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Oral administration of S-nitroso-N-acety.cy.teine prevents the onset of non alcoholic fatty.liver disease in rats

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World Journal of Gastroenterology 2006年第12期12卷 1905-1911页

作者： Claudia PMS de Oliveira Fernanda I Simplicio Vicencia MR de Lima Katia y.ahasi Fabio P Lopasso Venancio AF Alves Dulcinéia SP Abdalla Flair J Carrilho Francisco RM laurindo Marcelo G de Oliveira University.of Sāo Paulo School of Medicine Department of Gastroenterology Saoo Paulo SP Brazil School of Medicine Department of Pathology Sāo Paulo SP Brazil University.of So Paulo Medical School Heart Institute InCor Sāo Paulo SP Brazil University.of Sāo Paulo School of Pharmaceutical Sciences Department of Clinical and Toxicological Analysis Sao Paulo SP Brazil State University.of CamDinas. Chemistry.Department. Campinas. SE Brazil

AIM： To evaluate the potential of S-nitroso-N-acety.cy.teine （SNAC） in inhibition of lipid peroxidation and the effect of oral SNAC administration in the prevention of nonalcoholic fatty.liver disease （NAFLD） in an animal model.METHODS： NAFLD was induced in Wistar male rats by.choline-deficient diet for 4 wk. SNAC-treated animals （n=6）（1.4 mg/kg/day.of SNAC, orally. were compared to 2 control groups： one （n=6） received PBS solution and the other （n=6） received NAC solution （7 mg/kg/d）. Histological variables were semiquantitated with respect to macro and microvacuolar fat changes, its zonal distribution, foci of necrosis, portal and perivenular fibrosis, and inflammatory.infiltrate with zonal distribution. LOOHs from samples of liver homogenates were quantified by.HPLC. Nitrate levels in plasma of portal vein were assessed by.chemiluminescence. Aqueous low-density.lipoprotein （LDL） suspensions （200 pg protein/mL） were incubated with CuCl2 （300 μmol/L） in the absence and presence of SNAC （300 μmol/L） for 15 h at 37 ℃ Extent of LDL oxidation was assessed by.fluorimetry. Linoleic acid （la）（18.8 μmol/L） oxidation was induced by.soy.ean lipoxy.enase （SLO）（0.056 μmol/L） at 37 ℃ in the presence and absence of N-acety.cy.teine （NAC） and SNAC （56 and 560 pmol/L） and monitored at 234 nm. RESULTS： Animals in the control group developed moderate macro and microvesicular fatty.changes in periportal area. SNAC-treated animals display.d only.discrete histological alterations with absence of fatty.changes and did not develop liver steatosis. The absence of NAFLD in the SNAC-treated group was positively.correlated with a decrease in the concentration of LOOH in liver homogenate, compared to the control group （0.7±0.2 nmol/mg vs 3.2±0.4 nmol/mg protein, respectively. P〈0.05）, while serum levels of aminotransferases were unaltered. The ability.of SNAC in preventing lipid peroxidation was confirmed in in vitro experiments using la and LDL as model substrates. CONCLUSION： Oral

关键词： Nitric oxide S-nitroso-N-acety.cy.teine Oxidative stress Nonalcoholic fatty.liver disease

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安阳隋墓发掘报告

考古学报 1981年第3期 369-406+423-432页

作者： The Any.ng Archaeological Team of ia,CASS 中国社会科学院考古研究所安阳工作队

1966年至1975年,我队在殷墟先后发掘隋墓二十九座。其中有1973年在小屯村南地发掘十座,同年秋在小屯村北马家坟发掘二座;1966年夏在大司空村豫北纱厂西侧发掘六座;1974年春在梅园庄北地安阳钢厂东南边发掘九座;1975年夏在孝民屯安阳钢... 详细信息

1966年至1975年,我队在殷墟先后发掘隋墓二十九座。其中有1973年在小屯村南地发掘十座,同年秋在小屯村北马家坟发掘二座;1966年夏在大司空村豫北纱厂西侧发掘六座;1974年春在梅园庄北地安阳钢厂东南边发掘九座;1975年夏在孝民屯安阳钢厂东北边发掘二座(图一)。上述五处墓葬以小屯村南地和梅园庄北地分布比较密集,且排列有序(图二)。先后参加这一工作的有杨锡璋、戴彤心、刘一曼、曹定云、王金龙、杨宝成、屈如忠、孙秉根。吉林大学历史系姚孝遂同志也参加了部分发掘工作。

