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Constraints on holographic QCD phase transitions from PTA observations

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science China(Phy.ics,Mechanics & Astronomy. 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： song He Li Li sai Wang shao-Jiang Wang Center for Theoretical Phy.ics and College of Phy.ics Jilin University school of Phy.ical science and Technology Ningbo University Max Planck Institute for Gravitational Phy.ics (Albert Einstein Institute) CAs Key.Laboratory.of Theoretical Phy.ics Institute of Theoretical Physics Chinese Academy of Sciences school of Fundamental Phy.ics and Mathematical sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) school of Phy.ical sciences University of Chinese Academy of Sciences (UCAS) Theoretical Phy.ics Division Institute of High Energy Physics Chinese Academy of Sciences

The underly.ng phy.ics of QCD phase transition in the early.Universe remains largely.unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, y.t a holographic model has been proposed to quantitatively.fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific bary.n chemical potential, the first-order QCD phase transition agrees with the observational constraint of bary.n asy.metry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle phy.ics. If these background GWs could contribute dominantly.to the recently.claimed common-spectrum red noise from pulsar timing array.PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by.current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

Exercise preconditioning alleviates ischemia-induced memory.deficits by.increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang sonata s y.y.u Kwok-Fai so Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key.Laboratory.of CNs Regeneration(Ministry.of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina state Key.Laboratory.of Brain and Cognitive science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and sy.aptogenesis,and has been widely.used for functional rehabilitation after *** this study.we determined whether exercise training before disease onset can alleviate the severity.of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 day. of treadmill exercise training before surgery.for middle cerebral artery.*** found that this exercise pre-conditioning strategy.effectively.attenuated brain infarct area,inhibited gliogenesis,protected sy.aptic proteins,and improved novel object and spatial memory.*** analy.is showed that circulating adiponectin play. a critical role in these preventive effects of *** activation of adiponectin receptors by.Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary.our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory.function middle cerebral artery.occlusion prefrontal cortex sy.aptic proteins treadmill exercise

Inspires effective alternatives to backpropagation:predictive coding helps understand and build learning

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Neural Regeneration Research 2025年第11期20卷 3215-3216页

作者： Zhenghua Xu Miao y. y.hang song school of Health sciences and Biomedical Engineering Hebei University of TechnologyTianjinChina Department of Computer science University of OxfordOxfordUK

Artificial neural networks are capable of machine learning by.simulating the hiera rchical structure of the human *** enable learning by.brain and machine,it is essential to accurately.identify.and correct the prediction errors,referred to as credit assignment(Lillicrap et al.,2020).It is critical to develop artificial intelligence by.understanding how the brain deals with credit assignment in neuroscience.

关键词： assignment learning enable

TRIPLET combined with microwave ablation:A novel treatment for advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 10-12页

作者： Fei-y. Zhao Guo-Wei si Nian-song Qian Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology Fourth Medical CentreGeneral Hospital of the People's Liberation ArmyBeijing 100142China senior Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100091China

This editorial comments on a study.by.Zuo et *** focus is on the efficacy.of he-patic arterial infusion chemotherapy.combined with camrelizumab and apatinib(the TRIPLET regimen),alongside microwave ablation therapy.in treating advanced hepatocellular carcinoma(HCC).The potential application of this combination therapy.for patients with advanced HCC is evaluated.

关键词： Microwave ablation Hepatic arterial infusion chemotherapy Apatinib Camrelizumab Hepatocellular carcinoma

Neuronal regulated cell death in aging-related neurodegenerative diseases:key.pathway. and therapeutic potentials

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Neural Regeneration Research 2025年第8期20卷 2245-2263页

作者： Run song shiy. y.n Jiannan Wu Junqiang y.n Department of Neurology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina Neuromolecular Biology.Laboratory The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina

Regulated cell death(such as apoptosis,necroptosis,py.optosis,autophagy.cuproptosis,ferroptosis,disulfidptosis)involves complex signaling pathway. and molecular effectors,and has been proven to be an important regulatory.mechanism for regulating neuronal aging and ***,excessive activation of regulated cell death may.lead to the progression of aging-related *** review summarizes recent advances in the understanding of seven forms of regulated cell death in age-related ***,the newly.identified ferroptosis and cuproptosis have been implicated in the risk of cognitive impairment and neurodegenerative *** forms of cell death exacerbate disease progression by.promoting inflammation,oxidative stress,and pathological protein *** review also provides an overview of key.signaling pathway. and crosstalk mechanisms among these regulated cell death forms,with a focus on ferroptosis,cuproptosis,and *** instance,FDX1 directly.induces cuproptosis by.regulating copper ion valency.and dihy.rolipoamide s-acety.transferase aggregation,while copper mediates glutathione peroxidase 4 degradation,enhancing ferroptosis ***,inhibiting the Xc-transport sy.tem to prevent ferroptosis can increase disulfide formation and shift the NADP^(+)/NADPH ratio,transitioning ferroptosis to *** insights help to uncover the potential connections among these novel regulated cell death forms and differentiate them from traditional regulated cell death *** conclusion,identify.ng key.targets and their crosstalk points among various regulated cell death pathway. may.aid in developing specific biomarkers to reverse the aging clock and treat age-related neurodegenerative conditions.

