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Low-noise fluorescent detection of cardiac troponin I in human serum based on surface acoustic wave separation

Microsystems & Nanoengineering 2023年第6期9卷 261-272页

作者： Xuan Chen Chuanyu Zhang Xianglian Liu Yangchao Dong Hao Meng Xianming Qin Zhuangde Jiang xueyong wei State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong UniversityXian 710049China Department of Microbiology School of Preclinical MedicineFourth Military Medical UniversityXi'an 710032China The Second Affliated Hospital of Xi'an Jiaotong University Xi'an 710004China School of Mechano-Electronic Engineering Xidian UniversityXi'an 710071China

Acute myocardial infarction(AMI)is a life-threatening disease when sudden blockage of coronary artery *** the most specific biomarker,cardiac troponin I(cTnI)is usually checked separately to diagnose or eliminate AMI,and achieving the accurate detection of cTnI is of great significance to patients'life and *** with other methods,fluorescent detection has the advantages of simple operation,high sensitivity and wide ***,due to the strong fluorescence interference of biological molecules in body fluids,it is often difficult to obtain high *** order to solve this problem,in this study,surface acoustic wave separation is designed to purify the target to achieve more sensitive detection performance of fluorescent ***,the interference of background noise is almost completely removed on a microfluidic chip by isolating microbeads through acoustic radiation force,on which the biomarkers are captured by the immobilized detection *** then,the concentration of cTnI in human serum is detected by the fluorescence intensity change of the isolated functionalized *** this way,the detection limit of our biosensor calculated by 3σ/K method is 44 pg/mL and 0.34 ng/mL in PBS buffer and human serum ***,the reliability of this method has been validated by comparison with clinical tests from the nephelometric analyzer in hospital.

关键词： cardiac separation noise

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Fast frequency relocking for synchronization enhanced resonant accelerometer

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Microsystems & Nanoengineering 2022年第5期8卷 53-60页

作者： Liu Xu Yonghong Qi Zhuangde Jiang xueyong wei State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’anShaanxi 710049China

Synchronization,as a unique phenomenon,has been extensively studied in biology,chaotic systems,nonlinear dynamics,quantum information,and other *** from the characteristics of frequency amplification,noise suppression,and stability improvement,synchronization has been gradually applied in sensing,communication,time keeping,and other *** the sensing field,synchronization provides a new strategy to improve the performance of ***,the performance improvement is only effective within the synchronization range,and the narrow synchronization range has become a great challenge for the wide application of synchronizationenhanced sensing ***,we propose a frequency automatic tracking system(FATS)to widen the synchronization range and track the periodic acceleration signals by adjusting the frequency of the readout oscillator in real *** addition,a high-precision frequency measurement system and fast response control system based on FPGA(Field Programmable Gate Array)are built,and the tracking performance of the FATS for static and dynamic external signals is analyzed to obtain the optimal control *** results show that the proposed automatic tracking system is capable of static acceleration measurement,the synchronization range can be expanded to 975 Hz,and the relocking time is shortened to 93.4 ms at *** selecting the optimal PID parameters,we achieve a faster relocking time to meet the requirements of low-frequency vibration measurements,such as seismic detection and tidal monitoring.

关键词： synchronization locking acceleration

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Single-electron detection utilizing coupled nonlinear microresonators

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Microsystems & Nanoengineering 2020年第1期6卷 327-333页

作者： Xuefeng Wang xueyong wei Dong Pu Ronghua Huan Department of Mechanics Key Laboratory of Soft Machines and Smart Devices of Zhejiang ProvinceZhejiang UniversityHangzhou 310027People’s Republic of China State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’an 710049People’s Republic of China

Since the discovery of the electron,the accurate detection of electrical charges has been a dream of the scientific *** to some remarkable advantages,micro/nanoelectromechanical system-based resonators have been used to design electrometers with excellent sensitivity and ***,we demonstrate a novel ultrasensitive charge detection method utilizing nonlinear coupling in two micromechanical *** achieve single-electron charge detection with a high resolution up to 0.197±0.056 e=/√Hz Hz p at room *** findings provide a simple strategy for measuring electron charges with extreme accuracy.

关键词： temperature utilizing nonlinear

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Programmable synchronization enhanced MEMS resonant accelerometer

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Microsystems & Nanoengineering 2020年第1期6卷 654-663页

作者： Liu Xu Shudong Wang Zhuangde Jiang xueyong wei State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’an 710049China

Acceleration measurement is of great significance due to its extensive applications in military/industrial *** recent years,scientists have been pursuing methods to improve the performance of accelerometers,particularly through seeking new sensing ***,we present a synchronized oscillator-based enhancement approach to realize a fivefold resolution improvement of a microelectromechanical resonant *** the unidirectional electrical coupling method,we achieved synchronization of the sensing oscillator of the microelectromechanical resonant accelerometer and an external reading oscillator,which remarkably enhanced the stability of the oscillation system to 19.4 ppb and the resolution of the accelerometer to 1.91μ*** addition,the narrow synchronization bandwidth of conventional synchronized oscillators was discussed,and hence,we propose a novel frequency automatic tracking system to expand the synchronization bandwidth from 113 to 1246 Hz,which covers the full acceleration measurement range of±1 *** the first time,we utilized a unidirectional electrical synchronization mechanism to improve the resolution of resonant *** comprehensive scheme provides a general and powerful solution for performance enhancement of any microelectromechanical system(MEMS)resonant sensor,thereby enabling a wide spectrum of applications.

