Mechanisms of bone pain:Progress in research from bench to bedside

作     者：Gehua Zhen Yuhan Fu Chi Zhang Neil C.Ford Xiaojun Wu Qichao Wu Dong Yan Xueming Chen Xu Cao Yun Guan Gehua Zhen;Yuhan Fu;Chi Zhang;Neil C.Ford;Xiaojun Wu;Qichao Wu;Dong Yan;Xueming Chen;Xu Cao;Yun Guan

作者机构：Department of OrthopedicsJohns Hopkins UniversitySchool of MedicineBaltimoreMD 21205USA Department of Anesthesiology and Critical Care MedicineJohns Hopkins UniversitySchool of MedicineBaltimoreMD 21205USA Division of PathologySibley Memorial Hospital WashingtonWashingtonDC 20016USA Department of OncologyBeijing Luhe HospitalCapital Medical UniversityBeijing 100149China Department of OrthopedicsBeijing Luhe HospitalCapital Medical UniversityBeijing 100149China Department of Neurological SurgeryJohns Hopkins UniversitySchool of MedicineBaltimoreMD 21205USA 

出 版 物：《Bone Research》 (骨研究（英文版）)

年 卷 期：2022年第10卷第3期

页      面：440-453页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：CCM Johns Hopkins University, JHU Department of Anesthesiology, Medical College of Wisconsin 

主　　题：pain clinical diseases 

摘      要：The field of research on pain originating from various bone diseases is expanding rapidly, with new mechanisms and targets asserting both peripheral and central sites of action. The scope of research is broadening from bone biology to neuroscience,neuroendocrinology, and immunology. In particular, the roles of primary sensory neurons and non-neuronal cells in the peripheral tissues as important targets for bone pain treatment are under extensive investigation in both pre-clinical and clinical settings. An understanding of the peripheral mechanisms underlying pain conditions associated with various bone diseases will aid in the appropriate application and development of optimal strategies for not only managing bone pain symptoms but also improving bone repairing and remodeling, which potentially cures the underlying etiology for long-term functional recovery. In this review, we focus on advances in important preclinical studies of significant bone pain conditions in the past 5 years that indicated new peripheral neuronal and non-neuronal mechanisms, novel targets for potential clinical interventions, and future directions of research.