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Transplantation of BMP-7 gene-transfected bone marrow mesenchymal stem cells for the treatment of spinal cord injury in rats

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BIOCELL 2022年第9期46卷 2065-2072页

作者： xuyi wang WEN ZHANG LEI GAO KUANXIN LI Department of Orthopedics The First Affiliated Hospital of Bengbu Medical CollegeBengbu233000China Department of Orthopedics The Second Affiliated Hospital of Medical College of Shihezi UniversityUrumqi832000China Department of Spinal Surgery The Second Affiliated Hospital of Medical College of Shihezi UniversityUrumqi832000China

Background:Spinal cord injury(SCI)is a serious traumatic disease of the central nervous system,and there is currently no effective treatment for SCI because of its complicated *** marrow mesenchymal stem cells(BMSCs)have multidirectional differentiation *** study aims to explore the effects of bone morphogenetic protein 7(BMP-7)-modified BMSCs transplantation on the repair of SCI in ***:In this study,a rat spinal cord injury model was established with the modified Allen ***,BMSCs transfected with the BMP7 gene were transplanted to treat the spinal cord injury in *** Sprague-Dawley rats were randomly divided into the sham operation group(sham group),spinal cord injury group(model group),BMSC treatment group(BMSC group)and LV-BMP7-BMSC treatment group(LV-BMP7-BMSC group).The Basso,Beattie,and Bresnahan(BBB)score was used to evaluate the recovery of hindlimb function in the *** levels of neurofilament protein NF-200(NF-200)and glial fibrillary acidic protein(GFAP)were detected by immunofluorescence,RT-PCR and Western ***:At 14 d,21 d,and 28 d after treatment,the BBB score of the rats in the LV-BMP7-BMSC group was higher than that of the rats in the model group and BMSC *** results showed that NF-200 was expressed at the local spinal cord injury *** with that of the sham group,the NF-200 expression level of the BMSC group and LV-BMP7-BMSC group was increased(P<0.05).The results showed that the mRNA expression levels of NF-200 in the spinal cord tissue of the BMSC group and LV-BMP7-BMSC group were increased compared with those of the sham group(P<0.05).The western blotting results further confirmed the PCR ***:BMP-7 gene-modified BMSC transplantation can promote the repair of spinal cord functions after SCI in rats.

关键词： Bone morphogenetic protein 7 Bone marrow mesenchymal stem cells Spinal cord injury

双相障碍三种临床相边缘系统网络功能异常的研究

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中华精神科杂志 2024年第2期57卷 78-86页

作者：吕东升林武宏刘哲宁蒲唯丹姚萍王绪轶郭文斌赵靖平中南大学湘雅二医院精神科、国家精神疾病医学中心、国家精神心理疾病临床医学研究中心长沙410011 南方医科大学生物医学工程学院广州510515 内蒙古自治区精神卫生中心呼和浩特010010

目的探讨静息状态下双相障碍三种临床相边缘系统网络脑区间功能连接及脑区内低频振荡振幅(amplitude of low-frequency fluctuation,ALFF)是否有共性改变。方法于2019年7月至2021年12月纳入中南大学湘雅二医院精神卫生研究所确诊为双相... 详细信息

目的探讨静息状态下双相障碍三种临床相边缘系统网络脑区间功能连接及脑区内低频振荡振幅(amplitude of low-frequency fluctuation,ALFF)是否有共性改变。方法于2019年7月至2021年12月纳入中南大学湘雅二医院精神卫生研究所确诊为双相障碍的患者107例(双相障碍组)以及与之年龄、性别、受教育程度等相匹配的健康对照者46名(对照组)。根据杨氏躁狂评定量表(Young Mania Rating Scale,YMRS)及17项汉密尔顿抑郁量表(Hamilton Depression Rating Scale,HAMD17)评分将双相障碍患者分为双相躁狂组、双相抑郁组、双相缓解组。采集所有受试者静息态功能磁共振成像数据,采用基于种子点功能连接和ALFF的方法分析其边缘系统网络脑区间功能连接及脑区内功能活动状态,使用单因素方差分析及事后检验的方法比较组间功能连接值和ALFF值的差异。采用Pearson或Spearman对组间差异有统计学意义的脑区功能连接值和ALFF值与临床量表总分及各因子分进行相关分析。结果与对照组相比,双相障碍三种临床相边缘系统网络中前扣带回皮质与海马区的功能连接显著降低(t=-2.60~-2.07,Bonferroni校正,P<0.05),且三种临床相前扣带回皮质ALFF也显著降低(t=-4.41~-3.51,FDR校正,P<0.05)。双相抑郁组左侧前扣带回与左侧海马功能连接值与HAMD17中工作兴趣因子分呈负相关(r=-0.406,P=0.021)。结论双相障碍边缘系统网络中前扣带回的失连接和功能活动降低可能是双相障碍三种临床相情绪调节障碍的共性改变。

