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LDH conversion films for active protection of AZ31 Mg alloy

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Journal of Magnesium and Alloys 2023年第1期11卷 201-216页

作者： B.Pillado B.Mingo R.del Olmo E.Matykina A.M.Kooijman y.gonzalez−garcia R.Arrabal M.Mohedano Departamento de Ingeniería Química y de Materiales Facultad de Ciencias QuímicasUniversidad ComplutenseMadrid 28040Spain Department of Materials University of ManchesterOxford RoadManchester M139PLUK Institute of Optoelectronics Military University of Technology2 Kaliskiego Str.Warsaw 00-908Poland Materials Science and Engineering Department Delft University of TechnologyMekelweg 2Delft 2628 CDthe Netherlands

Zinc aluminium(Zn-Al)and lithium aluminium(Li-Al)–layered double hydroxides(LDH)coatings with incorporated inhibitors(Li-,Mo-and W-based)were successfully synthesized on AZ31 Mg ***-Al LDH W and Li-Al LDH Li showed the highest corrosion resistance and were selected for further *** cross-section examination revealed a bi-layer structure composed of an outer part with loose flakes and a denser inner ***,FTIR,and XPS analysis confirmed the incorporation of the ***-treatments with corrosion inhibitors containing solutions resulted in the selective dissolution of the most external layer of the LDH coating,reducing the surface roughness,hydrophilicity and paint adhesion of the *** corrosion properties were confirmed by SVET evaluation for the Zn-Al LDH W *** proposed active corrosion mechanism involves the ion-exchange of aggressive Cl-ions,deposition of hydroxides and competitive adsorption of W-rich corrosion inhibitors.

关键词： AZ31 Magnesium Layered double hydroxides Corrosion inhibitors Active corrosion protection

A Systematic Review of Cannabidiol Effects in Coronary Syndromes: Challenges to Clinical Translation

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Journal of Biosciences and Medicines 2024年第4期12卷 246-263页

作者： Mario E. Zuñiga-Ayala Alejandra Meaney-Martínez Alejandro Alcocer-Chauvet Vidal gonzalez-Coronado Nestor Rubio-Infante Gerardo garcia-Rivas Department of Cardiology Instituto de Seguridad Social and Trabajadores del Estado (ISSSTE) Hospital Regional Primero de Octubre Mexico City Mexico Department of Interventional Cardiology Instituto de Seguridad Social y Trabajadores del Estado (ISSSTE) Hospital Regional Primero de Octubre Mexico City Mexico Instituto Tecnó logico de Monerrey Escuela de Medicina and Ciencias de la Salud C&#225tedra de Cardiolog&#237a and Medicina Vascular Monterrey Mexico

Background: Myocardial ischemia in addition to other several cardiac syndromes represent a pathological proinflammatory state alongside a complex cellular microenvironment that can be modified by using cannabinoids. Cannabidiol (CBD), a non-psychoactive compound of cannabis has been recently proposed as an immudomodulatory and cardioprotective drug. Objectives: In this systematic review we sought to clarify and summarize the clinical and preclinical evidence of potential benefit of the use of CBD in coronary syndromes. Methods: We conducted a systematic search and review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Review of Animal Data from Experimental Studies (CAMARADES) guidelines, in the electronic database from PubMed, Web of Science and Scopus up to April 2022 using predefined search terms. Pre-specified exclusion and inclusion criteria were considered, finally 11 articles were chosen to be included for this peer review. Results: Currently there are no good-quality clinical trials with the use of CBD in acute or chronic coronary syndromes. A total of 11 preclinical studies where prescreened and 5 demonstrated reproducible positive cardiovascular outcomes on in-vivo models treated with CBD. Mechanisms of CBD cardioprotection observed: 1) reduction in oxidative stress and inflammation, 2) activation of adenosine receptors and 3) increased expression of angiotensin type 2-receptor. Experimental models included ischemia/reperfusion injury, myocardial infarction, arrhythmias, and metabolic syndrome-like conditions. Conclusion: No clinical recommendation can be issued with the current evidence, on the use of CBD in acute and chronic coronary syndromes. Based on preclinical evidence, we considered there is enough evidence to propose the development of well-designed clinical trials that include CBD in the management of coronary syndromes.

