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用MR自旋标记法MR成像显示脑脊液运动:正常和病理生理情况下的初步结果

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国际医学放射学杂志 2009年第1期32卷 68-68页

作者： S. yamada M. Miyazaki H. Kanazawa M. higashi y. Morohoshi S.Bluml 王大丽 Department of Neurosurgery Tokai University at Oiso Hospital Kanagawa Japan

这项研究获得了机构审查委员会的允许和病人的知情同意，并且遵从HIPAA。本研究的目的是使用非增强的磁共振技术无创地显示脑脊液的运动。时间-空间标记反转脉冲（SLIP）技术被用于标记感兴趣区的脑脊液。颅内和椎管内的被标记的脑脊液... 详细信息

这项研究获得了机构审查委员会的允许和病人的知情同意，并且遵从HIPAA。本研究的目的是使用非增强的磁共振技术无创地显示脑脊液的运动。时间-空间标记反转脉冲（SLIP）技术被用于标记感兴趣区的脑脊液。颅内和椎管内的被标记的脑脊液可以在脉冲标记后反转时间为1500～4500ms的影像上清楚地显示出来。

关键词：脑脊液 MR成像病理生理运动标记法自旋 HIPAA 磁共振技术

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声弹性成像诊断淋巴结转移癌的初步经验

中国口腔颌面外科杂志 2007年第3期5卷 224-224页

作者： Lyshehik A higashi T Asato R 王延安

该文旨在研究声弹性成像在鉴别甲状腺癌和下咽癌患者颈部淋巴结良、恶性的精确度。应用前瞻性研究方法，对141个颈部淋巴结（43例患者）进行检测，其中60个为转移性、81个为非转移性淋巴结。对诊断为甲状腺癌或下咽癌并准备接受手术的... 详细信息

该文旨在研究声弹性成像在鉴别甲状腺癌和下咽癌患者颈部淋巴结良、恶性的精确度。应用前瞻性研究方法，对141个颈部淋巴结（43例患者）进行检测，其中60个为转移性、81个为非转移性淋巴结。对诊断为甲状腺癌或下咽癌并准备接受手术的患者行颈部灰阶超声、多普勒和声弹性成像检查。在灰阶超声、多普勒检测的过程中，记录淋巴结的影像学特点，如淋巴结短轴直径、短长轴比、内部回声、钙化和血流特点。

关键词：淋巴结转移癌声弹性成像成像诊断初步经验转移性淋巴结颈部淋巴结多普勒检测甲状腺癌

EVOLUTIONARy DISCONTINUITy OF THE CARABINA GROUND BEETLES （COLEOPTERA, CARABIDAE） INFERRED FROM MOLECULAR PHyLOG-ENy

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EVOLUTIONARY DISCONTINUITY OF THE CARABINA GROUND BEETLES （...

VI型胶原缺乏Ullrich病患者的蛋白多糖表达异常

第十九届国际动物学大会

作者： Z.-H.Su y.Imura C.-G.Kim M.Okamoto S.Osawa JT Biohistory Research Hall 1-1 Murasaki-cho Takatsuki Osaka 569 - 1125 Japan Shinohara-cho 1249-8 Kohoku-ku Yokohama 222 - 0026 Japan JT Biohistory Research Hall 1-1 Murasaki-cho Takatsuki Osaka 569 - 1125 Japan Current address: Laboratory of Genomic Diversirty SAIC- Frederick Inc. NCI at Frederick Frederick MD 21702 USA Department of Laboratory Animal Science School of Veterinary Medicine Faculty of Agriculture Tottori University Tottori 680 -8553 Japan JT Biohistory Research Hall 1-1 Murasaki-cho Takatsuki Osaka 569 - 1125 Japan Current address: 2-4-7-1003 Ushita-Asahi Higashi-ku Hiroshima 732 - 0067 Japan

＜正＞The subfamily Carabinae （ Coleoptera, Carabidae） consist of two tribes, the Cychrini and the Carabini. The Carabini are further classified into two subtribes Carabina and Calosomina. The Carabina ground beetles are mostly hind-wingless and cannot fly, so that there is more chance of diversification by geographic isolation as compared with winged insects. The phy-logenetic relationships of the Carabina ground beetles of the world have been analyzed mainly by mitochon-drial ND5 gene sequences. The evolutionary pattern of the beetles was inferred by comparisons between morphological diversification and the molecular phy-logeny. Based on the dating by a mitochondrial DNA

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世界核心医学期刊文摘(神经病学分册) 2006年第4期 60-60页

作者： higashi K. Higuchi I. Niiyama T. 张慧 Department of Neurology and Geriatrics Faculty of Medicine Kagoshima University 8- 35- 1 Sakuragaoka Kagoshima 890- 8520 Japan.Dr

Patients with Ullrich’s disease have generalized muscle weakness, multiple contractures of the proximal joints, and hyperextensibility of the distal joints. Recently we found a marked reduction of fibronectin receptors in the skin and cultured fibroblasts of two patients with Ullrich’s disease with collagen VI deficiency, and speculated that an abnormality of cell adhesion may be involved in the pathogenesis of the disease. In this study, we investigated the expression of proteoglycans and adhesion molecules in Ullrich’s disease and other muscle diseases. We found a reduction of NG2 proteoglycan in the membrane of skeletal muscle but not in the skin in Ullrich’s disease. By contrast, we found the upregulation of tenascin C in the extracellular matrix of skeletal muscle in Ullrich’s disease. Our findings suggest that abnormal expression of proteoglycans and adhesion molecules may be involved in the pathogenesis of the dystrophic muscle changes in Ullrich’s disease.

