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Microsy.tems & Nanoengineering 2024年第2期10卷 133-141页

作者： Tatsuy. Fukuta Ry. Kato Takuo Tanaka Taka-aki yano Institute of Post-LED Photonics Tokushima University2-1 Minami-JosanjimaTokushima770-8506Japan Innovative Photon Manipulation Research Team RIKEN Center for Advanced PhotonicsWakoSaitama351-0198Japan Metamaterials Laboratory RIKEN Cluster for Pioneering ResearchWakoSaitama351-0109Japan

Silicon nanostructures with unique Mie resonances have garnered considerable attention in the field of ***,we present a simple and efficient method for the fabrication of silicon(Si)nanoparticle substrates using continuous-wave(CW)laser *** resulting silicon nanoparticles exhibit Mie resonances in the visible region,and their resonant wavelengths can be precisely.***,laser-annealed silicon nanoparticle substrates show a 60-fold enhancement in *** tunable and fluorescence-enhancing silicon nanoparticle platform has tremendous potential for highly.sensitive fluorescence sensing and biomedical imaging applications.

关键词： nanoparticles annealing resonant

Current hepatitis B virus infection situation in Indonesia and its genetic diversity

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World Journal of Gastroenterology 2016年第32期22卷 7264-7274页

作者： Maria Inge Lusida Juniastuti y.shihiko yano Institute of Tropical Disease Airlangga Health Science Institute Airlangga University Department of Microbiology.Faculty.of Medicine Airlangga University Center for Infectious Diseases Kobe University Graduate School of Medicine

Indonesia has a moderate to high endemicity.of hepatitis B virus(HBV) infection. The risk for chronic HBV infection is highest among those infected during infancy. Since 1997, hepatitis B(Hep B) vaccination of newborns has been fully.integrated into the National Immunization Program. Al though HBV infection has been reduced by.the universal newborn Hep B immunization program, it continues to occur in Indonesia. The low birth dose coverage and the presence of vaccine escape mutants might contribute to this endemicity.among children. Although limited information is available for an analy.is of occult HBV infection(OBI), several variations and substitutions in the pre-S/S region have been detected in Indonesian HBV strains. Additionally. persistent infection and disease progression of chronic hepatitis B are related to not only.viral factors but also the host genome. Indonesia is one of the most ethnically.heterogeneous nations, with Javanese and Sundanese as the two highest ethnic groups. This multi-ethnicity.makes genomic research in Indonesia difficult. In this article, we focused on and reviewed the following aspects: the current hepatitis B immunization program and its efficacy. OBI, HBV infection among high-risk patients, such as hemodialy.is patients, and research regarding the host genome in Indonesia.

关键词： Hepatitis B virus Immunization Occult infection Hemodialy.is Indonesia

Oncogenic role of p21 in hepatocarcinogenesis suggests a new treatment strategy

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World Journal of Gastroenterology 2015年第42期21卷 12150-12156页

作者： Shogo Ohkoshi Masahiko yano y.sunobu Matsuda Department of Internal Medicine School of Life Dentistry at Niigata The Nippon Dental University Division of Gastroenterology.and Hepatology Graduate School of Medical and Dental Sciences Niigata University

A well-known tumor suppressor, p21, acts parado-xically.by.promoting tumor growth in some cellular conditions. These conflicting functions have been demonstrated in association with the HBx gene and in hepatocarcinogenesis. The molecular behavior of p21 depends on its subcellular localization. Nuclear p21 may.inhibit cell proliferation and be proapoptotic, while cy.oplasmic p21 may.have oncogenic and anti-apoptotic functions. Because most ty.ical tumor suppressive proteins also have different effects according to subcellular localization, elucidating the regulatory.mechanisms underly.ng nucleo-cy.oplasmic transport of these proteins would be significant and may.lead to a new strategy.for anti-hepatocellular carcinoma(HCC) therapy. Chromosome region maintenance 1(CRM1) is a major nuclear export receptor involved in transport of tumor suppressors from nucleus to cy.oplasm. Expression of CRM1 is enhanced in a variety.of malignancies and in vitro studies have shown the efficacy.of specific inhibition of CRM1 against cancer cell lines. Interestingly. interferon may.keep p21 in the nucleus; this is one of the mechanisms of its anti-hepatocarcinogenic function. Here we review the oncogenic property.of p21, which depends on its subcellular localization, and discuss the rationale underly.ng a new strategy.for HCC treatment and prevention.

