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国际医学放射学杂志 2022年第2期 237-238页

作者： I.Au-yong y.higashi E.Giannotti A.Fogarty J.R.Morling M.Grainge 朱珍

摘要放射学所显示的严重程度可能有助于预测新型冠状病毒肺炎（COVID-19）病人的病情恶化和结局。目的评估3种胸部平片报告系统[肺水肿（RALE）、Brixia和阴影百分比

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Molybdenum sputtering film characterization for high gradient accelerating structures

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Chinese Physics C 2013年第9期37卷 73-79页

作者： S.Bini B.Spataro A.Marcelli S.Sarti V.A.Dolgashev S.Tantawi A.D.yeremian y.higashi M.G.Grimaldi L.Romano F.Rufno R.Parodi G.Cibin C.Marrelli M.Migliorati C.Caliendo INFN - LNF Via E. Fermi 40Frascati (RM) 00044 Italy NSRL University of Science and Technology of China Chinese Academy of Sciences University of Rome-Sapienza Dipartimento di FisicaPiazzale Aldo Moro 5Rome 00185Italy SLAC National Accelerator Laboratory 2575 Sand Hill RoadMenlo ParkCA 94025USA KEK 1-1 Oho TsukubaIbaraki 305Japan University of Catania Dipartimento di Fisica e Astronomia & MATIS-IMM-CNRVia S. Sofia 64Catania 95123Italy INFN-Genova Via Dodecaneso 33Genova 16146Italy Diamond Light Source ChiltonDidcotOxford OX110DEUK University of Roma-Sapienza Dipartimento di Scienze di Base e Applicate per l’IngegneriaVia A. ScarpaRoma 14-00161-Italy Istituto dei Sistemi Complessi ISC-CNRArea della Ricerca di Roma 1Via Salaria km 29.300MonterotondoRome 00040Italy

Technological advancements are strongly required to fulfill the demands of new accelerator devices with the highest accelerating gradients and operation reliability for the future colliders. To this purpose an extensive R^zD regarding molybdenum coatings on copper is in progress. In this contribution we describe chemical composition, deposition quality and resistivity properties of different molybdenum coatings obtained via sputtering. The deposited films are thick metallic disorder layers with different resistivity values above and below the molibdenum dioxide reference value. Chemical and electrical properties of these sputtered coatings have been characterized by Rutherford backscattering, XANES and photoemission spectroscopy. We will also consider multiple cells standing wave section coated by a molybdenum layer designed to improve the performance of X-Band accelerating systems.

关键词： linear accelerator cavities X-band coatings XANES resistivity

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Influences of Horticultural Therapy and Functional Recovery Training at a Day-Care Center for the Elderly and Text Mining of Care Records by AI

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Open Journal of Therapy and Rehabilitation 2024年第2期12卷 117-131页

作者： Seigo Koura Shinya Matsutani Kazuho Nagao yu Fukushima Akiko Ikeda Takeshi Oshikawa Tomohiro Inagaki Kentaro higashi Faculty of Graduate School Postdoctoral Course in Health Care Medicine Nishikyusyu University Kanzaki Japan Social Welfare Corporation Kanjikai Miyakonojyo Japan Sophia Phyto-Therapy College Tokyo Japan

Background: In Japan, due to the COVID-19 pandemic, various behavioral restrictions were implemented from March 2020, resulting in an increased number of elderly people with reduced participation in care and rehabilitation. As a result, the decline in motor and cognitive functions became more pronounced. Purpose: The study examined how activities combining passive horticultural therapy, which is always introduced, with active functional recovery training, which is used in the functional recovery training of patients with hemiplegia, influence the behavior of elder people using the facility. Methods: 36 elder people with care need 1 or 2 who regularly used the day-care facilities after the pandemic ended and who agreed to participate in the study was included. The assessment data were every three months from December 2021 to December 2023 after the COVID-19 pandemic, the MMSE and Moca-J, TMIG-Index, and GDS15. AI-based text mining was used to compare changes in visit reports before and after the introduction of the Posture Chart and Red Code, and the relationship between the language used. Results: The results of MMSE and Moca-J were both significantly higher in Group B and C than in Group A. TIMG assessment, was significantly higher in Group B and C than in Group A, and Group C was significantly higher than Group B. The GDS, an assessment of depression in old age, tended to be significantly higher in Group A than in Groups B and C. In the “Co-Occurrence Network Analysis” shown after the introduction of the latest functional recovery training equipment such as the Red Cord, its results showed a high association between the words Bathing and CARE and words such as POSTURE, Red-Code, and AI, App, which are used in functional training and rehabilitation, and their analysis. Conclusion: At day-care facilities specializing in functional recovery training and rehabilitation, a combination of horticultural therapy and the latest functional training equipment found to help m