关键词：武士俑发掘报告隋墓墓室图版随葬品随葬器物基址墓道埏道明器女侍俑安阳河南

基于欧洲标准研究内部硫酸盐反应对混凝土体积稳定性的影响

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新型建筑材料 2017年第6期44卷 5-8页

作者：向卫平兰聪陈景刘云鹏王发洲中建西部建设西南有限公司四川成都610052 武汉理工大学硅酸盐材料国家重点实验室湖北武汉430070

基于欧洲标准并采用残余膨胀试验和SEM测试方法,通过胶凝材料体系的组成差异,研究了内部硫酸盐反应对混凝土体积稳定性的影响并分析了其机理。结果表明:内部硫酸盐反应对混凝土体积稳定性存在影响,而胶凝体系中C_3A越多,能与体系或渗入... 详细信息

基于欧洲标准并采用残余膨胀试验和SEM测试方法,通过胶凝材料体系的组成差异,研究了内部硫酸盐反应对混凝土体积稳定性的影响并分析了其机理。结果表明:内部硫酸盐反应对混凝土体积稳定性存在影响,而胶凝体系中C_3A越多,能与体系或渗入的硫酸盐反应生成AFt和AFm就越多,内部硫酸盐反应将更剧烈;AFt水化产物主要在混凝土孔隙中生成并生长;而AFm主要与CSH凝胶胶结生成;而内部硫酸盐反应使混凝土产生体积膨胀,主要是AFm转化为AFt时体积膨胀所致。

关键词：内部硫酸盐反应体积稳定性扫描电镜钙矾石

Brief potentially.ictal rhy.hmic discharges on intraoperative electrocorticography.predict a good outcome of focal cortical dy.plasia after surgical resection: a case report

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Acta Epileptologica 2023年第3期6卷 163-167页

作者： Sofía S.Sánchez‑Boluarte Wilfor Aguirre‑Quispe Manuel Herrera Aramburú William O.Tatum Walter De la Cruz Ramírez School of Medicine Cesar Vallejo UniversityAv.Victor LarcoTrujilloTrujillo 1770Peru Departamento de Epilepsia Instituto Nacional de Ciencias NeurológicasJr.Ancash 1271LimaLima 15001Peru Neurosciences Clinical Effectiveness and Public Health Research GroupUniversidad Científica del SurPanamericana Sur 19Villa EL SalvadorLimaLima 15067Peru Department of Neurology Mayo ClinicMangurian Bldg.Fourth Floor4500 San Pablo RoadFL 32224 JacksonvilleUSA

Background Focal cortical dy.plasia(FCD)is a common cause of drug-resistant ***(EEG)biomarkers that predict good postoperative outcomes are essential for identify.ng patients with focal *** presentation We report the case of a 21-y.ar-old female with seizure onset at the age of 9,characterized by.left-hand dy.tonic posturing and impaired awareness,which evolved to bilateral tonic-clonic seizures,evaluated in a neurological referral center in Lima,*** 6-h video-EEG,interictal EEG revealing focal brief potentially.ictal rhy.hmic discharges(BIRDs)over the right frontal central region,lasting less than 10 *** ictal features were characterized by.low-voltage fast activity.over the same *** magnetic resonance imaging(MRI)demonstrated a focal lesion of focal cortical dy.plasia ty.e II in the right frontal *** patient underwent a lesionectomy.guided by.electrocorticography.which showed continuous *** showing a brief burst of spikes lasting longer than 0.5 s,were also identified on intraoperative electrocorticography.ECoG)and helped define the extent of *** patient obtained an Engel Outcome Class ia at 6 y.ars of *** The aty.ical BIRDs on ECoG can be used as a prognostic biomarker for prolonged seizure-freedom outcome in patients with *** reports are needed in developing countries with and without brain MRI lesions to advance outpatient presurgical evaluations despite limited resources.

关键词： Electrocorticography Cortical dy.plasia-focal epilepsy.sy.drome Drug-resistant epilepsy Frontal lobe epilepsy

Phy.ical-Mechanical Properties of Germanium Doped Monocry.talline Silicon

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材料科学与工程（中英文A版） 2013年第10期3卷 698-703页

作者： la Kurashvili ia Ekaterine Sanaia George Darsavelidze Guram Bokuchava Avtandil Sichinava iasha Tabatadzeand Vladimer Kuchukhidze Ilia Vekua Sukhumi Institute of Phy.ics and Technology Tbilisi 0186 Georgia

