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Effect of particle size on the transformation kinetics of flue gas desulfurization gypsum to α-calcium sulfate hemihydrate under hydrothermal conditions

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Particuology 2018年第5期16卷 98-104页

作者： Hailu Fu Caiyun Jia Qiaoshan Chen xueting cao Xiaomin Zhang Department of Environmental Engineering ChinaJiliang UniversityHangzhou 310018China Department of Environmental Engineering Zhejiang UnzversityHangzhou 310058China

The effect of particle size on the transformation kinetics of flue gas desulfurization (FGD)gypsum to α-calcium sulfate hemihydrate (α-HH)in calcium chloride (CaCl2)solutions was investigated to better guide value-added FGD gypsum *** samples from different sources were sieved into several size groups,and their transformation rates were *** results showed that using FGD gypsum with a smaller particle size accelerated the transformation to α-*** size effect accelerated nucleation kinetics of α-HH rather than its crystal growth rate (that is,the thermodynamic driving force for the transformation changed little with particle size variation).Analysis using a kinetics model revealed that a smaller gypsum particle size lowered the overall activation energy barrier for the *** is because the smaller gypsum particles had a larger relative specific surface area and thus provided more nucleation sites and crystalline defects to promote α-HH nucleation.A smaller particle size of FGD gypsum also gave a higher yield of fine α-HH particles because of the increased incidence of primary and secondary nucleation coupled with *** paper indicates the transformation of FGD gypsum into α-HH could be effectively promoted by regulating FGD gypsum particle size.

关键词： Particle size Gypsum Phase transformation Crystallization

基于网络药理学及分子对接探讨尿石素A治疗结肠癌的作用机制

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现代药物与临床 2024年第9期39卷 2235-2242页

作者：王珞王京龙郑丹丹曹雪婷张玉莲山东中医药大学药学院山东济南250355 枣庄学院食品科学与制药工程学院山东枣庄277160

目的通过网络药理学及分子对接探究尿石素A治疗结肠癌的主要生物过程和信号通路,阐明其作用机制。方法通过SwissTargetPrediction、Targets SUP-PRED和Cbligand等数据库预测尿石素A药物潜在作用靶点,检索DisGeNET、OMIM、GeneCards等... 详细信息

目的通过网络药理学及分子对接探究尿石素A治疗结肠癌的主要生物过程和信号通路,阐明其作用机制。方法通过SwissTargetPrediction、Targets SUP-PRED和Cbligand等数据库预测尿石素A药物潜在作用靶点,检索DisGeNET、OMIM、GeneCards等数据库获得结肠癌相疾病靶点;通过Venn图获得相关交集靶点。运用STRING数据库构建交集靶点的蛋白相互作用(PPI)网络;使用Cytoscape软件对STRING数据库筛选的靶点进行网络拓扑分析筛选关键靶点;运用David数据库对交集靶点进行基因本体(GO)和京都基因与基因组百科全书(KEGG)通路分析,最后通过分子对接明确尿石素A治疗结肠癌的作用机制。结果预测得到尿石素A靶点260个,筛选、去重得到结肠癌疾病靶点3 289个,最后得到交集靶点106个。核心靶点21个,得到蛋白激酶B1(Akt1)、表皮生长因子受体(EGFR)、胱天蛋白酶3(CASP3)、雌激素受体1(ESR1)、环加氧酶2(PTGS2)等10个核心靶点。GO和KEGG分析表示,尿石素A可能通过癌症通路、癌症相关蛋白聚糖通路等治疗结肠癌的作用。分子对接结果显示尿石素A与核心靶点对接结合能均小于-6.9 kcal/mol。结论尿石素A可通过多靶点和多通路的途径发挥治疗结肠癌的功效。

关键词：尿石素A 结肠癌网络药理学分子对接信号通路表皮生长因子受体胱天蛋白酶3 雌激素受体1

Smart light-responsive hierarchical metal organic frameworks constructed mixed matrix membranes for efficient gas separation

