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Immuno-Protective Efficiency of the Bivalent Inactivated Vaccine Against Vibrio scophthalmi and Aeromonas salmonicida Infections in Turbot(Scophthalmus maximus L.)

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Journal of Ocean University of China 2023年第4期22卷 1079-1086页

作者： ZHOU Shun ZHENG xujia DING Yuanyuan SU Lin HUANG Qing XIU Yunji School of Marine Science and Engineering Qingdao Agricultural UniversityQingdao 266109China

Vibrio scophthalmi and Aeromonas salmonicida can cause high turbot mortality and huge economic ***,vaccination is the most promising method for preventing communicable *** this study,we used formalin to kill *** and *** cells,and mixed with the mineralized oil adjuvant(Montanide^(TM)ISA 763 AVG)to prepare the bivalent inactivated *** results showed that turbot inoculated with the bivalent inactivated vaccine exhibited strong tolerance to the infection of *** and ***,and no obvious clinical symptoms and pathological changes were *** activities of enzymes lysozyme,acid phosphatase and complement C3 had significantly increased after the *** antibody titer response of vaccinated turbot was greatly boosted,which was positively connected with the immunological impact according to ELISA ***,the expression levels of immune-related genes such as MHC-IIα,MHC-IIβ,CD4,CD8,TNF-αand IL^(-1)βwere up-regulated,demonstrating that it might stimulate humoral and cellular immunological response in *** findings highlight the potential of the bivalent inactivated vaccine for controlling *** and *** infections in turbot.

关键词： Aeromonas salmonicida Vibrio scophthalmi bivalent inactivated vaccine immune response

A Compact High Power Laser-Diode Side-Pumped Tm,Ho：YAG Laser Nearly at Room Temperature with Intracavity Tm：YAG Laser

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Chinese Physics Letters 2014年第4期31卷 54-56页

作者： ZHANG Chao DU Shi-Feng NIU Yan-Xiong wang Cai-Li wang Zhi-Chao xujia-Lin BO Yong PENG Qin-Jun CUI Da-Fu XU Zu-Yan ~chool of Instrument Science and Optoelectronic Engineering Beihang University Beijing 100189 Research Center for Laser Physics and Technology Key Lab of Functional Crystal and Laser Technology Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190

We report a compact high power Tm,Ho：YAG laser nearly at room temperature. The laser-diode side-pumped Tm：YAG and Tm,Ho：YAG laser modules are operated in the same cavity. The laser yields 37.34 W of continuous wave output power under the temperature of 6℃, corresponding to a maximum slope efficiency of 16.7% when the output power lies from 5.1 W to 27.0 W. This is the first report on the combined Tm：YAG and Tm,Ho：YAG lasers for obtaining high power 2.1 μm laser.

关键词： Laser A Compact High Power same

CD36 promotes tubular ferroptosis by regulating the ubiquitination of FSP1 in acute kidney injury

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Genes & Diseases 2024年第1期11卷 449-463页

作者： Yixin Ma Lili Huang Zheng Zhang Pengfei Yang Qingsong Chen xujia Zeng Fangyan Tan Chunxia wang Xiongzhong Ruan Xiaohui Liao Department of Nephrology The Second Affiliated HospitalChongqing Medical UniversityChongqing 400010China Department of Cell Biology and Genetics Chongqing Medical UniversityChongqing 400016China Centre for Nephrology Royal Free and University College Medical SchoolUniversity College LondonRoyal Free CampusRowland Hill StreetLondon NW32PFUnited Kingdom Centre for Lipid Research Key Laboratory of Molecular Biology on Infectious DiseasesMinistry of EducationChongqing Medical UniversityChongqing 400016China Kuanren Laboratory of Translational Lipidology Centre for Lipid ResearchSecond Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