Monocry.talline Si-Ge alloy. have expected applications as a photo-detector, an X-ray.and neutron monochromator, a solar cell and a lattice-matched substrate for SiGe epitaxial growth instead of Si. Complex study.ng of bulk Si-Ge specimens is important for a problem of controlling of their structure and phy.ical characteristics. Present work deals with the investigations of microstructure, electrophy.ical characteristics, microhardness and amplitude dependences of internal friction and shear modulus of Si 1-x -Ge x (x ≤ 0.02) bulk single cry.tals. Si-Ge bulk cry.tals were grown by.Czochralski method in [111] cry.tallographic direction. Investigated monocry.talline Si and Si-Ge samples are characterized by.n- and p-ty.e conductivities, respectively. their carriers concentration varies in interval 5 ? 10 14 -1 ? 10 15 cm -3, dislocation density.5 ? 10 3 -1 ? 10 4 cm -2, and shear modulus 4,650-4,950 kgf/mm 2. Internal friction and dy.amic shear modulus amplitude dependences were studied at 20 and 650 °C temperatures. Multistage changes of inelastic characteristics were revealed in a wide interval of torsion oscillation amplitudes. The values of critical strain amplitude and elastic limit at the shear stress were determined. It is shown, that increasing of Ge concentration causes decrease of noticed characteristics. Observed changes are discussed from the point of view of interaction of various dislocations with point defects and their complexes in a real structure of monocry.talline Si-Ge alloy..

关键词：单晶硅物理机械性能硅锗动剪切模量掺杂微观结构外延生长载体浓度

Nitric oxide and cancer

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World Journal of Hepatology 2010年第9期2卷 337-344页

作者： Jordi Muntané Manuel De la Mata Liver Research Unit Maimonides Institute for Biomedical Research of Cordoba (IMIBIC)"Reina Sofia" University Hospital Biomedical Research Network Center for Liver and Digestive Diseases (CIBERehd) Digestive Clinical Unit Maimonides Institute for Biomedical Research of Cordoba (IMIBIC)"Reina Sof ia" University Hospital

Nitric oxide (NO) is a lipophilic,highly.diffusible and short-lived phy.iological messenger which regulates a variety.of important phy.iological responses including va sodilation,respiration,cell migration,immune resp onse and *** is sy.thesized by.three differ entially.gene-encoded NO sy.thase (NOS) in mammals: neuronal NOS (nNOS or NOS-1),inducible NOS (iNOS or NOS-2) and endothelial NOS (eNOS or NOS-3).All isof or ms of NOS cataly.e the reaction of L-arginine,NA DPH and oxy.en to NO,L-citrulline and *** may.exert its cellular action by.cGMP-dependent as well as by.cGMP-independent pathway. including postranslational modifications in cy.teine (S-nitrosy.ation or S-nit rosation) and ty.osine (nitration) residues,mixed disulf ide formation (S-nitrosoglutathione or GSNO) or prom ot ing further oxidation protein stages which have been related to altered protein function and gene transcription,genotoxic lesions,alteration of cell-cy.le check points,apoptosis and DNA *** sensitizes tumor cells to chemotherapeutic *** expression of NOS-2 and NOS-3 has been found to be increased ina variety.of human *** multiple actions of NO in the tumor environment is related to heterogeneous cell responses with particular attention in the regulation of the stress response mediated by.the hy.oxia inducible factor-1 and p53 generally.leading to growth arrest,apoptosis or adaptation.

关键词： Nitric oxide Cancer Carcinogenesis

Ty.e XIX collagen: a promising biomarker from the basement membranes

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Neural Regeneration Research 2020年第6期15卷 988-995页

作者： Ana C.Calvo laura Moreno Leticia Moreno Janne M.Toivonen Raquel Manzano Nora Molina Miriam de la Torre Tresa López Francisco J.Miana-Mena María J.Munoz Pilar Zaragoza Pilar larrodé Alberto García-Redondo Rosario Osta laboratory.of Genetics and Biochemistry.laGENBIO) University of ZaragozaFaculty of Veterinary SciencesInstituto de Investigación Sanitaria de Aragón(IIS)IA2CIBERNEDZaragozaSpain Hospital Clínico Universitario Lozano Blesa ZaragozaSpain Neurology.Department ALS UnitCIBERER U-723Health Research InstituteMadridSpain

Among collagen members in the collagen superfamily.ty.e XIX collagen has raised increasing interest in relation to its structural and biological *** XIX collagen is a Fibril-Associated Collagen with Interrupted Triple helices member,one main subclass of collagens in this *** collagen contains a triple helix composed of three poly.eptide segments aligned in parallel and it is associated with the basement membrane zone in different *** molecular structure of ty.e XIX collagen consists of five collagenous domains,COL1 to COL5,interrupted by.six non-collagenous domains,NCI to *** most relevant domain by.which this collagen exerts its biological roles is NCI domain that can be cleavage enzy.atically.to release matricry.tins,exerting anti-tumor and anti-angiogenic effect in murine and human models of *** phy.iological conditions,ty.e XIX collagen expression decreases after birth in different tissues although it is necessary.to keep its basal levels,mainly.in skeletal muscle and hippocampal and telencephalic interneurons in ***,in amy.trophic lateral sclerosis,altered transcript expression levels show a novel biological effect of this collagen bey.nd its structural role in basement membranes and its anti-tumor and anti-angiogenic *** XIX collagen can exert a compensatory.effect to ameliorate the disease progression under neurodegenerative conditions specific to amy.trophic lateral sclerosis in transgenic SOD1 G93 A mice and amy.trophic lateral sclerosis *** novel biological role highlights its nature as prognostic biomarker of disease progression in and as promising therapeutic target,paving the way.to a more precise prognosis of amy.trophic lateral sclerosis.

