regimen, in contrast to 3.4 months for patients in the standard-dose infusion regimen. There were no significant differences in either survival time or time to treatment failure or clinical benefits between the two groups, but the incidence of adverse reactions in patients administered the low-dose therapy was significantly lower than that in patients receiving the standard-dose therapy (P y than those in the low-dose regimen. Conclusions: These findings suggest that the low-dose gemcitabine infusion regimen can be continuously administered to patients with locally advanced and systemically spreading pancreatic cancer because of its reduced toxicity, resulting in bett

关键词：胰腺癌患者小剂量疗法标准剂量吉西他滨前瞻性随机研究小剂量治疗存活时间不良反应治疗失败临床疗效

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国际医学放射学杂志 2014年第3期 293-293页

作者： A.Hiwatashi T.yoshiura O.Togao K.yamashita K.Kikuchi y.Fujita 李晓琼 Department of Clinical Radiology Graduate School of Medical SciencesKyushu University3-1-1 MaidashiHigashi-kuFukuoka 812-8582Japan

摘要目的扩散敏感驱动平衡准备(DSDE-TFE)的3D扰相场回波对扩散加权(DW)成像是一种新的非平面回波技术。本研究的目的是通过DSDE-TFE生成的ADC鉴别眼眶

关键词：眼眶淋巴瘤 IgG4 脂肪抑制疾病相关性