关键词：双相情感障碍边缘系统磁共振成像功能连接低频振幅

污水处理厂生物气溶胶抗生素抗性污染特征、来源及潜在风险

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微生物学通报 2024年第1期51卷 36-49页

作者：姜波王旭一黄青隋心杨唐惠晓亮张展鹏高晓东青岛理工大学环境与市政工程学院山东青岛266520 青岛首创瑞海水务有限公司山东青岛266000

污水处理厂是抗生素抗性基因(antibiotic resistance genes,ARGs)和抗生素抗性细菌(antibiotic resistant bacteria,ARB)重要的源和汇,生物气溶胶是ARGs和ARB自污水处理厂向周边环境释放的关键载体。目前缺乏对污水处理厂生物气溶胶抗... 详细信息

污水处理厂是抗生素抗性基因(antibiotic resistance genes,ARGs)和抗生素抗性细菌(antibiotic resistant bacteria,ARB)重要的源和汇,生物气溶胶是ARGs和ARB自污水处理厂向周边环境释放的关键载体。目前缺乏对污水处理厂生物气溶胶抗生素抗性污染特征、来源及潜在风险的系统性总结。本文从采样方法、检测方法、逸散特征、来源、潜在危害和风险评估等方面对污水处理厂抗生素抗性污染研究现状进行综述。惯性采样法和过滤法是常用的污水处理厂抗生素抗性生物气溶胶主要采集方法,而宏基因组测序、组装和分箱为其ARGs组成、可移动性和宿主提供了有效的检测方法,抗多药类、抗杆菌肽类、抗氨基糖苷类、抗四环素类、抗β-内酰胺类、抗磺胺类、抗大环内酯类和抗糖肽类等抗性基因在污水处理厂PM10、PM_(2.5)和PM_(1.0)颗粒物中广泛检出。格栅间、生化反应池和污泥处理单元是污水处理厂PM10、PM_(2.5)和PM_(1.0)负载ARGs和ARB的主要释放单元。污水处理厂不同粒径生物气溶胶中致病性ARB的存在增加了抗生素治疗的难度,而污水和污泥对ARGs和ARB的释放起到了重要的源的贡献。本文在研究内容、研究技术和控制策略等方面也提出了相关展望,以期为污水厂生物气溶胶抗生素抗性污染的监测和防护提供参考和借鉴。

关键词：污水处理厂抗生素抗性污染特征来源潜在风险

Metal halide perovskite nanocrystals with enhanced photoluminescence and stability toward anti-counterfeiting highperformance flexible fibers

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Nano Research 2023年第2期16卷 3542-3551页

作者： Ranran Zhou Chi-An Cheng xuyi wang Kun Nie Jing Wu Mengyun Wu Xiuqiang Duan Ziyao Hu Injamam Ul Huq Hua wang Luoxin wang Lefu Mei Haikun Liu Xiaoxue Ma School of Materials Science and Engineering Hubei Key Laboratory for New Textile Materials and ApplicationsKey Laboratory of Polyphenylene Sulfide Fiber and Application in Textile Industryand State Key Laboratory of New Textile Materials&Advanced Processing TechnologyWuhan Textile UniversityWuhan 430200China Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes National Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of Geosciences(Beijing)Beijing 100083China Department of Bioengineering University of California Los AngelesLos Angeles 90095USA China Bluestar Chengrand Co. LtdHigh Tech Organic Fiber Key Laboratory of Sichuan ProvinceChengdu 610042China Department of Energy and Chemical Engineering Dongguan University of TechnologyDongguan 523808China

As a new type of light-collecting and luminescent material,all-inorganic cesium lead halide CsPbX_(3)(X=Cl,Br,I)perovskite nanocrystals(NCs)are expected to have a wide range of applications in the fields of photovoltaics,optoelectronics,and fluorescence anti-counterfeiting,***,improving the fluorescence performance and stability of CsPbX_(3)perovskite NCs to prompt their applications would promise both fundamental and practical significance for in-depth research in the field of halide *** this paper,we developed a modification strategy to introduce a halogen source,zinc bromide(ZnBr_(2))in hexane,to CsPbX_(3)perovskite that can be conducted under atmospheric conditions with reduced reaction cost and easier *** first work in this paper was to apply the modification strategy to CsPbI_(3)nanowires(NWs).Compared with the untreated NWs,the ZnBr_(2)/hexane modified CsPbI_(3)NWs exhibited better fluorescence ***,based on the study of perovskite NWs,we investigated perovskite nanocrystal-CsPbI_(3)nanorods(NRs)with different morphologies and *** was found that the luminescence properties of nanorods(NRs)were ***,we infiltrated the modified NRs into the aramid/polyphenylene sulfide(ACFs/PPS)composite paper yielded from our previous work to study its fluorescence performance for *** luminescence properties under ultraviolet light irradiation enable better performance in fluorescence *** ZnBr_(2)/hexane modification strategy and the applications studied in this work will expand the scope of perovskite research,laying the foundation for the applications of fluorescent anti-counterfeiting,nano-photoelectric devices,and fluorescent composite materials.