关键词：蛋白多糖 VI 粘蛋白型胶原 Ullrich 患者

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脑桥出血后听力丧失及四肢瘫痪1例

世界核心医学期刊文摘（神经病学分册） 2006年第5期2卷 49-50页

作者： Nakane H Sugimori H Wakugawa y. 牛亚利 National Hospital Organization Fukuoka Higashi Medical Center Cerebrovascular and Neurology Center Chidori 1- 1- 1 Koga City Fukuoka 811- 3195 Japan

We herein describe the case of a 50- year-old female who developed a pontine hemorrhage with consciousness disturbance and quadriplegia. Her respiratory condition was so bad that she needed to be intubated and put on artificial respiration. After her consciousness and respiratory condition gradually recovered, we noticed that she had developed a bilateral hearing loss. The auditory brain stem response test revealed only I waves on both sides, thus suggesting that her hearing loss had been caused by an injury to the hearing-conducting pathway including the cochlear nuclei. In this case, the hematoma extended from the lower to the upper part of pons and, furthermore, it was also located broadly in the dorsal part of the pons. As a result, the cochlear nuclei and corpus trapezoideum appeared to have been destroyed by the hematoma. However, since most cases with a brain stem hemorrhage showing bilateral hearing loss tend to be in a severe condition, this condition is often easy to overlook. We should therefore carefully evaluate patients’ reaction to hearing stimulation to avoid overlooking any hearing loss in such patients.

关键词：听力丧失脑桥出血四肢瘫痪听觉脑干反应女性患者蜗神经核意识障碍呼吸困难人工呼吸气管插管

Bioblock Method for Forest Vegetation Recovery in Japan

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Agricultural Science & Technology 2013年第2期14卷 340-344页

作者：季梅泽桑梓东三郎仓持寿夫尾谷百合子云南省林业科学院云南昆明650201 Bioblock技术推广联络委员会

Bioblock method is a planting method for forest vegetation recovery by just depositing bioblocks without digging planting holes. The process includes collecting objective tree’s seeds or cuttings, nurturing seedlings, preparing and filling ＂ Kaminekkon＂, processing bioblock, and field planting. Seedlings can be planted without damaging root system, can be planted in hard ground or frozen soil and can be planted throughout the year.

关键词： Bioblock Kaminekkon Assembly Curing Afforestation

^(13)C标记的磁共振波谱检查脑葡萄糖代谢:MELAS代谢变化的病例报道

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世界核心医学期刊文摘（神经病学分册） 2005年第9期1卷 15-16页

作者： Otsuki T. Kanamatsu T. Tsukada y. 黄卫东 Department of Neurosu rgery Natl. Ctr. Hosp. Mental Nerv./M. D. Natl. Ctr. of Neurol. and Psychiatry Ogawa-higashi-4-1-1 Kodaira Tokyo 187-8511 Japan Dr.

Background: Carbon 13-labeled magnetic resonance spectroscopy (13C-MRS) with [1-13C]-glucose administration, the 13C atom that behaves as a radio inacti ve tracer in the brain, can differentiate aerobic and anaerobic glucose metabolism by detecting [4-13C]-glutamate (Glu C4) and [3-13C]-lactat e (Lac C3). Objective: To investigate the cerebral metabolic derangement resulti ng from mitochondrial dysfunction in mitochondrial myopathy, encephalopathy, lac tic acidosis, and strokelike episodes (MELAS). Design: Application of a new 13C -MRS technique to a patient with MELAS compared with control subjects (n=7). Pa tient: A 19-year-old woman with an A3243G mitochondrial mutation who underwent 13C-MRS for 30 minutes after oral administration of [1-13C]-glucose (0.75 g/ kg). Result: Decreased Glu C4-labeling (P ynthesi s (> 2 SDs) compared with controls were demonstrated in the patient with MELAS. Conclusion: This first report on 13C-MRS observation of cerebral glucose metabo lism in a patient with MELAS demonstrated the presence of low glutamate producti on via the tricarboxylic acid cycle compared with high lactate synthesis by glyc olysis. The present findings suggest that the clinical use of 13C-MRS can be ex tended to diagnose mitochondrial dysfunction and monitor cerebral glucose metabo lism in a variety of mitochondrial disorders.

