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Upregulation of circ0000381 atienuates microglial/macrophage pyroptosis after spinal cord injury

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Neural Regeneration Research 2024年第6期19卷 1360-1366页

作者： Yan Zhang Wenkai Zhang Tao Liu Ziqian Ma Wenxiu Zhang Yun Guan xueming chen Central Laboratory Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Orthopedics Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Emergency Medicine Aerospace Center HospitalBeijingChina Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Neurological Surgery Johns Hopkins University School of MedicineBaltimoreMDUSA

Neuroinflammation exacerbates secondary damage after spinal cord injury,while microglia/macrophage pyroptosis is important to *** RNAs(circRNAs)play a role in the central nervous ***,the functional role and mechanism of circRNAs in regulating microglia/macrophage pyroptosis after spinal cord injury are still poorly *** the present study,we detected microglia/macrophage pyroptosis in a female rat model of spinal cord injury,along with upregulated levels of circ0000381 in the spinal *** further experimental results suggest that circ0000381 may function as a sponge to sequester endogenous microRNA423-3p(miR-423-3p),which can increase the expression of NOD-like receptor 3(NLRP3),a pyroptosis ***,upregulation of circ0000381 may be a compensatory change after spinal cord injury to attenuate microglia/macrophage ***,knockdown of circ0000381 expression exacerbated microglia/macrophage ***,our findings provide novel evidence for the upregulation of circ0000381,which may serve as a neuroprotective mechanism to attenuate microglia/macrophage pyroptosis after spinal cord ***,circ0000381 may be a novel therapeutic target for the treatment of spinal cord injury.

关键词： circ0000381 inflammasome macrophage microglia miR-423-3p neuroinflammation neuroprotection NLRP3 pyroptosis RNA-Seq spinal cord injury

Spinal Cord Stimulation for Pain Treatment After Spinal Cord Injury

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Neuroscience Bulletin 2019年第3期35卷 527-539页

作者： Qian Huang Wanru Duan Eellan Sivanesan Shuguang Liu Fei Yang Zhiyong chen Neil C.Ford xueming chen Yun Guan Department of Anesthesiology and Critical Care Medicine School of MedicineJohns Hopkins UniversityBaltimoreMD 21205USA Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Orthopedics Hong Hui HospitalAffiliated Hospital of the Medical SchoolXi'an Jiaotong UniversityXi'an 710004China Department of Neurobiology Capital Medical UniversityBeijing 100069China Department of Orthopedics Luhe HospitalCapital Medical UniversityBeijing 100020China Department of Neurological Surgery School of MedicineJohns Hopkins UniversityBaltimoreMD 21205USA

In addition to restoration of bladder, bowel, and motor functions, alleviating the accompanying debilitating pain is equally important for improving the quality of life of patients with spinal cord injury(SCI). Currently,however, the treatment of chronic pain after SCI remains a largely unmet need. Electrical spinal cord stimulation(SCS) has been used to manage a variety of chronic pain conditions that are refractory to pharmacotherapy. Yet, its efficacy, benefit profiles, and mechanisms of action in SCI pain remain elusive, due to limited research, methodological weaknesses in previous clinical studies, and a lack of mechanistic exploration of SCS for SCI pain control. We aim to review recent studies and outline the therapeutic potential of different SCS paradigms for traumatic SCI pain. We begin with an overview of its manifestations,classification, potential underlying etiology, and currentchallenges for its treatment. The clinical evidence for using SCS in SCI pain is then reviewed. Finally, future perspectives of pre-clinical research and clinical study of SCS for SCI pain treatment are discussed.

关键词： Pain Trauma Spinal cord injury Spinal cord stimulation Neuromodulation Analgesia

Assessing the Impacts of High Speed Rail Development in China’s Yangtze River Delta Megaregion

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Journal of Transportation Technologies 2013年第2期3卷 113-122页

作者： xueming chen L. Douglas Wilder School of Government and Public Affairs Virginia Commonwealth University Richmond USA

This paper assesses the impacts of high speed rail (HSR) development in the Yangtze River Delta (YRD) Megaregion, China. After giving an introduction and conducting a literature review, the paper proposes a pole-axis-network system (PANS) model guiding the entire study. On the one hand, the HSR projects in the YRD Megaregion are expected to generate significant efficiency-related transportation and non-transportation benefits. As a result, the spillover effects from Shanghai and other major cities (poles) will greatly promote the urban and regional developments along the major HSR corridors (axes), and the entire megaregion will become more integrated economically, socially, and culturally. But, on the other hand, the HSR projects will also create serious social and geographic inequity issues, which need to be addressed as soon as possible in a proper way. This empirical study confirms the PANS model proposed.

