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Two Dimensional Density FlUCtuation Measurements During the Non-Inductive Current Ramp-up Phase in the Compact Plasma Wall Interaction Experimental Device CPD

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Plasma Science and Technology 2009年第4期11卷 397-401页

作者： H.ZUSHI T.RyOUKAI K.KIKUKAWA T.MORISAKI R.BHATTACHARyAy T.yOSHINAGA K.HANADA T.SAKIMURA H.IDEI K.DONO N.NISHINO H.HONMA S.TASHIMA T.MUTOH S.KUBO K.NAGASAKI M.SAKAMOTO y.nakashima y.HIGASHIZONO K.N.SATO K.NAKAMURA M.HASEGAWA S.KAWASAKI H.nakashima A.HIGASHIJIMA RIAM Kyushu University IGSES Kyushu University National Institute for Fusion Science Hiroshima University Kyoto University University of Tsukuba

Two-dimensional structure of density fluctuations is examined during the current jump phase, indicating a change from the open magnetic fields to the closed ones. During the smooth current ramp-up phase the two-dimensional contour of the LiI intensity shows vertically alignment, consistent with the magnetic surfaces. At the inflection point in Ip ramp-up the LiI intensity contour becomes flat in the observation regime and then suddenly a steep gradient and higher intensity regime are formed in the vertical direction. This higher intensity corresponds to a burst of LiI waveform. According to these changes in the contour, it is found that, within ~1 ms around the burst of LiI, a low frequency coherent wave with a long wavelength rapidly grows. The relations with other signals （magnetic flux and microwave stray power） are discussed with respect to the topological change in the magnetic configuration and mode conversion of the incident electromagnetic waves.

关键词： Li sheet beam density fluctuations current ramp-up spherical tokamak

Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： Victor V.Chizhikov Igor y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

关键词： epithelium Figure center

Application of headed studs in steel fiber reinforced cementitious composite slab of steel beam-column connection

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Earthquake Engineering and Engineering Vibration 2012年第1期11卷 11-21页

作者： yao Cui Masayoshi nakashima Center for Urban Earthquake Engineering Tokyo Institute of Technology Japan Disaster Prevention Research Institute Kyoto University Gokashyo Uji Kyoto Japan

Steel fiber reinforced cementitous composites （SFRCC） is a promising material with high strength in both compression and tension compared with normal concrete. The ductility is also greatly improved because of 6% volume portion of straight steel fibers. A steel beam-column connection with Steel fiber reinforced cementitous composites （SFRCC） slab diaphragms is proposed to overcome the damage caused by the weld. The push-out test results suggested that the application of SFRCC promises larger shear forces transferred through headed studs allocated in a small area in the slab. Finite element models were developed to simulate the behavior of headed studs. The failure mechanism of the grouped arrangement is fiarther discussed based on a series of parametric analysis. In the proposed connection, the SFRCC slab is designed as an exterior diaphragm to transfer the beam flange load to the column face. The headed studs are densely arranged on the beam flange to connect the SFRCC slab diaphragms and steel beams. The seismic performance and failure mechanism of the SFRCC slab diaphragm beam-column connection were investigated based on the cyclic loading test. Beam hinge mechanism was achieved at the end of the SFRCC slab diaphragm by using sufficient studs and appropriate rebars in the SFRCC slab.

关键词： multi-directional transmitting artificial boundary viscous-spring artificial boundary saturated soilfoundation Biot's equations

Flexible substructure online hybrid test system using conventional testing devices

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Earthquake Engineering and Engineering Vibration 2013年第3期12卷 341-350页

作者： Wang Tao Masayoshi nakashima Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering Mechanics China Earthquake Administration Disaster Prevention Research Institute Kyoto University

This paper presents a substructure online hybrid test system that is extensible for geographically distributed tests. This system consists of a set of devices conventionally used for cyclic tests to load the tested substructures onto the target displacement or the target force. Due to their robustness and portability, individual sets of conventional loading devices can be transported and reconfigured to realize physical loading in geographically remote laboratories. Another appealing feature is the flexible displacement-force mixed control that is particularly suitable for specimens having large disparities in stiffness during various performance stages. To conduct a substructure online hybrid test, an extensible framework is developed, which is equipped with a generalized interface to encapsulate each substructure. Multiple tested substructures and analyzed substructures using various structural program codes can be accommodated within the single framework, simply interfaced with the boundary displacements and forces. A coordinator program is developed to keep the boundaries among all substructures compatible and equilibrated. An Interuet-based data exchange scheme is also devised to transfer data among computers equipped with different software environments. A series of online hybrid tests are introduced, and the portability, flexibility, and extensibility of the online hybrid test system are demonstrated.

