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On the Theory of Fragmentation Process with Initial Particle Volume

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Communications in Theoretical Physics 2017年第8期67卷 269-271页

作者： D.V.alexandrov Department of Theoretical and Mathematical Physics Laboratory of Multi-Scale Mathematical Modeling Ural Federal University

The problem of fragmentation(disintegration) process is theoretically studied with allowance for the initial particle volume. An exact analytical solution of integro-differential model governing the fragmentation phenomenon is obtained. The key role of a finite initial volume of particles leading to substantial changes of the particle-size distribution function is demonstrated.

关键词： Iphase transitions particle-size distribution fragmentation

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Toward Sustainable Revegetation in the Loess Plateau Using Coupled Water and Carbon Management

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Engineering 2022年第8期8卷 143-153页

作者： Fubo Zhao yiping Wu Xiaowei yin Georgii alexandrov Linjing Qiu Department of Earth and Environmental Science School of Human Settlements and Civil EngineeringXi’an Jiaotong UniversityXi’an 710049China A.M.Obukhov Institute of Atmospheric Physics Russian Academy of SciencesMoscow 119017Russia

The"Grain-for-Green"project on the Loess Plateau is the largest revegetation program in the ***,revegetation-induced land use changes can influence both water and carbon cycles,and the diverse consequences were not well ***,the reasonability and sustainability of revegetation measures are in *** study quantifies the impacts of revegetation-induced land use conversions on the water and carbon cycles in a typical watershed on the Loess Plateau and identifies suitable areas where revegetation of forest or grassland could benefit both soil and water conservation and carbon *** used a coupled hydro-biogeochemical model to simulate the changes of a few key components in terms of water and carbon by designing a variety of hypothetical land use conversion scenarios derived from revegetation *** to the baseline condition(land use in 2000),both sediment yield and water yield decreased substantially when replacing steep cropland with forest or *** cropland with slopes larger than 25°,15°,and 6°to forest(CTF)would enhance the carbon sequestration with a negligible negative effect on soil water content,while replacing cropland with grassland(CTG)would result in a decline in net primary production but with a substantial increase in soil water content(3.8%-14.9%).Compared to the baseline,the soil organic carbon would increase by 0.9%-3.2% in CTF and keep relatively stable in *** testing a variety of hypothetical revegetation scenarios,we identified potential priority areas for CTF and CTG,where revegetation may be appropriate and potentially beneficial to conserving soil and water and enhancing carbon *** study highlights the challenges in future water and carbon coupling management under revegetation policy,and our quantitative results and identification of potential areas for revegetation could provide information to policy makers for seeking optimal management on the Loess Plate

关键词： Carbon Land use change Loess Plateau Sediment SWAT-Day Cent Water resources

Creeping fat and gut microbiota in Crohn’s disease

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World Journal of Gastroenterology 2025年第1期31卷 16-23页

作者： Ana EV Quaglio Daniéla O Magro Marcello Imbrizi Ellen CS De Oliveira Luiz C Di Stasi Ligia y Sassaki Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department of Surgery Faculty of Medical SciencesState University of CampinasCampinas 13083-970São PauloBrazil Department of Gastroenterology Faculty of Medical SciencesUniversity of CampinasCampinas 13083-970São PauloBrazil Department of Internal Medicine Medical SchoolSão Paulo State UniversityBotucatu 18618-686São PauloBrazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State UniversityBotucatu 18618-689São PauloBrazil

In this article,we explored the role of adipose tissue,especially mesenteric adipose tissue and creeping fat,and its association with the gut microbiota in the pathophysiology and progression of Crohn’s disease(CD).CD is a form of inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract,influenced by genetic predisposition,gut microbiota dysbiosis,and environmental *** microbiota plays a crucial role in modulating immune response and intestinal inflammation and is associated with the onset and progression of ***,visceral adipose tissue,particularly creeping fat,a mesenteric adipose tissue characterized by hypertrophy and fibrosis,has been implicated in CD pathogenesis,inflammation,and *** bacteria from the gut microbiota may translocate into mesenteric adipose tissue,contributing to the formation of creeping fat and influencing CD *** creeping fat may be a protective barrier against bacterial invasion,its expansion can damage adjacent tissues,leading to *** gut microbiota through interventions such as fecal microbiota transplantation,probiotics,and prebiotics has shown potential in managing ***,more research is needed to clarify the mechanisms linking gut dysbiosis,creeping fat,and CD progression and develop targeted therapies for microbiota modulation and fat-related complications in patients with CD.

关键词： Creeping fat Mesenteric adipose tissue Gut microbiota Crohn’s disease Inflammatory bowel disease

Wide aperture piezoceramic deformable mirrors for aberration correction in high-power lasers

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High Power Laser Science and Engineering 2016年第1期4卷 22-28页

作者： Vadim Samarkin Alexander alexandrov Gilles Borsoni Takahisa Jitsuno Pavel Romanov Aleksei Rukosuev Alexis Kudryashov Moscow State University of Mechanical Engineering (MAMI) AKA Optics SAS Institute of Laser Engineering Osaka University

The deformable mirror with the size of 410 mmstacks was developed. The results ×468 mm controlled by the bimorph piezoceramic plates and multilayer piezoceramic of the measurements of the response functions of all the actuators and of the surface shape of the deformable mirror are presented in this paper. The study of the mirror with a Fizeau interferometer and a Shack–Hartmann wavefront sensor has shown that it was possible to improve the flatness of the surface down to a residual roughness of 0.033 μm(RMS). The possibility of correction of the aberrations in high-power lasers was numerically demonstrated.

