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Correlations of the expression of Cx43,SCFFBXW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in colon cancer tissues

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 207-213页

作者： Rong-Gang Luan Ming-Da Liu Zi-Feng Deng Cong-Lan Lu Mei-Ling yu Ming-yu Zhang Rong Liu Ran An you-Liang yao Dong-Bei Guo yong-Xing Zhang Lei Zhao Department of Gastrointestinal Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthXiamen UniversityXiamen 361102Fujian ProvinceChina Trauma Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina Department of Orthopaedics Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina

BACKGROUND Previous cellular studies have demonstrated that elevated expression of Cx43 promotes the degradation of cyclin E1 and inhibits cell proliferation through ***,reduced expression results in a loss of this capacity to facilitate cyclin E *** ubiquitination and degradation of cyclin E1 may be associated with phosphorylation at specific sites on the protein,with Cx43 potentially enhancing this process by facilitating the phosphorylation of these critical *** To investigate the correlation between expression of Cx43,SKP1/Cullin1/F-box(SCF)FBXW7,p-cyclin E1(ser73,thr77,thr395)and clinicopathological indexes in colon *** Expression levels of Cx43,SCFFBXW7,p-cyclin E1(ser73,thr77,thr395)in 38 clinical colon cancer samples were detected by immunohistochemistry and were analyzed by statistical methods to discuss their *** Positive rate of Cx43,SCFFBXW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in detected samples were 76.32%,76.32%,65.79%,5.26%and 55.26%*** expressions of these proteins were not related to the tissue type,degree of tissue differentiation or lymph node ***43 and SCFFBXW7(r=0.749),p-cyclin E1(Ser73)(r=0.667)and p-cyclin E1(Thr395)(r=0.457),SCFFBXW7 and p-cyclin E1(Ser73)(r=0.703)and p-cyclin E1(Thr395)(0.415)were correlated in colon cancer(Py correlated in colon *** Cx43 may facilitate the phosphorylation of cyclin E1 at the Ser73 and Thr195 sites through its interaction with SCFFBXW7,thereby influencing the ubiquitination and degradation of cyclin E1.

关键词： Colon cancer Cx43 SCFFBXW7 Phosphorylation of cyclin E1 Sites of cyclin E1 Correlation analysis

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The Credit-Risk Decision Mechanism on Fixed Loan Interest Rate with Imperfect Information

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Journal of Systems Engineering and Electronics 2001年第3期12卷 20-24页

作者： Pang, S. Liu, y. Wang, y. yao, H. Department of Mathematics Jinan University Guangzhou 510632 China

In this paper, decision mechanism of credit-risk for banks is studied when the loan interest rate is fixed with asymmetry information in credit market. We give out the designs of rationing and non-rationing on credit risky decision mechanism when collateral value provided by an entrepreneur is not less than the minimum demands of the bank. It shows that under the action of the mechanism, banks could efficiently identify the risk size of the project. Finally, the condition of the project investigation of bank is given over again.

关键词： Classification (of information) Financial data processing Risk assessment

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Advances in Microscale Laser Shock Peening

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Tsinghua Science and Technology 2004年第5期9卷 506-518页

作者： KySAR Jeffrey W. yao y.Lawrence Department of Mechanical Engineering Columbia University New York 10027 USADepartment of Mechanical Engineering Columbia University New York 10027 USA

The response of materials after microscale laser shock peening (μLSP) was experimentally characterized and compared with the theoretical prediction from the finite element method (FEM) analysis in microlength level. X-ray micro-diffraction technique was applied to the post-peened single crystal aluminum of (001) and (110) orientations, and X-ray profile was analyzed by sub-profiling and Fourier analysis method. Spatially resolved residual stress and strain deviation was quantified and explained in terms of the hetero- geneous dislocation cell structure. In-plane crystal lattice rotation induced by μLSP was measured by elec- tron backscatter diffraction (EBSD) and compared with the FEM simulation. Average mosaic size was evaluated from X-ray profile Fourier analysis and compared with the result from EBSD. Surface strength in- crease and dislocation cell structure formation were studied. The systematical characterization will lay the ground work for better understanding the effect of μLSP in microlength level and developing more realistic simulations.

关键词： laser shock peening X-ray micro-diffraction single crystal

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Amplitude modulation and extreme events in turbulent channel flow

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Acta Mechanica Sinica 2018年第1期34卷 1-9页

作者： y.C.yao W.X.Huang C.X.Xu AML Department of Engineering Mechanics Tsinghua University

Amplitude modulation of near-wall turbulence by large-scale structures in the outer layer is investigated by direct numerical simulation of turbulent channel flows at Reynolds number Re= 540, 1000, 2000. The effect of modulation is obvious in the two-point cross-section correlation map, and the correlation coefficients increase significantly with the Reynolds number. The influence of modulation is reflected in the tail of the probability density function of the near-wall flow signals, which expands as the Reynolds number increases. The flatness factor provides a quantitative description of the high fluctuation events due to modulation. Vortical structures associated with modulation are revealed by conditionally averaging the flow field of the near-wall extreme events, providing a depiction of how the influence of the large-scale structures penetrate towards the near-wall region.