Reactive oxidative species(ROos)production-driven ferroptosis plays a role in acute kidney injury(Akl).However,its exact molecular mechanism is poorly *** receptor CD36 has important roles in oxidizing lipids,lipid accumulation,metabolic syndrome,and insulin resistance in chronic kidney disease,but its roles remain unexplored in *** present study investigated the role and mechanism of CD36 in regulating proximal tubular cell ferroptosis and *** expression of CD36 was found to be significantly up-regulated in AKI renal tissues and correlated with renal function,which might serve as an independent biomarker for AKl ***,in adult mice subjected to AKl,deletion of CD36(CD36-/-)induced tubular cell Ros accumulation,ferroptosis activation,and renal ***,combining LC-MS/MS,co-IP,and ubiquitination analyses revealed that CD36 could specifically bind to ferroptosis suppressor protein 1(FSP1)and regulate its ubiquitination at sites K16 and K24,leading to FSP1 degradation and progression of ferroptosis in *** present results emphasize a novel mechanism of CD36 in cisplatin-induced *** discovery of the special CD36 roles in promoting ferroptosis and AKI development by regulating the ubiquitination of FSP1 in proximal tubular cells may be potential therapeutic targets for ***,CD36 may play a key role in the progression of ***,targeting CD36 may provide a promising treatment option for AKI.

关键词： Acute kidney injury CD36 Ferroptosis FSP1 Ubiquitin-dependent degradation

Wind regime for long-ridge yardangs in the Qaidam Basin, Northwest China

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Journal of Arid Land 2019年第5期11卷 701-712页

作者： GAO Xuemin DONG Zhibao DUAN Zhenghu LIU Min CUI xujia LI Jiyan Key Laboratory of Desert and Desertification Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China School of Tourism and Public Administration Jinzhong UniversityJinzhong 030619China School of Geography and Tourism Shaanxi Normal UniversityXi'an 710062China School of Geography Science Taiyuan Normal UniversityJinzhong 030619China Key Laboratory of Education Ministry on Environment and Resources in Tibetan Plateau Qinghai Normal UniversityXining 810008China

Yardangs are typical aeolian erosion landforms,which are attracting more and more attention of geomorphologists and geologists for their various morphology and enigmatic formation *** order to clarify the aeolian environments that influence the development of long-ridge yardangs in the northwestern Qaidam Basin of China,the present research investigated the winds by installing wind observation tower in the *** found that the sand-driving winds mainly blow from the north-northwest,northwest and north,and occur the most frequent in summer,because the high temperature increases atmospheric instability and leads to downward momentum transfer and active local convection during these *** annual drift potential and the ratio of resultant drift potential indicate that the study area pertains to a high-energy wind environment and a narrow unimodal wind *** wind energy decreases from northwest to southeast in the Qaidam Basin,with the northerly winds in the northwestern basin changing to more westerly in the southeastern *** strong and unidirectional wind regime for the long-ridge yardangs in the northwestern Qaidam Basin results from the combined effects of topographic obstacles such as the Altun Mountains and of the interaction between the air stream and the yardang *** study suggests that yardang evolution needs such strong and unidirectional winds in high-or intermediate-energy wind *** differs from sandy deserts or sandy lands,which usually develop at low-or intermediate-energy wind *** study clarifies the wind regime corresponding to the long-ridge yardangs'development,and lays firm foundation to put forward the formation mechanisms for yardangs in the Qaidam Basin.

关键词： aeolian landform yardang wind regime drift potential Qaidam Basin

Contribution of underlying terrain to sand dunes: evidence from the Qaidam Basin, Northwest China

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Journal of Arid Land 2021年第12期13卷 1215-1229页

作者： LI Jiyan QU Xin DONG Zhibao CAI Yingying LIU Min REN Xiaozong CUI xujia School of Geography Science Taiyuan Normal UniversityJinzhong 030619China School of Geography and Tourism Shaanxi Normal UniversityXi'an 710119China