关键词： p21 Tumor suppressors Oncogene Subcellular localiz

Variability.in salt flux and water circulation in Ota River Estuary. Japan

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Water Science and Engineering 2013年第3期6卷 283-295页

作者： Mohammad SOLTANIASL Kiy.si KAWANISI Junki yano Kazuhiko ISHIKAWA Department of Civil and Environmental Engineering Graduate School of Engineering Hiroshima University

In this study.the sub-tidal and intra-tidal variations of salt fluxes in the upstream section of a shallow estuary.（with a water depth of less than 3 m） were investigated. The salt fluxes were estimated based on the cross-sectional average salinity.and velocity.measured by.the fluvial acoustic tomography.sy.tem （FATS）. The results indicate that the magnitude of seaward fluxes is approximately.two times greater than that of landward fluxes under normal conditions. The results of short-term observation in the study.area indicate that there is a phase lag of the bottom and surface salinities between the regions with the largest and smallest depths. The vertical shear flux with a peak value of-0.7 m2/s during the ebb tide indicated an important contribution to the total salt flux compared with the advective flux. A phase lag occurred between the vertical shear terms in the regions with the largest and smallest depths, which resulted from the correlation between the vertical variations of the salinity.and velocity.and the existence of transversal velocity.circulations.

关键词： salt flux circulation fluvial acoustic tomography.sy.tem (FATS) Ota River Estuary

Effect of Intertidal Elevation at Tsuy.zaki Cove,Fukuoka,Japan on Survival Rate of Horseshoe Crab Tachy.leus tridentatus Eggs

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Journal of Ocean University.of China 2022年第3期21卷 601-610页

作者： ITAy. Shinji SHUUNO Mari ONIKURA Norio TAI Akira yano Shinichiro Environmental Fluid Dy.amics Laboratory Department of Urban and Environmental EngineeringGraduate School of EngineeringKyushu UniversityFukuoka819-0395Japan Tsuy.zaki Seaside Nature School Fukutsu811-3304Japan Fishery.Research Laboratory Department of Bioresource ScienceGraduate School of Bioenvironmental ScienceKyushu UniversityFukuoka819-0395Japan

Phy.ical factors affecting the survival of Tachy.leus tridentatus eggs were investigated by.translocating their eggs between the high intertidal zone and the low intertidal zone of a known spawning *** mean egg survival rates per day.were highest in the mid intertidal zone(45.1%±25.4%)and the lowest in the low intertidal zone(13.3%±27.6%).Differences in the elevation,air exposure time,and water content of the spawning ground were significant factors determining the egg survival *** or insufficient air exposure time resulted in inadequate water content at higher and lower intertidal zones and could reduce egg *** the other hand,moderate saturation and dehy.ration were repeated with each tidal movement in the mid intertidal *** dy.amic is considered as one of the crucial factors for the survival of eggs and is considered optimal for ***,the protection of the mid intertidal zone is imperative for maximizing the egg survival rate in Tsuy.zaki Cove where almost all suitable nesting sites have disappeared due to coastal *** protecting these optimal sites for spawning and recovering other optimal sites on suitable beaches,a positive contribution can be made to future management and *** study.also suggests that translocating eggs from marginal to optimal spawning sites might be a recovery.strategy.for this globally.endangered species.

关键词： air exposure time globally.endangered species intertidal elevation intertidal zone optimal spawning site Tachy.leus tridentatus translocated horseshoe crab eggs Tsuy.zaki Cove

Effect of Injection Position on In-Flight Melting Behavior of Granular Alkali-Free Glass Raw Material in 12-Phase AC Arc Plasma

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Plasma Science and Technology 2009年第6期11卷 699-703页

作者：姚耀春 K.y.TSUDA T.WATANABE T.yano National Engineering Laboratory.of Vacuum Metallurgy Kunming University of Science and Technology Department of Environmental Chemistry.and Engineering Tokyo Institute of TechnologyYokohama 226-8502Japan Department of Chemistry.and Materials Science Tokyo Institute of TechnologyTokyo 152-8550Japan

An innovative in-flight glass melting technology.with a multi-phase AC arc plasma was developed to save energy.and reduce emissions for the glass industry. The effect of the injection position on the in-flight melting behavior of granulated powders was investigated. Results show that the injection position has a strong effect on the melting behavior of alkali-free glass raw material. With the increase in injection distance, the vitrification, decomposition, and particle shrinkage of initial powders are improved. Longer injection distance causes much energy.to transfer to particles due to a longer residence time of powder in the high temperature zone. The high vitrification and decomposition degrees indicate that the new in-flight melting technology.with 12-phase AC arc can substantially.reduce the melting and refining time for glass production.

关键词： 12-phase AC arc plasma in-flight melting technology heat transfer glass production

Influence of oxy.en exposure on instabilities of perfluoropentacene transistor characteristics with different gate insulators

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Progress in Natural Science:Materials International 2011年第1期21卷 12-16页

作者： Hideharu UEKI Hiroaki yano Hirokuni OHUCHI y.taro TAKAy.NAGI y.sushiro NISHIOKA Department of Precision Machinery College of Science and TechnologyNihon UniversityChiba 274-8501Japan

Pentacene for p-channel organic field effect transistors（OTFTs） and perfluoropentacene for n-channel OTFTs have attracted strong attentions to be used as CMOS ty.e organic semiconductor materials for flexible organic display..n-channel OTFTs with different gate insulators of poly.mide（PI） and SiO2and perfluoropentacene as a semiconductor lay.r were fabricated,and their instability.of the transistor characteristics measured in air,vacuum and oxy.en was *** results show that both of the transistors exhibit a significant increase of mobility.when measured in ***,the mobility.of the transistors is significantly.reduced when measured in pure oxy.en,and the threshold voltages continuously.*** phenomena may.be related to water diffusion into the perfluoropentacene/gate insulator interface in air and oxidation of perfluoropentacene in oxy.en.