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Green Chemical Engineering 2022年第1期3卷 71-82页

作者： Qingping Xin xueting cao Dandan Huang Shuo Li Xinghui Zhang Guangyu Xuan Mengting Wei Lei Zhang Xiaoli Ding Yuzhong Zhang School of Materials Science and Engineering State Key Laboratory of Separation Membranes and Membrane ProcessesTiangong UniversityTianjin300387China

One type of new light-responsive hierarchical metal organic framework(MOF) has been successfully prepared using Co(NO_(3))_(3)·6H_(2)O as the metal salt and 4,4’-azobenzenedicarboxylic acid as the ligand by microwave method for the first time. It is found that MOF [Co(Az DC)] exhibits a light-responsive characteristic to SO_(2)adsorption due to the presence of azo group from the ligand. The light-responsive hierarchical MOFs are incorporated into Matrimid■ 5218(PI) matrix to prepare mixed matrix membranes(MMMs) for gas separation application. The morphology, crystallinity, chain mobility and thermal stability of MMMs are explored. Results show that Co(Az DC) may elevate both the CO_(2)(SO_(2)) permeability and CO_(2)(SO_(2))/N_(2)selectivity of the MMMs. In particular,the Co(Az DC) doped MMMs exhibit the significantly improved CO_(2)(SO_(2))/N_(2)selectivity from 33(123) for PI control membrane to 78(420) for MMMs, overcoming the 2008 Robeson upper bound for CO_(2)/N_(2)system. Sizesieving effect of Co(Az DC) with pore size 0.35 nm enhances the selectivity, while the –N=N– group from Co(Az DC) shows affinity to CO_(2)molecular rather than N_(2), also elevating selectivity of MMMs. In brief, enhanced selectivity of high-performance membrane is attributed to incorporation of Co(Az DC) particles, which displays synergistic effects both in size-sieving and CO_(2)-philic interaction for CO_(2)/N_(2)separation. Smart highly selective interface is constructed in MMMs by switching the configuration of MOFs from cis to trans. The SO_(2)permeability and SO_(2)/N_(2)selectivity of MMMs are investigated under both visible light and ultraviolet light states, and the SO_(2)/N_(2)separation performance under visible light is notably improved in comparison with that under ultraviolet light state.

关键词： Mixed matrix membranes Matrimid■5218 Metal-organic framework Light-responsive characteristic Gas separation

Water-soluble organic matter with various polarities in PM_(2.5) over Xi'an,China:Abundance,functional groups,and light absorption

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Particuology 2024年第1期84卷 281-289页

作者： xueting Yang Shasha Huang Dan Li Hongmei Xu Yaling Zeng Liu Yang Diwei Wang Ningning Zhang Junji cao Zhenxing Shen Department of Environmental Science and Engineering Xi'an Jiaotong UniversityXi'an710049China School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhen518055China State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy of SciencesXi'an710049China

Humic-like substances(HULIS)are a major component of brown carbon and consequently play a major role in climate *** this study,70 PM_(2.5) samples were collected from Xi'an in winter 2019 and summer *** HULIS(HULIS-n),acidic HULIS(HULIS-a),and high-polarity water-soluble organic compounds(HP-WSOC)were analyzed to determine their carbon concentrations and measure their ultraviolet-visible absorption and infrared *** the three components,HULIS-n had the highest carbon content in both winter(3.29±1.45μg m^(-3))and in summer(1.38±1.10μg m^(-3)).The semi-quantitative results for the functional groups revealed that HP-WSOC was rich in carboxylic acids and had high aromaticity in winter,whereas HULIS-n was rich in carboxylic acids in ***,HULJS-a was richer in nitrate esters and saturated aliphatic hydrocarbons in summer than in *** results for specific ultraviolet absorbance(SUVA)and E_(250)/E_(365) revealed that HULIS had higher molecular weight and aromaticity in winter than in ***-n dominated in the total light absorption of HULIS+HP-WSOC in both winter(73.08%)and summer(48.57%).Overall,the results on the carbon content,optical properties,and functional groups of WSOCs with differing polarity can improve un-derstanding of environmental and climatic effects.

