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Hybrid-Vlasov simulation of soft X-ray emissions at the Earth’s dayside magnetospheric boundaries

Earth and Planetary Physics 2024年第1期8卷 70-88页

作者： M.Grandin H.K.Connor S.Hoilijoki M.Battarbee y.pfau-kempf U.Ganse K.Papadakis M.Palmroth Department of Physics University of HelsinkiHelsinkiFinland NASA Goddard Space Flight Center GreenbeltMD20771USA Space and Earth Observation Centre Finnish Meteorological InstituteHelsinkiFinland

Solar wind charge exchange produces emissions in the soft X-ray energy range which can enable the study of near-Earth space regions such as the magnetopause,the magnetosheath and the polar cusps by remote sensing *** Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)and Lunar Environment heliospheric X-ray Imager(LEXI)missions aim to obtain soft Xray images of near-Earth space thanks to their Soft X-ray Imager(SXI)*** earlier modeling works have already simulated soft X-ray images as might be obtained by SMILE SXI during its mission,the numerical models used so far are all based on the magnetohydrodynamics description of the space *** investigate the possible signatures of ion-kinetic-scale processes in soft Xray images,we use for the first time a global hybrid-Vlasov simulation of the geospace from the Vlasiator *** simulation is driven by fast and tenuous solar wind conditions and purely southward interplanetary magnetic *** first produce global X-ray images of the dayside near-Earth space by placing a virtual imaging satellite at two different locations,providing meridional and equatorial *** then analyze regional features present in the images and show that they correspond to signatures in soft X-ray emissions of mirrormode wave structures in the magnetosheath and flux transfer events(FTEs)at the *** results suggest that,although the time scales associated with the motion of those transient phenomena will likely be significantly smaller than the integration time of the SMILE and LEXI imagers,mirror-mode structures and FTEs can cumulatively produce detectable signatures in the soft X-ray *** instance,a local increase by 30%in the proton density at the dayside magnetopause resulting from the transit of multiple FTEs leads to a 12%enhancement in the line-of-sight-and time-integrated soft X-ray emissivity originating from this ***,a proton density increase by 14%in the magnetosheath

关键词： magnetosphere magnetosheath numerical simulation SMILE LEXI soft X-ray emissions hybrid-Vlasov model polar cusp flux transfer events mirror-mode waves

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A new state of matter of quantum droplets

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Frontiers of physics 2021年第3期16卷 3-6页

作者： Mingyang Guo Tilman pfau 5.Physikalisches Institut and Center for Integrated Quantum Science and Technology Universität StuttgartPfaffenwaldring 5770569StuttgartGermany

Since the realization of Bose Einstein condensation(BEC)[1-3]and degenerate Fermi gases[4],ultracold quantum gases have become important platforms to study quantum phenomena and novel states of matter with precise control over both internal and external degrees of *** quantum gases arc typically dilute and weakly interacting,the interactions intrinsically determine their essential properties,such as the superfluidity of a BEC.

关键词： quantum gases dilute

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Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： Victor V.Chizhikov Igor y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

关键词： epithelium Figure center

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Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

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Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

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Attitudes of young scholars in Qingdao and Hamburg about climate changeand climate policy The role of culture for the explanation of differences

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Advances in Climate Change Research 2019年第3期10卷 158-164页

作者： Hans VON STORCH CHEN Xue-En Birgit pfau-EFFINGER Dennis BRAy Andreas ULLMANN Institute o f Coastal Research Helmholtz-Zentrum Geesthacht-Zentrum fur Material und KustenforschungGeesthacht21502Germany Ocean University o f China Qingdao266100China Hamburg University Hamburg20146Germany

This article analyses differences in the attitudes related to climate change of young scholars in environmental science in Qingdao (China) and Hamburg (Germany). The main aim of the article is to evaluate the role of cultural differences for their explanation. We expect no significant differences in the attitudes related to the findings of climate research, since scientific principles are the joint basis of the scientific discourse wordwide. However, we expect that there are differences in the attitudes of the young scholars about the role of science, of the state and of the civil society for dealing with the challenge of climate change. We suggest that these can be explained with substantial cultural differences between both societies, with regard to the role of the state and the civil society for the solution of environmental problems. In order to evaluate these hypotheses, we have conducted a comparative survey among environmental science students in Qingdao (China) and Hamburg (Germany) about their attitudes towards climate change. The findings support our main hypotheses. The young scholars in Qingdao and Hamburg differ substantially in their views of the role of science in society and policymaking. Plausibly, these differences may mainly be explained with differences in the cultural ideas about the role of the state and of the civil society for the solution of environmental problems. Gradual differences in the share of young scholars who think that climate change has anthropogenic causes, may be explained with differences in the curriculum but also by cultural habits. This article makes a new contribution to the scientific debate by exploring the role of cultural differences for differences in the attitudes of young scholars in environmental science in connection with climate change and climate policy in different cultural contexts.