关键词： perovskite nanocomposites photoluminescence fluorescent anti-counterfeiting aramid/polyphenylene sulfide compound paper

Application of artificial hibernation technology in acute brain injury

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Neural Regeneration Research 2024年第9期19卷 1940-1946页

作者： Xiaoni wang Shulian Chen Xiaoyu wang Zhen Song Ziqi wang Xiaofei Niu Xiaochu Chen xuyi Chen Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina

Controlling intracranial pressure,nerve cell regeneration,and microenvironment regulation are the key issues in reducing mortality and disability in acute brain *** is currently a lack of effective treatment *** has the characteristics of low temperature,low metabolism,and hibernation rhythm,as well as protective effects on the nervous,cardiovascular,and motor *** hibernation technology is a new technology that can effectively treat acute brain injury by altering the body’s metabolism,lowering the body’s core temperature,and allowing the body to enter a state similar to *** review introduces artificial hibernation technology,including mild hypothermia treatment technology,central nervous system regulation technology,and artificial hibernation-inducer *** summarizing the relevant research on artificial hibernation technology in acute brain injury,the research results show that artificial hibernation technology has neuroprotective,anti-inflammatory,and oxidative stress-resistance effects,indicating that it has therapeutic significance in acute brain ***,artificial hibernation technology can alleviate the damage of ischemic stroke,traumatic brain injury,cerebral hemorrhage,cerebral infarction,and other diseases,providing new strategies for treating acute brain ***,artificial hibernation technology is currently in its infancy and has some complications,such as electrolyte imbalance and coagulation disorders,which limit its *** research is needed for its clinical application.

关键词： cute brain injury artificial hibernation hypothermia low metabolism mild hypothermia

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栀子苷立方液晶凝胶的制备、表征及体外评价

湖南中医药大学学报 2024年第1期44卷 38-46页

作者：欧阳威黄星雨王旭易骆慧婷李爽谭颖颜红湖南中医药大学湖南长沙410208 巩义市人民医院河南郑州451200

目的为促进水溶性栀子苷的透皮性能而制备栀子苷立方液晶凝胶(geniposide cubic liquid crystal gel,GE-CLC-G),并对其进行表征及体外评价。方法以甘油单油酸酯(glyceryl monooleate,GMO)为基质材料,采用注入法制备GE-CLC-G,通过三元相... 详细信息

目的为促进水溶性栀子苷的透皮性能而制备栀子苷立方液晶凝胶(geniposide cubic liquid crystal gel,GE-CLC-G),并对其进行表征及体外评价。方法以甘油单油酸酯(glyceryl monooleate,GMO)为基质材料,采用注入法制备GE-CLC-G,通过三元相图筛选出空白立方液晶区域;采用单因素法优选GE-CLC-G的处方及工艺条件;建立栀子苷的HPLC含量测定方法;采用偏光显微镜(polarizing microscope,PLM)、小角X衍射仪(small angle X diffraction,SAXS)对产品进行表征;采用改良Franz扩散池,比较GE-CLC-G与栀子苷软膏的体外透皮特性;采用DHR-2流变仪,对比GE-CLC-G和栀子苷软膏的流变学性质。结果优选的GECLC-G处方及工艺为GMO∶无水乙醇∶水=64∶3∶33,1%栀子苷投药量,1%促渗剂(氮酮:丙二醇=1∶1),60℃涡旋3 min,25℃恒温箱密封、避光3 d。制得的GE-CLC-G为无色、澄明的凝胶状半固体;为立方相,其内部结构为双菱形(Pn3m)晶格;测得产品中栀子苷的含量为(9.94±0.02)mg/g,载药量较大,符合立方液晶的特点。含1%促渗剂的GE-CLC-G 24 h累积透皮率Q(%)和透皮速率常数Js明显高于不加促渗剂的栀子苷软膏和不加促渗剂的GE-CLC-G。流变学研究表明,GE-CLC-G属于非牛顿流体,生物黏附性好,结构更稳定。结论GE-CLC-G制备工艺简单,产品外观良好,PLM和SAXS可用于表征立方液晶凝胶,含量测定方法操作简单,专属性好;GE-CLC-G的体外透皮性能和流变学性质均明显优于栀子苷软膏。

关键词：立方液晶凝胶栀子苷三元相图体外透皮流变学

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经典名方沙参麦冬汤颗粒制备工艺及质量标准研究

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湖南中医药大学学报 2024年第7期44卷 1181-1192页

