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Long-chain acyl-CoA synthetase regulates systemic lipid homeostasis via glycosylation-dependent lipoprotein production

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Life Metabolism 2024年第2期3卷 38-54页

作者： Jie Li yue Dong tianxing Zhou He tian Xiahe Huang yong q.Zhang yingchun Wang Sin Man Lam Guanghou Shui State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100101China Lipidall Technologies Company Limited ChangzhouJiangsu 213000China

Interorgan lipid transport is crucial for organism development and the maintenance of physiological ***,we demonstrate that Drosophila long-chain acyl-CoA synthetase(dAcsl),which catalyzes the conversion of fatty acids into acyl-coenzyme As(acyl-CoAs),plays a critical role in regulating systemic lipid *** deficiency in the fat body led to the ectopic accumulation of neutral lipids in the gut,along with significantly reduced lipoprotein contents in both the fat body and *** aberrant phenotypes were rescued by fat body-specific overexpression of apolipophorin.A multi-omics investigation comprising lipidomics,metabolomics,and proteomics in conjunction with genetic screening revealed that glycosylation processes were suppressed in dAcsl knockdown *** of CG9035,human ortholog of which is implicated in the congenital disorder of glycosylation,ame-liorated gut lipid accumulation in *** lipoprotein glycosylation led to accelerated proteasome-related degradation and induced ER stress in dAcsl knockdown flies,impairing lipoprotein release into the circulation which compromised interorgan lipid transport between the fat body and the *** of ubiquitin-proteasome-dependent degradation alleviated the phenotype of gut ectopic fat accumulation in dAcsl knockdown ***,we verified that ACSL4,the human homolog of dAcsl,also regulated lipoprotein levels in HepG2 cells,indicating that the role of dAcsl in modulating lipoprotein secretion and systemic lipid homeostasis is possibly conserved in humans.

关键词： lipid homeostasis apolipoprotein glycosylation lipidomics metabolomics proteomics

Conceptual design and configurations selection of S/H-UAVs based on q-rung dual hesitant double layer FqFD

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Chinese Journal of Aeronautics 2024年第9期37卷 193-205页

作者： Dun yANG Li LIU Wencan BAI Weiyong tian School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China

For the conceptual design phase of Unmanned Aerial Vehicles(UAVs),a process for conceptual design and configuration selection of Solar/Hydrogen powered UAVs(S/H-UAVs)is *** design requirements of S/H-UAVs were analyzed *** proposed process used Fuzzy quality Function Deployment(FqFD)to establish logical and quantitative ***,in order to appropriately describe the hesitancy of experts while making decision,it used q-Rung Dual Hesitant Fuzzy Sets(qRDHFS)to score the *** addition,a decision-making framework is proposed to perform a logical selection of typical layouts based on defuzzi-fication method and Technique for Order Preference by Similarity to the Ideal Solution(TOPSIS).The present process has been applied for S/*** resulting set of design requirements con-sists of three categories:Mission Requirements(MRs),Engineering Characteristics(ECs)and Tech-nical Indicators(TIs).Four typical layouts of S/H-UAVs were sorted and *** performance of four typical layouts were evaluated and the Strut-Braced Wing(SBW)with external hydrogen storage was selected as the best layout for S/H-UAVs.

关键词： Hybrid powered UAV Conceptual design q-Rung Dual Hesitant Fuzzy Set(qRDHFS) quality function deployment Strut-braced wing

Associative Tasks Computing Offloading Scheme in Internet of Medical Things with Deep Reinforcement Learning

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China Communications 2024年第4期21卷 38-52页

作者： Jiang Fan qin Junwei Liu Lei tian Hui School of Communications and Information Engineering Xi’an University of Posts and TelecommunicationsXi’an 710121China State Key Laboratory of Networking and Switching Technology Beijing University of Posts and TelecommunicationsBeijing 100876China