关键词： resonant oscillator hence

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Multiple virus sorting based on aptamer-modified microspheres in a TSAW device

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微系统与纳米工程(英文) 2023年第3期9卷 309-318页

作者： Xianglian Liu Xuan Chen Yangchao Dong Chuanyu Zhang Xiaoli Qu Yingfeng Lei Zhuangde Jiang xueyong wei State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’an 710049China Department of Microbiology the Fourth Military Medical UniversityXi’an 710032China

Due to the overlapping epidemiology and clinical manifestations of flaviviruses,differential diagnosis of these viral diseases is complicated,and the results are *** is perpetual demand for a simplified,sensitive,rapid and inexpensive assay with less *** ability to sort distinct virus particles from a mixture of biological samples is crucial for improving the sensitivity of ***,we developed a sorting system for the subsequent differential diagnosis of dengue and tick-borne encephalitis in the early *** employed aptamer-modified polystyrene(PS)microspheres with different diameters to specifically capture dengue virus(DENV)and tick-borne encephalitis virus(TBEV),and utilized a traveling surface acoustic wave(TSAW)device to accomplish microsphere sorting according to particle *** captured viruses were then characterized by laser scanning confocal microscopy(LSCM),field emission scanning electron microscopy(FE-SEM)and reverse transcription-polymerase chain reaction(RT‒PCR).The characterization results indicated that the acoustic sorting process was effective and damage-free for subsequent ***,the strategy can be utilized for sample pretreatment in the differential diagnosis of viral diseases.

关键词： diagnosis epidemiology sorting

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Frequency unlocking-based MEMS bifurcation sensors

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微系统与纳米工程(英文) 2023年第3期9卷 171-181页

作者： Yan Qiao Zhan Shi Yutao Xu xueyong wei Alaaeldin Elhady Eihab Abdel-Rahman Ronghua Huan Wenming Zhang State Key Laboratory of Mechanical System and Vibration School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghaiChina Department of Mechanics Key Laboratory of Soft Machines and Smart Devices of Zhejiang ProvinceZhejiang UniversityHangzhouChina State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’anChina Department of Systems Design Engineering University of WaterlooWaterlooONCanada

MEMS resonators exhibit rich dynamic behaviors under the internal resonance regime. In this work, we present a novel MEMS bifurcation sensor that exploits frequency unlocking due to a 1:3 internal resonance between two electrostatically coupled micro-resonators. The proposed detection mechanism allows the sensor to operate in binary (digital) and analog modes, depending on whether the sensor merely detects a significant jump event in the peak frequency upon unlocking or measures the shift in the peak frequency after unlocking and uses it in conjunction with a calibration curve to estimate the corresponding change in stimulus. We validate the success of this sensor paradigm by experimentally demonstrating charge detection. High charge resolutions are achieved in binary mode, up to 0.137 fC, and in analog mode, up to 0.01 fC. The proposed binary sensor enables extraordinarily high detection resolutions due to the excellent frequency stability under internal resonance and the high signal-to-noise ratio of the shift in peak frequency. Our findings offer new opportunities for high-performance ultrasensitive sensors.

关键词： locking bifurcation binary

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Robot-aided fN∙m torque sensing within an ultrawide dynamic range

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Microsystems & Nanoengineering 2021年第1期7卷 51-61页

作者： Shudong Wang xueyong wei Haojian Lu Ziming Ren Zhuangde Jiang Juan Ren Zhan Yang Lining Sun Wanfeng Shang Xinyu Wu Yajing Shen State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’an 710049China Mechanical and Biomedical Engineering Department City University of Hong KongHong Kong SAR 999077China Department of Mechatronics Chang’an UniversityXi’an 710054China Robotics and Microsystems Center Soochow UniversitySuzhou 215021China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518055China Shenzhen Research Institute City University of Hong KongShenzhen 440305China

In situ scanning electron microscope(SEM)characterization have enabled the stretching,compression,and bending of micro/nanomaterials and have greatly expanded our understanding of small-scale ***,as one of the fundamental approaches for material analytics,torsion tests at a small scale remain a major challenge due to the lack of an ultrahigh precise torque sensor and the delicate sample assembly ***,we present a microelectromechanical resonant torque sensor with an ultrahigh resolution of up to 4.78 fN∙m within an ultrawide dynamic range of 123 ***,we propose a nanorobotic system to realize the precise assembly of microscale specimens with nanoscale positioning accuracy and to conduct repeatable in situ pure torsion tests for the first *** a demonstration,we characterized the mechanical properties of Si microbeams through torsion tests and found that these microbeams were five-fold stronger than their bulk *** proposed torsion characterization system pushes the limit of mechanical torsion tests,overcomes the deficiencies in current in situ characterization techniques,and expands our knowledge regarding the behavior of micro/nanomaterials at various loads,which is expected to have significant implications for the eventual development and implementation of materials science.

