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Long-term outcomes of brainstem arteriovenous malformations after different management modalities: a single-centre experience

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Stroke & Vascular Neurology 2021年第1期6卷 65-73页

作者： Yu Chen Ruinan Li Li Ma Xiangyu Meng Debin Yan Hao Wang xun ye Hengwei Jin Youxiang Li Dezhi Gao Shibin Sun Ali Liu Shuo Wang Xiaolin Chen Yuanli Zhao Department of Neurosurgery Beijing Tiantan HospitalBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Department of Interventional Neuroradiology Beijing Tiantan HospitalBeijingChina Stroke Center Beijing Institute for Brain DisordersBeijingChina Department of Neurosurgery Peking University International HospitalBeijingChina Department of Gamma-Knife Center Beijing Tiantan HospitalBeijingChina

Objective The aims of this study are to clarify the long-term outcomes of brainstem arteriovenous malformations(AVMs)after different management *** The authors retrospectively reviewed 61 brainstem AVMs in their institution between 2011 and *** rupture risk was represented by annualised haemorrhagic *** were divided into five groups:conservation,microsurgery,embolisation,stereotactic radiosurgery(SRS)and embolisation+*** outcomes were evaluated by the modified Rankin Scale(mRS).Subgroup analysis was conducted between different management modalities to compare the long-term outcomes in rupture or unruptured *** All of 61 brainstem AVMs(12 unruptured and 49 ruptured)were followed up for an average of 4.5 *** natural annualised rupture risk was 7.3%,and the natural annualised reruptured risk in the ruptured cohort was 8.9%.13 cases were conservative managed and 48 cases underwent intervention(including 6 microsurgery,12 embolisation,21 SRS and 9 embolisation+SRS).In the selection of interventional indication,diffuse nidus were often suggested conservative management(p=0.004)and nidus involving the midbrain were more likely to be recommended for intervention(p=0.034).The risk of subsequent haemorrhage was significantly increased in partial occlusion compared with complete occlusion and conservative management(p<0.001,p=0.036,respectively).In the subgroup analysis,the follow-up mRS scores of different management modalities were similar whether in the rupture cohort(p=0.064)or the unruptured cohort(p=0.391),as well as the haemorrhage-free survival(p=0.145).In the adjusted Bonferroni correction analysis of the ruptured cohort,microsurgery and SRS could significantly improve the obliteration rate compared with conservation(p<0.001,p=0.001,respectively)and SRS may have positive effect on avoiding new-onset neurofunctional deficit compared with microsurgery and embolisation(p=0.003,p=0.003,respectively).Conclusio

关键词： brainstem modalities conservative

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Preliminary exploration of the development of a collagenous artificial dura mater for sustained antibiotic release

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Chinese Medical Journal 2013年第17期126卷 3329-3333页

作者： WANG Hao DONG Hui KANG Cheng-gui LIN Cheng ye xun ZHAO Yuan-li Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Beijing TianXinFu Medical Appliance Company Ltd. China

Background Intracranial infection is one of the most common complications of open craniocerebral injury and of conventional craniotomy in neurosurgery. The presence of blood-brain barrier leads to lower drug concentrations in the cerebrospinal fluid than in the venous blood. Increasing the intravenous dosage or frequency carries the risk of systemic adverse reactions or infections in other parts of the body. Developing an artificial dura mater （ADM） for sustained antibiotic release for use during neurosurgery can solve the problems perfectly. Methods Three types of drug-loaded ADMs made of collagen and containing cefuroxime sodium, ceftriaxone sodium, or norvancomycin were prepared. The antibacterial activity and sustained release characteristics of the ADMs were examined using bacteriostatic and release tests. Results Single-layered collagen based ADMs （40 mm×50 mm×5 mm） containing 18 mg cefuroxime sodium or ceftriaxone sodium were not suitable for continued development because of drug preservation and stability issues. Using smaller ADMs （20 mm30 mm×7 mm）, containing 4.86 mg of norvancomycin, with increased collagen density and a three-layered film with two outer drug-free films above and below the antibiotic layer resulted in sustained cumulative release of 2.91 mg （59.9%） of norvancomycin over 72 hours. The similar factor （f2） comparison method proved that products from a same batch were statistically significant similar （f2 〉50）. Conclusions Artificial ADMs made of collagen can be processed to provide a mature dural repair material for the sustained release of norvancomycin. This system may provide a basis for developing sustained release materials for other drugs.