The Internet of Medical Things(Io MT) is regarded as a critical technology for intelligent healthcare in the foreseeable 6G era. Nevertheless, due to the limited computing power capability of edge devices and task-related coupling relationships, Io MT faces unprecedented challenges. Considering the associative connections among tasks, this paper proposes a computing offloading policy for multiple-user devices(UDs) considering device-to-device(D2D) communication and a multi-access edge computing(MEC)technique under the scenario of Io MT. Specifically,to minimize the total delay and energy consumption concerning the requirement of Io MT, we first analyze and model the detailed local execution, MEC execution, D2D execution, and associated tasks offloading exchange model. Consequently, the associated tasks’ offloading scheme of multi-UDs is formulated as a mixed-integer nonconvex optimization problem. Considering the advantages of deep reinforcement learning(DRL) in processing tasks related to coupling relationships, a Double DqN based associative tasks computing offloading(DDATO) algorithm is then proposed to obtain the optimal solution, which can make the best offloading decision under the condition that tasks of UDs are associative. Furthermore, to reduce the complexity of the DDATO algorithm, the cacheaided procedure is intentionally introduced before the data training process. This avoids redundant offloading and computing procedures concerning tasks that previously have already been cached by other UDs. In addition, we use a dynamic ε-greedy strategy in the action selection section of the algorithm, thus preventing the algorithm from falling into a locally optimal solution. Simulation results demonstrate that compared with other existing methods for associative task models concerning different structures in the Io MT network, the proposed algorithm can lower the total cost more effectively and efficiently while also providing a tradeoff between delay and energy co

关键词： associative tasks cache-aided procedure double deep q-network Internet of Medical Things(IoMT) multi-access edge computing(MEC)

STCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti q.An X.Z.Bai y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao q.H.Cao X.Cao Z.Cao q.Chang K.T.Chao D.y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen y.Chen y.q.Chen H.y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.y.Dong W.H.Dong V.Druzhinin D.S.Du y.J.Du Z.G.Du L.M.Duan D.Epifanov y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.q.Feng X.Feng y.T.Feng J.L.Fu J.Gao y.N.Gao P.S.Ge C.q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.q.Guo F.K.Guo J.C.Guo J.Guo y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.q.Hao J.B.He S.q.He X.G.He y.L.He Z.B.He Z.X.Heng B.L.Hou T.J.Hou y.R.Hou C.y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang q.y.Huang W.q.Huang X.T.Huang X.J.Huang y.B.Huang y.S.Huang N.Hüsken V.Ivanov q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin y.Lei E.Levichev C.H.Li C.Li D.y.Li F.Li G.Li G.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.J.Li X.Li X.H.Li X.q.Li X.H.Li y.Li y.y.Li Z.J.Li H.Liang J.H.Liang y.T.Liang G.R.Liao L.Z.Liao y.Liao C.X.Lin D.X.Lin X.S.Lin B.J.Liu C.W.Liu D.Liu F.Liu G.M.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.y.Liu K.Liu L.Liu q.Liu S.B.Liu T.Liu X.Liu y.W.Liu y.Liu y.L.Liu Z.q.Liu Z.y.Liu Z.W.Liu I.Logashenko y.Long C.G.Lu J.X.Lu N.Lu q.F.Lü y.Lu y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma y.Ma y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev y.Nefedov S.L.Olsen q.Ouyang P.Pakhlov G.Pakhlova X.Pan y.Pan E.Passemar y.P.Pei H.P.Peng L.Peng X.y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.qi y.q.qi W.B.qian y.qian C.F.qiao J.J.qin J.J.qin L.q.qin X.S.qin T.L.qiu J.Rademacker C.F.Redmer H.y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

Low-permittivity LiLn(PO_(3))_(4)(Ln=La,Sm,Eu)dielectric ceramics for microwave/millimeter-wave communication

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Journal of Advanced Ceramics 2024年第5期13卷 602-620页

作者： Huanrong tian Xiaohan Zhang Zidong Zhang yao Liu Haitao Wu Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) Shandong UniversityJinan 250061China School of Materials Science and Engineering Shandong UniversityJinan 250061China School of Environmental and Material Engineering Yantai UniversityYantai 264005China

The development of dielectric materials with low permittivity and low loss is a great challenge in wireless *** this study,LiLn(PO_(3))_(4)(Ln=La,Sm,Eu)ceramic systems were successfully prepared using the traditional solid-state method.X-ray diffraction analysis indicated that the LiLn(PO_(3))_(4)ceramics crystallized in a monoclinic structure when sintered at 850–940℃.The characteristic peak shifted to higher angles with variations in the Ln element,which was ascribed to a reduction in the cell *** analysis by structure refinement revealed that the reduction in the cell volume resulted from the decrease in chemical bond lengths and the compression of[LiO_(4)]and[PO_(4)]***,the LiLn(PO_(3))_(4)ceramic system displayed exceptional performance at low sintering temperatures(910–925℃),including a high quality factor(q·f)of 41,607–75,968 GHz,low temperature coefficient of resonant frequency(τ_(f))ranging from−19.64 to−47.49 ppm/℃,low permittivity(ε_(r))between 5.04 and 5.26,and low density(3.04–3.26 g/cm^(3)).The application of Phillips–van Vechten–Levine(P–V–L)theory revealed that the increased q·f value of the LiLn(PO_(3))_(4)systems can be attributed to the enhanced packing fraction,bond covalency,and lattice energy,and the stability of τ_(f) was associated with the increase in the bond ***,a prototype microstrip patch antenna using LiEu(PO_(3))_(4) ceramics was *** measurement results demonstrated excellent antenna performance with a bandwidth of 360 MHz and a peak gain of 5.11 dB at a central frequency of 5.08 ***,low-εr LiLn(PO_(3))_(4)ceramic systems are promising candidates for microwave/millimeter-wave communication.