关键词： Humic-like substances(HULIS) Aromaticity Fourier-transform infrared(FTIR) spectroscopy Light absorbance

科学计量工具冗余了吗?——基于常规分析路径的比较研究

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图书情报知识 2021年第4期38卷 93-101,92页

作者：曹雪婷余厚强南京理工大学经济管理学院南京210094

[目的/意义]通过对科学计量工具的分析比较,为用户选择提供参考,最大化地发挥不同科学计量分析工具的优势,更好地服务于科学计量研究。[研究设计/方法]选取了12款较为常用的科学计量工具,解析了科学计量常规分析路径,从支持的数据来源... 详细信息

[目的/意义]通过对科学计量工具的分析比较,为用户选择提供参考,最大化地发挥不同科学计量分析工具的优势,更好地服务于科学计量研究。[研究设计/方法]选取了12款较为常用的科学计量工具,解析了科学计量常规分析路径,从支持的数据来源、可提取的知识单元、提供的数据处理功能、可运用的分析方法、可选择的可视化视图五个方面,对路径下的可用工具进行了比较分析。[结论/发现]大多数科学计量工具只能完成常规路径下的部分阶段,只有少数科学计量工具对所有分析阶段的功能提供了支持;每个工具因其开发的目的不同,在功能的实现上各有侧重,功能相近的科学计量工具中存在冗余;一些工具在某个阶段凸显出了较为明显的优势,在实际的应用中可以相结合的进行选择。[创新/价值]从科学计量分析的实际需求出发,广泛调研了较为常用的科学计量工具,并将这些工具映射到常规分析路径中进行了比较。

关键词：科学计量分析科学计量工具常规路径数据获取数据准备数据分析可视化比较研究

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替代计量数据质量评估体系构建研究

图书情报知识 2019年第2期36卷 19-27,50页

作者：余厚强曹雪婷南京理工大学经济管理学院信息管理系南京210094 江苏省社会公共安全科技协同创新中心南京210094

[目的/意义]旨在构建具有通用意义的替代计量数据质量评估体系,为后续替代计量数据质量评估实证研究提供参考。[研究设计/方法]梳理了替代计量数据生产流程,识别了与数据质量相关的主体要素,据此归纳总结出评估维度。[结论/发现]构建了... 详细信息

[目的/意义]旨在构建具有通用意义的替代计量数据质量评估体系,为后续替代计量数据质量评估实证研究提供参考。[研究设计/方法]梳理了替代计量数据生产流程,识别了与数据质量相关的主体要素,据此归纳总结出评估维度。[结论/发现]构建了以准确性、及时性、复现性、透明性和一致性为评估维度的一级数据质量评估体系,以实现从数值、流程和政策三个方面全面评估替代计量数据质量;构建了每个一级维度评估指标下的二级评估体系,归纳出具体的终端评估维度,并结合已有研究做深入剖析。[创新/价值]构建的替代计量数据评估体系对于替代计量数据质量的管理和提升具有参考价值。

关键词：替代计量学数据质量数据质量评估评估体系

CRISPR-based genetic screens advance cancer immunology

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Science China Life Sciences 2024年

作者： Yuanfang cao xueting Li Yumu Pan Huahe Wang Siyu Yang Lingjuan Hong Lupeng Ye Institute of Modern Biology Nanjing University

CRISPR technologies have revolutionized research areas ranging from fundamental science to translational medicine. CRISPR-based genetic screens offer a powerful platform for unbiased screening in various fields, such as cancer immunology. Immune checkpoint blockade(ICB)therapy has been shown to strongly affect cancer treatment. However, the currently available ICBs are limited and do not work in all cancer patients. Pooled CRISPR screens enable the identification of previously unknown immune regulators that can regulate T-cell activation,cytotoxicity, persistence, infiltration into tumors, cytokine secretion, memory formation, T-cell metabolism, and CD4+T-cell *** novel targets can be developed as new immunotherapies or used with the current ICBs as new combination therapies that may yield synergistic efficacy. Here, we review the progress made in the development of CRISPR technologies, particularly technological advances in CRISPR screens and their application in novel target identification for immunotherapy.