关键词： intracranial infection drug release antibiotics artificial dura mater

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从侵犯商业秘密罪看全球化背景下刑民法之界域

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河北法学 2009年第10期27卷 112-116页

作者：胡业勋西南财经大学法学院四川成都610074

1997年侵犯商业秘密罪进入刑法典以来,司法实践中出现了很多问题。这就需要对侵犯商业秘密罪进行立罪反思,当前在侵犯商业秘密罪之立罪上,存在着立罪理念困惑、立罪依据迷茫以及立罪技巧混沌等问题。其症结在于侵犯商业秘密罪上存在着... 详细信息

1997年侵犯商业秘密罪进入刑法典以来,司法实践中出现了很多问题。这就需要对侵犯商业秘密罪进行立罪反思,当前在侵犯商业秘密罪之立罪上,存在着立罪理念困惑、立罪依据迷茫以及立罪技巧混沌等问题。其症结在于侵犯商业秘密罪上存在着刑民之交叉互动,未能对其进行界定,面对着全球化背景的冲击,必须在刑民之间厘定一条相对明晰的界域,来达到更好的对商业秘密保护之目的。

关键词：商业秘密立罪刑民交叉

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Postoperative incidence of seizure and cerebral infarction in pediatric patients with epileptic type moyamoya disease:a meta-analysis of single rate

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Chinese Neurosurgical Journal 2021年第3期7卷 157-164页

作者： Jingjing Liu Qinlan Xu Hongchuan Niu Rong Wang xun ye Xianzeng Liu Peking University International Hospital Department of NeurologyPeking UniversityBeijingChina Boston Children’s Hospital Division of Epilepsy and Clinical NeurophysiologyDepartment of NeurologyHarvard Medical SchoolBostonUSA Peking University International Hospital Department of NeurosurgeryPeking UniversityBeijingChina Beijing Tiantan Hospital Department of NeurosurgeryCapital Medical UniversityBeijingChina

Background:Surgery is a conventional mature treatment for moyamoya disease(MMD).However,whether surgery is also an effective therapy for epileptic type MMD has seldom been investigated *** study aims to summarize the pooled postoperative incidence of seizure and cerebral infarction in pediatric patients with epileptic type moyamoya ***:The study was a systematic review and critical appraisal with a meta-analysis of cohort studies,both prospective and *** were identified by a computerized search of PubMed,Embase,Web of Science,Wanfang,and CNKI *** a literature search,a total of 7 cohort studies were *** I2statistic was used to quantify heterogeneity.A fixed-effect model was used to synthesize the *** linear regression test of funnel plot asymmetry was used to estimate the potential publication ***:The pooled estimated postoperative incidence of seizure in pediatric patients with epileptic type moyamoya disease was 23.44%.The pooled estimated postoperative incidence of cerebral infarction in pediatric patients with epileptic type moyamoya disease was 9.12%.Low substantial heterogeneity and potential publication bias were ***:Evidence from this study suggests that the postoperative incidence of seizure and cerebral infarction is relatively *** is an effective and secure therapy for pediatric patients with epileptic type moyamoya disease.

关键词： Moyamoya disease Epileptic type Seizure Ischemic event Surgery

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Comparison of CT-guided aspiration to key hole craniotomy in the surgical treatment of spontaneous putaminal hemorrhage: a prospective randomized study

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Frontiers of Medicine 2007年第2期1卷 142-146页

作者： ZHAO Jizong ZHOU Liangfu ZHOU Dingbiao WANG Renzhi WANG Mei WANG Dejiang WANG Shuo YUAN Ge KANG Shuai JI Nan ZHAO Yuanli MD ye xun Department of Neurosurgery Beijing Tiantan HospitalCapital University of Medical SciencesBeijing 100050China Department of Neurosurgery Hua Shan HospitalFudan UniversityShanghai 200040China Department of Neurosurgery General Hospital of People’s Liberation ArmyBeijing 100853China Department of Neurosurgery Peking Union Medical College HospitalBeijing 100730China Institute of Hygienic Economics Beijing 100050China

