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学术之忧,评价之忧:社科类学术期刊引文著录错误调查

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出版科学 2014年第2期22卷 44-48页

作者：王学青南通大学杂志社南通226019

在当前的学术期刊评价体制中,影响因子是最重要的指标,因而决定影响因子的"引文数据"受到办刊者空前的重视和追捧。为验证这些"引文数据"的客观性与科学性,本文选取CSSCI来源期刊中六种较优秀的学术期刊,对其中文期刊类引文的著录情况... 详细信息

在当前的学术期刊评价体制中,影响因子是最重要的指标,因而决定影响因子的"引文数据"受到办刊者空前的重视和追捧。为验证这些"引文数据"的客观性与科学性,本文选取CSSCI来源期刊中六种较优秀的学术期刊,对其中文期刊类引文的著录情况进行调查。调查结果显示,六种期刊的中文类期刊引文著录平均错误率高达25.6%,其中最高的达39.3%。引文著录错误的产生,和期刊编辑的工作责任心有一定关系,但根本原因还在于作者日益浮躁的科研作风,以及人为制造"引文"的不健康的办刊导向。应该让"引文评价"回到它原本的位置,重新确立以学者为中心的学术生产、传播与评价机制,如此才能最终构建一个良好的学术生态系统。

关键词：社科类学术期刊引文著录引文评价学术风气

Proteomic analysis on cellular response induced by nanoparticles reveals the nano-trafficking pathway through epithelium

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Journal of Chinese Pharmaceutical Sciences 2021年第2期30卷 107-118页

作者： Jian Zhang Mengmeng Qin Dan Yang Wenbing Dai Hua Zhang xueqing wang Bing He Qiang Zhang State Key Luboratoty of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Beijing Key Laboratoty of Molecular Pharmaceutics and New Drug Delivery Systems School of Pharmaceutical SciencesPeking UniversityBeijing 100191China School of Food ami Biological Engineering Shaanxi University of Science and TechnologyXi'an 710021China

The application of nanomedicines in oral drug delivery effectively promotes the drug absorption and transportation through ***,the absence of mechanism studies on efficacy and safety limits their final translation in *** the vesicular trafficking has been verified as the general character for transport of nanomedicines,the deeper mechanism in molecular mechanism is still ***,the cellular transport of nanomedicines is a dynamic process involved by different organelles and ***,most of existing studies just pay attention to the static location of nanomedicines,but neglect the dynamic biological effects on cells caused by ***,we prepared gold nanoparticles(Au NPs)as the model and cultured epithelial cell monolayer to explore the nano-bio interactions at the molecular *** traditional pharmacological inhibition strategy and subcellular imaging technology elucidated the macropinocytosis/endosome/MVB/lysosome pathway during the transportation of Au *** strategy based on mass spectrometry(MS)was utilized to identify and quantify proteins involved in the cellular transport of *** proteins related to subcellular structure,signal transduction,energy transformation and metabolism regulation were demonstrated to be regulated by nanoparticle *** alterations of protein expression clarified the effects of intracellular proteins and verified the conventional *** importantly,it revealed a feedback mechanism of cells to the *** believed that these new regulatory mechanisms provided new insights into the efficient transport of nanomedicines through epithelial barriers.

关键词： Epithelium Gold nanoparticles Intracellular transport Proteomics Cellular response

基于改进广义极值分布的核管道最大腐蚀深度预测

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中南大学学报（自然科学版） 2013年第5期44卷 1926-1931页

作者：周国强王雪青刘锐天津大学管理与经济学部天津300072 交通运输部规划研究院北京100028 环境保护部核与辐射安全中心北京100082

针对核管道腐蚀的环境复杂性和过程随机性问题以及极值分布模型选择不当所引起的拟合误差问题,采用广义极值分布模型预测核管道腐蚀深度的发展规律,并提出基于免疫遗传算法参数优化的核管道最大腐蚀深度预测及评估方法:对核管道取样管... 详细信息