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Mendeley阅读指标的情境内涵及其应用研究评述

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图书馆杂志 2021年第11期40卷 14-21页

作者：余厚强曹雪婷中山大学信息管理学院广东广州510006 江苏省广播电视总台江苏南京210094

Mendeley阅读指标是目前最稳健的替代计量指标,具备覆盖率高、及时性好、数值较高等特点,本文旨在为其进一步研究和应用提供参考。通过评述相关文献,着重从情境内涵和应用研究两个主要热点研究方向,深入分析Mendeley阅读指标的研究进展... 详细信息

Mendeley阅读指标是目前最稳健的替代计量指标,具备覆盖率高、及时性好、数值较高等特点,本文旨在为其进一步研究和应用提供参考。通过评述相关文献,着重从情境内涵和应用研究两个主要热点研究方向,深入分析Mendeley阅读指标的研究进展,同时较为系统地归纳其局限性。总结来看,Mendeley阅读指标的来源数据提供了丰富的背景信息,有助于更加全面地理解学术论文的交流过程和影响对象;Mendeley阅读指标的标准化可借鉴引文指标的成熟经验,以消除国家、学科、时间等因素的影响,同时也表现出可根据目标群体进行标准化的特色;Mendeley阅读指标在多种情境下的科技评价、相关文献和学者的智能推荐,以及知识交流与结构的追踪挖掘方面,均取得了较好的应用进展。但是,该指标也存在用户分布不均、数据公开不足等局限,在实际应用中必须充分考虑其优势和不足。

关键词：替代计量学 Mendeley 替代计量指标 Mendeley阅读替代计量指标

Mendeley阅读指标视角下的中美国际论文影响力比较研究

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信息资源管理学报 2021年第3期11卷 77-87页

作者：余厚强曹雪婷中山大学信息管理学院广州510006 南京理工大学经济管理学院南京210094

选取社会科学门类下的图书情报学、心理学以及自然科学门类下的生物化学与分子生物学、机械工程学共四个学科作为样本学科,从Mendeley阅读替代计量指标视角更加细腻地揭示中美国国际学术论文影响力之受众与范围。研究发现:(1)基于Mende... 详细信息

选取社会科学门类下的图书情报学、心理学以及自然科学门类下的生物化学与分子生物学、机械工程学共四个学科作为样本学科,从Mendeley阅读替代计量指标视角更加细腻地揭示中美国国际学术论文影响力之受众与范围。研究发现:(1)基于Mendeley阅读指标来看,中国国际论文被阅读的比例高于美国,但是被阅读的强度低于美国。(2)中美国际论文所影响的读者身份以学生群体为主体(比例在60%左右),其中博士生读者占主导地位(比例在30%左右),但是读者身份分布存在学科差异。(3)中美两国的自科类学科论文的Mendeley读者学科分布呈现出一致性,社科类学科论文的则呈现出差异性。(4)中国在四个学科的国际论文主要影响其他国家的读者,来自中国的读者可见度较低。在机械工程学,中美学术论文影响最多的均是日本读者,并且中国论文影响了更多来自印度、巴西等发展中国家的读者,美国论文影响了更多英国、韩国等发达国家的读者。这些结论表明Mendeley阅读指标有利于追踪和比较不同学科、不同国家学术论文产生影响力的方向,为更加全面地理解学术论文的交流和影响提供参考。

关键词：替代计量学 Mendeley 科技评价影响力 Mendeley阅读指标