This study was designed to compare the approaches and efficacies of two different ways of neurosurgical management for spontaneous putaminal hemorrhage(SPH):computed tomographic-guided aspiration(CTGA)and the key-hole approach(KHA).The indications of the two approaches are also *** September 2001 to 2003,a total of 1077 cases of SPH distributed in 135 hospitals all over the mainland of China were included for *** cases had three-month follow-up *** study was designed in a single-blinded manner to compare the efficacies of the different *** were 563 cases in the CTGA group,165 in the KHA group,and 217 cases in the conventional open craniotomy(COC)*** the CTGA and KHA groups,the mortalities at one month after operation(M1m)were 17.9% and 18.3%,respectively,while the mortalities at three months after operation(M3m)were 19.4% and 19.4%,respectively(P>0.05).The postoperative complications due to CTGA(23.7%)were not significantly different from those due to KHA(25.7%)(P=0.420).The M3m of patients with Glasgow coma scale(GCS)h8 was 3.45 and 4.0 times as much as those with GCS>8,*** M3m of patients with complications was 3.92 times as much as those without *** M3m of patients with hemorrhage volume ≥70 mL was 2.67 times as much as those50 mL.

关键词： putaminal hemorrhage surgical procedures,operative craniotomy computed tomography guided aspiration key-hole approach

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Phase I study of CAR-T cells with PD-1 and TCR disruption in mesothelin-positive solid tumors

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Cellular & Molecular Immunology 2021年第9期18卷 2188-2198页

作者： Zhenguang Wang Na Li Kaichao Feng Meixia Chen Yan Zhang Yang Liu Qingming Yang Jing Nie Na Tang Xingying Zhang Chen Cheng Lianjun Shen Jiaping He xun ye Wei Cao Haoyi Wang Weidong Han Medical School of Chinese PLA BeijingChina Department of Biotherapeutic the First Medical CenterChinese PLA General HospitalBeijingChina State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina School of Life Sciences University of Science and Technology of ChinaHefeiChina Gracell Biotechnologies(Shanghai)Co. LtdShanghaiChina Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina

Programmed cell death protein-1(PD-1)-mediated immunosuppression has been proposed to contribute to the limited clinical efficacy of chimeric antigen receptor T(CAR-T)cells in solid *** generated PD-1 and T cell receptor(TCR)deficient mesothelin-specific CAR-T(MPTK-CAR-T)cells using CRISPR-Cas9 technology and evaluated them in a dose-escalation study.A total of 15 patients received one or more infusions of MPTK-CAR-T cells without prior *** dose-limiting toxicity or unexpected adverse events were observed in any of the 15 *** best overall response was stable disease(2/15 patients).Circulating MPTK-CAR-T cells peaked at days 7–14 and became undetectable beyond 1 ***-positive CAR-T cells rather than TCR-negative CAR-T cells were predominantly detected in effusion or peripheral blood from three patients after *** further confirmed the reduced persistence of TCR-deficient CAR-T cells in animal *** results establish the preliminary feasibility and safety of CRISPR-engineered CAR-T cells with PD-1 disruption and suggest that the natural TCR plays an important role in the persistence of CAR-T cells when treating solid tumors.

关键词： CAR-T CRISPR-Cas9 PD-1 TCR Mesothelin

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环境中氡及其子体的危害与控制

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现代地质 2008年第5期22卷 857-868页

作者：程业勋中国地质大学地下信息探测技术与仪器教育部重点实验室北京100383 中国地质大学地球物理与信息技术学院北京100083

简要回顾氡致肺癌的长时间认识过程和研究历史,简述了当年铀矿工人和矿工吸入氡及其子体与肺癌发病率的关系,指出环境中氡的危害。重点讨论了国内外室内氡和地下建筑物中氡浓度分布及其来源,从而启发人们研究环境中氡的地质来源以及控... 详细信息

简要回顾氡致肺癌的长时间认识过程和研究历史,简述了当年铀矿工人和矿工吸入氡及其子体与肺癌发病率的关系,指出环境中氡的危害。重点讨论了国内外室内氡和地下建筑物中氡浓度分布及其来源,从而启发人们研究环境中氡的地质来源以及控制室内氡水平的基本措施;进一步阐述了我国室内氡研究的成果和需要进一步研究的问题。

关键词：环境氡危害辐射氡的来源控制措施

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Electroencephalographic features in pediatric patients with moyamoya disease in China

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Chinese Neurosurgical Journal 2020年第1期6卷 20-27页

作者： Lu Jia Xia Qing Yang Tuanfeng Qiang Jun Liu Xianzeng ye xun Wang Rong Department of Neurology Peking University International HospitalNo.1 Life Park RoadChangping DistrictBeijing 102206China Department of Neurosurgery Peking University International HospitalBeijing 102206China Department of Neurosurgery Beijing Tiantan HospitalBeijing 100070China