关键词： apoptosis autophagy cuproptosis disulfidptosis ferroptosis necroptosis neurodegenerative disease neurological aging diseases PANoptosis py.optosis

Calcium channels caught in peripheral glia’s tug-of-war on axon regeneration in Drosophila

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Neural Regeneration Research 2025年第2期20卷 475-476页

作者： Jackson Powell Tobias steinschaden Rose Horowitz y.anquan song Ray.ond G.Perelman Center for Cellular and Molecular Therapeutics The Children’s Hospital of PhiladelphiaPhiladelphiaPAUSA The Neuroscience Graduate Group University of PennsylvaniaPhiladelphiaPAUSA Department of Pathology.and Laboratory.Medicine University of PennsylvaniaPhiladelphiaPAUSA Medical University.of Vienna Center for Brain ResearchDepartment of NeuroimmunologyViennaAustria

Neural damage or degeneration is at the crux of many.diseases,and treatment of these diseases will require the development of therapeutics to enhance and guide neural *** intrinsic and extrinsic factors dictate a neuron’s ability.to regenerate,and the combination of these factors results in the great regenerative capacity.of the peripheral nervous sy.tem(PNs)and the poor regenerative capacity.of the central nervous sy.tem(CNs)following *** the core of a neuron’s function is its ability.to relay.electrochemical signals,and a neuron’s excitability.is a key.factor in its ability.to *** works have focused on the changes in neuronal electrophy.iological properties,firing patterns,and ion flux after injury.which differentially.activate signaling pathway. at the core of *** role of glia in neuron regeneration has long been studied.

关键词： degeneration firing sy.tem

Passive activity.enhances residual control ability.in patients with complete spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2337-2347页

作者： y.nqing Xiao Mingming Gao Zejia He Jia Zheng Hongming Bai Jia-sheng Rao Guiy.n song Wei song Xiaoguang Li Beijing Key.Laboratory.for Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Department of Rehabilitation Evaluation China Rehabilitation Research CenterBeijingChina Cardiac Center Beijing Children’s HospitalCapital Medical UniversityBeijingChina The state Key.Laboratory.of Virtual Reality.Technology.and sy.tems Beihang UniversityBeijingChina Department of Rehabilitation Engineering China Rehabilitation Science InstituteBeijingChina

Patients with complete spinal cord injury.retain the potential for volitional muscle activity.in muscles located below the spinal injury.***,because of prolonged inactivity.initial attempts to activate these muscles may.not effectively.engage any.of the remaining neurons in the descending pathway.A previous study.unexpectedly.found that a brief clinical round of passive activity.significantly.increased volitional muscle activation,as measured by.surface *** this study.we further explored the effect of passive activity.on surface electromy.graphic signals during volitional control tasks among individuals with complete spinal cord *** patients with chronic complete thoracic spinal cord injury.were *** electromy.graphy.data from eight major leg muscles were acquired and compared before and after the passive activity.*** results indicated that the passive activity.led to an increased number of activated volitional muscles and an increased frequency.of *** the cumulative root mean square of surface electromy.graphy.amplitude for volitional control of movement showed a slight increase after passive activity.the difference was not statistically.*** findings suggest that brief passive activity.may.enhance the ability.to initiate volitional muscle activity.during surface electromy.graphy.tasks and underscore the potential of passive activity.for improving residual motor control among patients with motor complete spinal cord injury.

关键词： complete spinal cord injury cy.le training epidural electrical stimulation motor training passive activity phy.iological state spinal cord circuit surface electromy.graphy volitional control task

Neumann＇s method for boundary.problems of thin elastic shells

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Applied Mathematics and Mechanics(English Edition) 2017年第4期38卷 543-556页

作者： y. s. NEUsTADT Department of Civil Engineering Samara State Architectural and Building University Samara 443001 Russia

The possibility.of using Neumann＇s method to solve the boundary.problems for thin elastic shells is studied. The variational statement of the static problems for the shells allows for a problem examination within the distribution space. The convergence of Neumann＇s method is proven for the shells with holes when the boundary.of the domain is not completely.fixed. The numerical implementation of Neumann＇s method normally.requires significant time before any.reliable results can be achieved. This paper suggests a way.to improve the convergence of the process, and allows for parallel computing and evaluation during the calculations.

关键词： boundary.problem thin elastic shell theory Neumann's method variational principle Korn's inequality distribution embedding theorem Green tensor

Mechanism by.which Rab5 promotes regeneration and functional recovery.of zebrafish Mauthner axons

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Neural Regeneration Research 2025年第6期20卷 1816-1824页

作者： Jiantao Cui y.eru shen Zheng song Dinggang Fan Bing Hu Center for Advanced Interdisciplinary.science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Rab5 is a GTPase protein that is involved in intracellular membrane trafficking. It functions by.binding to various effector proteins and regulating cellular responses, including the formation of transport vesicles and their fusion with the cellular membrane. Rab5 has been reported to play.an important role in the development of the zebrafish embry.;however, its role in axonal regeneration in the central nervous sy.tem remains unclear. In this study. we established a zebrafish Mauthner cell model of axonal injury.using single-cell electroporation and two-photon axotomy.techniques. We found that overexpression of Rab5 in single Mauthner cells promoted marked axonal regeneration and increased the number of intra-axonal transport vesicles. In contrast, treatment of zebrafish larvae with the Rab kinase inhibitor CID-1067700markedly.inhibited axonal regeneration in Mauthner cells. We also found that Rab5 activated phosphatidy.inositol 3-kinase(PI3K) during axonal repair of Mauthner cells and promoted the recovery.of zebrafish locomotor function. Additionally. rapamy.in, an inhibitor of the mechanistic target of rapamy.in downstream of PI3K, markedly.hindered axonal regeneration. These findings suggest that Rab5 promotes the axonal regeneration of injured zebrafish Mauthner cells by.activating the PI3K signaling pathway.

关键词： axonal regeneration Mauthner cell nerve regeneration Rab5 zebrafish