关键词： low permittivity LiLn(PO_(3))_(4) microwave dielectric properties Phillips-van Vechten-Levine(P-V-L)theory microstrip patch antenna

quantum weak force sensing with squeezed magnomechanics

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 23-32页

作者： qian Zhang Jie Wang tian-Xiang Lu Ran Huang Franco Nori Hui Jing Key Laboratory of Low-Dimensional quantum Structures and quantum Control of Ministry of Education Department of Physics and Synergetic Innovation Center for Quantum Effects and ApplicationsHunan Normal UniversityChangsha 410081China Theoretical quantum Physics Laboratory Cluster for Pioneering ResearchRIKENWako-shi 351-0198Japan Center for quantum Computing RIKENWako-shi 351-0198Japan Department of Physics University of MichiganAnn Arbor 48109-1040USA College of Physics and Electronic Information Gannan Normal UniversityGanzhou 341000China Academy for quantum Science and Technology Zhengzhou University of Light IndustryZhengzhou 450002China

Cavity magnomechanics,exhibiting remarkable experimental tunability,rich magnonic nonlinearities,and compatibility with various quantum systems,has witnessed considerable advances in recent ***,the potential benefits of using cavity magnomechanical(CMM)systems in further improving the performance of quantum-enhanced sensing for weak forces remain largely *** we show that,by squeezing the magnons,the performance of a quantum CMM sensor can be significantly enhanced beyond the standard quantum limit(SqL).We find that,for comparable parameters,two orders of magnitude enhancement in the force sensitivity can be achieved in comparison with the case without magnon ***,we obtain the optimal parameter regimes of homodyne angle for minimizing the added quantum *** findings provide a promising approach for highly tunable and compatible quantum force sensing using hybrid CMM devices,with potential applications ranging from quantum precision measurements to quantum information processing.

关键词： quantum force sensing cavity magnomechanics magnon Kerr effect

Influence of Al_(2)O_(3)/SiO_(2) Ratio on the Structure and Properties of Na^(+)/K^(+)Ion Exchange Na_(2)O-MgO-Al_(2)O_(3)-SiO_(2) Glasses

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 606-612页

作者：吴建磊 CHEN Junzhu tian Xiaokun LI Jiahao GAO Wenkai yUE yunlong 康俊峰 School of Materials Science and Engineering University of JinanJinan 250022China CDGM GLASS Co.LTD Chengda 610199China

In this work,the structure,viscosity and ion-exchange process of Na_(2)O-MgO-Al_(2)O_(3)-SiO_(2) glasses with different Al_(2)O_(3)/SiO_(2) molar ratios were *** results showed that,with increasing Al_(2)O_(3)/SiO_(2) ratio,the simple structural units q_(1) and q_(2) transformed into highly aggregated structural units q_(3) and q_(4),indicating the increase of polymerization degree of glass ***,the coefficient of thermal expansion decreased from 9.23×10^(-6)℃^(-1) to 8.88×10^(-6)℃^(-1).The characteristic temperatures such as melting,forming,softening and glass transition temperatures increased with the increase of Al_(2)O_(3)/SiO_(2) ratio,while the glasses working temperature range became *** increasing Al_(2)O_(3)/SiO_(2) ratio and prolonging ion-exchange time enhanced the surface compressive stress(CS)and depth of stress layer(DOL).However,the increase of ion exchange temperature increased the DOL and decreased the CS affected by stress *** was a good linear relationship between stress relaxation and surface compressive *** strengthening significantly improved the hardness of glasses,which reached the maximum value of(622.1±10)MPa for sample with Al_(2)O_(3)/SiO_(2) ratio of 0.27 after heat treated at 410℃for 2 h.

