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Application Research on Real-Time Interactive Simulation System of Container Yard Based on Unity3D

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Open Journal of Modelling and Simulation 2022年第3期10卷 292-302页

作者： Rongrong Hu xumin zhou Yiping Yu Shanghai Maritime University Shanghai China Shanghai Tongsheng Logistics Park Investment and Development Co. Ltd. Shanghai China Department of Economic Management Xuhui University of Continuing Education Shanghai Shanghai China

In view of the limitations of the mathematical method used in the container terminal logistics system, this paper uses Unity3D to establish a computer simulation model for the container automated yard, which dynamically displays the operation process of the container automated yard logistics system in real time. Through the plane four-parameter coordinate conversion method and by taking the Shanghai urban construction coordinate system as the medium, it completes the conversion from the satellite positioning reference ellipsoid coordinates to the three-dimensional virtual scene coordinates. The example results show that the method is reliable and practical, improves the accuracy and efficiency of positioning, and provides a reliable reference basis for the container terminal logistics system.

关键词： Container Yard Unity3D GNSS Measurement Interactive Simulation

Abrogation of Hn RNP L enhances anti-PD-1 therapy efficacy via diminishing PD-L1 and promoting CD8^(+) T cell-mediated ferroptosis in castration-resistant prostate cancer

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Acta Pharmaceutica Sinica B 2022年第2期12卷 692-707页

作者： xumin zhou Libin Zou Hangyu Liao Junqi Luo Taowei Yang Jun Wu Wenbin Chen Kaihui Wu Shengren Cen Daojun Lv Fangpeng Shu Yu Yang Chun Li Bingkun Li Xiangming Mao Department of Urology Zhujiang HospitalSouthern Medical UniversityGuangzhou 510280China Second Department of Hepatobiliary Surgery Zhujiang HospitalSouthern Medical UniversityGuangzhou 510280China Nursing Department Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Urology Minimally Invasive Surgery Centerthe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Department of Urology Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Department of Urology Peking University Shenzhen HospitalShenzhen 518036China

Owing to incurable castration-resistant prostate cancer(CRPC)ultimately developing after treating with androgen deprivation therapy(ADT),it is vital to devise new therapeutic strategies to treat *** that target programmed cell death protein 1(PD-1)and programmed death ligand-1(PD-L1)have been approved for human cancers with clinical ***,many patients,especially prostate cancer,fail to respond to anti-PD-1/PD-L1 treatment,so it is an urgent need to seek a support strategy for improving the traditional PD-1/PD-L1 targeting *** the present study,analyzing the data from our prostate cancer tissue microarray,we found that PD-L1 expression was positively correlated with the expression of heterogeneous nuclear ribonucleoprotein L(Hn RNP L).Hence,we further investigated the potential role of Hn RNP L on the PD-L1 expression,the sensitivity of cancer cells to T-cell killing and the synergistic effect with anti-PD-1 therapy in ***,Hn RNP L knockdown effectively decreased PD-L1 expression and recovered the sensitivity of cancer cells to T-cell killing in vitro and in vivo,on the contrary,Hn RNP L overexpression led to the opposite effect in CRPC *** addition,consistent with the previous study,we revealed that ferroptosis played a critical role in T-cell-induced cancer cell death,and Hn RNP L promoted the cancer immune escape partly through targeting YY1/PD-L1 axis and inhibiting ferroptosis in CRPC ***,Hn RNP L knockdown enhanced antitumor immunity by recruiting infiltrating CD8^(+)T cells and synergized with anti-PD-1 therapy in CRPC *** study provided biological evidence that Hn RNP L knockdown might be a novel therapeutic agent in PD-L1/PD-1 blockade strategy that enhanced anti-tumor immune response in CRPC.

关键词： HnRNP L PD-L1 YY1 Ferroptosis Immune escape Immune checkpoint blockade Anti-PD-1 therapy Castration-resistant prostate cancer

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铁路网货车车流经路分配的优化模型及算法

铁道学报 1992年第4期14卷 43-48页

作者：高旭敏周潮顾炎西南交通大学

提出了铁路网车流经路选择的优化模型,它是一个线性规划问题。模型以路网总的运营费用最低作为目标函数,同时考虑了线路、车站的能力约束。由于LP模型的规模大,因此提出一种近似的网络算法,并通过实例计算,证明了方法的实用性。

关键词：铁路网车流经路选择网络算法

The Epitope Study on the SARS-CoV Nucleocapsid Protein

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Genomics, Proteomics & Bioinformatics 2003年第3期1卷 198-206页

作者： Shuting Li, Liang Lin, Hao Wang, Jianning Yin, Yan Ren, Zhe Zhao, Jie Wen, Cuiqi zhou, xumin Zhang, Xiaolei Li, Jingqiang Wang, Zhengfeng zhou, Jinxiu Liu, Jianmin Shao, Tingting Lei, Jianqiu Fang, Ningzhi Xu, and Siqi LiuBeijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China & Beijing Proteomics Institute, Beijing 101300, China Beijing Genomics Institute Chinese Academy of Sciences Beijing 101300 China.