关键词： Wall turbulence Amplitude modulation Flatness Extreme events

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Mediating role of health literacy in the relationship between social isolation and psychological distress among pre-frail older adults

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World Journal of Psychiatry 2025年第1期15卷 137-144页

作者： Juan Fang Li-Hui Li Ming-Qian He yue Ji Dong-yan Lu Li-Bing Zhang Jin-Lan yao School of Medicine Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Frailty has become a significant public health *** recent increase in the number of frail older adults has led to increased attention being paid to psycho-logical care services in *** social isolation of pre-frail older adults can impact their psychological *** To explore the mediating effect of health literacy between social isolation and psychological distress among communitydwelling older adults with *** This descriptive cross-sectional study was conducted with 254 pre-frail older individuals aged 60 years and *** isolation,health literacy,and psycholo-gical distress were comprehensively measured using the Lubben Social Network Scale-6,12-item Short-Form Health Literacy Questionnaire,and the Kessler Psy-chological Distress *** were evaluated using the SPSS 27.0 package program and the PROCESS macro *** statistical analyses,correlation analyses,and bootstrap mediation tests were used to assess associations between the *** The results showed that social isolation had an effect on health literacy among pre-frail older adults(β=0.240,Pycho-logical distress pre-frail older adults(β=-0.415,Py was identified effect on psychological distress among pre-frail older persons(β=-0.307,Py partially mediated the relationship between social isolation and psychological distress among community-dwelling older adults with pre-frailty,with a mediation effect of-0.074,accounting for 17.83%of the total effect.

关键词： Frail Ageing Psychological distress Health literacy Social isolation

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青稞分蘖角度的QTL定位

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作物学报 2025年第1期51卷 260-272页

作者：杨景发余鑫莲姚有华姚晓华王蕾吴昆仑李新青海大学农林科学院/青海省作物分子育种重点实验室/青海省青稞遗传育种重点实验室/青藏高原种质资源研究与利用实验室/青海大学省部共建三江源生态与高原农牧业国家重点实验室青海西宁810016

分蘖角度是青稞株型的主要构成因素,在提高青稞产量与抗倒伏性中发挥着极为重要的作用。为解析青稞分蘖角度的遗传机制,本研究以青稞品种‘达章紫’(株型松散)和‘昆仑10号’(株型紧凑)为亲本构建的RIL群体为材料,基于高密度遗传图谱,... 详细信息

分蘖角度是青稞株型的主要构成因素,在提高青稞产量与抗倒伏性中发挥着极为重要的作用。为解析青稞分蘖角度的遗传机制,本研究以青稞品种‘达章紫’(株型松散)和‘昆仑10号’(株型紧凑)为亲本构建的RIL群体为材料,基于高密度遗传图谱,在多环境中进行青稞分蘖角度的QTL定位,并利用RIL群体衍生的剩余杂合系,对鉴定到的主效QTLqTA7H-1进行精细定位。在青稞7条染色体上共检测到9个控制分蘖角度的QTL,解释表型变异为6.41%~33.57%,其中,qTA3H-1和qTA7H-1为多环境共检测的主效QTL,平均加性效应分别为5.42°(增效)和-3.87°(减效);在减效QTL qTA7H-1初定位区间筛选到4个剩余杂合体,自交衍生F8:9近等基因系,在置信区间内加密设计14对分子标记对RHL群体极端单株进行检测,利用获得的5种交换类型单株,将qTA7H-1进一步界定在PC08(32,252,397)与PA10(41,790,765)约9.54Mb的物理区间内。本研究初步揭示调控青稞分蘖角度的遗传因子,为开展分蘖角度性状的遗传改良与分子设计育种奠定了基础。

关键词：青稞分蘖角度 QTL定位主效位点

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Unified Control Strategy of Heterogeneous Thermostatically Controlled Loads with Market-based Mechanism

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Journal of Modern Power Systems and Clean Energy 2020年第6期8卷 1231-1239页

作者： yao yao Peichao Zhang Key Laboratory of Control of Power Transmission and Conversion of Ministry of Education Department of Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

This paper studies the coordination of heterogeneous thermostatically controlled loads(TCLs)to provide the real-time ancillary services.A market-based control framework is adopted for its *** first advantage is that the demand curve-oriented approach makes it possible to form a unified control scheme for heterogeneous loads without identifying their different *** second one is that the broadcast price signal helps simplify the downlink control and reduce the implementation ***,the separate demand curve construction strategies based on a virtual price for different types of TCLs are *** flexibility of each TCL is reflected through the curve,and its practical constraints,i.e.,comfort requirements of users and operation constraints of devices,are satisfied *** ensure the control fairness and full utilization for the regulation ability of TCL cluster,a comfort-levelequality principle is applied in demand curve *** are carried out to verify the effectiveness of the proposed method in providing frequency regulation services,for which a regulation capacity estimation method is ***,a series of case studies are conducted considering the practical situations,e.g.,model errors,imperfect communication and sudden load change after the end of services.

