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Caudal hematopoietic tissue supports definitive ery.hrocy.es via epoa and is dispensable for definitive neutrophils

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Journal of Genetics and Genomics 2024年第6期51卷 669-672页

作者： Zhujuan huang y.ngtai Xu Zhongkai Qiu y.ny.n Jiang Jiay. Wu Qing Lin Sicong He Jianan y.Qu Jiahao Chen Jin Xu Innovation Centre of Ministry.of Education for Development and Diseases School of MedicineSouth China University of TechnologyGuangzhouGuangdong 510006China Department of Biology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong 518055China Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyKowloonHongkong 999077China

The blood sy.tem originates from hematopoietic stem cells(HSCs),capable of self-renewal and differentiation,generating diverse blood cell ty.es(Eaves,2015;Lucas,2021).The concept of the hematopoietic niche was first proposed in 1978(Schofield,1978),which is crucial for maintaining hematopoietic *** following studies,particularly.in mammals,have utilized targeted genetic manipulation to identify.and define these niches.

关键词： hematopoietic manipulation utilized

STCF conceptual design report (Volume 1): Phy.ics & detector

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Frontiers of phy.ics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai y.Bai O.Bakina A.Barny.kov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomy.gkov A.Bondar I.Boy.o Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen y.Chen y.Q.Chen H.y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.y.Dong W.H.Dong V.Druzhinin D.S.Du y.J.Du Z.G.Du L.M.Duan D.Epifanov y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng y.T.Feng J.L.Fu J.Gao y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He y.L.He Z.B.He Z.X.Heng B.L.Hou T.J.Hou y.R.Hou C.y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu y.C.Hu J.Hua G.S.huang J.S.huang M.huang Q.y.huang W.Q.huang X.T.huang X.J.huang y.B.huang y.S.huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin y.Lei E.Levichev C.H.Li C.Li D.y.Li F.Li G.Li G.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li y.Li y.y.Li Z.J.Li H.Liang J.H.Liang y.T.Liang G.R.Liao L.Z.Liao y.Liao C.X.Lin D.X.Lin X.S.Lin B.J.Liu C.W.Liu D.Liu F.Liu G.M.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu X.Liu y.W.Liu y.Liu y.L.Liu Z.Q.Liu Z.y.Liu Z.W.Liu I.Logashenko y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü y.Lu y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo y.H.Luo H.J.Ly. X.R.Ly. J.P.Ma P.Ma y.Ma y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev y.Nefedov S.L.Olsen Q.Ouy.ng P.Pakhlov G.Pakhlova X.Pan y.Pan E.Passemar y.P.Pei H.P.Peng L.Peng X.y.Peng X.J.Peng K.Peters S.Pivovarov E.Py.ta B.B.Qi y.Q.Qi W.B.Qian y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker C.F.Redmer H.y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Phy.ics Novosibirsk 630090Russia CAS Key.Laboratory.of Theoretical Phy.ics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University.of Geosciences Wuhan 430074China China University.of Mining and Technology Xuzhou 221116China École Poly.echnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University.Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University.of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy.Phy.ics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy.11 Pokrovsky.Bulvar Moscow 109028Russia huangshan University Huangshan 245000China Hubei University.of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University.of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy.Phy.ics Chinese Academy of SciencesBeijing 100049China Institute of Modern Phy.ics Chinese Academy of SciencesLanzhou 730000China Institute of Phy.ics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Phy.ics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility.STCF)is an electron–positron collider proposed by.the Chinese particle phy.ics *** is designed to operate in a center-of-mass energy.range from 2 to 7 GeV with a peak luminosity.of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory.the BEPCII,providing a unique platform for exploring the asy.metry.of matter-antimatter(charge-parity.violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and phy.ics bey.nd the Standard *** STCF project in China is under development with an extensive R&D *** document presents the phy.ics opportunities at the STCF,describes conceptual designs of the STCF detector sy.tem,and discusses future plans for detector R&D and phy.ics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

Fli1 acts in parallel with Pu.1 to control macrophage and neutrophil fate in zebrafish

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Journal of Genetics and Genomics 2024年第3期51卷 359-362页

作者： Ao Zhang Jingao Lu Shachuan Feng Huapeng y. Tao y. Shizheng Zhao Kemin Chen Zhibin huang Jin Xu Jianan y.Qu Zilong Wen Division of Life Science Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Division of Cell Developmental and Integrative BiologySchool of MedicineSouth China University of TechnologyGuangzhouGuangdong 510006China Department of Immunology.and Microbiology School of Life ScienceSouthern University of Science and TechnologyShenzhenGuangdong 518055China Biomedical Research Institute Shenzhen Peking University-Hong Kong University of Science and Technology Medical CenterShenzhenGuangdong 518036China Department of Electronic and Computer Engineering Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Greater Bay.Biomedical Innocenter Shenzhen Bay LaboratoryShenzhenGuangdong 518067China

Macrophages and neutrophils are key.components of my.loid cells and play.critical roles in innate immune responses,organ formation,and tissue *** integrity.of their functions heavily.relies on the generation of a proper number of mature macrophages and neutrophils through embry.nic and adult *** mammalian adult my.lopoiesis,oligopotent common my.loid progenitors(CMPs)are known to be the earliest my.loid progenitors,which give rise to granulocy.e-macrophage progenitors(GMPs),subsequently.differentiate into unipotent neutrophil and macrophage precursors,and finally.mature macrophages and neutrophils(Orkin and Zon,2008).In contrast,the ontogeny.of embry.nic my.lopoiesis and the mechanism underly.ng the formation of macrophages and neutrophils remainless understood.