Underlying terrain strongly influences dune ***,the impacts of underlying terrain on the dune formation are poorly *** the present research,we focused on dunes that formed in the alluvial fans and dry salt flats in the Qaidam Basin,Northwest *** quantified the dunes'sediment characteristics on different types of underlying terrain and the terrain's effects on the surface quartz grains by analyzing grain-size distribution,soluble salt contents and grain surface *** showed that barchan dunes were dominated by medium sands with a unimodal frequency distribution,whose peak corresponded to the saltation *** dunes were mainly composed of fine sands with a bimodal frequency distribution,whose main peak represented the saltation load,and whose secondary peak represented the modified saltation or suspension *** was transported from source area by running water(inland rivers)over short distances and by wind over relatively longer ***,quartz grains had poor roundness and were dominated by sub-angular and angular *** micro-textures indicated that dune sands were successively transported by exogenic agents(glaciation,fluviation and wind).Soluble salt contents were low in dunes that developed in the alluvial fans,which represented a low-energy chemical environment,so the grain surface micro-textures mainly resulted from mechanical erosion,with weak micro-textures formed by SiO2 solution and ***,soluble salt contents were much higher in dunes that developed in the dry salt flats,which indicated a high-energy chemical ***,in addition to micro-structures caused by mechanical erosion,micro-textures formed by SiO2 solution and precipitation also well *** results improve understanding of the sediment characteristics of dune sands and the effects of underlying terrain on dune development in the Qaidam Basin,China.

关键词： dune grain-size distribution soluble salts surface micro-texture Qaidam Basin

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基于散乱点的增量式曲面逼近

计算机辅助设计与图形学学报 2006年第9期18卷 1408-1413页

作者：秦绪佳王青鲍虎军浙江工业大学软件学院杭州310032 浙江大学CAD&CG国家重点实验室杭州310027

针对用接触式三维点数据获取设备快速输入的物体表面散乱点云数据,提出了增量式B样条曲面快速逼近算法.该算法首先要获得重建曲面的边界数据,以生成初始曲面;然后对输入的散乱数据点云用投影法计算出其参数值;再用模板子块在曲面上移动... 详细信息

针对用接触式三维点数据获取设备快速输入的物体表面散乱点云数据,提出了增量式B样条曲面快速逼近算法.该算法首先要获得重建曲面的边界数据,以生成初始曲面;然后对输入的散乱数据点云用投影法计算出其参数值;再用模板子块在曲面上移动,反算出模块子块的控制点;最后更新整个曲面的相应控制点,实现边输入、边逼近,即增量式曲面逼近.在输入过程中可看到曲面逐渐逼近目标曲面的过程,在误差大的区域可以增加输入点来改善曲面逼近效果.对于复杂曲面进行多次投影计算散乱数据点参数及曲面逼近,可达到良好效果.

关键词：曲面重建逼近 B样条点云数据增量

Dynamic changes of capillarization and peri-sinusoid fibrosis in alcoholic liver diseases

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World Journal of Gastroenterology 2004年第2期10卷 238-243页

作者： Guang-FuXu Xin-Yuewang Gui-LingGe Peng-TaoLi xujia De-LuTian Liang-DuoJiang Jin-XiangYang DigestiveDepartmentoftheAffiliatedDongzhimenHospital BeijingUniversityofTraditionalChineseMedicineBeijing100700China CentralElectronicMicroscopeExaminationStudioofBeijingUniversityofTCM Beijing100029China. BasicMedicalCollegeofBeijingUniversityofTCM Beijing100029China

AIM:To investigate the dynamic changes of capillarization and peri-sinusoid fibrosis in an alcoholic liver disease model induced by a new ***:Male SD rats were randomly divided into 6 groups,namely normal,4d,2w,4w,9w and 11w *** animals were fed with a mixture of alcohol for designated days and then decollated,and their livers were harvested to examine the pathological changes of hepatocytes, hepatic stellate cells,sinusoidal endothelial cells,sinusoid, *** generation of three kinds of extra cellular matrix was also ***:The injury of hepatocytes became severer as modeling going *** electronic microscope,fatty vesicles and swollen mitochondria in hepatocytes,activated hepatic stellate cells with fibrils could been seen near or around *** of sinusoidal endothelial cells were decreased or disappeared,sinusoidal basement was *** light microscopy typical peri-sinusoid fibrosis, griddinglike fibrosis, broaden portal areas, hepatocyte's fatty and balloon denaturation,iron sediment,dot necrosis,congregated lymphatic cells and leukocytes were *** I collagen showed an increasing trend as modeling going on,slightly recovered when modeling stopped for 2 weeks. Meanwhile,type IV collagen decreased rapidly when modeling began and recovered after modeling stopped for 2 *** increased as soon as modeling began and did not recover when modeling stopped for 2 ***:The pathological changes of the model were similar to that of human ALD,but mild in *** had typical peri-sinusoid fibrosis, however,capillarization seemed to be *** may be related with the reduction of type IV collagen in the basement of sinusoid during modeling.

