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Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： Victor V.Chizhikov Igor y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

关键词： epithelium Figure center

A novel mitigation measure for normal fault-induced deformations on pile-raft systems

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 15-33页

作者： Mohammadreza jahanshahi Nowkandeh Mehdi Ashtiani Faculty of Civil Engineering Babol Noshirvani University of TechnologyBabolIran

Evidence from recent earthquakes has shown destructive consequences of fault-induced permanent ground movement on *** observations have increased the demand for improvements in the design of structures that are dramatically vulnerable to surface fault *** this study a novel connection between the raft and the piles is proposed to mitigate the hazards associated with a normal fault on pile-raft systems by means of 3D finite element(FE)*** embarking on the parametric study,the strain-softening constitutive law used for numerical modeling of the sand has been validated against centrifuge test *** exact location of the fix-head and unconnected pile-raft systems relative to the outcropping fault rupture in the free-field is parametrically investigated,revealing different failure *** performance of the proposed connection for protecting the pile-raft system against normal fault-induced deformations is assessed by comparing the geotechnical and structural responses of both types of *** results indicate that the pocket connection can relatively reduce the cap rotation and horizontal and vertical displacements of the raft in most *** proposed connection decreases the bending moment response of the piles to their bending moment capacity,verging on a fault offset of 0.6 m at bedrock.

关键词： normal fault rupture failure mechanism pile-raft system pocket connection finite element modeling

Fusion of color and hallucinated depth features for enhanced multimodal deep learning-based damage segmentation

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Earthquake Engineering and Engineering Vibration 2023年第1期22卷 55-68页

作者： Tarutal Ghosh Mondal Mohammad Reza jahanshahi Civil Architectural and Environmental EngineeringMissouri University of Science and TechnologyRollaMOUSA Lyles School of Civil Engineering Purdue UniversityWest LafayetteINUSA School of Electrical and Computer Engineering Purdue UniversityWest LafayetteINUSA

Recent advances in computer vision and deep learning have shown that the fusion of depth information can significantly enhance the performance of RGB-based damage detection and segmentation ***,alongside the advantages,depth-sensing also presents many practical *** instance,the depth sensors impose an additional payload burden on the robotic inspection platforms limiting the operation time and increasing the inspection ***,some lidar-based depth sensors have poor outdoor performance due to sunlight contamination during the *** this context,this study investigates the feasibility of abolishing depth-sensing at test time without compromising the segmentation *** autonomous damage segmentation framework is developed,based on recent advancements in vision-based multi-modal sensing such as modality hallucination(MH)and monocular depth estimation(MDE),which require depth data only during the model *** the time of deployment,depth data becomes expendable as it can be simulated from the corresponding RGB *** makes it possible to reap the benefits of depth fusion without any depth perception per *** study explored two different depth encoding techniques and three different fusion strategies in addition to a baseline RGB-based *** proposed approach is validated on computer-generated RGB-D data of reinforced concrete buildings subjected to seismic *** was observed that the surrogate techniques can increase the segmentation IoU by up to 20.1%with a negligible increase in the computation ***,this study is believed to make a positive contribution to enhancing the resilience of critical civil infrastructure.

关键词： multimodal data fusion depth sensing vision-based inspection UAV-assisted inspection damage segmentation post-disaster reconnaissance modality hallucination monocular depth estimation

Fouling of WO3 nanoparticle-incorporated PSf membranes in ultrafiltration of landfill leachate and dairy a combined wastewaters： An investigation using model

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Chinese Journal of Chemical Engineering 2017年第6期25卷 741-751页

作者： Majid Peyravi Mohsen jahanshahi Soodabeh Khalili Nanoenvironment Research Group Nanotechnology Institute Faculty of Chemical Engineering Babol Noshirvani University of Technolog~ Babol lran

As fouling has always been a major drawback of membrane technology, qualitative and quantitative understanding of membrane fouling mechanisms therefore becomes vital in order to help push membrane separation technologies forward. In this study, firstly, self-cleaning Polysulfone(PSf) membranes were synthesized by incorporation of WO_3nanoparticles(0–2 wt%) and subsequent UV irradiation for efficient ultrafiltration(UF)of landfill leachate and dairy wastewater. The membrane surface properties were characterized by scanning electron microscopy(SEM) and contact angle analysis. It was found that UV-irradiated membranes exhibited higher percent COD removals due to the hydrophilicity and photocatalytic properties of nano-WO_3. Subsequently, in order to analyze the fouling behavior of the membranes, a set of experimental data from cross-flow ultrafiltration of municipal landfill leachate and industrial dairy wastewater at 25 °C was obtained. A new model of membrane fouling was proposed based on a resistance in series concept and was fitted well with all experimental data *** all relative errors of prediction provided by the proposed model were less than 2.5%. In addition, it was revealed that this newly-developed model exhibited smooth transition between the common successive twostep pore blockage-cake filtration phenomena and thus eliminates the need to use separate equations for different mechanisms.