关键词： Horticultural Therapy Hand Care Treatment Senior Day-Care Center Functional Recovery Training KH-Corder

接受抗高血压药治疗的高血压患者夜间高血压的影响因素

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中华高血压杂志(中英文) 2024年第3期32卷 300-300页

作者： Maruhashi T Kinoshita y Ozono R Nakamaru M Ninomiya M Oiwa J Kawagoe T yoshida O Matsumoto T Fukunaga y Sumii K Ueda H Shiode N Takahari K Hayashi y Ono y Nakano y Takahashi M Kihara y.higashi y 刘青练桂丽

背景：通过家庭血压监测（home blood pressure monitoring,HBPM）设备评估的夜间高血压与心血管事件风险增加相关。然而，经常评估夜间血压仍然很困难。该项横断面研究的目的是确定设备对接受抗高血压药治疗的高血压患者采用HBPM设备...

背景：通过家庭血压监测（home blood pressure monitoring,HBPM）设备评估的夜间高血压与心血管事件风险增加相关。然而，经常评估夜间血压仍然很困难。该项横断面研究的目的是确定设备对接受抗高血压药治疗的高血压患者采用HBPM设备评估的夜间高血压的影响因素。方法：研究者使用HBPM设备连续7d测量365例接受药物治疗的高血压患者的夜间血压、早晨血压、晚上血压和睡前血压。

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CD8+T cell metabolic flexibility elicited by CD28-ARS2 axisdriven alternative splicing of PKM supports antitumor immunity

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Cellular & Molecular Immunology 2024年第3期21卷 260-274页

作者： G.Aaron Holling Colin A.Chavel Anand P.Sharda Mackenzie M.Lieberman Caitlin M.James Shivana M.Lightman Jason H.Tong Guanxi Qiao Tiffany R.Emmons Thejaswini Giridharan Shengqi Hou Andrew M.Intlekofer Richard M.higashi Teresa W.M.Fan Andrew N.Lane Kevin H.Eng Brahm H.Segal Elizabeth A.Repasky Kelvin P.Lee Scott H.Olejniczak Department of Immunology Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Department of Medicine Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Center for Environmental Systems Biochemistry Department of Toxicology and Cancer Biology and Markey Cancer CenterLexingtonKY 40536USA Department of Cancer Genetics and Genomics Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Present address:University of Colorado Boulder BoulderCO 80309USA Present address:Dana Farber Cancer Institute BostonMA 02215USA Present address:Massachusetts Institute of Technology BostonMA 02139USA Present address:Melvin and Bren Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202USA

Metabolic flexibility has emerged as a critical determinant of CD8+T-cell antitumor activity,yet the mechanisms driving the metabolic flexibility of T cells have not been *** this study,we investigated the influence of the nuclear cap-binding complex(CBC)adaptor protein ARS2 on mature T *** doing so,we discovered a novel signaling axis that endows activated CD8+T cells with flexibility of glucose ***2 upregulation driven by CD28 signaling reinforced splicing factor recruitment to pre-mRNAs and affected approximately one-third of T-cell activation-induced alternative splicing *** these effects,the CD28-ARS2 axis suppressed the expression of the M1 isoform of pyruvate kinase in favor of PKM2,a key determinant of CD8+T-cell glucose utilization,interferon gamma production,and antitumor effector ***,PKM alternative splicing occurred independently of CD28-driven PI3K pathway activation,revealing a novel means by which costimulation reprograms glucose metabolism in CD8+T cells.

关键词： Immunometabolism mRNA splicing CD8 T cells ARS2 PKM2

Potassium transporter KUP9 participates in K+distribution in roots and leaves under low K+stress

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Stress Biology 2022年第1期2卷 60-70页

作者： Taro yamanashi Takeshi Uchiyama Shunya Saito Taiki higashi Hayato Ikeda Hidetoshi Kikunaga Mutsumi yamagami yasuhiro Ishimaru Nobuyuki Uozumi Department of Biomolecular Engineering Graduate School of EngineeringTohoku UniversitySendai 980‑8579Japan Research Center for Electron Photon Science Tohoku UniversitySendai 980‑0826Japan Cyclotron and Radioisotope Center Tohoku UniversitySendai 980‑8578Japan Institute for Environmental Sciences RokkashoKamikitaAomori 039‑3212Japan

