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打浆釜内流场和功率特性数值模拟研究

广东化工 2024年第13期51卷 85-89,84页

作者：雷强方锦坤姜苏俊曹民黄江辉珠海万通特种工程塑料有限公司广东珠海519050 金发科技股份有限公司广东广州510663

针对打浆釜内颗粒悬浮和搅拌功耗问题,本文采用计算流体力学(Computational Fluid Dy.amics,CFD)方法,应用欧拉-欧拉双流体模型,对打浆釜内的流场和搅拌功率特性进行了数值模拟分析。得到了打浆釜内单相速度场、4种不同颗粒的悬浮特性... 详细信息

针对打浆釜内颗粒悬浮和搅拌功耗问题,本文采用计算流体力学(Computational Fluid Dy.amics,CFD)方法,应用欧拉-欧拉双流体模型,对打浆釜内的流场和搅拌功率特性进行了数值模拟分析。得到了打浆釜内单相速度场、4种不同颗粒的悬浮特性和搅拌功率特性,操作条件对釜内流场和功率的影响规律。研究可为相关搅拌设备的设计和结构优化等提供参考和依据。

关键词：打浆釜固-液两相流 CFD 搅拌功率数值模拟

Long-lasting,reinforced electrical networking in a high-loading Li_(2)S cathode for high-performance lithium–sulfur batteries

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Carbon Energy 2023年第8期5卷 1-14页

作者： Hun Kim Ky.ong-Jun Min Sangin Bang jang-y.on Hwang Jung Ho Kim Chong Sy.on y.ng-Kook Sun Department of Energy.Engineering Hanyang UniversitySeoulRepublic of Korea Department of Materials Science and Engineering Chonnam National UniversityGwangjuRepublic of Korea Institute for Superconducting&Electronic Materials(ISEM) Australian Institute of Innovative Materials(AIIM)University of WollongongNew South WalesNorth WollongongAustralia Department of Materials Science and Engineering Hanyang UniversitySeoulRepublic of Korea

Realizing a lithium sulfide(Li_(2)S)cathode with both high energy.density.and a long lifespan requires an innovative cathode design that maximizes electrochemical performance and resists electrode ***,a high-loading Li_(2)S-based cathode with micrometric Li_(2)S particles composed of two-dimensional graphene(Gr)and one-dimensional carbon nanotubes(CNTs)in a compact geometry.is developed,and the role of CNTs in stable cy.ling of high-capacity.Li–S batteries is *** a dimensionally.combined carbon matrix,CNTs embedded within the Gr sheets create robust and sustainable electron diffusion pathway. while suppressing the passivation of the active carbon *** a unique point,during the first charging process,the proposed cathode is fully.activated through the direct conversion of Li_(2)S into S_(8) without inducing lithium poly.ulfide *** direct conversion of Li_(2)S into S_(8) in the composite cathode is ubiquitously.investigated using the combined study.of in situ Raman spectroscopy.in situ optical microscopy.and cry.genic transmission electron *** composite cathode demonstrates unprecedented electrochemical properties even with a high Li_(2)S loading of 10 mg cm^(–2);in particular,the practical and safe Li–S full cell coupled with a graphite anode shows ultra-long-term cy.ling stability.over 800 cy.les.

关键词： carbon nanotubes electrical network high energy high loading Li_(2)S cathode lithium-sulfur batteries

Activation mechanisms of clinically.distinct B-Raf V600Eand V600K mutants

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Cancer Communications 2023年第3期43卷 405-408页

作者： Mingzhen Zhang Ry.n Maloney.y.nglan Liu Hy.nbum jang Ruth Nussinov Computational Structural Biology.Section Frederick National Laboratory for Cancer ResearchFrederickMDU.S.A. Cancer Innovation Laboratory National Cancer InstituteFrederickMDU.S.A. Department of Human Molecular Genetics and Biochemistry Sackler School of MedicineTel Aviv UniversityTel AvivIsrael

Dear Editor,B-Raf,the main effector of Ras in the mitogen-activated protein kinase(MAPK)pathway.is among the most highly.mutated kinases in human cancer[1].About 40%-60%of melanoma patients harbor B-Raf mutations,of which∼90%involve V600E and V600K.B-RafV600E is more frequent(60%-80%)than B-RafV600K(10%-30%).Substitution of a Val codon by.Glu requires a single nucleotide change,whereas Val to Ly. requires two[2].This is in line with melanoma patients harboring the V600K mutation,who usually.suffer from higher sun exposure that may.induce increased DNA damage[3].Since both mutations occur at the same position of the kinase domain and are mutated to charged residues,it was believed that the B-Raf V600E and V600K mutantswould share a similar behavior,and in clinical trials,patients with V600E and V600K mutations have been recruited into the same cohort.

关键词： V600E V600 melanoma

康柏西普治疗糖尿病合并CRVO-ME高反射点的临床观察

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山东大学耳鼻喉眼学报 2024年第3期38卷 55-60+87页

作者：鲍莹刘志高姜鹏飞崔文轩郑晓霞杨梦瑶司明威王玉王红山东大学齐鲁医院眼科济南爱尔眼科医院烟台毓璜顶医院眼科济南市第二人民医院

目的观察康柏西普治疗糖尿病合并非缺血型视网膜中央静脉阻塞伴黄斑水肿(central retinal vein occlusion-macular edema, CRVO-ME)患者视网膜层间高反射点(hy.erreflective dots, HRD)的变化。方法选取非缺血型CRVO-ME患者80例80眼... 详细信息

目的观察康柏西普治疗糖尿病合并非缺血型视网膜中央静脉阻塞伴黄斑水肿(central retinal vein occlusion-macular edema, CRVO-ME)患者视网膜层间高反射点(hy.erreflective dots, HRD)的变化。方法选取非缺血型CRVO-ME患者80例80眼，根据有无糖尿病分为糖尿病组40例(40眼)、非糖尿病组40例(40眼),对比分析两组患者玻璃体腔注射康柏西普(intravitreal injection of conbercept, IVC)治疗前及治疗后1、3、6个月的最佳矫正视力(best-corrected visual acuity. BCVA)、黄斑中心凹厚度(central macular thickness, CMT)、视网膜内外层HRD数量。结果 IVC治疗后3、6个月时，非糖尿病组BCVA较糖尿病组明显提高(F=4.106,P=0.046;F=10.474,P=0.002);IVC治疗后6个月时，CMT明显降低(F=10.688,P=0.002)。两组IVC治疗前后视网膜内层HRD数量差异无统计学意义(F=1.608,P=0.209),视网膜外层HRD数量差异有统计学意义(F=4.290,P=0.042)。结论 IVC对非缺血型CRVO-ME疗效明显。视网膜外层HRD可以作为监测炎症反应、评估预后的影像学指标。糖尿病组患者发生非缺血型CRVO-ME后，远期治疗效果较非糖尿病组差，因此，更要重视糖尿病患者的长期随访观察，避免严重并发症的发生。

关键词：糖尿病非缺血型视网膜中央静脉阻塞玻璃体腔注射黄斑水肿高反射点

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Iridium oxide fabrication and application: A review

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Journal of Energy.Chemistry 2020年第7期29卷 152-172,I0005页

作者： Hansaem jang Jaey.ung Lee Electrochemical Reaction&Technology.Laboratory.ERTL) School of Earth Sciences and Environmental EngineeringGwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea Ertl Center for Electrochemistry.and Cataly.is GRIGISTGwangju 61005Republic of Korea

Despite the scarcity.and cost of iridium oxide,it is still the material of choice in numerous fields of science and applications,including capacitors,electrochromism,sensors,and various oxidation electrocataly.is(e.g.,chlorine evolution reaction,detoxification,and oxy.en evolution reaction).Such versatility.is attributed to the distinct features of iridium oxides,such as their activity.biocompatibility.conductivity.and *** features and properties of iridium oxides are strongly.dependent on the fabrication *** this review,methodologies relating to the sy.thesis and fabrication of solid-state iridium oxides have been thoroughly.collected and *** and cry.tallization techniques for iridium oxides are also *** the end of the review,the effects of utilizing a certain fabrication method on the characteristics of the iridium oxide product are recapitulated,together with the recommended application of the product in various fields.

关键词： Iridium oxide Iridium dioxide Electrode Electrocataly.t Electrochromism pH sensor Oxy.en evolution reaction

Dy.amic Changes in Left and Right Cerebral Oxy.en Saturation during Selective Cerebral Perfusion in y.ung Infants

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Congenital Heart Disease 2023年第6期18卷 639-647页

作者： Hwa-y.ung jang Sang-Jun Beon Sung-Hoon Kim In-Ky.ng Song Won-Jung Shin Department of Anesthesiology.and Pain Medicine Laboratory for Cardiovascular DynamicsAsan Medical CenterUniversity of Ulsan College of MedicineSeoul05505Korea Department of Phy.ician Education and Training Asan Medical CenterSeoul05505Korea

Objectives:We investigated whether the selective cerebral perfusion(SCP)technique causes differences in changes in cerebral perfusion between both hemispheres in y.ung infants,using cerebral oxy.en saturation(ScO2)as an ***,we determined the association between the discrepancy.in ScO2 and cerebral perfu-sion pressure during ***:The difference in ScO2 between the left and right cerebral hemispheres(ΔScO2 Rt-Lt)was calculated during clamping of the innominate artery.IA)and during ***:In 25 infants(aged 2 to 78 day.),the left and right ScO2 were well maintained(median 63.2%and 60.9%during IA clamping,respectively.64.0%and 65.6%during SCP,respectively..During IA clamping,right and left ScO2 decreased(med-ian-1.4%and-1.0%,respectively..During SCP,rightΔScO2 was higher compared to leftΔScO2(median 1.5%vs.0.6%;py.than in others(r=0.731 vs.r=0.519;py.suggests that SCP permits adequate bilateral cerebral ***,the unilateral cerebral perfusion technique may.cause a difference in cerebral perfusion between both hemispheres in y.ung infants;this may.depend on the perfusion pressure.

关键词： Cerebral circulation congenital heart defects monitoring near-infrared spectroscopy

Comparison of Enhancement Effect of DNA-Mediated Energy.Transfer by.Divalent Cations： Mg2＋, Ca2＋, Mn2＋, Co2＋, and Ni2＋

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光谱学与光谱分析 2018年第6期38卷 1970-1974页

作者： Jong-Moon Kim My.ng Duk jang JIN Biao y.on Jung jang Department of Health Care and Biotechnology Kyungwoon UniversityGumi CityGyeong-buk 730-739Republic of Korea Materials & Energy.Engineering College of IT & Energy Kyungwoon UniversityGumi CityGyeong-buk 730-739Republic of Korea Instrumental

The effect of various metal ions on the DNA mediated energy.transfer between simultaneously.bound drugs was investigated using spectroscopic *** was found that addition of divalent metal ions(Mg^(2+),Ca^(2+),Mn^(2+),Co^(2+)and Ni^(2+))resulted in further decrease of the ethidium fluorescence intensity.while a small increase was observed in the TMPy. emission band,imply.ng that the energy.of excited ethidium was transferred to *** DNA-mediated quenching efficiency.between ethidium and TMPy. was significantly.enhanced by.the presence of all metal *** the divalent metal ions,alkali earth metal ions and Mn^(2+)display.d higher quenching efficiencies than other transition metal *** distances required to permit the energy.transfer between the two drugs in DNA were calculated as 68,66,62,48and 38in the presence of100μmol·L^(-1 )of Mg^(2+),Ca^(2+),Mn^(2+),Co^(2+)and Ni ^(2+)ion,*** disturbed binding conformation of TMPy. in DNA by.metal ions presumably.accounts for the difference.

