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Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Modeling ice thickness distribution and storage volume of glaciers in Chandra Basin,western Himalayas

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Journal of Mountain Science 2020年第8期17卷 2011-2022页

作者： Ankur pandit RAAJ RAMSANKARAN Inter Disciplinary Program(IDP)in Climate Studies Indian Institute of Technology BombayMumbai 400076India TCS Research and Innovation Thane400601 India Department of Civil Engineering Indian Institute of Technology BombayMumbai 400076India

This article reports modeled ice thickness distribution and total ice volume of the 65 selected glaciers(>0.5 km^2)of Chandra basin,located in the Western *** is a first-of-its-kind study that gives detailed insights about the current ice thickness distribution at an individual glacier level in the Western *** estimates are obtained using an optimally parameterized Glab Top2_IITB[Glacier Bed Topography Indian Institute of Technology Bombay(IITB)version]model with highresolution Digital Elevation Model(DEM)as an *** total estimated volume of all the 65 selected glaciers is about 55.32 km^3 covering a total area of about 591.03 km^*** hypsometric analysis,it is found that the maximum amount of ice volume,i.e.,about 12.79 km^3,is currently residing at the elevation range of 5200–5400 m *** thickness estimates obtained in the current study are compared with the ensemble estimates obtained in the Global Glacier Thickness Initiative(G2TI)project for three large glaciers,namely,Bada Shigri,Samudra Tapu,and Gepang Gath *** obtained results indicate that the difference between both the studies is marginal in terms of mean ice thickness and maximum ice thickness estimates except Samudra Tapu ***,the uncertainty of the estimated glacier ice volume from this study is about±15%whereas,from the G2TI project,it is about 25%.The main reasons for the difference could be the quality of the inputs used,model structure,model parameterization as well as the time stamp of the input *** obtained results from this study indicate that the use of appropriate shape factor and better DEM would result in more reliable glacier ice thickness estimates even by using a simple slopedependent model like Glab Top2_IITB.

关键词： Glacier ice thickness Glacier volume Glab Top2_IITB TanDEM-X DEM

Frame loss error concealment for SVC

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第5期7卷 677-683页

作者： pandit Purvin BOyCE Jill THOMSON Corporate Research Princeton NJ 08540 USA

Scalable video coding (SVC), as the Scalable Extension of H.264/AVC, is an ongoing international video coding standard designed for network adaptive or device adaptive applications and also offers high coding efficiency. However, packet losses often occur over unreliable networks even for base layer of SVC and have severe impact on the playback quality of compressed video. Until now, no literature has discussed error concealment support for standard SVC bit-stream. In this paper, we provide robust and effective error concealment techniques for SVC with spatial scalability. Experimental results showed that the proposed methods provide substantial improvement, both subjectively and objectively, without a significant complexity overhead.

关键词： Adaptive systems Coding errors Computer networks Image compression Robustness (control systems) Standards

Dynamic scheduling of market price-based combined heat–power-constrained renewable microgrid

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Clean Energy 2023年第4期7卷 859-872页

作者： Sunita Shukla Manjaree pandit Department of Electrical Engineering Madhav Institute of Technology&ScienceGwalior 474005India

In this paper,a market price-based combined heat–power dynamic dispatch model for a microgrid is *** microgrid comprises cogeneration units and wind and solar power-generation units.A battery and a heat storage tank are incorporated to optimally balance variations in heat-and-power load *** proposed model explores the impact of market prices of electricity,heat supply and load variability on the optimal schedule such that profit maximizes and emission,loss and waste heat are *** Weibull probability distribution function is applied to characterize the uncertain renewable power variable in the model and to find the over-and under-scheduling *** problem is solved using an improved differential evolution algorithm in which a fuzzy membership module is appended to obtain a solution having the highest attainment for the selected multiple *** results show that the proposed model can handle uncertain heat–power demand and price scenarios to produce feasible and optimal schedules with owner profits,heat utilization and renewable share varying between 10.55–115.97%,72.51–90.39%and 26.82–38.05%,respectively.

关键词： renewable energy combined heat power(CHP) microgrid(MG) economic dispatch MG profit

Cohesion mechanisms for bioadhesives

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Bioactive Materials 2022年第7期7卷 105-118页

作者： yazhong Bu Abhay.pandit Institute of Medical Engineering Department of BiophysicsSchool of Basic Medical SciencesHealth Science CenterXi’an Jiaotong UniversityXi’an710061China CÚRAM SFI Research Centre for Medical Devices National University of IrelandGalwayIreland

Due to the nature of non-invasive wound closure,the ability to close different forms of leaks,and the potential to immobilize various devices,bioadhesives are altering clinical *** one of the vital factors,bioadhesives’strength is determined by adhesion and cohesion *** well as being essential for adhesion strength,the cohesion mechanism also influences their bulk functions and the way the adhesives can be *** there are many published reports on various adhesion mechanisms,cohesion mechanisms have rarely been *** this review,we have summarized the most used cohesion ***,the relationship of cohesion strategies and adhesion strategies has been discussed,including employing the same functional groups harnessed for adhesion,using combinational approaches,and exploiting different strategies for cohesion *** providing a comprehensive insight into cohesion strategies,the paper has been integrated to offer a roadmap to facilitate the commercialization of bioadhesives.