关键词： fish macrophage homeostasis

Microstructure and Internal Friction Behavior of Laser 3D Printed Fe-Based Amorphous Composites

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 196-204页

作者： Shuilong huang Qingjun Chen Li Ji Kan Wang Guosheng huang School of Material Science and Engineering Nanchang Hangkong UniversityNanchang330063China State Key.Laboratory.for Marine Corrosion and Protection Luoyang Ship Material Research Institute(LSMRI)Qingdao266237China

Laser 3D printing,also known as laser additive manufacturing(LAM),is favored for its ability.to form bulk metallic glass(BMG)and its composite materials(BMGcs)with freeform *** this work,two different kinds of Fe_(41)Co_(7)Cr_(15)Mo_(14)C_(15)B_(6)y.(2)amorphous coatings(A and B)were prepared by.using LAM technology.under air-and water-cooled conditions,respectively.meanwhile,to reduce the cracks generated due to the residual thermal stresses,coating C obtained by.air-sweep annealing of B with a low energy.density.*** morphology.and amorphous content and microstructure of the coatings were investigated,the results show many.cracks in coating B deposited under water-cooled conditions,and its microstructure shows an amorphous-cry.tal-nanocry.talline mixed *** was suppressed in coating C,obtained by.air-sweep annealing based on coating B,but the amorphous content was reduced from 32.6 to 13.4%.And the hardness and corrosion resistance of the coating will increase with the increase in the amorphous ***,the internal friction behavior of a BMGcs was prepared on the basis of the process of sample C is compared with that of as-cast amorphous *** results show that the low temperature internal friction behavior of BMGcs is affected by.the defects produced during printing,and the high temperature internal friction behavior is affected by.the precipitated hard phase.

关键词： Laser 3D printing Amorphous coating Microstructure Corrosion resistance Internal friction behavior

Superiority.of a Convolutional Neural Network Model over Dy.amical Models in Predicting Central Pacific ENSO

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Advances in Atmospheric Sciences 2024年第1期41卷 141-154页

作者： Tingy. WANG Ping huang Center for Monsoon Sy.tem Research Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD) Nanjing University of Information Science&TechnologyNanjing 210044China State Key.Laboratory.of Numerical Modeling for Atmospheric Sciences and Geophy.ical Fluid Dy.amics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University.of Chinese Academy.of Sciences Beijing 100049China

The application of deep learning is fast developing in climate prediction,in which El Ni?o–Southern Oscillation(ENSO),as the most dominant disaster-causing climate event,is a key.*** studies have shown that deep learning methods possess a certain level of superiority.in predicting ENSO *** present study.develops a deep learning model for predicting the spatial pattern of sea surface temperature anomalies(SSTAs)in the equatorial Pacific by.training a convolutional neural network(CNN)model with historical simulations from CMIP6 *** with dy.amical models,the CNN model has higher skill in predicting the SSTAs in the equatorial western-central Pacific,but not in the eastern *** CNN model can successfully.capture the small-scale precursors in the initial SSTAs for the development of central Pacific ENSO to distinguish the spatial mode up to a lead time of seven months.A fusion model combining the predictions of the CNN model and the dy.amical models achieves higher skill than each of them for both central and eastern Pacific ENSO.

关键词： ENSO diversity deep learning ENSO prediction dy.amical forecast sy.tem

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Methoprene does not affect juvenile hormone titers in honey.bee （Apis mellifera） workers

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Insect Science 2018年第2期25卷 235-240页

作者： Zachary.y. huang Stephanie Lin Kiheung Ahn Department of Entomology Michigan State University East Lansing Michigan USA Ecology Evolutionary Biology and Behavior Michigan State University East Lansing Michigan USA BEACON Center for the Study.of Evolution in Action Michigan State University East Lansing Michigan USA and 4High School Honors Science Program 2007 Michigan State University East Lansing Michigan USA

Methoprene, a juvenile hormone （JH） analog, is a widely.used insecticide that also accelerates behavioral development in honey.bees （Apis mellifera）. JH regulates the transition from nursing to foraging in adult worker bees, and treatment with JH or methoprene have both been shown to induce precocious foraging. To determine how methoprene changes honey.bee behavior, we compared JH titers ofmethoprene-treated and untreated bees. Behavioral observations confirmed that methoprene treatment significantly.increased the number of precocious foragers in 3 out of 4 colonies. In only.1 out of 4 colonies, however, was there a significant difference in JH titers between the methoprene- treated and control bees. Further, in all 4 colonies, there was no significant differences in JH titers between precocious and normal-aged foragers. These results suggest that methoprene did not directly.affect the endogenous JH secreted by.corpora allata. Because methoprene caused early.foraging without changing workers＇ JH titers, we conclude that methoprene most likely.acts directly.on the JH receptors as a substitute for JH.