关键词： High Speed Rail China Yangtze River Delta Megaregion Impacts

Peracetic acid(PAA)-based pretreatment effectively improves medium-chain fatty acids(MCFAs)production from sewage sludge

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Environmental Science and Ecotechnology 2024年第4期20卷 154-166页

作者： Yufen Wang Haixiao Guo Xuecheng Li xueming chen Lai Peng Tingting Zhu Peizhe Sun Yiwen Liu School of Environmental Science and Engineering Tianjin UniversityTianjin300072China Fujian Provincial Engineering Research Center of Rural Waste Recycling Technology College of Environment and Safety EngineeringFuzhou UniversityFujian350116China Hubei Key Laboratory of Mineral Resources Processing and Environment Wuhan University of TechnologyLuoshi Road 122WuhanHubei430070China School of Resources and Environmental Engineering Wuhan University of TechnologyLuoshi Road 122WuhanHubei430070China

Peracetic acid(PAA),known for its environmentally friendly properties as a oxidant and bactericide,is gaining prominence in decontamination and disinfection *** primary product of PAA oxidation is acetate that can serve as an electron acceptor(EA)for the biosynthesis of medium-chain fatty acids(MCFAs)via chain elongation(CE)***,PAA-based pretreatment is supposed to be beneficial for MCFAs production from anaerobic sludge fermentation,as it could enhance organic matter availability,suppress competing microorganisms and furnish EA by providing ***,such a hypothesis has rarely been *** we reveal that PAA-based pretreatment leads to significant exfoliation of extracellular polymeric substances(EPS)from sludge flocs and disruption of proteinic secondary structures,through inducing highly active free radicals and singlet *** production of MCFAs increases substantially to 11,265.6 mg COD L^(-1),while the undesired byproducts,specifically long-chain alcohols(LCAs),decrease to 723.5 mg COD L^(-1).Microbial activity tests further demonstrate that PAA pretreatment stimulates the CE process,attributed to the up-regulation of functional genes involved in fatty acid biosynthesis *** comprehensive findings provide insights into the effectiveness and mechanisms behind enhanced MCFAs production through PAA-based technology,advancing our understanding of sustainable resource recovery from sewage sludge.

关键词： Sewage sludge Medium-chain fatty acids(MCFAs) Extracellular polymeric substances(EPS) Peracetic acid(PAA) Metabolic activity

Oroxyloside protects against dextran sulfate sodium-induced colitis by inhibiting ER stress via PPARγ activation

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Chinese Journal of Natural Medicines 2024年第4期22卷 307-317页

作者： TAO Lei DOU Renjie chen xueming CAO Yu DAI Zhen HU Ziyan MA Zhi GE Xiaoming ZHANG Ling WANG Xiaoping Nanjing Institute for Food and Drug Control Nanjing 211198China State Key Laboratory of Natural Medicines School of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjing 211198China

Ulcerative colitis (UC), a prevalent form of inflammatory bowel disease (IBD), may result from immune system dysfunction, leading to the sustained overproduction of reactive oxygen species (ROS) and subsequent cellular oxidative stress damage. Recent studies have identified both peroxisome proliferator-activated receptor-γ (PPARγ) and endoplasmic reticulum (ER) stress as critical targets for the treatment of IBD. Oroxyloside (C22H20O11), derived from the root of Scutellaria baicalensis Georgi, has traditionally been used in treating inflammatory diseases. In this study, we investigated the molecular mechanisms by which oroxyloside mitigates dextran sulfate sodium (DSS)-induced colitis. We examined the effects of oroxyloside on ROS-mediated ER stress in colitis, including the protein expressions of GRP78, p-PERK, p-eIF2α, ATF4, and CHOP, which are associated with ER stress. The beneficial impact of oroxyloside was reversed by the PPARγ antagonist GW9662 (1 mg·kg^(−1), i.v.) in vivo. Furthermore, oroxyloside decreased pro-inflammatory cytokines and ROS production in both bone marrow-derived macrophages (BMDM) and the mouse macrophage cell line RAW 264.7. However, PPARγ siRNA transfection blocked the anti-inflammatory effect of oroxyloside and even abolished ROS generation and ER stress activation inhibited by oroxyloside in vitro. In conclusion, our study demonstrates that oroxyloside ameliorates DSS-induced colitis by inhibiting ER stress via PPARγ activation, suggesting that oroxyloside might be a promising effective agent for IBD.

关键词： Oroxyloside ER stress PPARγ Colitis

Conditioned medium from human dental pulp stem cells treats spinal cord injury by inhibiting microglial pyroptosis

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Neural Regeneration Research 2024年第5期19卷 1105-1111页

作者： Tao Liu Ziqian Ma Liang Liu Yilun Pei Qichao Wu Songjie Xu Yadong Liu Nan Ding Yun Guan Yan Zhang xueming chen Department of Orthopedic Surgery Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Orthopedic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Department of Stomatology Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Anesthesiology and Critical Care Medicine School of MedicineJohns Hopkins UniversityBaltimoreMDUSA Department of Neurological Surgery School of MedicineJohns Hopkins UniversityBaltimoreMDUSA

Human dental pulp stem cell transplantation has been shown to be an effective therapeutic strategy for spinal cord ***,whether the human dental pulp stem cell secretome can contribute to functional recovery after spinal cord injury remains *** the present study,we established a rat model of spinal cord injury based on impact injury from a dropped weight and then intraperitoneally injected the rats with conditioned medium from human dental pulp stem *** found that the conditioned medium effectively promoted the recovery of sensory and motor functions in rats with spinal cord injury,decreased expression of the microglial pyroptosis markers NLRP3,GSDMD,caspase-1,and interleukin-1β,promoted axonal and myelin regeneration,and inhibited the formation of glial *** addition,in a lipopolysaccharide-induced BV2 microglia model,conditioned medium from human dental pulp stem cells protected cells from pyroptosis by inhibiting the NLRP3/caspase-1/interleukin-1β*** results indicate that conditioned medium from human dental pulp stem cells can reduce microglial pyroptosis by inhibiting the NLRP3/caspase-1/interleukin-1βpathway,thereby promoting the recovery of neurological function after spinal cord ***,conditioned medium from human dental pulp stem cells may become an alternative therapy for spinal cord injury.