关键词： MELAS 脑葡萄糖代谢磁共振波谱线粒体肌病代谢变化卒中样发作乳酸盐线粒体突变无氧酵解线粒体功能

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卒中介入治疗培训指南：国际多学会共识文件

国际脑血管病杂志 2017年第5期25卷 396-399页

作者： Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru y yoshknura S Ezura M Fujinaka T Iihara K Ishii A higashi T Hirohata M Hyodo A Ito y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto y Miyachi S Murayama y Nagata I Nakahara I Nemoto S Niimi y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I yavagal D Liebeskind D Novakovic R Pongpech S 许岩孙瑞郭芮兵 From the American Association of Neurological Surgeons/Congress of Neurological Surgeons (AANS/CNS) Rolling Meadows IL USA American Society of Neuroradiology (ASNR) Oak Brook IL USA Asian Australasian Federation of lnterventional and Therapeutic Neuroradiology (AAFITN) Bali Indonesia Australian and New Zealand Society of Neuroradiobgy-Conjomt Committee for Recognition of Training in Interventional Neuroradiology (CCINR) representing the RANZCR (ANZSNR) ANZAN and NSA Sydney Australia Canadian Interventional Neuro Group (CING) Edmonton AB Canada World Federation of Interventional and Therapeutic Neuroradiology (WFITN) Gold Coast Australia European Society of Neuroradiology (ESNR) Milan Italy European Society of Minimally Invasive Neurologic Therapy (ESMINT) Nice France Japanese Society for Neuroendovascular therapy (JSNET) Okayama Japan Sociedad Ibero Latino Americana de Neuroradiologica (SILAN) Cartagena Colombia Society of Neurolnterventional Surgery (SNIS) Washington DC USA Society of Vascular and Interventional Neurology (SVIN) Brooklyn NY USA 南京大学医学院附属金陵医院(南京军区南京总医院)神经内科 210002 解放军第一0一医院(无锡太湖医院)神经内科无锡214004

1背景缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞（emergent large vesselocclusion，ELVO）患者都会遗留长期残疾。事实上，这些颅内大动脉闭塞经常会导致大面积脑损伤，进而造成患者死亡或严重致残。

关键词：缺血性卒中培训指南介入治疗文件学会国际血管闭塞动脉闭塞

慢性肝病病人肝脏乏血供结节:发展为富血供肝细胞肝癌的危险因素

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国际医学放射学杂志 2013年第2期 171-171页

作者： T. Hyodo T. Murakami y. Imai M. Okada M. Hori y. Kagawa 李宁 Departments of Radiology and Internal Medicine Kinki University Faculty of Medicine 377-2 Ohno-Higashi Osaka-Sayama Osaka 589-8511 Japan

目的确定慢性肝病病人的特征及MR成像表现与钆塞酸增强MR肝胆管期成像显示为低信号的乏血供结节继发性血管过度生成的相关性。材料与方法经机构审查委员会批准,免除病人知情同意。回顾性分析经多次钆塞酸增强MR随访检查的68例病人的160... 详细信息

目的确定慢性肝病病人的特征及MR成像表现与钆塞酸增强MR肝胆管期成像显示为低信号的乏血供结节继发性血管过度生成的相关性。材料与方法经机构审查委员会批准,免除病人知情同意。回顾性分析经多次钆塞酸增强MR随访检查的68例病人的160个乏血供结节。建立用于评估血管过度生成的Cox回归模型来探索包括病人因素[Child-Pugh分级、肝病病因、肝细胞肝癌(HCC)的局部治疗史,以及并存的富血供HCC]及MR成像特征(脂肪成分、T2加权成像信号强度及结节大小)在内的病人基本特征的相关性。此外,通过肿瘤体积倍增时间的倒数来计算增长速度并采用受试者操作特征曲线和Kaplan-Meier分析研究其与继发性血管过度生成的相关性。结果继发性血管过度生成的发生率为31%(50/160结节)。独立Cox多变量预测血管过度生成增加的危险因素为T2加权成像高信号[风险比(HR)=8.7;95%CI:3.6～20.8]、曾经局部治疗的富血供HCC(HR=5.0;95%CI:1.8～13.6)、Child-PughB级肝硬化(HR=3.6;95%CI:1.4～9.5)和并存富血供HCC(HR=2.0;95%CI:1.0～3.8)。出现继发性血管过度生成结节的平均生长速度明显高于没有血管过度生成的结节。基于受试者操作特征曲线临界值[1.8×10-3/d(肿瘤倍增时间,542d)]的Kaplan-Meier分析显示生长速度快的结节,其血管过度生成的发生率明显增高(P=5.2×10-8,log-rank检验)。结论慢性肝病病人乏血供结节T2加权成像高信号是其继发性血管过度生成的独立和显著的基本危险因素。肿瘤体积倍增时间<542d与继发性血管过度生成发生率的增高具有相关性。

关键词：血供局部治疗病人 HCC 危险因素危险隐患肝细胞肝癌结节