关键词： substructure online hybrid test conventional loading device displacement-force mixed control coordinator program Interuet-based data exchange scheme

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

A tendon system to re-center steel moment frames with weak stories

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Earthquake Engineering and Engineering Vibration 2024年第4期23卷 1057-1072页

作者： Wang Tao Wang Fei Masayoshi nakashima Institute of Engineering Mechanics China Earthquake AdministrationBeijing 100190China Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina Earthquake AdministrationHarbin 150080China Disaster Prevention Research Institute Kyoto UniversityGokashoUjiKyoto 611-0011Japan

A wide open bottom story of a frame building is often expected by owners for use as a garage or ***,this leads to weak stories due to abrupt changes in lateral stiffness and often results in unexpected story collapse as observed in many previous *** retrofit frame buildings that have experienced weak story damage,a tendon system is proposed in this study,which consists of a set of swaying columns and *** swaying columns are used to uniformly redistribute the lateral deformation along the height,while the tendons provide extra lateral stiffness and renders the entire structural system a re-centering *** avoid unnecessary forces to swaying columns,pin-connections are used at the *** are placed over the entire story to gain large elastic *** analysis reveals that the swaying column,with a stiffness of about 0.9 times that of the weak story,and the tendons attached at the roof,with a stiffness of 0.04 times that of the weak story,can provide the optimal performance with a maximum residual story drift angle of less than 0.5%.Online hybrid tests were carried out,which demonstrated that uniformly distributed story drifts and acceptable residual deformation could be achieved by the proposed tendon system.

关键词： tendon system re-centering capability residual deformation rehabilitation collapse prevention

Differences in dinucleotide frequencies of thermophilic genes encoding water soluble and membrane proteins

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第6期12卷 419-427页

作者： Hiroshi nakashima yuka KURODA Department of Clinical Laboratory Science Graduate Course of Medical Science and TechnologySchool of Health SciencesKanazawa University

The occurrence frequencies of the dinucleotides of genes of three thermophilic and three mesophilic species from both archaea and eubacteria were investigated in this study. The genes encoding water soluble proteins were rich in the dinucleotides of purine dimers, whereas the genes encoding membrane proteins were rich in pyrimidine dimers. The dinucleotides of purine dimers are the counterparts of pyrimidine dimers in a double-stranded DNA. The purine/pyrimidine dimers were favored in the thermophiles but not in the mesophiles, based on comparisons of observed and expected frequencies. This finding is in agreement with our previous study which showed that purine/pyrimidine dimers are positive factors that increase the thermal stability of DNA. The dinucleotides AA, AG, and GA are components of the codons of charged residues of Glu, Asp, Lys, and Arg, and the dinucleotides TT, CT, and TC are components of the codons of hydrophobic residues of Leu, Ile, and Phe. This is consistent with the suitabilities of the different amino acid residues for water soluble and membrane proteins. Our analysis provides a picture of how thermophilic species produce water soluble and membrane proteins with distinctive characters: the genes encoding water soluble proteins use DNA sequences rich in purine dimers, and the genes encoding membrane proteins use DNA sequences rich in pyrimidine dimers on the opposite strand.

关键词： Water soluble and membrane proteins Purine/pyrimidine dimers Thermophilic and mesophilic species Dinucleotide frequencies

Statistical evaluation of cluster formation of relapse in neuromyelitis optica spectrum disorder

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Neural Regeneration Research 2024年第9期19卷 1888-1889页

作者： Tetsuya Akaishi Ichiro nakashima Department of Neurology Tohoku UniversitySendaiJapan Department of Neurology Tohoku Medical and Pharmaceutical UniversitySendaiJapan

Evaluating the cluster formation of clinical attacks in chronic relapsing diseases is an important statistical issue because the presence of attack clusters may influence therapeutic strategies for relapse *** recently reported the occurrence of unevenly clustered attacks in patients with anti-aquaporin-4(AQP4)antibody-positive neuromyelitis optica spectrum disorder(NMOSD)(Akaishi et al.,2020a).

关键词： AQP4 relapse

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute