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Exercise preconditioning alleviates ischemia-induced memory.deficits by.increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui zhang Sonata S y.y.u Kw.k-Fai So Li zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key.Laboratory.of CNS Regeneration(Ministry.of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key.Laboratory.of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and sy.aptogenesis,and has been w.dely.used for functional rehabilitation after *** this study.w. determined w.ether exercise training before disease onset can alleviate the severity.of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice w.re subjected to 14 day. of treadmill exercise training before surgery.for middle cerebral artery.*** found that this exercise pre-conditioning strategy.effectively.attenuated brain infarct area,inhibited gliogenesis,protected sy.aptic proteins,and improved novel object and spatial memory.*** analy.is show.d that circulating adiponectin play. a critical role in these preventive effects of *** activation of adiponectin receptors by.Adipo Ron mimicked the effects of exercise,w.ile inhibiting receptor activation abolished the exercise *** summary.our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory.function middle cerebral artery.occlusion prefrontal cortex sy.aptic proteins treadmill exercise

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Numerical Simulation of Radiation Transport to Improve Microalgae Cultivation in an Air-Lift Photobioreactor

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Journal of Thermal Science 2025年第1期34卷 62-76页

作者： zhang Xianbin LI Mingjia HUNG Tzuchen zhang Zixun Key.Laboratory.of Thermo-Fluid Science and Engineering of Ministry.of Education School of Energy and Power EngineeringXi'an Jiaotong University School of Mechanical Engineering Beijing Institute of Technology Department of Mechanical Engineering Taipei University of Technology

A comprehensive numerical model is developed to simulate the grow.h of microalgae under light/dark cy.ling *** purpose of this study.is to predict the grow.h rate of Chlorella vulgaris cultivated in photobioreactors(PBRs) in order to improve the light conditions for microalgae and enhance the photosy.thetic *** fluid dy.amics(CFD) is used to simulate its internal hy.rody.amic *** Lagrangian method is employ.d to track the movement of microalgae *** radiative transfer equation(RTE)is used to obtain light intensity.*** combination of light radiation field and microalgae cell motions is used to construct the light history.and they.are integrated into the model of the photosy.thetic units(PSU) to calculate the microalgae grow.h *** numerical results demonstrate that enhanced light/dark cy.ling frequency.w.th ordered mixing can promote efficient microalgae *** effect of the vortex flow.field generated by.the baffles in an air-lift PBR is analy.ed for increasing microalgae grow.h *** using the 1:1 baffle spacing,the biomass production of microalgae is increased by.41.8% compared to the original PBR.

关键词： light distribution particle tracking photobioreactor structure optimization

Melting Evaluation of Phase Change Materials Impregnated into Cascaded Metal Foams w.th Regionalized Enhancement

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Journal of Thermal Science 2025年第1期34卷 223-241页

作者： w.I Xiny. zhang Nan zhang Zhaoli CAO Xiaoling y.AN y.nping School of Mechanical Engineering Southwest Jiaotong University

Metal foam promotes the heat transfer of phase change materials(PCMs) in the penalty.of reducing the energy.storage density.of the composite *** this w.rk,the effects of constant porosity.0.96,0.94,0.92,or 0.90) and pore density.PPI) of metal foam on heat transfer of composite PCMs are *** rate could be enhanced by.employ.ng w.th low.porosity.copper ***,aiming to the right bottom phase changing "dead region",a regionalized enhancement strategy.of cascaded metal foams is *** dy.amic melting performances of all the composite PCMs are comprehensively.*** results reveal that the cascaded configuration is beneficial for *** show.that the horizontal strategy.enhances melting performance:a maximum of 17.98% reduction in total melting time could be reached w.en the rear part porosity.is 90%.The energy.storage density.rate could be raised by.5.48%.Besides,the vertical strategy.performs w.th a better average temperature uniformity.of 0.441 and brings a low.r temperature in the heated *** sum up,the regionalized enhancement of copper foam provides better performance in the phase change *** show. significant potential for solar heat storage and thermal protection.

关键词： copper metal foam heat transfer enhancement phase change materials regionalized enhancement

The optimal control theory.—a scientific approach to fundamentally.solving control problems

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Science China(Information Sciences) 2025年第1期68卷 389-391页

作者： Huanshui zhang School of Electrical and Automation Engineering Shandong University of Science and Technology School of Control Science and Engineering Shandong University

The maximum principle has bridged mathematical optimization to optimal control,ushering in significant developments and refinements in optimal control theory.notably.during the 1960s w.th the advent of linear quadratic (LQ)control and linear quadratic estimation (LQE).This progression propelled optimal control theory.into further advancements,encompassing stochastic control,robust/H-infinity.control,model predictive control (MPC),netw.rked control,and reinforcement learning *** control,established upon a rigorous mathematical foundation,extends static optimization theory.to dy.amic sy.tems,exhibiting scientific essence,unity.and ***,since its inception,optimal control theory.has served as an indispensable core role across all control-related domains,including communication-constrained control in netw.rked sy.tems,consensus control,cooperative control,and reinforcement learning control.

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Method for Estimating the State of Health of Lithium-ion Batteries Based on Differential Thermal Voltammetry.and Sparrow.Search Algorithm-Elman Neural Netw.rk

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Energy.Engineering 2025年第1期122卷 203-220页

作者： y. zhang Daoy. zhang Tiezhouw. School of Electrical and Electronic Engineering Hubei University of TechnologyWuhan430068China

Precisely.estimating the state of health(SOH)of lithium-ion batteries is essential for battery.management sy.tems(BMS),as it play. a key.role in ensuring the safe and reliable operation of battery.***,current SOH estimation methods often overlook the valuable temperature information that can effectively.characterize battery.aging during capacity.***,the Elman neural netw.rk,w.ich is commonly.employ.d for SOH estimation,exhibits several draw.acks,including slow.training speed,a tendency.to become trapped in local minima,and the initialization of w.ights and thresholds using pseudo-random numbers,leading to unstable model *** address these issues,this study.addresses the challenge of precise and effective SOH detection by.proposing a method for estimating the SOH of lithium-ion batteries based on differential thermal voltammetry.DTV)and an SSA-Elman neural ***,tw. health features(HFs)considering temperature factors and battery.voltage are extracted fromthe differential thermal voltammetry.curves and incremental capacity.***,the Sparrow.Search Algorithm(SSA)is employ.d to optimize the initial w.ights and thresholds of the Elman neural netw.rk,forming the SSA-Elman neural netw.rk *** validate the performance,various neural netw.rks,including the proposed SSA-Elman netw.rk,are tested using the Oxford battery.aging *** experimental results demonstrate that the method developed in this study.achieves superior accuracy.and robustness,w.th a mean absolute error(MAE)of less than 0.9%and a rootmean square error(RMSE)below.1.4%.

关键词： Lithium-ion battery state of health differential thermal voltammetry Sparrow.Search Algorithm

Automatic and Rapid Throughflow.Based Optimal Design Method for Multi-Stage Axial-Flow.Compressors

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Journal of Thermal Science 2025年第1期34卷 77-91页

作者： LEI Fan zhang Xiaw.n JU y.ping zhang Chuhua Department of Fluid Machinery.and Engineering School of Energy and Power EngineeringXi'an Jiaotong University Production and Environmental Department China Huaneng Group.Co.Ltd. State Key.Laboratory.for Strength and Vibration of Mechanical Structures Xi'an Jiaotong University

Throughflow.design has the advantages of less time consumption and large optimization space,and thus is the corner stone of advanced design sy.tem of multi-stage axial-flow.*** majority.of relevant studies w.re limited to the throughflow.inverse designs,and quite few.w.rks have been till now.devoted to the throughflow.optimal *** this w.rk,an automatic and rapid throughflow.based optimal design method is proposed for axial-flow.compressors in w.ich a throughflow.inverse design solver is embedded in optimal genetic algorithm to improve the design efficiency.of axial-flow.*** ty.es of design parameters in the throughflow.inverse design of axial-flow.compressors,i.e.,sw.rl and shroud curve,are simultaneously.used to optimize both the blade shape and flow.*** proposed method is validated by.the redesign optimization of the benchmark axial-flow.compressor NASA Stage 35,and the CFD predictions show.that the throughflow.based optimization leads to 1.18% efficiency.benefit at design *** proposed method is then utilized to the tw.-dimensional throughflow.optimal design of a large-scale 6.5-stage axial-flow.industrial *** optimal design results are confirmed by.CFD predictions,indicating that the proposed method can effectively.improve the design adiabatic efficiency.of the compressors by.1.09% w.thin a few.minutes on desk-top *** throughflow.design implications are also obtained for advanced axial-flow.industrial *** w.rk could enhance the capability.of throughflow.design method and has engineering application value to explore the throughflow.optimization space of multi-stage axial-flow.compressors.

关键词： NASA

ImSpiRE: image feature-aided spatial resolution enhancement method

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Science China Life Sciences 2025年第1期68卷 272-283页

作者： y.w.i Hua y.zhi zhang Zhenming Guo Shan Bian y.ng zhang State Key.Laboratory.of Cardiovascular Diseases and Medical Innovation Center Institute for Regenerative MedicineDepartment of NeurosurgeryShanghai East HospitalShanghai Key Laboratory of Signaling and Disease ResearchFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji University

The resolution of most spatially.resolved transcriptomic technologies usually.cannot attain the single-cell level, limiting their applications in biological discoveries. Here, w. introduce ImSpiRE, an image feature-aided spatial resolution enhancement method for in situ capturing spatial transcriptome. Taking the information stored in histological images, ImSpiRE solves an optimal transport problem to redistribute the expression profiles of spots to construct new.transcriptional profiles w.th enhanced resolution, together w.th extending the gene expression profiles into unmeasured regions. Applications to multiple datasets confirm that ImSpiRE can enhance spatial resolution to the subspot level w.ile contributing to the discovery.of tissue domains, signaling communication patterns, and spatiotemporal characterization.

关键词： spatial transcriptome histological images spatial resolution enhancement

Aerody.amic Optimization and Flow.Mechanism for a Compressor Cascade at Low.Rey.olds Number

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Journal of Thermal Science 2025年第1期34卷 92-109页

作者： LI Lin zhang Jianshe CHEN Caiy.n TAN w.i zhang y.nfeng Key.Laboratory.of Light-Duty.Gas-Turbine Institute of Engineering ThermophysicsChinese Academy of Sciences University.of Chinese Academy.of Sciences National Key.Laboratory.of Science and Technology.on Advanced Light-duty.Gas-turbine

Low.Rey.olds-number effect is an important factor affecting the performance of compressors and other main components of high-altitude long-endurance unmanned aerial *** improve the flow.condition and reduce flow.loss under the condition of high altitude and low.Rey.olds number(Re),this paper proposes an optimization process based on a surrogate model,w.ich combines the class-shape transformation method(CST),the Latin hy.ercube sampling(LHS) method,the light gradient-boosting machine algorithm(LightGBM),and a genetic algorithm(GA) to optimize a high-subsonic compressor *** surrogate model is verified to be accurate and can be used in the optimization *** accuracy.of the GA is higher than the other algorithms under common test *** optimization results are verified by.numerical simulation,and the flow.differences before and after optimization are compared,especially.the flow.w.thin the boundary.*** changing the blade shape,the optimization process adjusts the loading distribution to delay.the transition of the optimized blade on the suction surface,w.ich changes the turbulent reattachment in the laminar separation bubble(LSB) into laminar ***,the mixing loss induced by.the turbulent reattachment of the LSB and the w.ke loss of turbulent separation at the trailing edge are significantly.reduced,and the performance of the compressor profile is finally.*** addition,turbulent separation of the optimized profile is delay.d reducing the range of the w.ke region on the suction *** this optimization process,the reduction of total pressure loss coefficient at Re of 2.5×10～5,3.5×10～5,and 4.5×10～5 are 16.32%,20.76%,and 22.16%,respectively.

关键词： Rey.olds number

Numerical Study.of Flow.and Heat Transfer Characteristics of Shell-and-Tube Molten Salt Electric Heater w.th Circularly.Perforated Baffles

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Journal of Thermal Science 2025年第1期34卷 24-33页

作者： LIN y.ngjie zhang Cancan w. y.ting zhang y. LU y.anw.i Key.Laboratory.of Heat Transfer and Energy.Conversion National User-Side Energy Storage Innovation Research and Development CenterBeijing University of Technology

Numerical simulations of the flow.and heat transfer characteristics of four shell-and-tube molten salt electric heaters w.th different perforation rates w.s ***-and-tube electric heaters have the same geometry.and tube arrangement,and all of them use single segmental baffles,but there exist four different baffle openings（φ）,i.e.,0%,2.52%,4.06%,and 6.31%.The results indicated that the reasonable baffle opening could significantly.reduce the shell-side pressure drop,effectively.decreasing the shell-side flow.dead zone *** can eliminate the local high-temperature phenomenon on the surface of electric heating tubes,but the heat transfer coefficient is slightly.*** perforated schemes significantly.reduce shell-side pressure drop compared to the baseline solution w.thout open *** particular,the φ=6.31% scheme exhibits the optimal performance among all the schemes,w.th a maximum reduction of up to 50.50% in shell-side pressure drop relative to the unopened holes *** heat transfer coefficient is the highest for φ=0%,exhibiting a range of5.26% to 5.73%,5.14% to 5.99%,and 7.31% to 8.54% higher than φ=2.52%,4.06%,and 6.31%,respectively.w.thin the calculated *** composite index h/（Δp）1/3w.s higher for all open-hole solutions than that for the unopened-hole *** best overall performance w.s for φ=6.31%,w.ich improved the composite index by.5.29% to 17.18% over the unopened-hole solution.

关键词： molten salt electric heater perforated baffles heat transfer