Potassium(K)is a major essential element in plant cells,and KUP/HAK/KT-type K+transporters participate in the absorption of K+into roots and in the long-distance transport to above-ground *** Arabidopsis thaliana,KUP9 is involved in the transport of K+and Cs+in *** this study,we investigated KUP9 function in relation to the K+status of the *** expression of KUP9 was upregulated in older leaves on K+-depleted medium,compared to the expression of the other 12 KUP genes in the KUP/HAK/KT family in *** grown on low K+medium,the kup9 mutant had reduced chlorophyll content in seedlings and chlorosis in older rosette ***-specific expression of KUP9 determined by KUP9 promoter:GUS assay depended on the K+status of the plants:In K+sufficient medium,KUP9 was expressed in the leaf blade towards the leaf tip,whereas in K+depleted medium expression was mainly found in the *** accordance with this,K+accumulated in the roots of kup9 *** short-term 43K+tracer measurement showed that 43K was transferred at a lower rate in roots and shoots of kup9,compared to the wild *** data show that KUP9 participates in the distribution of K+in leaves and K+absorption in roots under low K+conditions.

关键词： Potassium KUP9 Arabidopsis thaliana KUP/HAK/KT

Essential cellular modules for the proliferation of the primitive cell

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Geoscience Frontiers 2018年第4期9卷 1155-1161页

作者： Koichi higashi yoshikazu Kawai Tomoya Baba Ken Kurokawa Taku Oshima Genome Evolution Laboratory National Institute of Genetics Centre for Bacterial Cell Biology Institute for Cell and Molecular BiosciencesMedical SchoolNewcastle University Advanced Genomics Center National Institute of Genetics Earth-Life Science Institute Tokyo Institute of Technology Graduate School of Biological Sciences Nara Institute of Science and Technology

Bacteria appeared early in the evolution of cellular life on planet Earth, and therefore the universally essential genes or biological pathways found across bacterial domains may represent fundamental genetic or cellular systems used in early life. The essential genes and the minimal gene set required to support bacterial life have recently been experimentally and computationally identified. It is, however,still hard to estimate the ancient genes present in primitive cells compared to the essential genes in contemporary bacteria, because we do not know how ancestral primitive cells lived and proliferated, and therefore cannot directly evaluate the essentiality of the genes in ancestral primitive cells. The cell wall is normally essential for bacterial proliferation and cellular division of walled bacterial cells is normally highly controlled by the essential FtsZ cell division machinery. But, bacteria are capable of reverting to their cell wall deficient ancestral form, called the ＂L-form＂. Unlike ＂normal＂ cells, L-forms divide by a simple physical mechanism based on the effects of membrane dynamics, suggesting a mode of primitive proliferation before the appearance of the cell wall. In this review, we summarize the experimental and computational investigations of minimal gene sets and discuss the minimal cellular modules required to support the proliferation of primitive cells, based on L-form proliferation.

关键词： L-form Essential genes Minimal gene set KEGG module Bacteria

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Folate receptor-targeted near-infrared photodynamic therapy for folate receptor-overexpressing tumors

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World Journal of Clinical Oncology 2022年第11期13卷 880-895页

作者： Winn Aung Atsushi B Tsuji Kenjiro Hanaoka Tatsuya higashi Department of Molecular Imaging and Theranostics Institute for Quantum Medical ScienceNational Institutes for Quantum and Radiological Science and TechnologyChiba 263-8555Japan Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences Keio UniversityTokyo 105-8512Japan

BACKGROUND Photodynamic therapy(PDT)is a minimally invasive form of cancer therapy,and the development of a novel photosensitizer(PS)with optimal properties is important for enhancing PDT *** receptor(FR)membrane protein is frequently overexpressed in 40%of human cancer and a good candidate for tumor-specific *** active targeting of PS to FR can be achieved by conjugation with the folate moiety.A folate-linked,near-infrared(NIR)-sensitive probe,folate-Si-rhodamine-1(FolateSiR-1),was previously developed and is expected to be applicable to *** To investigate the therapeutic efficacy of NIR-PDT induced by FolateSiR-1,a FRtargeted PS,in preclinical cancer *** FolateSiR-1 was developed by conjugating a folate moiety to the Si-rhodamine derivative through a negatively charged tripeptide *** expression in the designated cell lines was examined by western blotting(WB).The selective binding of FolateSiR-1 to FR was confirmed in FR overexpressing KB cells(FR+)and tumors by fluorescence microscopy and in vivo fluorescence *** FR expressing OVCAR-3 and A4 cell lines were used as negative controls(FR-).The NIR light(635±3 nm)-induced phototoxic effect of FolateSiR-1 was evaluated by cell viability imaging *** time-dependent distribution of FolateSiR-1 and its specific accumulation in KB tumors was determined using in vivo longitudinal fluorescence *** PDT effect of FolateSiR-1 was evaluated in KB tumor bearing mice divided into four experimental groups:(1)FolateSiR-1(100μmol/L)alone;(2)FolateSiR-1(100μmol/L)followed by NIR irradiation(50 J/cm2);(3)NIR irradiation(50 J/cm2)alone;and(4)no *** volume measurement and immunohistochemical(IHC)and histological examinations of the tumors were performed to analyze the effect of *** High FR expression was observed in the KB cells by WB,but not in the OVCAR-3 and A4 *** FR-specific binding of FolateSiR-1 was observed by in vitro an