关键词： Cannabis Cannabidiol Acute Coronary Syndromes Myocardial Infarction Myocardial Ischemia and Oxidative Stress

Common interacting genetic variation shapes susceptibility to type 1 diabetes in a Colombian Caribbean community:In search of shared genetic markers

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Genes & Diseases 2024年第4期11卷 106-108页

作者： Gloria Garavito-De Egea Alex Dominguez-Vargas Jorg e l.Velez Gustavo Aroca Luis Fagng Elkin Navarro-Quiroz Zilac Espitaleta Kenny Del Toro-Camargo Leticia Martinez-Ariza Tatiana gonzalez-Vargas Susana garcia Mauricio Arcos-Burgos Eduardo Egea Universidad del Norte Division Ciencias de la SaludBarranquillaColombia Universidad Simon Bolivar Facultad de Ciencias de la SaludBarranquillaColombia Clinica de la Costa Grupo de Investigacion en NefrologiaBarranquillaColombia Universidad de Antioquia Grupo de Investigacion en Psiquiatria(GIPSI)Departamento de PsiquiatriaInstituto de Investigaciones MedicasFacultad de MedicinaMedellinColombia

Genome-wide association studies(GWASs)have identified hundreds of loci across the human genome conferring susceptibility to autoimmune diseases(AIDs),some of which are shared between more than two ***,this univariate ... 详细信息

关键词： susceptibility diseases diabetes

Thermo-electro-mechanical microstructural interdependences in conductive thermoplastics

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npj Computational Materials 2023年第1期9卷 955-965页

作者： Javier Crespo-Miguel Sergio Lucarini Angel Arias Daniel garcia-gonzalez Department of Continuum Mechanics and Structural Analysis Universidad Carlos III de MadridAvda.de la Universidad 3028911 LeganésMadridSpain Department of Civil and Environmental Engineering Imperial College of LondonSouth Kensington CampusLondon SW72AZUK

Additive manufacturing has enabled the design of thermoplastic components that provide structural support,electrical conductivity and heat generation modulated by mechanical *** mechanisms and interplays that govern the material response at the microstructural level remain,however,***,we develop an experimental method to characterise conductive filaments from a combined mechanical,electrical and thermal *** approach is used to unravel exciting material interplays of conductive polylactic *** overcome experimental limitations that prevent a complete microstructural analysis of the problem,we develop a full-field homogenisation framework and implement it for finite *** framework accounts for viscoplasticity,electrical and thermal conduction,convection and heat generation via Joule effect,as well as for the interdependences between *** experimental validation,the framework is applied to virtually optimise fabrication requirements to obtain desired properties in final products,i.e.,stiffer products,filaments with higher conductivities or with better sensing capabilities.

关键词： conductive electrical overcome

Hybrid magnetorheological elastomers enable versatile soft actuators

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npj Computational Materials 2022年第1期8卷 1546-1559页

作者： Miguel Angel Moreno-Mateos Mokarram Hossain Paul Steinmann Daniel garcia-gonzalez Department of Continuum Mechanics and Structural Analysis Universidad Carlos III de MadridAvda.de la Universidad 3028911LeganésMadridSpain Zienkiewicz Centre for Computational Engineering Faculty of Science and EngineeringSwansea UniversitySA18ENSwanseaUK Institute of Applied Mechanics University of Erlangen-NurembergEgerland Str.5ErlangenGermany Glasgow Computational Engineering Centre School of EngineeringUniversity of GlasgowG128QQGlasgowUK

Recent advances in magnetorheological elastomers(MREs)have posed the question on whether the combination of both soft-and hard-magnetic particles may open new routes to design versatile multifunctional ***,we conceptualise ultra-soft hybrid MREs(≈1–10 kPa stiffness)combining experimental and computational ***,a comprehensive experimental characterisation is *** results unravel that the magneto-mechanical performance of hybrid MREs can be optimised by selecting an adequate mixing ratio between ***,a multi-physics computational framework provides insights into the synergistic magneto-mechanical interactions at the *** particles amplify the magnetisation and hard particles contribute to torsional *** numerical results suggest that the effective response of hybrid MREs emerges from these intricate ***,we uncover exciting possibilities to push the frontiers of MRE *** are demonstrated by simulating a bimorph beam that provides actuation flexibility either enhancing mechanical bending or material stiffening,depending on the magnetic stimulation.