关键词： anti-tumor and anti-angiogenic properties C1 domain COL19A1 gene and protein levels compensatory.effect FACIT collagens hippocampal interneurons matricry.tins multiplexins NC1 domain regenerative response skeletal muscle ty.e XIX collagen

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沧东凹陷带的结构及勘探前景

石油学报 1989年第3期10卷 31-39页

作者：李志文大港石油管理局

长期以来,人们普遍认为,沧东凹陷带属结构简单的箕状断陷,油气运移指向缓坡隆起,对缓坡带给予重视,而对凹陷中心及陡坡带则置于次要地位。这种倾向的产生、源于对凹陷内幕了解不够。事实上、据笔者结合近年地震剖面和有关钻探成果分析,... 详细信息

长期以来,人们普遍认为,沧东凹陷带属结构简单的箕状断陷,油气运移指向缓坡隆起,对缓坡带给予重视,而对凹陷中心及陡坡带则置于次要地位。这种倾向的产生、源于对凹陷内幕了解不够。事实上、据笔者结合近年地震剖面和有关钻探成果分析,证明其内幕亦很复杂,既有前第三系的基岩隆起,也有第三纪以来形成的基岩阶地和与之相关的盖层圈闭,为寻找多种类型油气藏奠定了基础。沧东凹陷带的结构同第三系沉积前的古构造背景及第三纪以来的块断活动有关,印支—燕山期因太平洋板块作北西向挤压,形成北东向的背斜隆起,隆起部位大致对应现今的沧东断裂带,隆起顶部因受压上隆产生张裂系,地层遭受剥蚀。第三纪始,沿顶部张裂系自东而西被拉张下滑,并被同期的沉积所披盖形成沧东凹陷带。显然这类凹陷的基底同沉积盖层关系密切;凹陷缓坡基底对应于古隆起东翼,由中生界—古生界地层组成,始新世被拉张,上覆始新统地层,构成黄骅断陷中央隆起带西北翼,前第三系地层下倾尖灭,第三系盖层上倾断超减薄,有利于基岩断块油藏和盖层背斜油藏的形成;凹陷中心基底则对应于古隆起顶,受剥强烈,中生界与古生界有的地区缺失,渐新世被拉张,上覆渐新统地层,形成古高今低的断阶结构,有利于新生古储油藏的形成;凹陷陡坡基底是由不同时代地层组成的断面斜坡,形态复杂。上覆地层自下而上断超于其上,若上倾方向封堵条件好,基底可形成古地貌油藏,盖层可形成构造岩性油藏;而古隆起西北翼则属于现今沧县隆起和文安斜坡基底的组成部分。沧东凹陷带的这个结构,不仅为凹陷缓坡开阔了找油领域,同时也为凹陷中心和陡坡带的勘探展示了美好的前景。

关键词：沧东凹陷带结构圈闭油气藏

后颅窝血管母细胞瘤CT、MRI表现及临床病理学研究

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陕西医学杂志 2017年第6期46卷 737-739页

作者：刘佳李连翔崔晓景治涛中国医科大学第一附属医院神经外科沈阳110001

目的:探讨后颅窝血管母细胞瘤的CT、MRI及病理特点。方法:回顾性分析经病理证实的55例手术治疗的后颅窝血管母细胞瘤的临床症状、CT、MRI以及病理特点。结果:囊结节型CT多为低密度影,瘤结节为高密度影;MRI中囊液多表现为长T1、长T2信号... 详细信息

目的:探讨后颅窝血管母细胞瘤的CT、MRI及病理特点。方法:回顾性分析经病理证实的55例手术治疗的后颅窝血管母细胞瘤的临床症状、CT、MRI以及病理特点。结果:囊结节型CT多为低密度影,瘤结节为高密度影;MRI中囊液多表现为长T1、长T2信号,瘤结节多表现为等T1、等或长T2信号,增强均匀。实质型肿瘤CT呈高密度影或混杂密度影,呈TIW等信号,T2W等或高信号,增强后明显均匀强化。结论:后颅窝血管母细胞瘤具有自身独特的影像学特征结合临床特点可与其他肿瘤进行鉴别。

关键词：血管母细胞瘤/诊断磁共振成像/方法体层摄影术,X线计算机/方法