关键词： Photodynamic therapy Near-infrared Photosensitizer Folate receptor Fluorescence Cancer

Overproduction of reactive oxygen species–obligatory or not for induction of apoptosis by anticancer drugs

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Chinese Journal of Cancer Research 2016年第4期28卷 383-396页

作者： Donika Ivanova Zhivko Zhelev Ichio Aoki Rumiana Bakalova Tatsuya higashi Medical Faculty Trakia University Institute of Biophysics & Biomedical Engineering Bulgarian Academy of Sciences Department of Molecular Imaging and Theranostics National Institute of Radiological SciencesNational Institute for Quantum and Radiological Science and Technology Medical Faculty Sofia University

Many studies demonstrate that conventional anticancer drugs elevate intracellular level of reactive oxygen species （ROS） and alter redox-homeostasis of cancer cells. It is widely accepted that anticancer effect of these chemotherapeutics is due to induction of oxidative stress and ROS-mediated apoptosis in cancer. On the other hand, the harmful side effects of conventional anticancer chemotherapy are also due to increased production of ROS and disruption of redox-homeostasis of normal cells and tissues. This article describes the mechanisms for triggering and modulation of apoptosis through ROS-dependent and ROS^independent pathways. We try to answer the question：＂Is it possible to induce highly specific apoptosis only in cancer cells, without overproduction of ROS, as well as without harmful effects on normal cells and tissues？＂ The review also suggests a new therapeutic strategy for selective killing of cancer cells, without significant impact on viability of normal cells and tissues, by combining anticancer drugs with redox-modulators, affecting specific signaling pathways and avoiding oxidative stress.

关键词： Cancer reactive oxygen species chemotherapy ROS-independent apoptosis ROS-dependent apoptosis

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Assessment for the minimal invasiveness of laparoscopic liver resection by interleukin-6 and thrombospondin-1

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World Journal of Hepatology 2022年第1期14卷 234-243页

作者： Takayoshi Kaida Hiromitsu Hayashi Hiroki Sato Shotaro Kinoshita Takashi Matsumoto yuta Shiraishi yuki Kitano Takaaki higashi Katsunori Imai yo-ichi yamashita Hideo Baba Gastroenterological Surgery Graduate School of Life SciencesKumamoto UniversityKumamoto 860-8556Japan

BACKGROUND Laparoscopic surgery has been introduced as a minimally invasive technique for the treatment of various ***,there are few reports that have scientifically investigated the minimally invasive nature of laparoscopic liver resection(LLR).AIM To investigate whether LLR is scientifically less invasive than open liver *** During December 2011 to April 2015,blood samples were obtained from 30 patients who treated with laparoscopic(n=10,33%)or open(n=20,67%)partial liver resection for liver *** levels of serum interleukin-6(IL-6)and plasma thrombospondin-1(TSP-1)were measured using ELISA kit at four time points including preoperative,immediate after operation,postoperative day 1(POD1)and ***,we investigated the impact of the operative approaches during partial hepatectomy on the clinical time course including IL-6 and *** Serum level of IL-6 on POD1 in laparoscopic hepatectomy was significantly lower than those in open hepatectomy(8.7 vs 30.3 pg/mL,respectively)(P=0.003).Plasma level of TSP-1 on POD3 in laparoscopic hepatectomy was significantly higher than those in open hepatectomy(1704.0 vs 548.3 ng/mL,respectively)(P=0.009),and have already recovered to preoperative level in laparoscopic *** patients with higher IL-6 Levels on POD1,plasma level of TSP-1 on POD3 was significantly lower than those in patients with lower IL-6 Levels on *** analysis showed that open approach was the only independent factor related to higher level of IL-6 on POD1[odds ratio(OR),7.48;95%confidence interval(CI):1.28-63.3;P=0.02].Furthermore,the higher level of serum IL-6 on POD1 was significantly associated with lower level of plasm TSP-1 on POD3(OR,5.32;95%CI:1.08-32.2;P=0.04)in multivariate *** In partial hepatectomy,laparoscopic approach might be minimally invasive surgery with less IL-6 production compared to open approach.

关键词： Laparoscopic surgery Liver resection Hepatectomy Minimal invasiveness Interleukin-6 Thrombospondin-1