针对核管道腐蚀的环境复杂性和过程随机性问题以及极值分布模型选择不当所引起的拟合误差问题,采用广义极值分布模型预测核管道腐蚀深度的发展规律,并提出基于免疫遗传算法参数优化的核管道最大腐蚀深度预测及评估方法:对核管道取样管段上腐蚀深度进行统计分析,计算相应的累计概率;利用免疫遗传算法优化广义极值分布函数的统计参数,得到核管道最大腐蚀深度的概率分布函数;由小样本腐蚀深度预测整条管道的最大腐蚀深度ydi,并评估超过最大腐蚀深度ydi的概率。利用不同核管道腐蚀深度进行计算机预测仿真。研究结果表明:改进后的广义极值分布模型不会受限于样本极值数据的具体分布,具有较好的通用性,且模型参数寻优过程收敛速度快,拟合效果较理想。

关键词：广义极值分布免疫遗传算法核管道腐蚀深度预测

Correction of a CADASIL point mutation using adenine base editors in hiPsCsandbloodvessel organoids

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Journal of Genetics and Genomics 2024年第2期51卷 197-207页

作者： Jingwen wang Lei Zhang Guanglan Wu Jinni Wu Xinyao Zhou Xiaolin Chen Yongxia Niu Yiren Jiao Qianyi Liu Puping Liang Guang Shi xueqing Wu Junjiu Huang MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510275China Key Laboratory of Reproductive Medicine of Guangdong Province The First Affiliated Hospital and School of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510275China Center of Reproductive Medicine Children's Hospital of Shanxi and Women Health Center of ShanxiTaiyuanShanxi 030013China

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic small vessel disease caused by mutations in the NOTCH3 gene. However, the pathogenesis of CADASIL remains unclear, and patients have limited treatment options. Here, we use human induced pluripotent stem cells (hiPSCs) generated from the peripheral blood mononuclear cells of a patient with CADASIL carrying a heterozygous NOTCH3 mutation (c.1261C>T, p.R421C) to develop a disease model. The correction efficiency of different adenine base editors (ABEs) is tested using the HEK293T-NOTCH3 reporter cell line. ABEmax is selected based on its higher efficiency and minimization of predicted off-target effects. Vascular smooth muscle cells (VSMCs) differentiated from CADASIL hiPSCs show NOTCH3 deposition and abnormal actin cytoskeleton structure, and the abnormalities are recovered in corrected hiPSC-derived VSMCs. Furthermore, CADASIL blood vessel organoids generated for in vivo modeling show altered expression of genes related to disease phenotypes, including the downregulation of cell adhesion, extracellular matrix organization, and vessel development. The dual adeno-associated virus (AAV) split-ABEmax system is applied to the genome editing of vascular organoids with an average editing efficiency of 8.82%. Collectively, we present potential genetic therapeutic strategies for patients with CADASIL using blood vessel organoids and the dual AAV split-ABEmax system.

关键词： CADASIL Induced pluripotent stem cells Adenine base editors AAV Blood vessel Organoid

基于GA改进BP神经网络的建设工程投标报价研究

维普期刊数据库评论

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维普期刊数据库

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土木工程学报 2007年第7期40卷 93-98页

作者：王雪青喻刚孟海涛天津大学天津300072

在建设工程项目投标报价过程中,如何来确定标高金直接关系到承包商能否中标和盈利以及施工企业今后的生存与发展。提出基于遗传算法(GA)优化BP神经网络的标高金预测方法。在分析BP神经网络基本原理的基础上,主要阐述了如何应用遗传算法... 详细信息

在建设工程项目投标报价过程中,如何来确定标高金直接关系到承包商能否中标和盈利以及施工企业今后的生存与发展。提出基于遗传算法(GA)优化BP神经网络的标高金预测方法。在分析BP神经网络基本原理的基础上,主要阐述了如何应用遗传算法来改进BP神经网络收敛速度慢和易于陷入极小值等缺点。对BP神经网络模型隐含层节点数进行优选后,建立起GA改进BP神经网络的标高金预测模型;最后应用该模型和一般BP神经网络模型对20个典型国际工程实例的标高金进行计算和预测。计算结果对比发现,经遗传算法改进后的BP神经网络模型在降低计算和预测平均误差的同时,迭代次数比一般BP神经网络模型也大大减少了。因此,该模型适用于求解如建设工程投标报价等非线性问题。