关键词：酒精性肝病肝纤维化肝功能动物模型病理特点超微结构

Dynamic changes in the expression of matrix metalloproteinases and their inhibitors,TIMPs,during hepatic fibrosis induced by alcohol in rats

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World Journal of Gastroenterology 2004年第24期10卷 3621-3627页

作者： Guang-FuXu Peng-TaoLi Xin-Yuewang xujia De-LuTian Liang-DuoJiang Jin-XiangYang DepartmentofinfectiousDiseases 1^stAffiliatedDongzhimenHospitalBeijingUniversityofTraditionalChineseMedicineBeijing100700China DepartmentofDigestiveDiseases 1^stAffiliatedDongzhimenHospitalBeijingUniversityofTraditionalChineseMedicineBeijing100700China BasicMedicineCollegeofBeijingUniversityofTraditionalChineseMedicine Beijing100029China

AIM: To determine the dynamic changes in the expression of matrix metalloproteinases (MMPs) and the endogenous tissue inhibitors of MMPs inhibitors (TIMPs) during hepatic fibrosis induced by ***: Male Sprague-Dawley rats were randomly divided into normal, 4 d, 2 wk, 4 wk, 9 wk and 11 wk groups, and the model rats were fed with a mixture of alcohol by gastric infusion at the designed time, respectively, then decollated and their livers were harvested for the examination of MMP-2, MMP-3, MMP-9, MMP-13, TIMP-1 and TIMP-2 by immunohistochemistry, zymograghy and Western blotting, ***: Normal rats had moderate expression of MMP-2,which was decreased in the model rats except in the 11 wk group, where MMP-2 expression slightly increased. MMP-3 had the similar changing pattern to MMP-2 despite weaker expression. MMP-9 expression decreased in the 4 d and 2 wk groups, rose in the 4 wk group, decreased again in the 9 wk group and returned to normal levels in the 11 wk ***-13 expression decreased in the 4 d and 2 wk groups,and returned to normal levels in the 4 wk, 9 wk and 11 wk groups. TIMP-1 expression decreased in the 4 d and 2 wk groups, but sharply increased in the 4 wk group and sustained at a high level even after modeling was stopped for 2 wk. In normal rats TIMP-2 expression was strong. However, it decreased as soon as modeling began, and then gradually rose, but remained to a level lower than that in normal rats even after modeling was stopped for 2 ***: MMP-2 may not always expresses at a high level during hepatic fibrosis. MMP-13 and MMP-3 are acutely affected by TIMP-1. In this model TIMP-1 is the most powerful factor imposed on capillarization and peri-sinusoidal fibrosis. TIMP-2 is the most effective regulator on the metabolism of type Ⅳ collagen located in the basement of sinus.

关键词：动力变化基因表达矩阵金属蛋白抑制剂 TIMPs 肝纤维化诱导作用酒精老鼠消化系统

Synthesis and Crystal Structure of N-Methyl-9-(3,4-dimethoxylphenyl)-1,8-dioxo-1,2,3,4,5,6,7,8,9,10- decahydroacridine under Microwave Irradiation

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Chinese Journal of Structural Chemistry 2005年第2期24卷 131-134页

作者： ZHANGXiao-Jing TUShu-Jiang ZHUXiao-Tong ZHANGJin-Peng xujia-Ning wangQian DepartmentofChemistry XuzhouNormalUniversity KeyLabofBiotechnologyforMedicinalPlantsofJiangsuProvince XuzhouJiangsu221009China

The crystal structure of the title compound (C26H33NO4 (C25.68H32.04N0.68O4.32, Mr = 419.35)) has been determined by single-crystal X-ray diffraction. The crystal is of triclinic, space P21/c with a = 7.519(2), b = 28.933(5), c = 10.654(3) ?, β = 91.78(2)°, V = 2316.7(7) ?3, Z = 4, Dc = 1.202 g/cm3, μ = 0.081 mm-1, F(000) = 902, Mr = 423, the final R = 0.0424 and wR = 0.0911. In the structure, the pyridine ring adopts a boat conformation.

关键词： acridine microwave crystal structure