关键词： versatile magneto enable

Liver cirrhosis and diabetes:Risk factors,pathophysiology,clinical implications and management

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World Journal of Gastroenterology 2009年第3期15卷 280-288页

作者： Diego garcia-Compean Joel Omar Jaquez-Quintana Jose Alberto gonzalez-gonzalez Hector Maldonado-Garza Department of Gastroenterology Faculty of MedicineUniversity HospitalAve Madero y GonzalitosCol Mitras CentroMonterrey 64700Mexico

About 30% of patients with cirrhosis have diabetes mellitus(DM).Nowadays,it is a matter for debate whether type 2 DM in the absence of obesity and hypertriglyceridemia may be a risk factor for chronic liver ***,which develops as a complication of cirrhosis,is known as "hepatogenous diabetes".Insulin resistance in muscular and adipose tissues and hyperinsulinemia seem to be the pathophysiologic bases of diabetes in liver *** impaired response of the islet β-cells of the pancreas and hepatic insulin resistance are also contributory ***-alcoholic fatty liver disease,alcoholic cirrhosis,chronic hepatitis C(CHC) and hemochromatosis are more frequently associated with *** resistance increases the failure of the response to treatment in patients with CHC and enhances progression of *** in cirrhotic patients may be *** diabetes is clinically different from that of type 2 DM,since it is less frequently associated with microangiopathy and patients more frequently suffer complications of *** increases the mortality of cirrhotic *** of the diabetes is complex due to liver damage and hepatotoxicity of oral hypoglycemic *** manuscript will review evidence that exists in relation to:type 2 DM alone or as part of the metabolic syndrome in the development of liver disease;factors involved in the genesis of hepatogenous diabetes;the impact of DM on the clinical outcome of liver disease;the management of DM in cirrhotic patients and the role of DM as a risk factor for the occurrence and exacerbation of hepatocellular carcinoma.

关键词： Insulin resistance Type 2 diabetes mellitus Liver cirrhosis Hepatocellular carcinoma Chronic hepatitis C

Non-technical approach to the challenges of ecological architecture： Learning from Van der Laan

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Frontiers of Architectural Research 2016年第2期5卷 202-212页

作者： Maria-Jesus gonzalez-Diaz Justo garcia-Navarro Department of Agroforestry Engineering Construction Unit Universidad Politécnica de Madrid Madrid 28040 Spain

Up to now, ecology has a strong influence on the development of technical and instrumental aspects of architecture, such as renewable and efficient of resources and energy, COz emissions, air quality, water reuse, some social and economical aspects. These concepts define the physical keys and codes of the current ＇sustainable＇ architecture, normally instrumental but rarely and insufficiently theorised. But is not there another way of bringing us to nature？ We need a theoretical referent. This is where we place the Van der Laan＇s thoughts： he considers that art completes nature and he builds his theoretical discourse on it, trying to better understand many aspects of architecture. From a conceptual point of view, we find in his works sense of timelessness, universality, special attention on the ＇locus＇ and a strict sense of proportions and use of materials according to nature. Could these concepts complement our current sustainable architecture？ How did Laan apply the current codes of ecology in his architecture？ His work may help us to get a theoretical interpretation of nature and not only physical. This paper develops this idea through the comparison of thoughts and works of Laan with the current technical approach to ＇sustainable＇ architecture.