关键词： Survey Ocean University of China CLiSAP Hamburg Western science cuture China science culture Climate science and policy

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Magnetostratigraphy of the Zanda basin in southwest Tibet Plateau and its tectonic implications

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Chinese Science Bulletin 2008年第9期53卷 1393-1400页

作者： WANG ShiFeng ZHANG WeiLin FANG XiaoMin DAI Shuang Oliver kempf Institute of Tibetan Plateau Research Chinese Academy Sciences Beijing 100085 China Key Laboratory of Western China's Environmental Systems Ministry of Education of China & College of Resources and Environ- ment Lanzhou University Lanzhou730000 China Institut fer Umweltgeologie Technische University Braunschweig Braunschweig 38106 Germany

The Zanda basin is one of the very important basins at the north slope of the Himalaya Range. Thus the study of the basin strata will provide critical information about the tectonic evolution of the Himalayan Orogenic Belt. 268 oriented block samples were collected in the 750-m-thick sections of the Zanda ba- sin. The characteristic remanent magnetization (ChRM) was isolated that decays linearly to the origin between 500oC and 690oC for most studied samples. An age range of 9.5―2.6 Ma was estimated from the correlation between our observed polarity column and the Geomagnetic Polarity Time Scale (GPTS). The age of the Zanda basin does not support the models that the South Tibetan Detach system (STDS) is one of the basin controlling faults. Given the sedimentological features in the basin and the tectonic features at the north edge of the basin, the Zanda basin was a half graben that was possibly controlled by the Karakorum fault on the northeast.

关键词：盆地磁性地层学断层西藏南部

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Malargüe Site Remediation:A Successful Solution for Uranium Mill Tailings

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原子能科学技术 2024年第10期58卷 2088-2094页

作者： BARARI E DíAZ J G GIOMIA kempf R A National Atomic Energy Commission Av.Del Libertador 8250Ciudad Autónoma de Buenos AiresC1429BNPArgentina

Comisión Nacional de Energía Atómica (CNEA) has the responsibility for restoring uranium mining facilities once the operations have ***,within its Environmental Program and in compliance with its legal responsibilities,decides to implement a restoration project for all sites related to the mining and processing of uranium *** Malargüe Site is located within the Province of Mendoza in the city of Malargü*** is the first site to successfully complete its *** activities consist of relocation of tailings to an engineering *** tailings management(encapsulation) and rehabilitation of the area was finished in June *** remediation alternative for the ore tailings was selected after conducting comparative studies and submitted the project to the society for *** objective of the encapsulation of the mineral tails is to isolate them from the environment,also proceeding with the decontamination and rehabilitation of the area (landscaping,post-closure monitoring and 20 years monitoring period).Encapsulation consisted of the construction of a containment cell for the mine tailings,to isolate them and prevent pollutants from entering the environment through the transfer *** clean the impacted areas,the soil was removed,it was incorporated into the encapsulation,and the filling was carried out with natural soils from the *** prevents radon transfer to the environment,as ^(222)Ra is an alpha emitter with a half-life of four days,which produces its own radioactive *** progeny are solids,and when a ^(222)Ra nucleus emits an alpha particle into the air,the resulting ^(218)Po nucleus,momentarily electrically charged,adheres to any dust *** prevents the discharge into the air containing radon and also containing dust particles charged with intensely radioactive radon *** tasks mentioned make it possible to decrease radon emanation,reduce radiological risks to the public and pre

关键词： remediation radionuclide transfer tailings encapsulation solution sustainable

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Advances in the treatment of autism spectrum disorder:Wharton jelly mesenchymal stem cell transplantation

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World Journal of Methodology 2025年第1期15卷 72-79页

作者： Serdar Kabatas ErdinçCivelek Eyüp Can Savrunlu Umut Karaaslan Özlem yıldız Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Pediatric Allergy-Immunology Institute of Health Sciences Marmara UniversityIstanbul 34865Türkiye Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry Kocaeli University Faculty of MedicineKocaeli 41001Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Autism spectrum disorder(ASD)is a complex neurodevelopmental disorder with multifaceted *** recent studies,neuroinflammation and immune dysregulation have come to the forefront in its *** are studies suggesting that stem cell therapy may be effective in the treatment of *** To evolve the landscape of ASD treatment,focusing on the potential benefits and safety of stem cell *** A detailed case report is presented,displaying the positive outcomes observed in a child who underwent intrathecal and intravenous Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)transplantation combined with *** The study demonstrates a significant improvement in the child’s functional outcomes(Childhood Autism Rating Scale,Denver 2 Developmental Screening Test),especially in language and gross motor *** serious side effects were encountered during the 2-year *** The findings support the safety and effectiveness of WJ-MSC transplantation in managing ASD.

关键词： Autism spectrum disorder Neurorehabilitation Stem cell transplantation Wharton jelly mesenchymal stem cells Inflammation

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Neurofibrillary tangles in Alzheimer＇s disease： elucidation of the molecular mechanism by immunohistochemistry and tau protein phospho-proteomics

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Neural Regeneration Research 2016年第10期11卷 1579-1581页

作者： athanasios metaxas stefan j.kempf institute of molecular medicine university of southern denmark department of biochemistry and molecular biology university of southern denmark

As a key contributor to memory storage, the synapse is one of the earliest affected neuronal components in Alzheimer＇s disease （AD）. Under physiological conditions, the synaptic con- nections between neurons undergo activity-dependent func- tional and morphological re-organisation. This dynamic, ＇plastic＇ neural ability critically depends on the structural integrity of the synapse. Thus, proteins that are implicated in preserving the organisation and dynamics of synaptic connections, including microtubules of the cytoskeleton and associated proteins, have attracted much focus for their involvement in the malfunction- ing AD synapse.

关键词： Neurofibrillary tangles in Alzheimer’s disease elucidation of the molecular mechanism by immunohistochemistry and tau protein phospho-proteomics NFT

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