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Advanced Control Scenario of High-Performance Steady-State Operation for JT-60 Superconducting Tokamak

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Plasma Science and Technology 2004年第3期6卷 2281-2285页

作者： H.Tamai G.Kurita M.Matsukawa K.Urata S.Sakurai K.Tsuchiya A.Morioka y.M.Miura K.Kizu y.kamada A.Sakasai S.Ishida Japan Atomic Energy Research Institute Naka Ibaraki 311-0193 Japan

Plasma control on high-β_N steady-state operation for JT-60 superconductingmodification is discussed. Accessibility to high-β_N exceeding the free-boundary limit isinvestigated with the stabilising wall of reduced-activated ferritic steel and the active feedbackcontrol of the ill-vessel non-axisymmetric field coils. Taking the merit of superconducting magnet,advanced plasma control for steady-state high performance operation could be expected.

关键词： plasma control superconducting tokamak JT-60

Progress in Physics and Technology Developments for the Modification of JT-60

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Plasma Science and Technology 2004年第1期6卷 2141-2150页

作者： H.Tamai M.Matsukawa G.Kurita N.Hayashi K.Urata y.M.Miura K.Kizu K.Tsuchiya A.Morioka y.Kudo S.Sakurai K.Masaki T.Suzuki M.Takechi y.kamada A.Sakasai S.Ishida K.Abe A.Ando T.Cho T.Fujii T.Fujita S.Goto K.Hananda A.Hatayama T.Hino H.Horiike N.Hosogane M.Ichimura Tsuji-Iio S.Itoh M.Katsurai M.Kikuchi A.Kohyama H.Kubo M.Kuriyama M.Matsuoka y.Miura N.Miya T.Mizuuchi K.Nagasaki H.Ninomiya N.Nishino y.Ogawa K.Okano T.Ozeki M.Saigusa M.Sakamoto M.Satoh M.Shimada R.Shimada M.Shimizu T.Takagi y.Takase T.Tanabe K.Toi y.Ueda y.Uesugi K.Ushigusa y.yagi T.yamamoto K.yatsu K.yoshikawa Japan Atomic Energy Research Institute Naka Ibarahi 311-0193 Japan Tohoku University University of Tsukuba Osaka University Kyushu University Keio University Hokkaido University Tokyo Institute of Technology the University of Tokyo Kyoto University Mie University Hiroshima University Central research Institute of Electric Power Industry Ibaraki University ITER JCT Nagoya University National Institute for Fusion Science Kanazawa University National Institute of Advanced Industrial Science and Technology

Recent progress in the physics and engineering design study for themodification programme of JT-60 is presented. In order to achieve a steady state high-βplasmaoperation, which is the dominant issue of this programme, physics design for the MHD control and thestability analysis is investigated. Engineering design and the R & D for the superconducting coils,irradiation shield are performed well towards the mission of programme.

关键词： modification of JT-60 physics design technology developments

Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： Victor V.Chizhikov Igor y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

关键词： epithelium Figure center

Successful treatment of warfarin-induced skin necrosis using oral rivaroxaban: A case report

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World Journal of Clinical Cases 2019年第24期7卷 4285-4291页

作者： Momoka kamada Tsuneaki Kenzaka Department of Internal Medicine Hyogo Prefectural Tamba Medical CenterTamba 669-3395Japan Division of Community Medicine and Career Development Kobe University Graduate School of MedicineKobe 652-0032Japan

BACKGROUND Heparin is commonly recommended for warfarin-induced skin necrosis;however, there is currently no established therapy for this disease. We present a serious case of warfarin-induced skin necrosis that was successfully treated with oral rivaroxaban, a factor Xa *** SUMMARy A 48-year-old woman was admitted to the hospital for cellulitis of the right lower extremity. After antibiotic treatment, she developed pain and swelling of the left lower extremity, and deep vein thrombosis of both lower extremities was diagnosed. She was treated with a continuous heparin injection;subsequently,oral warfarin was concomitantly administered. Heparin was terminated after the therapeutic range was reached. On the following day, the patient had swelling and pain in the left lower extremity. In addition to decrease in protein S activity due to systemic lupus erythematosus, warfarin also reduced protein C activity,resulting in further hypercoagulation and skin necrosis. Warfarin was discontinued, and continuous heparin injection was resumed. Although the patient had to undergo amputation of the distal end of her left foot, continuous heparin injection was switched to oral rivaroxaban, and she was eventually discharged from the hospital in *** Administration of direct oral anticoagulants instead of warfarin is important in patients with decreased protein S and C activity.

