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The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng Ye Daijun zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

A review:biosynthesis of plant-derived labdane-related diterpenoids

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Chinese Journal of Natural Medicines 2021年第9期19卷 666-674页

作者： gAO Ke zha Wen-Long ZHU Jian-xun ZHENg Cheng ZI Jia-Chen College of Pharmacy Jinan UniversityGuangzhou 510632China Zhejiang Institute for Food and Drug Control NMPA Key Laboratory for Quality Evaluation of Traditional Chinese MedicineHangzhou 310052China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Plant-derived labdane-related diterpenoids(LRDs)represent a large group of *** possess either a labdane-type bicyclic core structure or more complex ring systems derived from labdane-type skeletons,such as abietane,pimarane,kaurane,*** to their various pharmaceutical activities and unique properties,many of LRDs have been widely used in pharmaceutical,food and perfume *** of various LRDs has been extensively studied,leading to characterization of a large number of new biosynthetic *** biosynthetic pathways of important LRDs and the relevant enzymes(especially diterpene synthases and cytochrome P450 enzymes)were summarized in this review.

关键词： Biosynthesis Cytochrome P450 enzyme Diterpene synthase Labdane-related diterpenoids

晋西黄土区不同植被恢复阶段土壤生态化学计量特征

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水土保持研究 2025年第1期32卷 30-38+47页

作者：高连炜张红丽查同刚北京林业大学水土保持学院水利部水土保持监测中心

[目的]开展土壤生态化学计量特征随植被恢复进程的变化研究，探究植被恢复引起土壤养分变化规律及其作用机制，对认识植被恢复与土壤养分的关系，指导植被恢复实践具有重要意义。[方法]以晋西黄土区不同植被恢复阶段(撂荒地、草地、灌... 详细信息

[目的]开展土壤生态化学计量特征随植被恢复进程的变化研究，探究植被恢复引起土壤养分变化规律及其作用机制，对认识植被恢复与土壤养分的关系，指导植被恢复实践具有重要意义。[方法]以晋西黄土区不同植被恢复阶段(撂荒地、草地、灌木林、先锋阔叶林、针叶林)的5种林(草)地为研究对象，通过调查采样和室内分析，探究土壤生态化学计量特征随植被恢复的进程变化及其影响因素。[结果](1)随着植被的恢复，先锋阔叶林和针叶林阶段的SOC含量较上一阶段增加19.8%,土壤TN含量较上一阶段增加17.6%,而土壤TP含量较上一阶段减少12.4%;(2)随着植被恢复的发展，土壤C∶P和N∶P显著增加，C∶N的变化无明显规律，在先锋阔叶林和针叶林阶段的土壤C∶P较上一阶段增加26.6%;先锋阔叶林和针叶林阶段在0—40 cm土层的土壤N∶P较上一阶段增加40.2%,40—100 cm土层的土壤N∶P较上一阶段增加35.7%;土壤C∶N在不同植被恢复阶段间的变化未见明显规律，研究区土壤逐渐由C,N的限制转变为P的限制；(3)各植被恢复阶段土壤C∶P和N∶P主要与砂粒含量呈显著负相关，与孔隙度呈显著正相关，土壤C∶N与其他因子的相关性不明显。[结论]植被恢复有利于土壤C,N含量增加，改善土壤理化性质，在植被恢复过程应同时注重P元素的调控，以提高晋西黄土区植被生态恢复水平。

关键词：植被恢复土壤养分生态化学计量特征

Production of anthocyanins in metabolically engineered microorganisms:Current status and perspectives

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Synthetic and Systems Biotechnology 2017年第4期2卷 259-266页

作者： Jian zha Mattheos A.g.Koffas Department of Chemical and Biological Engineering Center for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNYUSA Department of Biological Sciences Center for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNYUSA

Microbial production of plant-derived natural products by engineered microorganisms has achieved great success thanks to large extend to metabolic engineering and synthetic ***,the water-soluble colored pigments found in terrestrial plants that are responsible for the red,blue and purple coloration of many flowers and fruits,are extensively used in food and cosmetics industry;however,their current supply heavily relies on complex extraction from plant-based materials.A promising alternative is their sustainable production in metabolically engineered ***,we review the recent progress on anthocyanin biosynthesis in engineered bacteria,with a special focus on the systematic engineering modifications such as selection and engineering of biosynthetic enzymes,engineering of transportation,regulation of UDP-glucose supply,as well as process *** promising engineering strategies will facilitate successful microbial production of anthocyanins in industry in the near future.

关键词： Anthocyanin Enzyme engineering Metabolic engineering Microbial production

Berberine Attenuates Cigarette Smoke Extract-induced Airway Inflammation in Mice:Involvement of TgF-β1/Smads Signaling Pathway

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Current Medical Science 2019年第5期39卷 748-753页

作者： Wen WANg gan zha Jin-jing ZOU xun WANg Chun-nian LI Xiao-jun WU Department of Respiratory and Critical Care Medicine Rentnin Hospital of Wuhan UniversityWuhan 430060China

Although several studies confirmed that berberine may attenuate airway inflammation in mice with chronic obstructive pulmonary disease(COPD),its underlying mechanisms were not clear until *** aimed to establish an experiment mouse model for COPD and to investigate the effects of berberine on airway inflammation and its possible mechanism in COPD model mice induced by cigarette smoke extract(CSE).Twenty SPF C57BL/6 mice were randomly divided into PBS control group,COPD model group,low-dose berberine group and high-dose berberine group,5 mice in each *** neutrophils and macrophages were examined by Wright's *** levels of inflammatory cytokines TNF-α and IL-6 in bronchoalveolar lavage fluid(BALF)were detennined by enzyme-linked immunosorbent *** expression levels of TgF-β1,Smad2 and Smad3 mRNA and proteins in lung tissues were respectively detected by quantitative real-time polymerase chain reaction and Western *** was found that CSE increased the number of inflammation cells in BALF,elevated lung inflammation scores,and enhanced the TgF-β1/Smads signaling activity in ***-dose berberine restrained the alterations in the COPD mice induced by *** was concluded that high-dose berberine ameliorated CSE-induced airway inflammation in COPD ***-β1/Smads signaling pathway might be involved in the *** findings suggested a therapeutic potential of high-dose berberine on the CSE-induced airway inflammation.

关键词： berberine cigarette smoke extract chronic obstructive pulmonary disease TgF-β1/Smads signaling pathway

Correction: Long non-coding RNA LINC02163 accelerates malignant tumor behaviors in breast cancer by regulating the microRNA-511-3p/HMgA2 axis as a competing endogenous RNA

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Oncology Research 2024年第9期32卷 1517-1522页

作者： CHENgLIN QIN LINFANg JIN JIA LI WENzha.g zha HUIMINg DINg XIAORONg LIU xun ZHU Department of Thyroid and Breast Surgery The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215000China Department of general Surgery The Fourth Affiliated Hospital of Nantong Medical CollegeYancheng City No.1 People’s HospitalYanchengJiangsu 224001China Department of Pathology Affiliated Hospital of Jiangnan University(Wuxi Fourth People’s Hospital)WuxiJiangsu 214062China Department of general Surgery Affiliated Hospital of Nantong UniversityNantongJiangsu 226001China Department of general Surgery The Second Affiliated Hospital of Jiaxing UniversityJiaxingZhejiang 314000China

In the article“Long non-coding RNA LINC02163 accelerates malignant tumor behaviors in breast cancer by regulating the microRNA-511-3p/HMgA2 axis as a competing endogenous RNA”(Oncology Research,2020,Vol.28,No.5,pp.483–***:10.3727/096504020X15928179818438),there was an error in the processing of *** further confirm our observation,we repeated multiple experiments involving in this study,including Flow Cytometry,Transwell Cell Migration and Invasion Assays,Xenograft Tumor Model,and Western *** have revised the figures to correct these *** versions of the Figs.2,4,5,6,and 7 are *** corrections do not change any results or conclusion of the *** apologize for any inconvenience caused.