关键词： network structure viscosity ion exchange aluminosilicate glass

Effects of loneliness and isolation on cardiovascular diseases:a two sample Mendelian Randomization Study

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Journal of Geriatric Cardiology 2024年第3期21卷 340-348页

作者： Jia-yin CAI Xin WANG Cong-yi ZHENG Xue CAO Zhen HU Run-qing GU yi-Xin tian ye tian Lan SHAO Lin-Feng ZHANG Zeng-Wu WANG Division of Prevention and Community Health National Center for Cardiovascular DiseaseNational Clinical Research Center of Cardiovascular DiseaseState Key Laboratory of Cardiovascular DiseaseFuwai HospitalPeking Union Medical College&Chinese Academy of Medical SciencesBeijingChina

BACKGROUND Loneliness and isolation are associated with multiple cardiovascular diseases(CVDs),but there is a lack of research on whether they were causally *** conducted a Mendelian Randomization(MR)study to explore causal relationships between loneliness and isolation and multiple *** Single nucleotide polymorphisms associated with loneliness and isolation were identified from a genome-wide association study(GWAS)of 455,364 individuals of European ancestry in the IEU GWAS *** data for 15 CVDs were also obtained from the IEU GWAS *** used three MR methods including inverse variance weighting,MR-Egger,and weighted median estimation to assess the causal effect of exposure on ***'s q test and MR-Egger intercept test were used to evaluate the heterogeneity and *** MR analysis showed that loneliness and isolation were significantly associated with essential hypertension(OR=1.07,95%CI:1.03-1.12),atherosclerotic heart disease(OR=1.04;95%CI:1.02-1.06),myocardial infarction(OR=1.02;95%CI:1-1.04)and angina(OR=1.04;95%CI=1.02-1.06).No heterogeneity and pleiotropy effects were found in this *** Causal relationship of loneliness and isolation with CVDs were found in this study.

关键词： diseases cardiovascular angina

Self-adaptive hydrogel for breast cancer therapy via accurate tumor elimination and on-demand adipose tissue regeneration

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Chinese Chemical Letters 2024年第1期35卷 371-378页

作者： Ran tian Xinyu qiu Wenyun Mu Bolei Cai Zhongning Liu Shiyu Liu Xin Chen School of Chemical Engineering and Technology Department of Chemical EngineeringShaanxi Key Laboratory of Energy Chemical Process IntensificationXi'an Jiao Tong UniversityXi'an 710049China School of Stomatology State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Clinical Research Center for Oral DiseasesDepartment of Preventive DentistryThe Fourth Military Medical UniversityXi'an 710032China School of Stomatology State Key Laboratory of Military StomatologyDepartment of Oral and Maxillofacial SurgeryThe Fourth Military Medical UniversityXi'an 710032China Department of Prosthodontics Peking University School and Hospital of StomatologyNational Clinical Research Center for Oral DiseasesNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory of Digital StomatologyBeijing 100081China School of Stomatology State Key Laboratory of Military StomatologyNational Clinical Research Center for Oral DiseasesShaanxi International Joint Research Center for Oral DiseasesCenter for Tissue EngineeringThe Fourth Military Medical UniversityXi'an 710032China

The irregular defects and residual tumor tissue after surgery are challenges for effective breast cancer ***,a smart hydrogel with self-adaptable size and dual responsive cargos release was fabricated to treat breast cancer via accurate tumor elimination,on-demand adipose tissue regeneration and effective infection *** hydrogel consisted of thiol groups ended polyethylene glycol(SH-PEG-SH)and doxorubicin encapsulated mesoporous silica nanocarriers(DOX@MSNs)double crosslinked hyaluronic acid(HA)after loading of antibacterial peptides(AP)and adipose-derived stem cells(ADSCs).A pH-cleavable unsaturated amide bond was pre-introduced between MSNs and HA frame to perform the tumor-specific acidic environment dependent DOX@MSNs release,meanwhile an esterase degradable glyceryl dimethacrylate cap was grafted on MSNs,which contributed to the selective chemotherapy in tumor cells with over-expressed *** bond cleavage between MSNs and HA would also cause the swelling of the hydrogel,which not only provide sufficient space for the growth of ADSCs,but allows the hydrogel to fully fill the irregular defects generated by surgery and residual tumor atrophy,resulting in the on-demand regeneration of adipose ***,the sustained release of AP could be simultaneously triggered along with the size change of hydrogel,which further avoided bacterial infection to promote tissue regeneration.

关键词： Smart hydrogel with self-adaptable size Breast cancer therapy Dual responsive cargoes release Selective tumor elimination On-demand adipose tissue regeneration Effective bacteria inhibition