关键词： BP神经网络遗传算法投标报价标高金

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穿地龙机器人转向机构设计与校核

中国机械工程 2006年第6期17卷 580-583页

作者：张忠林孟庆鑫汪学清王华哈尔滨工程大学哈尔滨150001

通过对国内外非开挖技术中的方向可控气动冲击矛转向机理的研究,提出了穿地龙机器人转向机构的设计方案,运用有限元计算方法校核了机器人头部和转向机构关键零部件的强度,理论与实验分析和校核结果表明了该转向机构设计的可行性。研究... 详细信息

通过对国内外非开挖技术中的方向可控气动冲击矛转向机理的研究,提出了穿地龙机器人转向机构的设计方案,运用有限元计算方法校核了机器人头部和转向机构关键零部件的强度,理论与实验分析和校核结果表明了该转向机构设计的可行性。研究结果可为穿地龙机器人的总体设计提供参考。

关键词：穿地龙机器人非开挖技术有限元方法转向机构

中国设计的启程?——从北京Icograda大会的举办看中国设计

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南京艺术学院学报（美术与设计） 2010年第4期 77-79页

作者：王雪青中国美术学院设计艺术学院浙江杭州310002

本文简要叙述了北京Icograda大会的举办,初步探讨了这一盛会对中国设计的意义,概括性指出中国目前在设计人才培养、设计师队伍的活动状态、整体设计环境所存在的问题。

关键词： Icograda 世界设计大会中国设计

STUDY ON THE FACTORS INFLUENCING PREMIUM RATE OF ENGINEER PROFESSIONAL LIABILITY INSURANCE

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STUDY ON THE FACTORS INFLUENCING PREMIUM RATE OF ENGINEER PR...

中国的·时代的·国际的——关于中国艺术设计教育改革的思考

2005年中国机械工程学会年会

作者： REN Hao, wang xueqing (School of Management ,Tianjin University, Tianjin, 300072)

＜正＞The engineer professional liability insurance has been carrying out merely for over three years in China. And when the insurance companies make policies for the different engineering consultant companies, the influencing factors are inadequately considered because of lacking enough statistical data, as a result, the method of formulating premium rates is pretty naive. Firstly, in light of the statistical data and tables of premium rates which were established by insurance companies, as well as the experience of western countries, this article figured out the most important six factors which have great impacts on the engineer professional liability insurance premium rates, those were: ①qualification of the engineering consultant company ②the deductible ③annul turnover④the type of the project⑤records of claim for compensation ⑥the location of the project;Then considering these factors are classified by importance level ,they were carefully studied with the method of FAHP, and then their weights were figured out, consequently which were contributive to formulation of premium rates;Finally, with the consideration of the unique situation about the development of engineer professional liability insurance in China, this article highlighted the factors which should be taken into consideration when formulating premium rates scientifically.

关键词： engineer professional liability insurance premium rate weights FAHP

来源： cnki会议评论

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cnki会议

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装饰 2007年第4期 116-118页

作者：王雪青中国美术学院设计学院

针对如何面对中国21世纪的艺术设计教育这一命题,本文作者提出了“中国的·时代的·国际的”的设计教育改革的基本定位与目标。与此同时,作者从课程的梳理与整合、知识点与知识链的确立,到师资队伍的培养以及如何为学生提供适应时代的... 详细信息

针对如何面对中国21世纪的艺术设计教育这一命题,本文作者提出了“中国的·时代的·国际的”的设计教育改革的基本定位与目标。与此同时,作者从课程的梳理与整合、知识点与知识链的确立,到师资队伍的培养以及如何为学生提供适应时代的养料等几个方面阐述了对我国艺术设计教育改革的看法与建议。

关键词：艺术设计教育/ 中国的/时代的/ 国际的