关键词： oxy.en exposure OTFT perfluoropentacene gate insulator poly.mide SiO2

Variations and mutations in the hepatitis B virus genome and their associations with clinical characteristics

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World Journal of Hepatology 2015年第3期7卷 583-592页

作者： y.shihiko yano Takeshi Azuma y.shitake Hay.shi Department of Gas-troenterology Kobe University Graduate School of Medicine Center for Infectious Diseases Kobe University Graduate School of Medicine

Hepatitis B virus(HBV) infection is major global issue, because chronic HBV infection is strongly.associated with liver cancer. HBV spread worldwide with variousmutations and variations. This variability. called quasispecies, is derived from no proof-reading capacity.of viral reverse transcriptase. So far, thousands of studies reported that the variety.of genome is closely.related to the geographic distribution and clinical characteristics. Recent technological advances including capillary.sequencer and next generation sequencer have made in easier to analy.e mutations. The variety.of HBV genome is related to not only.antigenicity.of HBs-antigen but also resistance to antiviral therapies. Understanding of these variations is important for the development of diagnostic tools and the appropriate therapy.for chronic hepatitis B. In this review, recent publications in relation to HBV mutations and variations are updated and summarized.

关键词： Hepatitis B virus Mutation Quasispecies

Design and evaluation of an extended-release matrix tablet formulation; the combination of hy.romellose acetate succinate and hy.roxy.ropy.cellulose

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Asian Journal of Pharmaceutical Sciences 2017年第2期12卷 149-156页

作者： Sachiko Fukui Hideki yano Shuichi y.da Tsuy.shi Mikkaichi Hidemi Minami Formulation Technology.Research Laboratories Daiichi Sankyo Co.Ltd.1-2-58HiromachiShinagawa-kuTokyo 140-8710Japan Drug Metabolism&Pharmacokinetics Research Laboratories Daiichi Sankyo Co.Ltd.1-2-58HiromachiShinagawa-kuTokyo 140-8710Japan

The purpose of this study.was to develop an extended-release(ER) matrix tablet that shows robust dissolution properties able to account for the variability.of pH and mechanical stress in the GI tract using a combination of enteric poly.er and hy.rophilic poly.er. Hy.romellose acetate succinate(HPMCAS) and hy.roxy.ropy.cellulose(HPC) were selected as ER poly.ers for the ER matrix tablet(HPMCAS/HPC ER matrix tablet). Oxy.odone hy.rochloride was employ.d as a model drug. Dissolution properties of the HPMCAS/HPC ER matrix tablets were evaluated and were not affected by.the pH of the test medium or paddle rotating *** a USP apparatus 3(bio-relevant dissolution method), dissolution profiles of the HPMCAS/HPC ER matrix tablets containing oxy.odone hy.rochloride were similar to that of the reference product(Oxy. ontin). Moreover, in vivo performance after oral administration of the HPMCAS/HPC ER matrix tablets to humans was simulated by.GastroP lus based on dissolution profiles from the USP apparatus 3. The plasma concentration-time profile simulated was similar to that of the reference product. These results suggest that the combination of HPMCAS and HPC shows a robust dissolution profile against pH and paddle rotating speed and indicates the appropriate extended-release profile in humans.

关键词： Extended-release matrix tablet Hy.romellose acetate succinate Hy.roxy.ropy.cellulose Robust dissolution USP apparatus 3

Application of In-Flight Melting Technology.by.RF Induction Thermal Plasmas to Glass Production

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Plasma Science and Technology 2008年第3期10卷 344-347页

作者：姚耀春 M.M.HOSSAIN T.WATANABE F.FUNABIKI T.yano National Engineering Laboratory.of Vacuum Metallurgy Kunming University of Science and Technology Kunming 650093 China Department of Environmental Chemistry and Engineering Tokyo Institute of Technology Yokohama 226-8502 Japan Department of Environmental Chemistry.and Engineering Tokyo Institute of TechnologyYokohama 226-8502 Japan Department of Chemistry.and Materials Science Tokyo Institute of Technology Tokyo 152-8550 Japan

An innovative in-flight glass melting technology.with induced thermal plasmas was developed for the purpose of energy.conservation and environmental protection. Two-dimensional modeling was used to simulate the thermofluid fields in the plasma torch. The in-flight melting behavior of glass raw material was investigated by.various analy.is methods. Results showed that the plasma temperature was up to 10000 K with a maximum velocity.over 30 m/s, which made it possible to melt the granulated glass raw material within milliseconds. The carbonates in the raw material decomposed completely.and the compounds in the raw material attainted 100% vitrification during the in-flight time from the nozzle exit to substrate. The particle melting process is similar to the unreacted-core shrinking model.

关键词： induced thermal plasmas in-flight melting plasma heat transfer glass production