关键词： Nature Architecture Van-der-Laan Ecology Ethics Environment

Empowered Stakeholders: Female University Students’ Leadership During the COVID-19-Triggered On-campus Evictions in Canada and the United States

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International Journal of Disaster Risk Science 2021年第4期12卷 581-592页

作者： Haorui Wu Marla Perez-Lugo Cecilio Ortiz garcia Frances gonzalez Crespo Adriana Castillo Canada Research Chair in Resilience School of Social WorkDalhousie UniversityHalifaxNSB3H 4R2Canada Natural Hazards Center University of Colorado BoulderBoulderCO80309USA Department of Social Sciences University of Puerto Rico MayagüezMayagüezPR00682USA The RISE Network MayagüezPR00680USA

The study of disaster-specific leadership of female university students has been largely neglected,especially during on-campus emergency eviction and *** on the COVID-19-triggered,on-campus evictions across Canada and the United States,this cross-national partnership examined the out-of-province/state and international female university students’leadership during the entire eviction *** in-depth interviews,this study revealed the female university students’leadership behaviors during three stages:(1)pre-eviction:their self-preparedness formed an emotional foundation to support others;(2)peri-eviction:their attitude and leadership behavior enabled them to facilitate(psychologically and physically)their peers’eviction process;and(3)post-eviction:they continued to support their peers virtually and raised the general public’s awareness regarding the plight of vulnerable and marginalized *** article argues that the female university students’leadership that emerged during the eviction process became complementary to and even augmented the universities’official efforts and *** leadership represents empirical evidence that contributes to the existing literature on gender and leadership by demonstrating female youth as empowered stakeholders rather than as merely passive *** studies could develop detailed stratification of gender and age dimensions in order to portray a more comprehensive picture of the younger generation’s leadership in hazards and disaster research and practice.

关键词： Canada COVID-19 Female leadership Gender and disaster On-campus evictions United States University students

Land-use change and windstorms legacies drove the recolonization dynamics of laurel forests in Tenerife, Canary islands

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Forest Ecosystems 2023年第1期10卷 113-124页

作者： Vicente Rozas Maria A.garcia-Lopez Jose M.Olano Gabriel Sanguesa-Barreda Miguel garcia-Hidalgo Susana Gomez-gonzalez Roberto Lopez-Rubio Jose M.Fernandez-Palacios Ignacio garcia-gonzalez Laura Lozano-Lopez Paula garcia-gonzalez Ana I.garcia-Cervigon EiFAB-iuFOR Universidad de ValladolidCampus Duques de Soria42004SoriaSpain Departamento de Biologia-IVAGRO Universidad de CadizCampus Rio San Pedro11510Puerto RealSpain Center for Climate and Resilience Research(CR)2 Blanco Encalada 20028370449SantiagoChile Area de Biodiversidad y Conservacion Universidad Rey Juan Carlosc/Tulipan s/n28933MostolesSpain Grupo de Ecologia y Biogeografia Insular Universidad de La Laguna38206La LagunaTenerifeSpain BIOAPLIC Departamento de BotanicaEscola Politecnica Superior de EnxenariaCampus TerraUniversidade de Santiago de CompostelaLugo27002Spain

Laurel forests are quite relevant for biodiversity conservation and are among the island ecosystems most severely damaged by human *** the past,Canary laurel forests have been greatly altered by logging,livestock and *** remains of laurel forests are currently protected in the Canary Islands(Spain).However,we miss basic information needed for their restoration and adaptive management,such as tree longevity,growth potential and responsiveness to natural and anthropogenic *** dendrochronological methods,we studied how forest dynamic is related to land-use change and windstorms in two well-preserved laurel forests on Tenerife *** cores were collected from over 80 trees per stand at three stands per *** used ring-width series to estimate tree ages and calculate annual basal area increments(BAI),cumulative diameter increases,and changes indicative of released and suppressed *** tree species were found in all stands,with Laurus novocanariensis,Ilex canariensis and Morella faya being the most common *** some individuals were over 100 years old,61.8%-88.9% of the trees per stand established between 1940 and 1970,coinciding with a post-war period of land abandonment,rural exodus and the onset of a tourism *** trees have shown growth rates larger than 1 cm diameter per year and most species have had increasing BAI trends over the past *** growth releases occurred after windstorms at both sites,but the effects of windstorms were site-dependent,with the 1958 storm affecting mainly the eastern tip of the island(Anaga massif)and the 1991 storm the western tip(Teno massif).Given the great ability of laurel forest trees to establish after land use cessation and to increase growth after local disturbances such as windstorms,passive restoration may be sufficient to regenerate this habitat in currently degraded areas.

关键词： Canary islands Dendroecology Disturbance Forest structure Macaronesia Management cessation Tree rings