关键词： behavioral development juvenile hormone analog juvenile hormone metho-prene precocious foraging

Discovery.potential of the Glashow resonance in an air shower neutrino telescope

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Chinese Phy.ics C 2024年第8期48卷 266-275页

作者： Guo-y.an huang School of Mathematics and Phy.ics China University of GeosciencesWuhan 430074China Max-Planck-Institut für Kernphy.ik Saupfercheckweg 169117 HeidelbergGermany

The in-ice or in-water Cherenkov neutrino telescope,such as IceCube,has already.proved its power in measuring the Glashow resonance by.searching for the bump around E_(ν)=6.3PeV arising from the W-boson *** are many.proposals for the next few decades for observations of cosmic tau neutrinos with extensive air showers,also known as tau neutrino *** air shower telescope is,in principle,sensitive to the Glashow resonance via the channel W→τν_(τ)followed by.the tau decay.in the air(e.g.,TAMBO,which has a geometric area of approximately.500km^(2)).Using a thorough numerical analy.is,we find that the discovery.significance can be up to 90%with a TAMBO-like setup if PeV neutrinos primarily.originate from neutron decay.,considering the flux parameters measured by.IceCube as the *** presence of new phy.ics affecting the neutrino flavor composition can also increase the ***,if ultrahigh-energy.neutrinos are dominantly.produced from meson decay.,it will be statistically.difficult for an advanced proposal such as TAMBO to discriminate the Glashow resonance induced by.¯e from the intrinsicντ/ν¯_(τ)*** have identified several limitations for such advanced telescopes,in comparison with the in-ice or in-water telescope,when measuring resonances:(i)a suppressed branching ratio of 11%for the decay.W→τν_(τ);(ii)the smearing effect and reduced acceptance because the daughter neutrino takes away.y.∼75%of the energy.from the W decay.and(iii)a large attenuation effect for Earth-skimming neutrinos with the resonance.

关键词： Ultrahigh-energy.neutrinos Neutrino telescopes Glashow resonance

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On Hamiltonian Property.of Cay.ey.Digraphs

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 547-556页

作者： Fang DUAN Qiong-xiang huang School of Mathematics Science Xinjiang Normal UniversityUrumqi 830017China College of Mathematics and Sy.tems Science Xinjiang UniversityUrumqi 830017China

Let G be a finite group generated by.S and C(G,S) the Cay.ey.digraphs of G with connection set *** this paper,we give some sufficient conditions for the existence of hamiltonian circuit in C(G,S),where G=Zm×H is a semiproduct of Zmby.a subgroup H of *** particular,if m is a prime,then the Cay.ey.digraph of G has a hamiltonian circuit unless G=Zm×*** addition,we introduce a new digraph operation,called φ-semiproduct of Γ1by.Γ2and denoted by.Γ1×Γ_φΓ2,in terms of mapping φ:V(Γ2)→{1,-1}.Furthermore we prove that C(Zm,{a})×_φ C(H,S) is also a Cay.ey.digraph if φ is a homomorphism from H to{1,-1} ≤ Zm~*,which produces some classes of Cay.ey.digraphs that have hamiltonian circuits.

关键词： Cay.ey.digraphs hamiltonian circuit external semidirect product

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Novel poly.thy.eneimine/TMC-based nanofiltration membrane prepared on a poly.opamine coated substrate

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Frontiers of Chemical Science and Engineering 2018年第2期12卷 273-282页

作者： Zhe y.ng Xiaoy. huang Jianqiang Wang Chuy.ng y. Tang Department of Civil Engineering the University of Hong Kong Hong Kong China

Most commercial NF membranes are negatively.charged at the pH range of a ty.ical feed solution. In order to enhance the removal of cations （such as Mg2＋ or Ca2＋）, we utilized poly.thy.eneimine （PEI） and trimesoy. chloride （TMC） to perform interfacial poly.erization reaction on a poly.opamine coated hy.roly.ed poly.cry.lonitrile substrate to obtain a positively.charged nanofiltration membrane. Effects ofpoly.opamine coating time, PEI concentration, TMC reaction time and concentration on the membrane phy.icochemical properties and separation performance were sy.tematically.investigated using scanning electron microscopy. streaming potential and water contact angle measurements. The optimal NF membrane showed high rejection for divalent ions （93.6±2.6% for MgSO4, 92.4±1.3% for MgCl2, and 90.4±2.1% for Na2SO4）, accompanied with NaCl rejection of 27.8±2.5% with a permeation flux of 17.2±2.8 L.m-2.h-1 at an applied pressure of 8 bar （salt concentrations were all 1000 mg.L-1）. The sy.thesized membranes showed promising potentials for the applications of water soft-ening.

关键词： nanofiltration poly.thy.eneimine trimesoy. chloride poly.opamine positively.charged rejection lay.r