关键词： Skin necrosis Warfarin Heparin Rivaroxaban Systemic lupus erythematosus Case report

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Creeping fat and gut microbiota in Crohn’s disease

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World Journal of Gastroenterology 2025年第1期31卷 16-23页

作者： Ana EV Quaglio Daniéla O Magro Marcello Imbrizi Ellen CS De Oliveira Luiz C Di Stasi Ligia y Sassaki Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department of Surgery Faculty of Medical SciencesState University of CampinasCampinas 13083-970São PauloBrazil Department of Gastroenterology Faculty of Medical SciencesUniversity of CampinasCampinas 13083-970São PauloBrazil Department of Internal Medicine Medical SchoolSão Paulo State UniversityBotucatu 18618-686São PauloBrazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State UniversityBotucatu 18618-689São PauloBrazil

In this article,we explored the role of adipose tissue,especially mesenteric adipose tissue and creeping fat,and its association with the gut microbiota in the pathophysiology and progression of Crohn’s disease(CD).CD is a form of inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract,influenced by genetic predisposition,gut microbiota dysbiosis,and environmental *** microbiota plays a crucial role in modulating immune response and intestinal inflammation and is associated with the onset and progression of ***,visceral adipose tissue,particularly creeping fat,a mesenteric adipose tissue characterized by hypertrophy and fibrosis,has been implicated in CD pathogenesis,inflammation,and *** bacteria from the gut microbiota may translocate into mesenteric adipose tissue,contributing to the formation of creeping fat and influencing CD *** creeping fat may be a protective barrier against bacterial invasion,its expansion can damage adjacent tissues,leading to *** gut microbiota through interventions such as fecal microbiota transplantation,probiotics,and prebiotics has shown potential in managing ***,more research is needed to clarify the mechanisms linking gut dysbiosis,creeping fat,and CD progression and develop targeted therapies for microbiota modulation and fat-related complications in patients with CD.

关键词： Creeping fat Mesenteric adipose tissue Gut microbiota Crohn’s disease Inflammatory bowel disease

Study on Blade Surface Flow around Wind Turbine by Using LDV Measurements

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Journal of Thermal Science 2015年第2期24卷 131-139页

作者： Tinnapob Phengpom yasunari kamada Takao Maeda Junsuke Murata Shogo Nishimura Tasuku Matsuno Division of System Engineering Mie University Division of Mechanical Engineering Mie University

This paper has attempted to study a mechanism of three-dimensional flow around a horizontal axis wind turbine(HAWT) rotor blade. An experimental study of the flow phenomenon in the vicinity of the wind turbine blade is a challenging endeavor. In this research, the HAWT model with 2.4 m diameter was tested in the large wind tunnel. The flow around the rotating blade surface was measured simultaneously for three velocity components, and two probes were used for the synchronized measurement of three-dimensional flow components. The local velocity was detected for the single seeding particle measured in the point where three pairs of laser beams intersected. Blade sections of interest in this study are composed of radial positions r/R = 0.3, 0.5 and 0.7. Optimum and low tip speed ratio flow characteristics were also compared. The velocity flow vector, skin friction coefficient and bound circulation were calculated from LDV measurements, and the experimental research showed reasonably and clearly the experimental results.

关键词： LDV measurement Sectional performance Wind turbine Boundary layer flow Span-wise flow

Analysis of Aerodynamic Load on Straight-bladed Vertical Axis Wind Turbine

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Journal of Thermal Science 2014年第4期23卷 315-324页

作者： Qing’an LI Takao MAEDA yasunari kamada Junsuke MURATA Toshiaki KAWABATA Kazuma FURUKAWA Division of System Engineering Mie University1577 Kurimamachiya-choTsuMie 514-8507JAPAN Division of Mechanical Engineering Mie University1577 Kurimamachiya-choTsuMie 514-8507JAPAN

This paper presents a wind tunnel experiment for the evaluation of energy performance and aerodynamic forces acting on a small straight-bladed vertical axis wind turbine(VAWT) depending on several values of tip speed ratio. In the present study, the wind turbine is a four-bladed VAWT. The test airfoil of blade is symmetry airfoil(NACA0021) with 32 pressure ports used for the pressure measurements on blade surface. Based on the pressure distributions which are acted on the surface of rotor blade measured during rotation by multiport pressure-scanner mounted on a hub, the power, tangential force, lift and drag coefficients which are obtained by pressure distribution are discussed as a function of azimuthally position. And then, the loads which are applied to the entire wind turbine are compared with the experiment data of pressure distribution. As a result, it is clarified that aerodynamic forces take maximum value when the blade is moving to upstream side, and become small and smooth at downstream side. The power and torque coefficients which are based on the pressure distribution are larger than that by torque meter.

关键词： Wind Turbine Wind Energy Straight-bladed VAWT Tip Speed Ratio Pressure Distribution