The nucleocapsid protein (N protein) has been found to be an antigenic protein in a number of coronaviruses. Whether the N protein in severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is antigenic remains to be elucidated. Using Western blot and Enzyme-linked Immunosorbent Assay (ELISA), the recombinant N proteins and the synthesized peptides derived from the N protein were screened in sera from SARS patients. All patient sera in this study displayed strong positive immunoreactivities against the recombinant N proteins, whereas normal sera gave negative immunoresponses to these proteins, indicating that the N protein of SARS-CoV is an antigenic protein. Furthermore, the epitope sites in the N protein were determined by competition experiments, in which the recombinant proteins or the synthesized peptides competed against the SARS-CoV proteins to bind to the antibodies raised in SARS sera. One epitope site located at the C-terminus was confirmed as the most antigenic region in this protein. A detailed screening of peptide with ELISA demonstrated that the amino sequence from Codons 371 to 407 was the epitope site at the C-terminus of the N protein. Understanding of the epitope sites could be very significant for developing an effective diagnostic approach to SARS.

关键词： SARS coronavirus nucleocapsid protein antigenicity epitope

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关于上海中心城区优秀历史建筑重生的思考

住宅科技 2011年第11期31卷 40-46页

作者：周旭民上海黄浦置地(集团)有限公司

通过对上海中心城区优秀历史建筑现状及背景分析,指出历史建筑重生依然面临种种困境。优秀历史建筑的保护、改造和利用工作任重道远,需要学习和借鉴国外先进的保护管理经验和保护修缮技术,进一步完善历史建筑保护和管理的法律法规,加速... 详细信息

通过对上海中心城区优秀历史建筑现状及背景分析,指出历史建筑重生依然面临种种困境。优秀历史建筑的保护、改造和利用工作任重道远,需要学习和借鉴国外先进的保护管理经验和保护修缮技术,进一步完善历史建筑保护和管理的法律法规,加速专业技术和管理人才的培养。

关键词：上海中心城区优秀历史建筑重生保护性置换修缮

浅论上海中心城区优秀历史建筑保护性改造中的风险与对策

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住宅科技 2011年第6期31卷 56-59页

作者：周旭民上海黄浦置地(集团)有限公司

以上海市中心城区申达大楼的修缮改造为例,分析了优秀历史建筑保护与利用的重要性与实施改造存在的难点,针对实际改造过程中存在的风险,制定行之有效的消除风险的对策,通过严格做好风险评估,科学确定改造设计方案,切实解决施工难点,创... 详细信息

以上海市中心城区申达大楼的修缮改造为例,分析了优秀历史建筑保护与利用的重要性与实施改造存在的难点,针对实际改造过程中存在的风险,制定行之有效的消除风险的对策,通过严格做好风险评估,科学确定改造设计方案,切实解决施工难点,创新施工工艺,对工程进行全过程的风险监管,较好地完成对申达大楼的修缮改造与功能扩展。

关键词：上海市优秀历史建筑修缮改造保护利用风险控制

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大断面切眼支护设计的探讨

能源与节能 2019年第1期 119-120,171页

作者：周续敏大同煤矿集团同家梁矿山西大同037025

分析研究了挖金湾煤业公司山4#层一盘区8103切眼的支护方案。通过采取安全、经济、合理的支护方式,实现了安全、经济、高效的掘进目的。

关键词：大断面切眼支护设计

高海拔条件下PODE/柴油着火与燃烧特性研究

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工程热物理学报 2024年第1期45卷 286-294页

作者：董素荣刘泽坤焦宇飞赵旭敏周广猛张众杰刘瑞林陆军军事交通学院天津300161 曼彻斯特大学曼彻斯特M139PL 武警部队研究院北京100012

基于柴油与PODE化学反应机理,构建了TRF-PODE化学反应动力学模型(包含219种组分、903个基元反应)并验证,开展了高海拔条件下PODE/柴油着火与燃烧特性数值模拟研究。结果表明:在高海拔低压力下,PODE增加了着火瞬时放热率,降低了着火最高... 详细信息