关键词： Fouling model Leachate wastewater Ultrafiltration Whey wastewater Chemical oxygen demand

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Surface modification of broom sorghum-based activated carbon via functionalization with triethylenetetramine and urea for CO2 capture enhancement

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Frontiers of Chemical Science and Engineering 2017年第2期11卷 252-265页

作者： Elaheh Mehrvarz Ali A. Ghoreyshi Mohsen jahanshahi Chemical Engineering Department Babol University of Technology Shariati Av. Babol Mazandaran 47148-71167 Iran

A new type of activated carbon （AC） was synthesized using broom sorghum stalk as a low cost carbon source through chemical activation with H3PO4 and KOH. The AC obtained by KOH had the largest BET surface area of 1619 m^2·g^-1 and the highest micropore volume of 0.671 cm^3·g^-1. CO2 adsorption was enhanced by functionalizing the AC with two different amines： triethylenetetramine （TETA） and urea. The structure of the prepared ACs was characterized by Brunauer-Emmett-Teller method, scanning electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis and acid-base Boehm titration analyses. The adsorption behavior of CO2 onto raw and amine-functionalized ACs was investigated in the temperature range of 288-308 K and pressures up to 25 bar. The amount of CO2 uptake at 298 K and 1 bar achieved by AC-TETA and AC-urea was 3.22 and 2.33 mmol·g^-1 which shows a 92% and 40% improvement compared to pristine AC （1.66 mmol·g^-1）, respectively. Among different model isotherms used to describe the adsorption equilibria, Sips isotherm presented a perfect fit in all cases. Gas adsorption kinetic study revealed a fast kinetics of CO2 adsorption onto the ACs. The evaluation of the isosteric heat of adsorption demonstrated the exothermic nature of the CO2 adsorption onto unmodified and modified samples.

关键词： activated carbon broom sorghum functionalization CO2 capture

Application of adaptive neuro-fuzzy inference system and data mining approach to predict lost circulation using DOE technique (case study: Maroon oilfield)

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Petroleum 2020年第4期6卷 423-437页

作者： Farough Agin Rasool Khosravanian Mohsen Karimifard Amirhosein jahanshahi Department of Petroleum Engineering Amirkabir University of Technology(Tehran Polytechnic)424 Hafez AvenueTehran15875-4413Iran Research Institute of Petroleum Industry(RIPI) West Blvd.Near Azadi Sports ComplexTehran14857-33111Iran Department of Petroleum Engineering Petroleum University of TechnologyAhwazIran School of Mining Engineering College of EngineeringUniversity of Tehran14174-66191TehranIran

Lost circulation is the most common problem encountered while drilling oil *** of such a problem can cause a lot of time and cost *** order to drill oil wells,a fast and profitable way is necessary to predict and solve lost circulation *** system is a method used lately for problems that deal with *** this paper,three approaches are carried out for prediction of lost circulation *** approaches include design of experiments(DOE),data mining,and adaptive neuro-fuzzy inference system(ANFIS).Data of 61 wells of Maroon oilfield are selected and sorted as the feed of the *** variables are used as inputs of the approaches and one variable is used as the ***,DOE is conducted to observe the effects of ***-Burman method is used to determine the effects of variables on lost *** that,data mining is conducted to predict the amount of lost *** class of regression is used to determine a function to model the data and the error of the ***,ANFIS is applied to predict the amount of lost *** chosen data are used in order to train,test,and control the ***,subtractive clustering is used to train the fuzzy inference system(FIS)of the *** performance of the ANFIS model is assessed through the root mean squared error(RMSE).The results suggest that ANFIS method can be successfully applied to establish lost circulation prediction *** addition,results of ANFIS and data mining are investigated through their prediction *** comparison of both methods reveals that ANFIS error is much lower than data mining.

关键词： Lost circulation Maroon oilfield ANFIS RMSE Expert system

Simulation of particles settling in power-law fluids by combined lattice Boltzmann-smoothed profile methods

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International Journal of Sediment Research 2021年第5期36卷 637-655页

作者： Hamideh Rouhani Tazangi Ataallah Soltani Goharrizi Ebrahim jahanshahi Javaran Department of Chemical Engineering Shahid Bahonar University of Kerman Department of Mechanical Engineering Shahid Bahonar University of Kerman

In the current study, the settling, interaction, drafting, kissing, and tumbling of two identical and nonidentical circular particles were simulated in a two-dimensional box in shear-thinning, Newtonian,and shear-thickening fluids by using the combined lattice Boltzmann-smoothed profile ***, the drag coefficient of one particle settling for different power-law indexes and Archimedes numbers was calculated. Also, the effect of the diameter ratio of the two particle pairs was considered during settling. The developed method was validated by simulating the settling of one particle and two identical particles in a Newtonian fluid. To consider two non-identical particles, two cases were examined. In Case A, the larger particle was above the smaller one and in the Case B, the smaller particle was above the larger one. The results showed that the two non-identical particles were separated more easily than the identical ones. In the settling of two particles under the same Archimedes number, the drafting and kissing time considerably increased by changing the non-Newtonian fluid behavior from a shearthinning one to a shear-thickening one. Also, when the larger particle was above the smaller one, the time duration of the kissing stage increased with the decrease in the diameter ratio.

关键词： Lattice Boltzmann method Smoothed profile method DKT phenomenon Power-law fluids Particulate flow Drag coefficient