关键词： deformable mirror high-power laser piezoelectric actuator wavefront sensor

Numerical Modeling of One-Dimensional Binary Solidification with a Mushy Layer Evolution

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Numerical Mathematics(Theory,Methods and Applications) 2012年第2期5卷 157-185页

作者： Daniel Lee Dmitri alexandrov H.-N.Huang Department of Applied Mathematics Tunghai UniversityTaichungTaiwan 40704 Ural Federal University Department of Mathematical PhysicsLenin ave.51Ekaterinburg 620083Russian Federation

The numerical modeling of a binary solidification with a mushy layer mechanism is considered in this *** nonlinear coupled system of equations describes the heat and mass diffusions of a one-dimensional spatial variable in the semiinfinite *** formulated is a transformed system in a finite *** propose numerical methods for solving the nonlinear system using a threshold strategy based on fixed computation-domain *** calculated results and those from the LeadEx field experiment are well-matched in their tendencies.

关键词： Direct numerical simulation Heat and mass transfer Mushy layer Solidification Stefan problem

每核子14.6和60GeV能量下氧离子诱发核反应的带电粒子谱

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高能物理与核物理 1989年第10期13卷 865-869页

作者： M.I.Adamovich M.M.A■■arwal R.Arora y.a.alexandrov S.A.Azimov S.K.Badyal E.Basova K.B.Bhalla A.Bhasin V.S.Badyal R.A.Bomadarenko T.H.Burnett 蔡(冒力) L.P.Chernova M.M.Chernyavski B.Dressel E.M.Friedlander S.I.Gerassimov E.R.Ganssau■e S.Garpman S.G.Gerassimov A.Gill J.Grote K.G.Gulamov V.G.Gulyamov V.K.Gupta S.Hackel H.H.Heckman B.Jakobsson B.Judek S.Katroo F.G.Kadyrov H.Kallies L.Karlsson G.L.Kaul M.Kaur S.P.Kharlamov J.Kohli V.Kumar P.Lal V.G.Larinova P.J.Lindstrom 刘连寿 S.Lokanathan J.Lord N.S.Lukicheva L.K.Man■otra N.V.Maslennikova I.S.Mitta E.Monnand S.Moolerjee C.Mueller S.H.Nasyrov V.S.Nvtny G.I.Orlova I.Otterlund N.G.Peresadko S.Persson N.V.Petrov 钱琬燕 R.Raniwala S.Raniwana N.K.Rao J.y.Rhee N.Shaidkhanov N.G.Salmanova W.Schulz F.Schussler V.S.Shukla D.Skeldin■ K.Soderstrom E.Stanlund R.S.Storey 孙君芬 L.N.Svechnilova M.I.Tretyakova T.P.Trofimova 王海桥翁智群 R.J.Wilkes 许国发张东海郑蒲英周代翠周景晨列比切夫研究所旁加贝大学物理技术研究所查漠大学拉加斯坦大学核物印研究所华盛顿大学华中师范大学菲利浦斯大学劳伦斯-伯克利实验室隆德大学国家研究委员会原子能研究中心 )列比切夫研究所山西师范大学高能物理研究所

本文给出了每核子14.6和60GeV能量下氧离子诱发核反应的带电粒子多重数分布和赝快度分布.实验数据取自EMU-01乳胶叠,并与Lund Monte Carlo模型(FRITIOF)作了比较.

关键词：氧离子诱发核反应带电粒子谱

Unsupervised phase mapping of X-ray diffraction data by nonnegative matrix factorization integrated with custom clustering

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npj Computational Materials 2018年第1期4卷 295-304页

作者： Valentin Stanev Velimir V.Vesselinov A.Gilad Kusne Graham Antoszewski Ichiro Takeuchi Boian S.alexandrov Department of Materials Science and Engineering University of MarylandCollege ParkMD 20742USA Center for Nanophysics and Advanced Materials University of MarylandCollege ParkMD 20742USA Joint Quantum Institute University of MarylandCollege ParkMD 20742USA Los Alamos National Laboratory Earth Science DivisionLos AlamosNM 87545USA National Institute of Standards and Technology GaithersburgMD 20899USA Department of Mathematics University of MarylandCollege ParkMD 20742USA Los Alamos National Laboratory Theoretical DivisionLos AlamosNM 87545USA

Analyzing large X-ray diffraction(XRD)datasets is a key step in high-throughput mapping of the compositional phase diagrams of combinatorial materials *** and automating this task can help accelerate the process of discovery of materials with novel and desirable ***,we report a new method for pattern analysis and phase extraction of XRD *** method expands the Nonnegative Matrix Factorization method,which has been used previously to analyze such datasets,by combining it with custom clustering and cross-correlation *** new method is capable of robust determination of the number of basis patterns present in the data which,in turn,enables straightforward identification of any possible peak-shifted ***-shifting arises due to continuous change in the lattice constants as a function of composition and is ubiquitous in XRD datasets from composition spread *** identification of the peak-shifted patterns allows proper quantification and classification of the basis XRD patterns,which is necessary in order to decipher the contribution of each unique single-phase structure to the multi-phase *** process can be utilized to determine accurately the compositional phase diagram of a system under *** presented method is applied to one synthetic and one experimental dataset and demonstrates robust accuracy and identification abilities.

关键词： properties. phase nonnegative