基于柴油与PODE化学反应机理,构建了TRF-PODE化学反应动力学模型(包含219种组分、903个基元反应)并验证,开展了高海拔条件下PODE/柴油着火与燃烧特性数值模拟研究。结果表明:在高海拔低压力下,PODE增加了着火瞬时放热率,降低了着火最高温度对应时间;PODE对燃料着火起到促进作用,着火促进率最大值出现在负温度特性(NTC)区域范围内,且随着PODE掺混比例的增加而增大;高海拔条件下低温氧化中PODE增加了反应中OH·生成,促进nC7H16前期氧化,反应中羟基的最高摩尔分数随压力下降明显增加,使基元反应速率降低;高温条件下,PODE本身含氧增加了反应中的OH·的生成,降低了O_(2)参与生成OH·反应的比例,使更多的O_(2)能够氧化反应中的小分子,促进自由离子生成,提升反应活性,改善柴油机高海拔燃烧特性。

关键词：柴油聚甲氧基二甲醚高海拔着火与燃烧特性

槌果藤提取物对CIA小鼠模型Treg和Th17细胞及相关细胞因子的影响

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浙江中西医结合杂志 2017年第3期27卷 193-198页

作者：应旭旻周夏娟杭州市红十字会医院 310003 杭州市急救中心浙江中医药大学附属第一医院全科医学科杭州310006

目的探讨槌果藤对胶原诱导关节炎(CIA)模型小鼠全血和脾脏的Treg和Th17细胞比例及IL-17和TGFβ1水平的影响。方法 25只DBA/1J小鼠,采用牛Ⅱ型胶原蛋白制备CIA小鼠模型后根据踝关节病变总积分分为正常组(n=5)、生理盐水组(n=5)、槌果藤... 详细信息

目的探讨槌果藤对胶原诱导关节炎(CIA)模型小鼠全血和脾脏的Treg和Th17细胞比例及IL-17和TGFβ1水平的影响。方法 25只DBA/1J小鼠,采用牛Ⅱ型胶原蛋白制备CIA小鼠模型后根据踝关节病变总积分分为正常组(n=5)、生理盐水组(n=5)、槌果藤低剂量组(0.5g/kg,n=5)、中剂量组(1.0g/kg,n=5)和高剂量组(1.5g/kg,n=5)。免疫后第21天开始给予槌果藤提取物灌胃,共4周。采用细胞流式仪检测小鼠血和脾脏Treg和Th17细胞百分比,ELISA法检测血IL-17和TGFβ1水平。结果 (1)牛Ⅱ型胶原蛋白诱导的CIA小鼠3周后开始首只小鼠足趾出现红肿,第7周到达高峰,小鼠造模成功率达90%以上。(2)与正常组比较,生理盐水组小鼠血和脾脏Treg细胞百分比明显下降[血:(1.17±0.36)%比(7.09±3.86)%,P<0.01);脾脏:(1.56±0.48)%比(8.03±1.75)%,P<0.01)];Th17细胞百分比显著上升[血:(3.96±2.05)%比(0.57±1.60)%,P<0.01);脾脏:(8.32±1.62)%比(0.94±0.30)%,P<0.01)];与生理盐水组比较,槌果藤低、中、高剂量组血、脾脏Treg细胞百分比上升[血:(2.30±0.21)%、(3.78±1.68)%、(4.51±1.58)%比(1.17±0.36)%,P均<0.01);脾脏:(2.75±0.74)%、(4.19±1.45)%、(5.28±1.76)%比(1.56±0.48)%,P均<0.01)],Th17细胞下降[血:(1.78±0.50)%、(1.35±0.36)%、(0.91±0.31)%比(3.96±2.05)%,P均<0.01;脾脏:(3.66±1.69)%、(2.67±0.74)%、(1.70±0.44)%比(8.32±1.62)%,P均<0.01];(3)与正常组比较,生理盐水组小鼠血清IL-17水平明显上升[(31.81±7.33)pg/mL比(12.26±4.89)pg/mL,P<0.01],TGFβ1水平明显下降[(191.62±112.47)pg/mL比(637.33±97.42)pg/mL,P<0.01];与生理盐水组比较,槌果藤低、中、高剂量组血清IL-17水平显著降低[(17.16±2.34)pg/mL、(16.02±2.78)、(10.46±1.83)pg/mL比(31.81±7.33)pg/mL,P<0.01],TGFβ1水平显著升高[(342.63±41.78)pg/mL、(484.76±43.64)pg/mL、(500.83±40.80)pg/mL比(191.62±112.47)pg/mL,P<0.01]。结论槌果藤提取物对CIA模型小鼠血和脾脏Treg和Th17细胞比例及血IL-17和TGFβ1水平具有调节作用。

关键词：小鼠类风湿关节炎胶原诱导性关节炎槌果藤 Treg和Th17细胞细胞因子