关键词： Thermostatically controlled load(TCL) market-based control coordination control frequency regulation

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Interior-collapsing mechanism by hydrothermal process of the MgAl_(2)O_(4)/MgO porous ceramic

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Journal of Advanced Ceramics 2022年第5期11卷 814-824页

作者： yao yao yue ZHANG Key Laboratory of Aerospace Materials and Performance(Ministry of Education) School of Materials Science and EngineeringBeihang UniversityBeijing 100191China

Ceramic core is a critical component in the super-alloy turbine blade *** our previous work,a novel multi-phase MgAl_(2)O_(4)/MgO porous ceramic was prepared for this *** most important property was that it crumbled completely after hydrothermal treatment in just pure water,due to the hydration of *** this work,the hydration process of the MgO embedded in the inert matrix was investigated in *** collapse behaved as an interior destruction without any bulk expansion of the *** hydration percentage was the only factor related to the *** morphology of hydration product indicated that the reaction advanced in particular *** on the finite element analysis for the expansion effect on the porous structure,the interiorcollapsing mechanism was *** the hydration process,the MgO grains exerted pressure to the surrounding matrix and induced the collapse in the adjacent *** process took place throughout the ***,the sample crumbled completely to the *** bulk dilatation was detected before the powdering,indicating that the collapse process would not exert pressure *** the alloy blade would not be damaged during the removal of the ceramic *** was also predicted that the decrease in the MgO grain size was beneficial to the water-collapsibility.

关键词： ceramic cores porous structure MgO hydration interior-collapsing mechanism

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Designs to Improve Capability of Neural Networks to Make Structural Predictions

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Chinese Journal of Polymer Science 2023年第9期41卷 1477-1485,I0009页

作者： Tian-yao Wang Jian-Feng Li Hong-Dong Zhang Jeff Z.y.Chen Department of Macromolecular Science State Key Laboratory of Macromolecular Engineering of PolymersFudan UniversityShanghai200438China Department of Physics and Astronomy University of WaterlooWaterlooN2L 3G1Canada

A deep neural network model generally consists of different modules that play essential roles in performing a *** optimal design of a module for use in modeling a physical problem is directly related to the success of the *** this work,the effectiveness of a number of special modules,the self-attention mechanism for recognizing the importance of molecular sequence information in a polymer,as well as the big-stride representation and conditional random field for enhancing the network ability to produce desired local configurations,is numerically *** models containing these modules are trained by using the well documented data of the native structures of the HP model and assessed according to their capability in making structural predictions of unseen *** specific network design of self-attention mechanism adopted here is modified from a similar idea in natural language *** big-stride representation module introduced in this work is shown to drastically improve network's capability to model polymer segments of strong lattice position correlations.

关键词： Deep neural network Self-attention mechanism Big-stride representation Conditional random methods

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论健康数据科学研究合法性基础的证成与适用

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科技与法律（中英文） 2025年第1期 57-67页

作者：姚旭鑫华东政法大学卫生健康法治与政策研究院上海200042 安特卫普大学法学院安特卫普2000

现有的个人信息处理合法性基础框架难以满足健康数据科学研究的需要。将科学研究作为健康数据处理的合法性基础,是国家促进、实现科学研究自由和健康权的要求,并可通过对“公共利益”的解释得到证成。科学研究主体应当隶属于以科学研究... 详细信息

现有的个人信息处理合法性基础框架难以满足健康数据科学研究的需要。将科学研究作为健康数据处理的合法性基础,是国家促进、实现科学研究自由和健康权的要求,并可通过对“公共利益”的解释得到证成。科学研究主体应当隶属于以科学研究为主要目的范围的组织机构。科学研究不排斥商业目的,但商业程度的不同,决定了研究主体是否需要向数据主体付酬。科学研究主体对健康数据的访问需要依托健康数据协调机构加以实现。在适用科学研究这一合法性基础对健康数据进行处理时,应将对数据主体的影响控制在最小范围。原则上对健康数据去标识化,对科学研究有重要意义的标识符可依申请予以保留。标识符的保留和健康数据科学研究的黑箱属性,决定了要对健康数据科学研究课以更高标准的公开透明要求。同时相关规则具有较大自由裁量空间,自由裁量应以风险收益平衡原则为基本遵循。科学研究和其他合法性基础可能存在重合或冲突,只有在数据主体未明示反对的前提下,才可适用科学研究这一合法性基础。当科学研究与其他法定数据处理情形相重合时,科学研究作为特别情形,应优先于一般情形的适用。

关键词：健康数据科学研究合法性基础适用规则

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