关键词： HMgA2 endogenous breast

HOMOMORPHISMS BETWEEN CHEVALLEY gROUPS OF TYPES C_nAND g_2 OVER FINITE FIELDS

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Chinese Annals of Mathematics,Series B 1997年第2期18卷 167-172页

作者： zha JIANgUO Department of Applied Mathematics Tongji UniversityShanghai 200092China

It is known that there exists an isogeny sort of Chevalley groups g (Σ, F) associated to any indecomposable root system Σ and any field F . In this paper the author determines all nontrivial homomorphisms from g(Σ, k) to g(Σ, K) when the root system Σ is of type C n or g 2 , and the fields k and K are finite fields of characteristic p .

关键词： Chevalley group Homomorphism Finite field

geometric Error Identification of gantry-Type CNC Machine Tool Based on Multi-Station Synchronization Laser Tracers

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 150-162页

作者： Jun zha Huijie zha.g School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China Xi’an Jiaotong University Suzhou Academy Suzhou 215123China

Laser tracers are a three-dimensional coordinate measurement system that are widely used in industrial *** propose a geometric error identification method based on multi-station synchronization laser tracers to enable the rapid and high-precision measurement of geometric errors for gantry-type computer numerical control(CNC)machine *** method also improves on the existing measurement efficiency issues in the single-base station measurement method and multi-base station time-sharing measurement *** consider a three-axis gantry-type CNC machine tool,and the geometric error mathematical model is derived and established based on the combination of screw theory and a topological analysis of the machine kinematic *** four-station laser tracers position and measurement points are realized based on the multi-point positioning principle.A self-calibration algorithm is proposed for the coordinate calibration process of a laser tracer using the Levenberg-Marquardt nonlinear least squares method,and the geometric error is solved using Taylor’s first-order linearization *** experimental results show that the geometric error calculated based on this modeling method is comparable to the results from the Etalon laser *** a volume of 800 mm×1000 mm×350 mm,the maximum differences of the linear,angular,and spatial position errors were 2.0μm,2.7μrad,and 12.0μm,respectively,which verifies the accuracy of the proposed *** research proposes a modeling method for the precise measurement of errors in machine tools,and the applied nature of this study also makes it relevant both to researchers and those in the industrial sector.

关键词： Multi-point positioning Multi-station synchronization CNC machine tool geometric error Error separation

Evasion strategies of a three-player lifeline game

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Science China(Information Sciences) 2018年第11期61卷 144-154页

作者： Fan zha.g Wenzhong zha School of Automation Beijing Institute of Technology State Key Laboratory of Intelligent Control and Decision of Complex System Information Science Academy China Electronics Technology Group Corporation

This study examines a multi-player pursuit-evasion game, more specifically, a three-player lifeline game in a planar environment, where a single evader is tasked with reaching a lifeline prior to capture. A decomposition method based on an explicit policy is proposed to address the game qualitatively from two main aspects:(1) the evader’s position distribution to guarantee winning the game(i.e., the escape zone),which is based on the premise of knowing the pursuers’ positions initially, and(2) evasion strategies in the escape zone. First, this study decomposes the three-player lifeline game into two two-player sub-games and obtains an analytic expression of the escape zone by constructing a barrier, which is an integration of the solutions of two sub-games. This study then explicitly partitions the escape zone into several regions and derives an evasion strategy for each region. In particular, this study provides a resultant force method for the evader to balance the active goal of reaching the lifeline and the passive goal of avoiding capture. Finally,some examples from a lifeline game involving more than one pursuer are used to verify the effectiveness and scalability of the evasion strategies.

关键词： lifeline game three-player pursuit-evasion game barrier evasion strategy game of kind