关键词： BV2 conditioned medium dental pulp stem cells GSDMD microglia neuroinflammation NLRP3 pyroptosis spinal cord injury

Mechanisms of bone pain:Progress in research from bench to bedside

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Bone Research 2022年第3期10卷 440-453页

作者： Gehua Zhen Yuhan Fu Chi Zhang Neil C.Ford Xiaojun Wu Qichao Wu Dong Yan xueming chen Xu Cao Yun Guan Department of Orthopedics Johns Hopkins UniversitySchool of MedicineBaltimoreMD 21205USA Department of Anesthesiology and Critical Care Medicine Johns Hopkins UniversitySchool of MedicineBaltimoreMD 21205USA Division of Pathology Sibley Memorial Hospital WashingtonWashingtonDC 20016USA Department of Oncology Beijing Luhe HospitalCapital Medical UniversityBeijing 100149China Department of Orthopedics Beijing Luhe HospitalCapital Medical UniversityBeijing 100149China Department of Neurological Surgery Johns Hopkins UniversitySchool of MedicineBaltimoreMD 21205USA

The field of research on pain originating from various bone diseases is expanding rapidly, with new mechanisms and targets asserting both peripheral and central sites of action. The scope of research is broadening from bone biology to neuroscience,neuroendocrinology, and immunology. In particular, the roles of primary sensory neurons and non-neuronal cells in the peripheral tissues as important targets for bone pain treatment are under extensive investigation in both pre-clinical and clinical settings. An understanding of the peripheral mechanisms underlying pain conditions associated with various bone diseases will aid in the appropriate application and development of optimal strategies for not only managing bone pain symptoms but also improving bone repairing and remodeling, which potentially cures the underlying etiology for long-term functional recovery. In this review, we focus on advances in important preclinical studies of significant bone pain conditions in the past 5 years that indicated new peripheral neuronal and non-neuronal mechanisms, novel targets for potential clinical interventions, and future directions of research.

关键词： pain clinical diseases

罗莎·卢森堡对伯恩斯坦、考茨基修正主义的批判

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学海 2009年第2期 72-79页

作者：陈学明复旦大学哲学系教授、博士生导师上海200433

在第二国际发展史中,罗莎.卢森堡始终站在反对修正主义的最前列。她先后对伯恩斯坦和考茨基的修正主义进行了深刻批判,揭露了两人的理论实质,捍卫了马克思主义理论的纯洁性,同时也发展了马克思主义理论。卢森堡对伯恩斯坦和考茨基的批... 详细信息

在第二国际发展史中,罗莎.卢森堡始终站在反对修正主义的最前列。她先后对伯恩斯坦和考茨基的修正主义进行了深刻批判,揭露了两人的理论实质,捍卫了马克思主义理论的纯洁性,同时也发展了马克思主义理论。卢森堡对伯恩斯坦和考茨基的批判对我们具有强烈的现实意义。

关键词：卢森堡伯恩斯坦考茨基修正主义

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评"西方马克思主义"的最新理论成果

毛泽东邓小平理论研究 2005年第1期 36-43页

作者：陈学明复旦大学当代国外马克思主义研究中心

马克思主义是批判资本主义的象征,只要资本主义仍然是一种罪恶的制度,马克思主义作为一种批判的武器就不会失去光芒。马克思主义之所以被千千万万的人们向往和追求,不仅在于人们对现存资本主义的不满,而且在于人们怀有争取更高的社会价... 详细信息

马克思主义是批判资本主义的象征,只要资本主义仍然是一种罪恶的制度,马克思主义作为一种批判的武器就不会失去光芒。马克思主义之所以被千千万万的人们向往和追求,不仅在于人们对现存资本主义的不满,而且在于人们怀有争取更高的社会价值理想的愿望。推出"市场社会主义"和"生态社会主义"这两个概念并加以系统阐述,是"西方马克思主义"在社会主义研究方面最新的主要理论成果。全球化的实质是"资本主义的全球化",也就是说,是资本主义生产方式和自由市场经济的全球化。所以,"全球化"就是帝国主义的同义词。在"新帝国主义"时代,西方发达资本主义国家不仅拥有了世界性的政治和经济霸权,而且也已经拥有了世界性的文化霸权。

关键词：发达资本主义国家马克思主义 “新帝国主义” 社会主义研究理论成果生态社会主义全球化经济霸权资本主义生产方式自由市场经济