Background:Moyamoya disease(MMD)is a relatively important and common disease,especially in East Asian *** are few reports about EEG in children with MMD in China till *** study is aimed to analyze the electroencephalographic features of MMD in pediatric patients in China ***:Pediatric patients with MMD who were hospitalized in Peking University International Hospital and Beijing Tiantan Hospital from January 2016 to December 2018 were *** and electroencephalography(EEG)findings were analyzed ***:A total of 110 pediatric patients with MMD were involved,and 17(15.5%)cases had a history of seizure or *** stroke was associated with a 1.62-fold relative risk of seizure.A subset of 15 patients with complete EEG data was *** for EEG in patients with MMD included limb shaking,unilateral weakness,or generalized *** EEG was seen in 14(93.3%)cases,with the most common findings being focal slowing 12(80.0%),followed by epileptiform discharge 10(66.7%),and diffuse slowing 9(60.0%)."Rebuild up"phenomenon on EEG was observed in one ***:Seizure and abnormal background activity or epileptiform discharge on EEG were common in pediatric patients with *** may play a role in differential diagnosis among the transient neurological events in MMD such as transient ischemic attack and seizure.

关键词： Electroencephalography Moyamoya disease pediatric seizure epilepsy

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基于高斯型窗函数的基小波构造

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数学的实践与认识 2008年第6期38卷 183-187页

作者：郑勋烨中国地质大学信息工程学院北京100083

阐述了基于高斯型窗函数的可容基小波构造,讨论了若干类基小波.首先引入若干经典基小波如墨西哥草帽小波、莫莱小波、DOG犬小波和盖博解析小波,作者发现它们具有统一的结构,即均由高斯窗函数生成;进而在犬小波结构的启示下,构造了由高... 详细信息

阐述了基于高斯型窗函数的可容基小波构造,讨论了若干类基小波.首先引入若干经典基小波如墨西哥草帽小波、莫莱小波、DOG犬小波和盖博解析小波,作者发现它们具有统一的结构,即均由高斯窗函数生成;进而在犬小波结构的启示下,构造了由高斯窗函数的差形成的犬小波族,对之验证了可容性条件;并且将它推广为有限个高斯窗函数的线性组合形成的小波,确定了带通条件.

关键词：小波变换基小波可容性条件高斯型窗函数

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糖尿病大鼠肾皮质节活化正常T细胞表达与分泌因子和desmin表达及其干预的研究

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中国临床药理学杂志 2015年第1期31卷 31-33,37页

作者：叶迅洪郁芝浙江中医药大学附属广兴医院杭州市中医院内分泌代谢科杭州310007

目的研究糖尿病大鼠肾皮质RANTES和desmin表达及雷公藤内酯醇对其干预作用。方法 SD大鼠随机分为正常组(NG)、模型组(DM)和小、大剂量雷公藤内酯醇组(T1,T2:0.2,0.4 mg·kg-1),灌胃。实验第4,8,12周,检测各组5只大鼠的血糖、肾重、24 h... 详细信息

目的研究糖尿病大鼠肾皮质RANTES和desmin表达及雷公藤内酯醇对其干预作用。方法 SD大鼠随机分为正常组(NG)、模型组(DM)和小、大剂量雷公藤内酯醇组(T1,T2:0.2,0.4 mg·kg-1),灌胃。实验第4,8,12周,检测各组5只大鼠的血糖、肾重、24 h尿白蛋白;同时观察肾皮质中RANTES和demin mRNA的表达。结果 DM组,肾皮质RANTES和demin的表达在第4,8,12周较NG组显著升高(P<0.05),且从第4周末起,逐渐增高到12周末(P<0.05);T1、T2组较DM组表达量显著降低(P<0.01);且T2组较T1组各周的表达更低(P<0.05);从第4周末起,T1组的RANTES mRNA表达逐渐下降至12周末(P<0.05);与第4周末相比,T2组的RANTES mRNA表达在第12周末显著下降(P<0.01);T1组和T2组的desmin mRNA表达在第12周末均较第4周末均显著下降(P<0.05)。DM组RANTES mRNA的表达与desmin mRNA的表达和24 h尿蛋白显著正相关。结论雷公藤内酯醇可能通过抑制糖尿病大鼠肾皮质RANTES的过度表达,缓解足细胞损伤,减轻蛋白尿。

关键词：雷公藤内酯醇糖尿病肾脏疾病节活化正常T细胞表达与分泌因子

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