关键词： torsion precise dynamic

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薄膜微结构换能元温度测量技术研究

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传感技术学报 2022年第8期35卷 1011-1017页

作者：张一中韦学勇张国栋赵玉龙平川张蕊任炜西安交通大学机械制造系统工程国家重点实验室陕西西安710054 陕西应用物理化学研究所应用物理化学国家级重点实验室陕西西安710061

为了适应火工品微型化、集成化和智能化等发展趋势,薄膜微结构换能元的引发温度测试已成为一项亟需解决的关键问题。采用MEMS技术将薄膜铂电阻和薄膜微结构换能元集成在氮化硅基底上,利用原子力显微镜等设备对薄膜铂电阻的几何尺寸进行... 详细信息

为了适应火工品微型化、集成化和智能化等发展趋势,薄膜微结构换能元的引发温度测试已成为一项亟需解决的关键问题。采用MEMS技术将薄膜铂电阻和薄膜微结构换能元集成在氮化硅基底上,利用原子力显微镜等设备对薄膜铂电阻的几何尺寸进行了表征,通过实验测量了薄膜微结构换能元在不同直流激励下铂电阻的阻值变化,从而得到了薄膜微结构换能元的温度响应曲线。此外,测得斯蒂芬酸铅的点火温度平均为318℃,与理论值330~350℃接近,验证了将薄膜铂电阻与薄膜微结构换能元集成于一体测量微小尺寸条件下发火温度的可行性与有效性。

关键词： MEMS火工品引发温度薄膜微结构换能元薄膜铂电阻

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参数调制微谐振器中的频率梳现象

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Acta Mechanica Sinica 2022年第11期38卷 79-88页

作者：王雪峰阳琪琪施展宦荣华朱位秋景兴建邓子辰韦学勇 Department of Engineering Mechanics MIIT Key Laboratory of Dynamics and Control of Complex SystemsNorthwestern Polytechnical UniversityXi’an710072China Department of Mechanics Key Laboratory of Soft Machines and Smart Devices of Zhejiang ProvinceZhejiang UniversityHangzhou310027China State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’an710049China Department of Mechanical Engineering City University of Hong KongHong Kong999077China

作为光频率梳的一种拓展,MEMS谐振器中的频率梳逐渐成为研究热点.本文利用一个具有参数调制功能的菱形微谐振器报道了频率梳现象.当静电驱动的菱形微谐振器通过低频周期激励进行轴向调制时,微谐振器的频域信号出现了具有等距梳齿的梳状... 详细信息

作为光频率梳的一种拓展,MEMS谐振器中的频率梳逐渐成为研究热点.本文利用一个具有参数调制功能的菱形微谐振器报道了频率梳现象.当静电驱动的菱形微谐振器通过低频周期激励进行轴向调制时,微谐振器的频域信号出现了具有等距梳齿的梳状振动响应.频率梳的梳齿间距与调制频率完全一致,同时梳齿的数量和幅度可通过调制低频周期激励的强度进行调整.另外,当微谐振器受到两个不同的低频激励共同调制时,混合频率梳进一步产生额外的梳齿.通过调整两个低频激励的频率之间的关系,本文首次实现了具有不等间距梳齿的频率梳,为实际应用提供了更灵活的齿间距调控.最后,基于动力学模型的理论分析很好地解释了相应的实验结果.

关键词：参数调制调制频率周期激励微谐振器频率梳静电驱动频域信号 MEMS谐振器

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1980—2016年中国北方风蚀气候侵蚀力的变化

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地理科学 2024年第4期44卷 703-710页

作者：刘伟邹学勇刘博王汝幸王祖正天津师范大学地理学部天津300387 北京师范大学地理科学学部北京100875 中国环境科学研究院北京100012 合肥大学旅游与会展学院安徽合肥230601

随着修订风蚀方程(RWEQ)的提出,采用增加了冻结因子的气候因子(WF)表达风蚀气候侵蚀力更具有科学性和必要性。基于中国北方风蚀区157个气象站1980—2016年的观测数据,逐月计算了各站点气候因子,并探讨了气候因子时空分布变化特征及影响... 详细信息

随着修订风蚀方程(RWEQ)的提出,采用增加了冻结因子的气候因子(WF)表达风蚀气候侵蚀力更具有科学性和必要性。基于中国北方风蚀区157个气象站1980—2016年的观测数据,逐月计算了各站点气候因子,并探讨了气候因子时空分布变化特征及影响因素。结果表明:①1980—1997年,年气候因子值表现为快速下降,从940.46 kg/m下降到273.03 kg/m;而1998—2016年,年气候因子值表现相对稳定,在139.81~398.85 kg/m范围内波动。②春季气候因子值约占全年63%,其变化也显著高于其它季节,这也是土壤风蚀发生在春季的主要原因。③气候因子的高值区分布在新疆东部、青海西部、40°N以北的内蒙古中西部,这与气压中心和高大山体地形分布有关。

关键词：气候因子土壤风蚀全球变暖北方风蚀区

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