关键词： Bioadhesive Cohesion Hydrogel Medical device fixation Sealant

Sulfonic acid-functionalized mesoporous silica catalyst with different morphology for biodiesel production

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Frontiers of Chemical Science and Engineering 2022年第8期16卷 1198-1210页

作者： Vinayak Hegde Parimal pandit Pranita Rananaware Varsha PBrahmkhatri Centre for Nano and Material Sciences Jain UniversityJain Global CampusBengaluru 562112India

Sulfonic acid functionalized mesoporous silica based solid acid catalysts with different morphology were designed and *** synthesized materials were characterized by various physicochemical and spectroscopic techniques like scanning electron microscopeenergy dispersive X-ray spectroscopy,Fourier transform infrared spectroscopy,Brunauer–Emmett–Teller surface area,thermogravimetric analysis and n-butylamine *** shape of catalysts particles plays an important role in its *** sulfonic acid functionalized mesoporous silica catalysts of spherical shape and the cube shape were assessed for catalytic activity in biodiesel *** catalytic biodiesel production reaction over the catalysts were studied by esterification of free fatty acid,oleic acid with *** effect of various reaction parameters such as catalyst concentration,acid/alcohol molar ratio,catalyst amount,reaction temperature and reaction time on catalytic activity were investigated to optimize the conditions for maximum *** was sulfonated cubic shape mesoporous silica which exhibited better activity as compared to the spherical shape silica ***,the catalyst was regenerated and reused up to three cycles without any significant loss in *** present catalysts exhibit superior performance in biodiesel production and it can be used for the several biodiesel feedstock’s that are rich in free fatty acids.

关键词： solid acid catalyst mesoporous silica sulfonic acid biodiesel esterification oleic acid

Geochemistry and geochronology of A-type basement granitoids in the north-central Aravalli Craton: Implications on Paleoproterozoic geodynamics of NW Indian Block

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Geoscience Frontiers 2021年第4期12卷 138-150页

作者： Manoj K.pandit Hitesh Kumar WeiWang Department of Geology University of RajasthanJaipur 302004India Department of Mines and Geology Government of RajasthanJaipurRajasthanIndia State Key Laboratory of Geological Processes and Mineral Resources School of Earth Sciences and ResourcesChina University of GeosciencesWuhan 430074China

The basement granite gneisses from the north-central Aravalli Craton in NW India were investigated for geochemistry and *** a peneplain terrain,the granite gneiss outcrops are scanty and samples were collected mainly from two small hills and several ground-level exposures in the Sakhun–Ladera *** granite gneiss is the dominant lithology that also hosts dark,lenticular enclaves,and is in turn,intruded by mafic *** granite gneiss has silica content ranging from 61.37 wt.%to 68.27 wt.%that marks a slight overlap with the enclaves(54.32wt.%to 62.17wt.%).Both groups have a highK2O/Na2O(~2 or higher)***,the granite gneiss classify as granite–granodiorite,and enclaves as *** In-situ LA-ICP-MS zircon U–Pb geochronology of granite gneiss has yielded a statistically valid 1721±9 Ma age that we interpret as the emplacement age for the granitic *** characteristics of granite gneiss underline fractional crystallization of an I-type melt as themain process,and continuity of trends in enclaves underlines their mutual genetic *** genetic association is further verified by a consistency in the trace element characteristics and REE *** Nd-isotope signatures define a single grouping for both granite gneiss and enclaves,withεNd(t)values ranging from−6.38 to−6.61,further substantiating a common *** geochemical tectonic discrimination schemes consistently point toward an extensional setting and A-type characteristics for granite gneiss and *** are analogous to the coeval(1.72–1.75 Ga),A-type granitoids from the Khetri and Alwar basin in the North Delhi Fold Belt,implying a much larger areal extent for the Paleoproterozoic anorogenic magmatism in the northern segment of the Aravalli *** Paleoproterozoic age for the presumed‘Archean’basement in this region offers tacit evidence that the BGC–II is a stratigraphically younger terrane as compared to the Archean age,

关键词： Basement granite Geochemistry Zircon U–Pb geochronology A-type granites Aravalli Craton NWIndian Block

Improved energy recovery from dark fermented cane molasses using microbial fuel cells

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Frontiers of Chemical Science and Engineering 2014年第1期8卷 43-54页

作者： Soumya pandit Balachandar G Debabrata Das Department of Biotechnology Indian Institute of Technology Kharagpur West Bengal India

A major limitation associated with fermenta- tive hydrogen production is the low substrate conversion efficiency. This limitation can be overcome by integrating the process with a microbial fuel cell （MFC） which converts the residual energy of the substrate to electricity. Studies were carried out to check the feasibility of this integration. Biohydrogen was produced from the fermen- tation of cane molasses in both batch and continuous modes. A maximum yield of about 8.23 mol Hz/kg CODremoved was observed in the batch process compared to 11.6 mol Hz/kg CODremoved in the continuous process. The spent fermentation media was then used as a substrate in an MFC for electricity generation. The MFC parameters such as the initial anolyte pH, the substrate concentration and the effect ofpre-treatment were studied and optimized to maximize coulombic efficiency. Reductions in COD and total carbohydrates were about 85% and 88% respectively. A power output of 3.02 W/m3 was obtained with an anolyte pH of 7.5 using alkali pre-treated spent media. The results show that integrating a MFC with dark fermentation is a promising way to utilize the substrate energy.

关键词： dark fermentation biohydrogen microbialfuel cell volatile fatty acid anolyte