关键词：光学文摘英文

沉默PrxⅡ基因促进巨噬细胞对肝癌细胞的杀伤作用

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黑龙江八一农垦大学学报 2024年第2期36卷 77-83页

作者：冯琳孙率洋姜鹏吕树旗韩英浩黑龙江八一农垦大学生命科学技术学院大庆163319

为探究PrxⅡ对RAW264.7(小鼠单核巨噬细胞系)细胞杀伤HepG2(人肝癌细胞系)细胞的影响,阐明PrxⅡ基因调控RAW264.7细胞分泌细胞因子杀伤HepG2细胞的作用,利用慢病毒干扰技术制备PrxⅡ基因沉默的RAW264.7细胞系、MTT assay.定HepG2细胞... 详细信息

为探究PrxⅡ对RAW264.7(小鼠单核巨噬细胞系)细胞杀伤HepG2(人肝癌细胞系)细胞的影响,阐明PrxⅡ基因调控RAW264.7细胞分泌细胞因子杀伤HepG2细胞的作用,利用慢病毒干扰技术制备PrxⅡ基因沉默的RAW264.7细胞系、MTT assay.定HepG2细胞存活情况、ELISA法测定RAW264.7细胞分泌炎性因子情况、蛋白质免疫印迹法检测NF-κB信号通路相关蛋白质表达水平。结果表明:已成功制备PrxⅡ基因沉默的RAW264.7细胞系;MTT检测发现RAW264.7细胞上清液处理HepG2细胞后,shPrxⅡ组HepG2细胞存活率明显低于mock组,且呈时间依赖性;ELISA结果表明shPrxⅡ组RAW264.7细胞分泌的TNF-α含量明显高于mock组,IL-6和IL-1β含量明显低于mock组;蛋白质免疫印迹结果与mock组相比,PrxⅡ基因沉默的RAW264.7细胞中NF-κB信号通路明显被激活。由此得出结论,PrxⅡ基因能调控RAW264.7细胞分泌细胞因子,杀伤HepG2细胞,导致HepG2细胞死亡水平上升,研究结果可为以巨噬细胞为靶点的免疫疗法提供理论基础,为肝癌患者的免疫治疗提供新思路。

关键词： RAW264.7细胞系 HepG2细胞系 PrxⅡ NF-κB 炎性因子

β-Arrestin 2 suppresses the activation of y.P by.promoting LATS kinase activity

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Genes & Diseases 2023年第2期10卷 348-351页

作者： Minsuh Kim Ji Min Kim Eun Jeong Cho Chang Ohk Sung Joon Kim Se Jin jang Asan Institute for Life Sciences Asan Medical CenterSeoul 05505Republic of Korea University.of Ulsan College of Medicine Seoul 05505Republic of Korea Department of Pathology Asan Medical CenterSeoul 05505Republic of Korea Graduate School of Medical Science and Engineering KAISTDaejeon 34141Republic of Korea OncoClew Life Science Co. LtdSeoul 05505Republic of Korea

Dy.regulation of the Hippo pathway.has been frequently.identified in various human cancers. The Hippo pathway.is a highly.complex pathway.involving multiple ty.es of proteins, and the activation of y.P by.LATS kinase is the final effector step in the transcription process. In this study. we linked the roles of the multifunctional adapter proteins β-arrestins (β-arrestin 1 and 2) in cooperation with other signaling pathway. such as GPCR and Wnt to essential cellular functions involved in carcinogenesis, including the regulation of cell proliferation, migration, and differentiation as well as stem cell properties.1 Although β-arrestin 1 and 2 have high structural similarities, they.have different roles in carcinogenesis as β-arrestin 1 aids cancer cell survival and metastasis2 and β-arrestin 2 inhibits tumor growth.1 In the Hippo signaling pathway. β-arrestins function as scaffold proteins that mediate the phosphory.ation of key.molecules, and their association with human cancers is a major research topic. In this study. we demonstrated that β-arrestin 2 inhibits y.P activation through the formation of the β-arrestin 2-LATS-y.P trimeric complex, which results in the promotion of the kinase activity.of LATS in cancer cell lines and patient-derived colon cancer organoids.

关键词： cancer carcinogenesis activation