作者：彭志荣王旭易欧阳威雷雨菁李爽夏新华颜红湖南中医药大学药学院湖南长沙410208 湖南中医药高等专科学校附属第一医院(湖南省直中医医院) 湖南株洲412000

目的制备经典名方沙参麦冬汤颗粒,并建立沙参麦冬汤颗粒的质量标准。方法以熵权法及正交实验优选沙参麦冬汤回流提取工艺,与古法煎煮工艺进行对比,并进一步筛选颗粒的成型工艺。采用高效液相色谱法(high performance liquid chromatogra... 详细信息

目的制备经典名方沙参麦冬汤颗粒,并建立沙参麦冬汤颗粒的质量标准。方法以熵权法及正交实验优选沙参麦冬汤回流提取工艺,与古法煎煮工艺进行对比,并进一步筛选颗粒的成型工艺。采用高效液相色谱法(high performance liquid chromatography,HPLC)建立沙参麦冬汤颗粒的指纹图谱和甘草苷、甘草酸的含量测定方法,并考察基准样品(煎液、冻干粉)、颗粒剂生产各环节(提取液、中间体、成品)指纹图谱的相似度和甘草苷的转移率。采用薄层色谱法(thin layer chromatography,TLC)对方中麦冬、桑叶、天花粉、白扁豆、甘草5味药材进行鉴别。结果优化的回流提取工艺为浸泡0 h,提取两次,加水量分别为10、8倍,提取时间分别为2.0、1.5 h;成型工艺为以90%乙醇为润湿剂,加入20%的糊精制软材,经16目筛挤压制粒,60℃下干燥,过80筛整粒制备沙参麦冬汤颗粒。10批沙参麦冬汤颗粒、基准样品与颗粒生产各环节的指纹谱图相似度均大于0.90;基准煎液、冻干粉、提取液、中间体、成品的甘草苷转移率分别为75.60%、75.24%、91.67%、90.22%、73.57%。5味中药的TLC特征斑点清晰,且阴性无干扰。结论指纹图谱相似度结果表明,各批次、各生产环节沙参麦冬汤颗粒的质量相对稳定,且与基准样品保持一致。经回流提取、浓缩、干燥、制粒后,甘草苷的转移率有所下降,颗粒的甘草苷转移率与原方汤剂的较为接近。本研究所建立的沙参麦冬汤颗粒制备工艺稳定可靠,质量标准检测方法简便可行,重复性好,以期为沙参麦冬汤颗粒的规模生产及其质量控制提供参考。

关键词：经典名方沙参麦冬汤颗粒剂指纹图谱制备工艺质量标准

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C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi wang Xiaofei Niu Yingkai wang Yang Liu Cheng Yang xuyi Chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

3D printing of poly(ethyleneimine)-functionalized Mg-Al mixed metal oxide monoliths for direct air capture of CO_(2)

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Journal of Energy Chemistry 2024年第9期96卷 491-500页

作者： Qingyang Shao Zhuozhen Gan Bingyao Ge xuyi Liu Chunping Chen Dermot O’Hare Xuancan Zhu Research Center of Solar Power&Refrigeration School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Chemistry Research Laboratory Department of ChemistryUniversity of OxfordOxford OX13TAUK

Direct air capture(DAC)of CO_(2)plays an indispensable role in achieving carbon-neutral goals as one of the key negative emission *** large air flows are required to capture the ultradilute CO_(2)from the air,lab-synthesized adsorbents in powder form may cause unacceptable gas pressure drops and poor heat and mass transfer efficiencies.A structured adsorbent is essential for the implementation of gas-solid contactors for cost-and energy-efficient DAC *** this study,efficient adsorbent poly(ethyleneimine)(PEI)-functionalized Mg-Al-CO_(3)layered double hydroxide(LDH)-derived mixed metal oxides(MMOs)are three-dimensional(3D)printed into monoliths for the first time with more than 90%adsorbent *** printing process has been optimized by initially printing the LDH powder into monoliths followed by calcination into MMO *** structure exhibits a 32.7%higher specific surface area and a 46.1%higher pore volume,as compared to the direct printing of the MMO powder into a *** impregnation of PEI,the monolith demonstrates a large adsorption capacity(1.82 mmol/g)and fast kinetics(0.7 mmol/g/h)using a CO_(2)feed gas at 400 ppm at 25℃,one of the highest values among the shaped DAC *** of the amino-polymers during the post-printing process affects the diffusion of CO_(2),resulting in slower adsorption kinetics of pre-impregnation monoliths compared to post-impregnation *** optimal PEI/MeOH ratio for the post-impregnation solution prevents pores clogging that would affect both adsorption capacity and kinetics.

关键词： 3D printing Mixed metal oxides Amine functionalization Structured adsorbent Direct air capture